| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:25055962 | IVR | 31.3 mg/kg | 31.3 mg/kg | Decreased triglycerides level | Metabolic endocrine-mediated perturbations |
| IVR | 31.3 mg/kg | 31.3 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 31.3 mg/kg | 31.3 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 62.5 mg/kg | 62.5 mg/kg | Decreased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 15.6 mg/kg | 15.6 mg/kg | Decreased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 15.6 mg/kg | 15.6 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Affects cholesterol biosynthesis | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Affects cholesterol metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| PMID:26476359 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased progestagens levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased progestagens levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1.3 mg/kg/day | - | No significant effects observed | - |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.