Spironolactone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000165 Mapk cascade Increases phenotype PMID:19590239
GO:0001541 Ovarian follicle development Affects phenotype PMID:33359182
GO:0002027 Regulation of heart rate Decreases phenotype PMID:9302344
GO:0003094 Glomerular filtration Decreases phenotype PMID:1103606; PMID:18382267
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:33359182
GO:0006289 Nucleotide-excision repair Affects phenotype PMID:33562002
GO:0006304 Dna modification Affects phenotype PMID:33562002
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:20609311
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:33359182
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33359182
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33359182; PMID:37328115
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29162470
GO:0006811 Monoatomic ion transport Increases phenotype PMID:18414392
GO:0006914 Autophagy Increases phenotype PMID:30734886
GO:0006915 Apoptotic process Affects phenotype PMID:16528473; PMID:17051331; PMID:17587755; PMID:19114643; PMID:19590239
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25204689
GO:0006979 Response to oxidative stress Decreases phenotype PMID:18414392; PMID:18586661
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:33359182
GO:0008217 Regulation of blood pressure Affects phenotype PMID:15674406; PMID:15842549; PMID:18382267; PMID:19534021; PMID:6998872; PMID:764929; PMID:17984673; PMID:18586661; PMID:19633453; PMID:20042665; PMID:3463439; PMID:369652; PMID:764929; PMID:8723367
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29149346
GO:0010765 Positive regulation of sodium ion transport Increases phenotype PMID:1328298
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:29782964
GO:0016042 Lipid catabolic process Affects phenotype PMID:33359182
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:31295448
GO:0032868 Response to insulin Decreases phenotype PMID:31295448
GO:0035810 Positive regulation of urine volume Increases phenotype PMID:6986745
GO:0035812 Renal sodium excretion Increases phenotype PMID:12014310; PMID:19732095; PMID:7015845; PMID:9595286; PMID:844248
GO:0042310 Vasoconstriction Decreases phenotype PMID:18586661
GO:0042554 Superoxide anion generation Increases phenotype PMID:24101390
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:31295448
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:33562002; PMID:39218321
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:31295448
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:37328115
GO:0045599 Negative regulation of fat cell differentiation Increases phenotype PMID:29782964
GO:0046466 Membrane lipid catabolic process Decreases phenotype PMID:19114643
GO:0048386 Positive regulation of retinoic acid receptor signaling pathway Increases phenotype PMID:26820057
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37328115; PMID:39218321
GO:0060016 Granulosa cell development Affects phenotype PMID:33359182
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33359182
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:31295448
GO:0071493 Cellular response to uv-b Affects phenotype PMID:33562002
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:37328115
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:39218321
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:39218321
GO:1990266 Neutrophil migration Increases phenotype PMID:24101390
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:31295448
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:31295448; PMID:37328115
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:25204689
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.