Diethylstilbestrol

Target genes for Diethylstilbestrol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
DiethylstilbestrolNR1H3ATG_DR4_LXR_CIS_dn
DiethylstilbestrolESR1CEETOX_H295R_ESTRONE_noMTC_dn
DiethylstilbestrolESR1CEETOX_H295R_ESTRADIOL_noMTC_up
DiethylstilbestrolESR1CEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolNACEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolNACEETOX_H295R_ANDR_noMTC_dn
DiethylstilbestrolCCL26BSK_4H_Eotaxin3_down
DiethylstilbestrolCOL3A1BSK_hDFCGF_CollagenIII_down
DiethylstilbestrolADORA1NVS_GPCR_hAdoRA1
DiethylstilbestrolCSF1BSK_CASM3C_MCSF_down
DiethylstilbestrolCSF1BSK_LPS_MCSF_down
DiethylstilbestrolCSF1BSK_hDFCGF_MCSF_down
DiethylstilbestrolADRA2CNVS_GPCR_hAdra2C
DiethylstilbestrolADRB1NVS_GPCR_hAdrb1
DiethylstilbestrolADRB2NVS_GPCR_hAdrb2
DiethylstilbestrolADRB3NVS_GPCR_hAdrb3
DiethylstilbestrolCYP3A4NVS_ADME_hCYP3A4
DiethylstilbestrolCYP19A1NVS_ADME_hCYP19A1
DiethylstilbestrolCYP19A1TOX21_Aromatase_Inhibition
DiethylstilbestrolCYP24A1TOX21_VDR_BLA_antagonist_ratio
DiethylstilbestrolDRD1NVS_GPCR_hDRD1
DiethylstilbestrolDRD2NVS_GPCR_hDRD2s
DiethylstilbestrolEGR1ATG_EGR_CIS_up
DiethylstilbestrolSLC29A1NVS_TR_hAdoT
DiethylstilbestrolESR1OT_ER_ERaERb_1440
DiethylstilbestrolESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
DiethylstilbestrolESR1ACEA_ER_80hr
DiethylstilbestrolESR1TOX21_ERa_BLA_Antagonist_ratio
DiethylstilbestrolESR1OT_ER_ERaERa_1440
DiethylstilbestrolESR1OT_ER_ERaERb_0480
DiethylstilbestrolESR1OT_ER_ERaERa_0480
DiethylstilbestrolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
DiethylstilbestrolESR1TOX21_ERa_LUC_VM7_Agonist
DiethylstilbestrolESR1ATG_ERa_TRANS_up
DiethylstilbestrolESR1CEETOX_H295R_ESTRADIOL_noMTC_up
DiethylstilbestrolESR1OT_ERa_EREGFP_0120
DiethylstilbestrolESR1CEETOX_H295R_ESTRONE_noMTC_dn
DiethylstilbestrolESR1TOX21_ERa_BLA_Agonist_ratio
DiethylstilbestrolESR1ATG_ERE_CIS_up
DiethylstilbestrolESR1OT_ERa_EREGFP_0480
DiethylstilbestrolESR1NVS_NR_hER
DiethylstilbestrolESR1CEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolESR2OT_ER_ERaERb_0480
DiethylstilbestrolESR2CEETOX_H295R_ESTRADIOL_noMTC_up
DiethylstilbestrolESR2OT_ER_ERbERb_1440
DiethylstilbestrolESR2OT_ER_ERaERb_1440
DiethylstilbestrolESR2OT_ER_ERbERb_0480
DiethylstilbestrolESR2TOX21_ERb_BLA_Agonist_ratio
DiethylstilbestrolESR2TOX21_ERb_BLA_Antagonist_ratio
DiethylstilbestrolESR2CEETOX_H295R_ESTRONE_noMTC_dn
DiethylstilbestrolESR2CEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolESRRATOX21_PGC_ERR_Antagonist
DiethylstilbestrolESRRATOX21_ERR_Antagonist
DiethylstilbestrolF3BSK_3C_TissueFactor_down
DiethylstilbestrolF3BSK_CASM3C_TissueFactor_down
DiethylstilbestrolF3BSK_LPS_TissueFactor_down
DiethylstilbestrolFGFR1NVS_ENZ_hFGFR1
DiethylstilbestrolFOSATG_AP_1_CIS_up
DiethylstilbestrolNR3C1TOX21_GR_BLA_Antagonist_ratio
DiethylstilbestrolNR3C1CEETOX_H295R_DOC_noMTC_dn
DiethylstilbestrolNR3C1CEETOX_H295R_CORTISOL_noMTC_dn
DiethylstilbestrolNR3C1NVS_NR_hGR
DiethylstilbestrolNR3C1CEETOX_H295R_CORTIC_noMTC_dn
DiethylstilbestrolNR3C1CEETOX_H295R_11DCORT_noMTC_dn
DiethylstilbestrolHIF1ATOX21_HRE_BLA_Agonist_ratio
DiethylstilbestrolHLA-DRABSK_BE3C_HLADR_down
DiethylstilbestrolHLA-DRABSK_3C_HLADR_down
DiethylstilbestrolHSF1ATG_HSE_CIS_up
DiethylstilbestrolHSF1TOX21_HSE_BLA_agonist_ratio
DiethylstilbestrolHTR6NVS_GPCR_h5HT6
DiethylstilbestrolICAM1BSK_3C_ICAM1_down
DiethylstilbestrolICAM1BSK_KF3CT_ICAM1_down
DiethylstilbestrolIL1ABSK_LPS_IL1a_down
DiethylstilbestrolIL1ABSK_KF3CT_IL1a_down
DiethylstilbestrolIL1ABSK_BE3C_IL1a_down
DiethylstilbestrolCXCL8BSK_3C_IL8_down
DiethylstilbestrolCXCL8BSK_LPS_IL8_down
DiethylstilbestrolCXCL8BSK_SAg_IL8_down
DiethylstilbestrolCXCL8BSK_CASM3C_IL8_down
DiethylstilbestrolCXCL10BSK_hDFCGF_IP10_down
DiethylstilbestrolCXCL10BSK_BE3C_IP10_down
DiethylstilbestrolCXCL10BSK_KF3CT_IP10_down
DiethylstilbestrolARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
DiethylstilbestrolARACEA_AR_antagonist_80hr
DiethylstilbestrolAROT_AR_ARSRC1_0960
DiethylstilbestrolARNVS_NR_hAR
DiethylstilbestrolARCEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolARTOX21_AR_BLA_Antagonist_ratio
DiethylstilbestrolAROT_AR_ARSRC1_0480
DiethylstilbestrolARCEETOX_H295R_ANDR_noMTC_dn
DiethylstilbestrolARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
DiethylstilbestrolJUNATG_AP_1_CIS_up
DiethylstilbestrolLDLRBSK_CASM3C_LDLR_down
DiethylstilbestrolESR1CEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolESR1CEETOX_H295R_ESTRADIOL_noMTC_up
DiethylstilbestrolESR1CEETOX_H295R_ESTRONE_noMTC_dn
DiethylstilbestrolNACEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolNACEETOX_H295R_ESTRADIOL_noMTC_up
DiethylstilbestrolNACEETOX_H295R_ESTRONE_noMTC_dn
DiethylstilbestrolARCEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolARCEETOX_H295R_ANDR_noMTC_dn
DiethylstilbestrolCXCL9BSK_3C_MIG_down
DiethylstilbestrolCXCL9BSK_hDFCGF_MIG_down
DiethylstilbestrolCXCL9BSK_BE3C_MIG_down
DiethylstilbestrolCXCL9BSK_SAg_MIG_down
DiethylstilbestrolNR3C2CEETOX_H295R_CORTISOL_noMTC_dn
DiethylstilbestrolNR3C2CEETOX_H295R_CORTIC_noMTC_dn
DiethylstilbestrolNR3C2CEETOX_H295R_DOC_noMTC_dn
DiethylstilbestrolNR3C2CEETOX_H295R_11DCORT_noMTC_dn
DiethylstilbestrolMMP1BSK_hDFCGF_MMP1_down
DiethylstilbestrolMMP1BSK_BE3C_MMP1_down
DiethylstilbestrolMMP9BSK_KF3CT_MMP9_down
DiethylstilbestrolMTF1ATG_MRE_CIS_up
DiethylstilbestrolNFE2L2ATG_NRF2_ARE_CIS_up
DiethylstilbestrolNFE2L2TOX21_ARE_BLA_agonist_ratio
DiethylstilbestrolOPRL1NVS_GPCR_hORL1
DiethylstilbestrolOPRM1NVS_GPCR_hOpiate_mu
DiethylstilbestrolSERPINE1BSK_hDFCGF_PAI1_down
DiethylstilbestrolSERPINE1BSK_BE3C_PAI1_down
DiethylstilbestrolPAX6ATG_Pax6_CIS_up
DiethylstilbestrolLEF1ATG_TCF_b_cat_CIS_dn
DiethylstilbestrolPGRTOX21_PR_BLA_Antagonist_ratio
DiethylstilbestrolPIK3CANVS_ENZ_hPI3Ka
DiethylstilbestrolPLATBSK_BE3C_tPA_down
DiethylstilbestrolPLAUBSK_KF3CT_uPA_down
DiethylstilbestrolPLAUBSK_BE3C_uPA_down
DiethylstilbestrolPLAURBSK_3C_uPAR_down
DiethylstilbestrolPLAURBSK_BE3C_uPAR_down
DiethylstilbestrolPLAURBSK_4H_uPAR_down
DiethylstilbestrolPOU2F1ATG_Oct_MLP_CIS_up
DiethylstilbestrolPPARGTOX21_PPARg_BLA_antagonist_ratio
DiethylstilbestrolPTENNVS_ENZ_hPTEN
DiethylstilbestrolPTGER2BSK_LPS_PGE2_down
DiethylstilbestrolRXRBATG_RXRb_TRANS_up
DiethylstilbestrolSAA1BSK_CASM3C_SAA_down
DiethylstilbestrolCCL2BSK_4H_MCP1_down
DiethylstilbestrolCCL2BSK_CASM3C_MCP1_up
DiethylstilbestrolCCL2BSK_SAg_MCP1_down
DiethylstilbestrolCCL2BSK_3C_MCP1_down
DiethylstilbestrolCCL2BSK_LPS_MCP1_down
DiethylstilbestrolCCL2BSK_KF3CT_MCP1_down
DiethylstilbestrolSELEBSK_SAg_Eselectin_down
DiethylstilbestrolSELEBSK_LPS_Eselectin_down
DiethylstilbestrolSELEBSK_3C_Eselectin_down
DiethylstilbestrolSELPBSK_4H_Pselectin_down
DiethylstilbestrolSLC5A5NIS_RAIU_inhibition
DiethylstilbestrolSLC6A3NVS_TR_hDAT
DiethylstilbestrolTBXA2RNVS_GPCR_hTXA2
DiethylstilbestrolTCF7ATG_TCF_b_cat_CIS_dn
DiethylstilbestrolTCF7L2ATG_TCF_b_cat_CIS_dn
DiethylstilbestrolTGFB1BSK_KF3CT_TGFb1_down
DiethylstilbestrolTGFB1BSK_BE3C_TGFb1_down
DiethylstilbestrolTSPONVS_MP_hPBR
DiethylstilbestrolTIMP1BSK_hDFCGF_TIMP1_down
DiethylstilbestrolTIMP2BSK_KF3CT_TIMP2_down
DiethylstilbestrolTNFBSK_LPS_TNFa_down
DiethylstilbestrolTP53APR_HepG2_p53Act_24h_up
DiethylstilbestrolTP53TOX21_p53_BLA_p5_ratio
DiethylstilbestrolTP53TOX21_p53_BLA_p1_ratio
DiethylstilbestrolTP53TOX21_p53_BLA_p2_ratio
DiethylstilbestrolTP53APR_HepG2_p53Act_72h_up
DiethylstilbestrolTP53TOX21_p53_BLA_p4_ratio
DiethylstilbestrolTP53TOX21_p53_BLA_p3_ratio
DiethylstilbestrolTSHRTOX21_TSHR_Agonist_ratio
DiethylstilbestrolNR1H2ATG_DR4_LXR_CIS_dn
DiethylstilbestrolVCAM1BSK_CASM3C_VCAM1_down
DiethylstilbestrolVCAM1BSK_hDFCGF_VCAM1_down
DiethylstilbestrolVCAM1BSK_LPS_VCAM1_down
DiethylstilbestrolVCAM1BSK_3C_VCAM1_down
DiethylstilbestrolVCAM1BSK_4H_VCAM1_down
DiethylstilbestrolVDRTOX21_VDR_BLA_antagonist_ratio
DiethylstilbestrolVDRATG_VDRE_CIS_up
DiethylstilbestrolNACEETOX_H295R_TESTO_noMTC_dn
DiethylstilbestrolNACEETOX_H295R_ANDR_noMTC_dn
DiethylstilbestrolXBP1ATG_Xbp1_CIS_up
DiethylstilbestrolTCF7L1ATG_TCF_b_cat_CIS_dn
DiethylstilbestrolNR1I2ATG_PXR_TRANS_up
DiethylstilbestrolNR1I2CEETOX_H295R_OHPROG_noMTC_dn
DiethylstilbestrolNR1I2ATG_PXRE_CIS_up
DiethylstilbestrolCD38BSK_SAg_CD38_down
DiethylstilbestrolCD40BSK_LPS_CD40_down
DiethylstilbestrolCD40BSK_SAg_CD40_down
DiethylstilbestrolCD69BSK_SAg_CD69_down
DiethylstilbestrolNR1I3TOX21_CAR_Antagonist
DiethylstilbestrolNR1H4TOX21_FXR_BLA_antagonist_ratio
DiethylstilbestrolNR1H4ATG_IR1_CIS_dn

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.