Endosulfan


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:15261991IVTH0.000001 - 0.000025 M 0.000001 - 0.000025 MAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
PMID:15832825IVTH0.000005 M -No significant effects observed-
IVTH0.0005 M 0.0005 MCancer phenotypeEndocrine-mediated cancer
IVTH0.00005 M 0.00005 MCancer phenotypeEndocrine-mediated cancer
PMID:22198180IVR0.6 mg/kg 0.6 mg/kgAffects development of reproductive systemDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.6 mg/kg 0.6 mg/kgAffects expression of progesterone receptor (PR)Reproductive endocrine-mediated perturbations
IVR0.006 mg/kg 0.006 mg/kgAffects expression of progesterone receptor (PR)Reproductive endocrine-mediated perturbations
PMID:28559116IVR0.06 mg/kg/day 0.06 mg/kg/dayCompromised endometrial receptivityReproductive endocrine-mediated perturbations
IVR0.006 mg/kg/day 0.006 mg/kg/dayCompromised endometrial receptivityReproductive endocrine-mediated perturbations
PMID:3827596IVR5 mg/L -No significant effects observed-
IVR20 mg/L 20 mg/LChanges in white blood cell (WBC) populationsImmunological endocrine-mediated perturbations
IVR20 mg/L 20 mg/LAlterations in immune responsesImmunological endocrine-mediated perturbations
IVR10 mg/L 10 mg/LChanges in white blood cell (WBC) populationsImmunological endocrine-mediated perturbations
IVR10 mg/L 10 mg/LAlterations in immune responsesImmunological endocrine-mediated perturbations
PMID:8593856IVTH0.00001 M 0.00001 MOccurrence of mammary gland tumorEndocrine-mediated cancer;Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.