| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10630580 | IVR | 24 mg/kg/day | - | No significant effects observed | - |
| IVR | 50 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:10641015 | IVR | 15 - 25 mg/kg | 15 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 15 - 25 mg/kg | 15 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| PMID:11248141 | IVR | 24 mg/kg/day | 24 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 24 mg/kg/day | 24 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| PMID:15187238 | IVTH | 0.00001 - 0.00005 M | 0.00001 - 0.00005 M | Affects corticosterone metabolism | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVTH | 0.00001 - 0.00005 M | 0.00001 - 0.00005 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 - 0.00005 M | 0.00001 - 0.00005 M | Affects cholesterol biosynthesis | Metabolic endocrine-mediated perturbations | |
| PMID:15884376 | IVTH | 0.0000003 - 0.00001 M | 0.000003 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000003 - 0.00001 M | 0.0000003 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000003 - 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:16710696 | IVR | 6.25 mg/kg/day | 6.25 mg/kg/day | Decreased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased weights of vagina | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased uterine weights | Reproductive endocrine-mediat | |
| PMID:16935330 | IVTH | 0.0000001 - 0.00005 M | 0.00002 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000001 - 0.00005 M | 0.00002 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00005 M | 0.00002 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00005 M | 0.00002 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00005 M | 0.00002 M | Affects corticosterone metabolism | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:16962624 | IVTH | 0.00000001 - 0.00001 M | 0.000001 - 0.000003 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.00001 M | 0.000001 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.00001 M | 0.0000001 - 0.000003 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:17558187 | IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:17679765 | IVR | 1 mg/kg | 1 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| PMID:18067565 | IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:18626888 | IVTH | 0.00000005 - 0.0001 M | 0.00001 M | Decrease in cortisol levels | Neurological endocrine-mediated perturbations |
| IVTH | 0.00000005 - 0.0001 M | 0.00001 M | Decreased aldosterone levels | Metabolic endocrine-mediated perturbations | |
| PMID:20087668 | IVTH | 0.00000001 - 0.0001 M | 0.00000003 - 0.0001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.0001 M | 0.00000003 - 0.0001 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000001 - 0.0001 M | 0.000001 - 0.0001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:20708073 | IVTH | 0.0000001 - 0.00003 M | 0.000003 - 0.00003 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000001 - 0.00003 M | 0.000001 - 0.00003 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00003 M | 0.0000001 - 0.00003 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:23616146 | IVTH | 0.000001 - 0.01 mmol/L | 0.0003 - 0.01 mmol/L | Decrease in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVTH | 0.000001 - 0.01 mmol/L | 0.0003 - 0.01 mmol/L | Decrease in cortisol levels | Neurological endocrine-mediated perturbations | |
| PMID:31330226 | IVTH | 0.00000001 M | - | No significant effects observed | - |
| IVTH | 0.000000001 M | - | No significant effects observed | - | |
| IVTH | 0.0000000314 M | 0.0000000314 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000314 M | 0.0000000314 M | Increased pregnenolone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000314 M | 0.0000000314 M | Affects corticosterone metabolism | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased 11-Deoxy-corsticosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased pregnenolone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000314 M | 0.00000314 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000314 M | 0.00000314 M | Decreased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000314 M | 0.00000314 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00000314 M | 0.00000314 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Decreased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased pregnenolone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased androstenedione levels | Reproductive endocrine- | |
| IVTH | 0.000000314 M | 0.000000314 M | Decreased 11-Deoxy-corsticosterone levels | ||
| IVTH | 0.0000001 M | 0.0000001 M | Decreased progesterone levels | ||
| IVTH | 0.0000001 M | 0.0000001 M | Decreased pregnenolone levels | ||
| IVTH | 0.0000001 M | 0.0000001 M | Decreased 11-Deoxy-corsticosterone levels |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.