Endosulfan

Target genes for Endosulfan is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
EndosulfanCCL26BSK_4H_Eotaxin3_down
EndosulfanCOL3A1BSK_hDFCGF_CollagenIII_down
EndosulfanCSF1BSK_hDFCGF_MCSF_down
EndosulfanCSF1BSK_LPS_MCSF_down
EndosulfanCSF1BSK_CASM3C_MCSF_down
EndosulfanCYP2B6CLD_CYP2B6_6hr
EndosulfanCYP2B6NVS_ADME_hCYP2B6
EndosulfanCYP2B6CLD_CYP2B6_24hr
EndosulfanCYP2B6CLD_CYP2B6_48hr
EndosulfanCYP2C19NVS_ADME_hCYP2C19
EndosulfanCYP3A4CLD_CYP3A4_6hr
EndosulfanCYP3A4CLD_CYP3A4_48hr
EndosulfanCYP3A4CLD_CYP3A4_24hr
EndosulfanCYP19A1TOX21_Aromatase_Inhibition
EndosulfanCYP24A1TOX21_VDR_BLA_antagonist_ratio
EndosulfanCYP24A1TOX21_VDR_BLA_agonist_ratio
EndosulfanESR1TOX21_ERa_BLA_Agonist_ratio
EndosulfanESR1ATG_ERa_TRANS_up
EndosulfanESR1TOX21_ERa_LUC_VM7_Agonist
EndosulfanESR1TOX21_ERa_BLA_Antagonist_ratio
EndosulfanESR1ATG_ERE_CIS_up
EndosulfanESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
EndosulfanESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
EndosulfanESR2TOX21_ERb_BLA_Antagonist_ratio
EndosulfanESR2OT_ER_ERbERb_0480
EndosulfanESRRATOX21_PGC_ERR_Antagonist
EndosulfanESRRATOX21_ERR_Antagonist
EndosulfanF3BSK_LPS_TissueFactor_down
EndosulfanF3BSK_3C_TissueFactor_down
EndosulfanATF6TOX21_ESRE_BLA_ratio
EndosulfanNR3C1TOX21_GR_BLA_Agonist_ratio
EndosulfanNR3C1NVS_NR_hGR
EndosulfanHIF1ATOX21_HRE_BLA_Agonist_ratio
EndosulfanHLA-DRABSK_BE3C_HLADR_down
EndosulfanHLA-DRABSK_CASM3C_HLADR_down
EndosulfanHLA-DRABSK_3C_HLADR_down
EndosulfanHSF1TOX21_HSE_BLA_agonist_ratio
EndosulfanICAM1BSK_3C_ICAM1_down
EndosulfanICAM1BSK_KF3CT_ICAM1_down
EndosulfanIL1ABSK_KF3CT_IL1a_down
EndosulfanIL1ABSK_LPS_IL1a_down
EndosulfanIL1ABSK_BE3C_IL1a_down
EndosulfanCXCL8BSK_3C_IL8_down
EndosulfanCXCL8BSK_LPS_IL8_down
EndosulfanCXCL8BSK_CASM3C_IL8_down
EndosulfanCXCL8BSK_hDFCGF_IL8_down
EndosulfanCXCL8BSK_SAg_IL8_down
EndosulfanCXCL10BSK_BE3C_IP10_down
EndosulfanCXCL10BSK_hDFCGF_IP10_down
EndosulfanCXCL10BSK_KF3CT_IP10_down
EndosulfanARTOX21_AR_BLA_Antagonist_ratio
EndosulfanARACEA_AR_antagonist_80hr
EndosulfanARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
EndosulfanARTOX21_AR_BLA_Agonist_ratio
EndosulfanAROT_AR_ARSRC1_0960
EndosulfanAROT_AR_ARSRC1_0480
EndosulfanARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
EndosulfanJUNTOX21_AP1_BLA_Agonist_ratio
EndosulfanKDRBSK_4H_VEGFRII_down
EndosulfanFOSTOX21_AP1_BLA_Agonist_ratio
EndosulfanCXCL9BSK_SAg_MIG_down
EndosulfanCXCL9BSK_hDFCGF_MIG_down
EndosulfanCXCL9BSK_BE3C_MIG_down
EndosulfanCXCL9BSK_CASM3C_MIG_down
EndosulfanCXCL9BSK_3C_MIG_down
EndosulfanMMP1BSK_BE3C_MMP1_down
EndosulfanMMP1BSK_hDFCGF_MMP1_down
EndosulfanMMP9BSK_KF3CT_MMP9_down
EndosulfanNFE2L2TOX21_ARE_BLA_agonist_ratio
EndosulfanNFKB1TOX21_NFkB_BLA_agonist_ratio
EndosulfanSERPINE1BSK_hDFCGF_PAI1_down
EndosulfanSERPINE1BSK_BE3C_PAI1_down
EndosulfanPGRTOX21_PR_BLA_Antagonist_ratio
EndosulfanABCB1CLD_ABCB1_48hr
EndosulfanPLATBSK_BE3C_tPA_down
EndosulfanPLAUBSK_BE3C_uPA_down
EndosulfanPLAUBSK_KF3CT_uPA_down
EndosulfanPLAURBSK_CASM3C_uPAR_down
EndosulfanPLAURBSK_BE3C_uPAR_down
EndosulfanPLAURBSK_3C_uPAR_down
EndosulfanPLAURBSK_4H_uPAR_down
EndosulfanUGT1A1CLD_UGT1A1_24hr
EndosulfanPPARDTOX21_PPARd_BLA_agonist_ratio
EndosulfanRARAATG_DR5_CIS_up
EndosulfanRARBATG_DR5_CIS_up
EndosulfanRARGATG_DR5_CIS_up
EndosulfanSAA1BSK_CASM3C_SAA_down
EndosulfanCCL2BSK_SAg_MCP1_down
EndosulfanCCL2BSK_LPS_MCP1_down
EndosulfanCCL2BSK_CASM3C_MCP1_down
EndosulfanCCL2BSK_4H_MCP1_down
EndosulfanCCL2BSK_3C_MCP1_down
EndosulfanCCL2BSK_KF3CT_MCP1_down
EndosulfanSELEBSK_SAg_Eselectin_down
EndosulfanSELEBSK_3C_Eselectin_down
EndosulfanSELEBSK_LPS_Eselectin_down
EndosulfanSELPBSK_4H_Pselectin_down
EndosulfanSLC5A5NIS_RAIU_inhibition
EndosulfanSLC6A3NVS_TR_hDAT
EndosulfanTGFB1BSK_BE3C_TGFb1_down
EndosulfanTHBDBSK_CASM3C_Thrombomodulin_up
EndosulfanTIMP1BSK_hDFCGF_TIMP1_down
EndosulfanTIMP2BSK_KF3CT_TIMP2_down
EndosulfanTNFBSK_LPS_TNFa_down
EndosulfanTP53TOX21_p53_BLA_p4_ratio
EndosulfanTP53TOX21_p53_BLA_p1_ratio
EndosulfanTP53TOX21_p53_BLA_p2_ratio
EndosulfanTP53TOX21_p53_BLA_p5_ratio
EndosulfanTSHRTOX21_TSHR_Agonist_ratio
EndosulfanVCAM1BSK_LPS_VCAM1_down
EndosulfanVCAM1BSK_hDFCGF_VCAM1_down
EndosulfanVCAM1BSK_CASM3C_VCAM1_down
EndosulfanVCAM1BSK_3C_VCAM1_down
EndosulfanVCAM1BSK_4H_VCAM1_down
EndosulfanVDRTOX21_VDR_BLA_antagonist_ratio
EndosulfanVDRTOX21_VDR_BLA_agonist_ratio
EndosulfanNR1I2ATG_PXRE_CIS_up
EndosulfanCD38BSK_SAg_CD38_down
EndosulfanCD40BSK_LPS_CD40_down
EndosulfanCD40BSK_SAg_CD40_down
EndosulfanCD69BSK_SAg_CD69_down
EndosulfanNR1I3ATG_PBREM_CIS_up
EndosulfanNR1I3NVS_NR_hCAR_Antagonist
EndosulfanNR1I3TOX21_CAR_Agonist
EndosulfanNR1H4TOX21_FXR_BLA_antagonist_ratio
EndosulfanNR1H4OT_FXR_FXRSRC1_0480
EndosulfanNR1H4TOX21_FXR_BLA_agonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.