Ketoconazole

Target genes for Ketoconazole is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
KetoconazoleNR1H3ATG_DR4_LXR_CIS_dn
KetoconazoleESR1ATG_ERE_CIS_dn
KetoconazoleESR1CEETOX_H295R_TESTO_dn
KetoconazoleESR1CEETOX_H295R_ESTRONE_dn
KetoconazoleNACEETOX_H295R_ANDR_dn
KetoconazoleNACEETOX_H295R_TESTO_dn
KetoconazoleCCL26BSK_4H_Eotaxin3_down
KetoconazoleCREB3ATG_CRE_CIS_up
KetoconazoleCOL3A1BSK_hDFCGF_CollagenIII_down
KetoconazoleCSF1BSK_LPS_MCSF_down
KetoconazoleCSF1BSK_hDFCGF_MCSF_down
KetoconazoleCYP19A1TOX21_Aromatase_Inhibition
KetoconazoleCYP24A1TOX21_VDR_BLA_antagonist_ratio
KetoconazoleEGR1ATG_EGR_CIS_up
KetoconazoleAHRATG_Ahr_CIS_up
KetoconazoleAHRTOX21_AhR_LUC_Agonist
KetoconazoleESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
KetoconazoleESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
KetoconazoleESR1OT_ERa_EREGFP_0480
KetoconazoleESR1ATG_ERE_CIS_dn
KetoconazoleESR1OT_ERa_EREGFP_0120
KetoconazoleESR1CEETOX_H295R_ESTRONE_dn
KetoconazoleESR1TOX21_ERa_BLA_Antagonist_ratio
KetoconazoleESR2CEETOX_H295R_ESTRONE_dn
KetoconazoleESR2TOX21_ERb_BLA_Antagonist_ratio
KetoconazoleESRRATOX21_ERR_Antagonist
KetoconazoleESRRATOX21_PGC_ERR_Antagonist
KetoconazoleF3BSK_3C_TissueFactor_down
KetoconazoleF3BSK_LPS_TissueFactor_down
KetoconazoleATF6TOX21_ESRE_BLA_ratio
KetoconazoleSIRT2NVS_ENZ_hSIRT2
KetoconazoleFOSATG_AP_1_CIS_up
KetoconazoleNR3C1CEETOX_H295R_DOC_up
KetoconazoleNR3C1TOX21_GR_BLA_Agonist_ratio
KetoconazoleNR3C1CEETOX_H295R_CORTISOL_dn
KetoconazoleNR3C1CEETOX_H295R_11DCORT_dn
KetoconazoleNR3C1CEETOX_H295R_CORTIC_dn
KetoconazoleHIF1ATOX21_HRE_BLA_Agonist_ratio
KetoconazoleHIF1AATG_HIF1a_CIS_up
KetoconazoleHLA-DRABSK_BE3C_HLADR_down
KetoconazoleHLA-DRABSK_3C_HLADR_down
KetoconazoleHSF1ATG_HSE_CIS_up
KetoconazoleHSF1TOX21_HSE_BLA_agonist_ratio
KetoconazoleICAM1BSK_KF3CT_ICAM1_down
KetoconazoleIL1ABSK_LPS_IL1a_down
KetoconazoleIL1ABSK_KF3CT_IL1a_down
KetoconazoleCXCL8BSK_SAg_IL8_down
KetoconazoleCXCL8BSK_LPS_IL8_down
KetoconazoleCXCL8BSK_3C_IL8_down
KetoconazoleCXCL8BSK_hDFCGF_IL8_down
KetoconazoleCXCL10BSK_KF3CT_IP10_down
KetoconazoleCXCL10BSK_BE3C_IP10_down
KetoconazoleCXCL10BSK_hDFCGF_IP10_down
KetoconazoleIRF1ATG_ISRE_CIS_dn
KetoconazoleARCEETOX_H295R_ANDR_dn
KetoconazoleARCEETOX_H295R_TESTO_dn
KetoconazoleAROT_AR_ARSRC1_0960
KetoconazoleAROT_AR_ARSRC1_0480
KetoconazoleARTOX21_AR_BLA_Agonist_ratio
KetoconazoleARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
KetoconazoleARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
KetoconazoleARACEA_AR_antagonist_80hr
KetoconazoleARTOX21_AR_BLA_Antagonist_ratio
KetoconazoleJUNATG_AP_1_CIS_up
KetoconazoleJUNTOX21_AP1_BLA_Agonist_ratio
KetoconazoleLDLRBSK_CASM3C_LDLR_up
KetoconazoleESR1ATG_ERE_CIS_dn
KetoconazoleESR1CEETOX_H295R_ESTRONE_dn
KetoconazoleESR1CEETOX_H295R_TESTO_dn
KetoconazoleFOSTOX21_AP1_BLA_Agonist_ratio
KetoconazoleNAATG_ERE_CIS_dn
KetoconazoleNACEETOX_H295R_TESTO_dn
KetoconazoleNACEETOX_H295R_ESTRONE_dn
KetoconazoleSMAD1ATG_BRE_CIS_up
KetoconazoleARCEETOX_H295R_ANDR_dn
KetoconazoleARCEETOX_H295R_TESTO_dn
KetoconazoleCXCL9BSK_3C_MIG_down
KetoconazoleCXCL9BSK_hDFCGF_MIG_down
KetoconazoleCXCL9BSK_SAg_MIG_down
KetoconazoleNR3C2CEETOX_H295R_DOC_up
KetoconazoleNR3C2CEETOX_H295R_CORTISOL_dn
KetoconazoleNR3C2CEETOX_H295R_11DCORT_dn
KetoconazoleNR3C2CEETOX_H295R_CORTIC_dn
KetoconazoleMMP1BSK_hDFCGF_MMP1_down
KetoconazoleMMP9BSK_KF3CT_MMP9_down
KetoconazoleMTF1ATG_MRE_CIS_up
KetoconazoleNFIAATG_NFI_CIS_up
KetoconazoleNFE2L2TOX21_ARE_BLA_agonist_ratio
KetoconazoleNFE2L2ATG_NRF2_ARE_CIS_up
KetoconazoleNFKB1TOX21_NFkB_BLA_agonist_ratio
KetoconazoleNR4A2ATG_NURR1_TRANS_up
KetoconazoleSERPINE1BSK_hDFCGF_PAI1_down
KetoconazolePAX6ATG_Pax6_CIS_up
KetoconazoleLEF1ATG_TCF_b_cat_CIS_dn
KetoconazolePGRCEETOX_H295R_OHPROG_dn
KetoconazolePGRTOX21_PR_BLA_Antagonist_ratio
KetoconazolePGRCEETOX_H295R_OHPREG_dn
KetoconazolePLAUBSK_KF3CT_uPA_down
KetoconazolePLAURBSK_4H_uPAR_down
KetoconazolePLAURBSK_3C_uPAR_down
KetoconazolePOU2F1ATG_Oct_MLP_CIS_up
KetoconazolePPARAATG_PPRE_CIS_dn
KetoconazolePPARDATG_PPRE_CIS_dn
KetoconazolePPARDTOX21_PPARd_BLA_antagonist_ratio
KetoconazolePPARGTOX21_PPARg_BLA_antagonist_ratio
KetoconazolePPARGTOX21_PPARg_BLA_Agonist_ratio
KetoconazolePPARGATG_PPRE_CIS_dn
KetoconazolePTGER2BSK_LPS_PGE2_up
KetoconazoleRORAATG_RORE_CIS_up
KetoconazoleRORBATG_RORE_CIS_up
KetoconazoleRORCATG_RORE_CIS_up
KetoconazoleRXRBATG_RXRb_TRANS_dn
KetoconazoleCCL2BSK_SAg_MCP1_down
KetoconazoleCCL2BSK_4H_MCP1_down
KetoconazoleCCL2BSK_3C_MCP1_down
KetoconazoleCCL2BSK_LPS_MCP1_down
KetoconazoleSELEBSK_SAg_Eselectin_down
KetoconazoleSELEBSK_LPS_Eselectin_down
KetoconazoleSELPBSK_4H_Pselectin_down
KetoconazoleSLC5A5NIS_RAIU_inhibition
KetoconazoleSLC6A2NVS_TR_hNET
KetoconazoleSLC6A3NVS_TR_hDAT
KetoconazoleSLC6A4NVS_TR_hSERT
KetoconazoleSP1ATG_Sp1_CIS_up
KetoconazoleSREBF1ATG_SREBP_CIS_up
KetoconazoleTCF7ATG_TCF_b_cat_CIS_dn
KetoconazoleTCF7L2ATG_TCF_b_cat_CIS_dn
KetoconazoleTFAP2AATG_AP_2_CIS_up
KetoconazoleTFAP2BATG_AP_2_CIS_up
KetoconazoleTGFB1BSK_KF3CT_TGFb1_down
KetoconazoleTIMP1BSK_hDFCGF_TIMP1_down
KetoconazoleTIMP2BSK_KF3CT_TIMP2_down
KetoconazoleTNFBSK_LPS_TNFa_down
KetoconazoleTP53APR_HepG2_p53Act_72h_up
KetoconazoleTP53TOX21_p53_BLA_p3_ratio
KetoconazoleTP53TOX21_p53_BLA_p4_ratio
KetoconazoleTP53TOX21_p53_BLA_p5_ratio
KetoconazoleTP53TOX21_p53_BLA_p1_ratio
KetoconazoleTP53TOX21_p53_BLA_p2_ratio
KetoconazoleTSHRTOX21_TSHR_Agonist_ratio
KetoconazoleTSHRTOX21_TSHR_Antagonist_ratio
KetoconazoleNR1H2ATG_DR4_LXR_CIS_dn
KetoconazoleUSF1ATG_E_Box_CIS_dn
KetoconazoleVCAM1BSK_LPS_VCAM1_down
KetoconazoleVCAM1BSK_hDFCGF_VCAM1_down
KetoconazoleVDRATG_VDRE_CIS_up
KetoconazoleVDRTOX21_VDR_BLA_antagonist_ratio
KetoconazoleNACEETOX_H295R_ANDR_dn
KetoconazoleNACEETOX_H295R_TESTO_dn
KetoconazoleXBP1ATG_Xbp1_CIS_up
KetoconazoleTCF7L1ATG_TCF_b_cat_CIS_dn
KetoconazoleTFAP2DATG_AP_2_CIS_up
KetoconazoleNR1I2ATG_PXRE_CIS_up
KetoconazoleCD38BSK_SAg_CD38_down
KetoconazoleCD40BSK_SAg_CD40_down
KetoconazoleCD40BSK_LPS_CD40_down
KetoconazoleCD69BSK_SAg_CD69_down
KetoconazoleNR1I3NVS_NR_hCAR_Antagonist
KetoconazoleNR1I3ATG_CAR_TRANS_dn
KetoconazoleNR1I3TOX21_CAR_Antagonist
KetoconazoleNR1I3TOX21_CAR_Agonist
KetoconazoleNR1H4NVS_NR_hFXR_Antagonist
KetoconazoleNR1H4OT_FXR_FXRSRC1_0480
KetoconazoleNR1H4ATG_IR1_CIS_dn
KetoconazoleNR1H4TOX21_FXR_BLA_antagonist_ratio

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