Simvastatin

Target genes for Simvastatin is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
SimvastatinNR1H3ATG_DR4_LXR_CIS_dn
SimvastatinNACEETOX_H295R_PROG_dn
SimvastatinCCL26BSK_4H_Eotaxin3_down
SimvastatinCOL3A1BSK_hDFCGF_CollagenIII_down
SimvastatinADORA1NVS_GPCR_hAdoRA1
SimvastatinCSF1BSK_hDFCGF_MCSF_down
SimvastatinCSF1BSK_CASM3C_MCSF_down
SimvastatinCSF1BSK_LPS_MCSF_down
SimvastatinCYP2C19NVS_ADME_hCYP2C19
SimvastatinCYP2C9NVS_ADME_hCYP2C9
SimvastatinCYP3A4NVS_ADME_hCYP3A4
SimvastatinCYP19A1TOX21_Aromatase_Inhibition
SimvastatinDIO1NHEERL_MED_hDIO1_dn
SimvastatinDUSP3NVS_ENZ_hDUSP3
SimvastatinSLC29A1NVS_TR_hAdoT
SimvastatinESR1ATG_ERE_CIS_up
SimvastatinESR1TOX21_ERa_LUC_VM7_Agonist
SimvastatinESR2TOX21_ERb_BLA_Antagonist_ratio
SimvastatinESRRATOX21_ERR_Agonist
SimvastatinF3BSK_3C_TissueFactor_down
SimvastatinF3BSK_LPS_TissueFactor_up
SimvastatinF3BSK_CASM3C_TissueFactor_down
SimvastatinNR3C1TOX21_GR_BLA_Agonist_ratio
SimvastatinNR3C1NVS_NR_hGR
SimvastatinNR3C1CEETOX_H295R_11DCORT_dn
SimvastatinNR3C1TOX21_GR_BLA_Antagonist_ratio
SimvastatinNR3C1CEETOX_H295R_DOC_dn
SimvastatinHIF1AATG_HIF1a_CIS_dn
SimvastatinHLA-DRABSK_CASM3C_HLADR_down
SimvastatinHLA-DRABSK_3C_HLADR_down
SimvastatinHLA-DRABSK_BE3C_HLADR_down
SimvastatinHSF1TOX21_HSE_BLA_agonist_ratio
SimvastatinHTR5ANVS_GPCR_h5HT5A
SimvastatinHTR7NVS_GPCR_h5HT7
SimvastatinICAM1BSK_KF3CT_ICAM1_down
SimvastatinIL1ABSK_KF3CT_IL1a_down
SimvastatinIL1ABSK_BE3C_IL1a_down
SimvastatinIL1ABSK_LPS_IL1a_down
SimvastatinCXCL8BSK_CASM3C_IL8_down
SimvastatinCXCL8BSK_SAg_IL8_up
SimvastatinCXCL8BSK_hDFCGF_IL8_down
SimvastatinCXCL8BSK_3C_IL8_down
SimvastatinCXCL10BSK_KF3CT_IP10_down
SimvastatinCXCL10BSK_BE3C_IP10_down
SimvastatinCXCL10BSK_hDFCGF_IP10_down
SimvastatinARACEA_AR_antagonist_80hr
SimvastatinARTOX21_AR_BLA_Antagonist_ratio
SimvastatinAROT_AR_ARSRC1_0960
SimvastatinARTOX21_AR_LUC_MDAKB2_Agonist
SimvastatinJUNTOX21_AP1_BLA_Agonist_ratio
SimvastatinKDRBSK_4H_VEGFRII_down
SimvastatinLDLRBSK_CASM3C_LDLR_down
SimvastatinFOSTOX21_AP1_BLA_Agonist_ratio
SimvastatinCXCL9BSK_BE3C_MIG_down
SimvastatinNR3C2CEETOX_H295R_DOC_dn
SimvastatinNR3C2CEETOX_H295R_11DCORT_dn
SimvastatinMMP1BSK_BE3C_MMP1_down
SimvastatinMMP9BSK_KF3CT_MMP9_down
SimvastatinNFE2L2TOX21_ARE_BLA_agonist_ratio
SimvastatinSERPINE1BSK_hDFCGF_PAI1_down
SimvastatinSERPINE1BSK_BE3C_PAI1_down
SimvastatinPGRTOX21_PR_BLA_Antagonist_ratio
SimvastatinPGRCEETOX_H295R_PROG_dn
SimvastatinPGRCEETOX_H295R_OHPROG_dn
SimvastatinPLATBSK_BE3C_tPA_down
SimvastatinPLAUBSK_BE3C_uPA_down
SimvastatinPLAUBSK_KF3CT_uPA_down
SimvastatinPLAURBSK_3C_uPAR_down
SimvastatinPLAURBSK_4H_uPAR_down
SimvastatinPLAURBSK_CASM3C_uPAR_down
SimvastatinPLAURBSK_BE3C_uPAR_down
SimvastatinPPARGTOX21_PPARg_BLA_antagonist_ratio
SimvastatinPPARGNVS_NR_hPPARg
SimvastatinPTPN12NVS_ENZ_hPTPN12
SimvastatinRARAATG_RARa_TRANS_dn
SimvastatinRARBATG_RARb_TRANS_dn
SimvastatinRXRAOT_NURR1_NURR1RXRa_1440
SimvastatinSAA1BSK_CASM3C_SAA_down
SimvastatinCCL2BSK_3C_MCP1_down
SimvastatinCCL2BSK_4H_MCP1_down
SimvastatinCCL2BSK_CASM3C_MCP1_down
SimvastatinCCL2BSK_SAg_MCP1_down
SimvastatinCCL2BSK_LPS_MCP1_down
SimvastatinCCL2BSK_KF3CT_MCP1_down
SimvastatinSELEBSK_SAg_Eselectin_up
SimvastatinSELEBSK_LPS_Eselectin_up
SimvastatinSELEBSK_3C_Eselectin_down
SimvastatinSELPBSK_4H_Pselectin_down
SimvastatinSLC6A2NVS_TR_hNET
SimvastatinSLC6A3NVS_TR_hDAT
SimvastatinSREBF1ATG_SREBP_CIS_up
SimvastatinTGFB1BSK_KF3CT_TGFb1_down
SimvastatinTGFB1BSK_BE3C_TGFb1_down
SimvastatinTHBDBSK_CASM3C_Thrombomodulin_up
SimvastatinTHBDBSK_3C_Thrombomodulin_up
SimvastatinTIMP1BSK_hDFCGF_TIMP1_down
SimvastatinTIMP2BSK_KF3CT_TIMP2_down
SimvastatinTNFBSK_LPS_TNFa_up
SimvastatinTP53APR_HepG2_p53Act_24h_up
SimvastatinTP53APR_HepG2_p53Act_72h_up
SimvastatinNR1H2ATG_DR4_LXR_CIS_dn
SimvastatinVCAM1BSK_CASM3C_VCAM1_down
SimvastatinVCAM1BSK_LPS_VCAM1_down
SimvastatinVCAM1BSK_4H_VCAM1_down
SimvastatinVCAM1BSK_3C_VCAM1_down
SimvastatinVCAM1BSK_hDFCGF_VCAM1_down
SimvastatinVDRATG_VDRE_CIS_up
SimvastatinNR1I2ATG_PXR_TRANS_up
SimvastatinNR1I2ATG_PXRE_CIS_up
SimvastatinCD38BSK_SAg_CD38_down
SimvastatinCD40BSK_LPS_CD40_down
SimvastatinCD40BSK_SAg_CD40_down
SimvastatinCD69BSK_SAg_CD69_down
SimvastatinNR1I3TOX21_CAR_Antagonist
SimvastatinNR1I3ATG_CAR_TRANS_dn
SimvastatinNR1H4OT_FXR_FXRSRC1_1440
SimvastatinNR1H4OT_FXR_FXRSRC1_0480

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