Ziram

Target genes for Ziram is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ZiramCCL26BSK_4H_Eotaxin3_down
ZiramCOL3A1BSK_hDFCGF_CollagenIII_down
ZiramCSF1BSK_LPS_MCSF_down
ZiramCSF1BSK_CASM3C_MCSF_down
ZiramCSF1BSK_hDFCGF_MCSF_down
ZiramCYP19A1TOX21_Aromatase_Inhibition
ZiramCYP24A1TOX21_VDR_BLA_antagonist_ratio
ZiramESR1OT_ERa_EREGFP_0120
ZiramESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ZiramESR1OT_ER_ERaERb_1440
ZiramESR1OT_ERa_EREGFP_0480
ZiramESR1TOX21_ERa_BLA_Antagonist_ratio
ZiramESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
ZiramESR1TOX21_ERa_BLA_Agonist_ratio
ZiramESR2TOX21_ERb_BLA_Antagonist_ratio
ZiramESR2OT_ER_ERaERb_1440
ZiramESRRATOX21_ERR_Antagonist
ZiramESRRATOX21_PGC_ERR_Antagonist
ZiramF3BSK_LPS_TissueFactor_down
ZiramF3BSK_3C_TissueFactor_down
ZiramATF6TOX21_ESRE_BLA_ratio
ZiramNR3C1NVS_NR_hGR
ZiramNR3C1TOX21_GR_BLA_Agonist_ratio
ZiramNR3C1TOX21_GR_BLA_Antagonist_ratio
ZiramHDAC1TOX21_HDAC_Inhibition
ZiramHIF1ATOX21_HRE_BLA_Agonist_ratio
ZiramHLA-DRABSK_CASM3C_HLADR_down
ZiramHLA-DRABSK_BE3C_HLADR_down
ZiramHLA-DRABSK_3C_HLADR_down
ZiramHSF1TOX21_HSE_BLA_agonist_ratio
ZiramICAM1BSK_3C_ICAM1_down
ZiramICAM1BSK_KF3CT_ICAM1_down
ZiramIL1ABSK_KF3CT_IL1a_down
ZiramIL1ABSK_BE3C_IL1a_down
ZiramIL1ABSK_LPS_IL1a_down
ZiramIL6BSK_CASM3C_IL6_down
ZiramCXCL8BSK_CASM3C_IL8_down
ZiramCXCL8BSK_SAg_IL8_down
ZiramCXCL8BSK_3C_IL8_down
ZiramCXCL8BSK_hDFCGF_IL8_down
ZiramCXCL8BSK_LPS_IL8_down
ZiramCXCL10BSK_KF3CT_IP10_down
ZiramCXCL10BSK_hDFCGF_IP10_down
ZiramCXCL10BSK_BE3C_IP10_down
ZiramINSRNVS_ENZ_hInsR_Activator
ZiramARACEA_AR_antagonist_80hr
ZiramARTOX21_AR_BLA_Antagonist_ratio
ZiramAROT_AR_ARSRC1_0960
ZiramAROT_AR_ARSRC1_0480
ZiramARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
ZiramARTOX21_AR_BLA_Agonist_ratio
ZiramARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
ZiramJUNTOX21_AP1_BLA_Agonist_ratio
ZiramKDRBSK_4H_VEGFRII_down
ZiramLDLRBSK_CASM3C_LDLR_down
ZiramFOSTOX21_AP1_BLA_Agonist_ratio
ZiramCXCL9BSK_3C_MIG_down
ZiramCXCL9BSK_CASM3C_MIG_down
ZiramCXCL9BSK_BE3C_MIG_down
ZiramCXCL9BSK_hDFCGF_MIG_down
ZiramCXCL9BSK_SAg_MIG_down
ZiramMMP1BSK_BE3C_MMP1_down
ZiramMMP1BSK_hDFCGF_MMP1_down
ZiramMMP9BSK_KF3CT_MMP9_down
ZiramSERPINE1BSK_hDFCGF_PAI1_down
ZiramSERPINE1BSK_BE3C_PAI1_down
ZiramPGRTOX21_PR_BLA_Antagonist_ratio
ZiramPLATBSK_BE3C_tPA_down
ZiramPLAUBSK_KF3CT_uPA_down
ZiramPLAUBSK_BE3C_uPA_down
ZiramPLAURBSK_BE3C_uPAR_down
ZiramPLAURBSK_3C_uPAR_down
ZiramPLAURBSK_CASM3C_uPAR_down
ZiramPLAURBSK_4H_uPAR_down
ZiramPPARDTOX21_PPARd_BLA_antagonist_ratio
ZiramPPARDTOX21_PPARd_BLA_agonist_ratio
ZiramPPARGTOX21_PPARg_BLA_antagonist_ratio
ZiramPPARGTOX21_PPARg_BLA_Agonist_ratio
ZiramPTGER2BSK_LPS_PGE2_down
ZiramPTPN1NVS_ENZ_hPTPN1
ZiramPTPN9NVS_ENZ_hPTPN9
ZiramSAA1BSK_CASM3C_SAA_down
ZiramCCL2BSK_SAg_MCP1_down
ZiramCCL2BSK_CASM3C_MCP1_down
ZiramCCL2BSK_3C_MCP1_down
ZiramCCL2BSK_LPS_MCP1_down
ZiramCCL2BSK_KF3CT_MCP1_down
ZiramCCL2BSK_4H_MCP1_down
ZiramSELEBSK_LPS_Eselectin_down
ZiramSELEBSK_SAg_Eselectin_down
ZiramSELEBSK_3C_Eselectin_down
ZiramSELPBSK_4H_Pselectin_down
ZiramSLC5A5NIS_RAIU_inhibition
ZiramSLC6A2NVS_TR_hNET
ZiramTGFB1BSK_BE3C_TGFb1_down
ZiramTGFB1BSK_KF3CT_TGFb1_down
ZiramTHBDBSK_3C_Thrombomodulin_up
ZiramTHBDBSK_CASM3C_Thrombomodulin_up
ZiramTIMP1BSK_hDFCGF_TIMP1_down
ZiramTIMP2BSK_KF3CT_TIMP2_down
ZiramTNFBSK_LPS_TNFa_down
ZiramTP53TOX21_p53_BLA_p4_ratio
ZiramTP53APR_HepG2_p53Act_72h_up
ZiramTP53TOX21_p53_BLA_p5_ratio
ZiramTP53TOX21_p53_BLA_p1_ratio
ZiramTP53TOX21_p53_BLA_p3_ratio
ZiramTP53TOX21_p53_BLA_p2_ratio
ZiramTSHRTOX21_TSHR_Antagonist_ratio
ZiramVCAM1BSK_LPS_VCAM1_down
ZiramVCAM1BSK_4H_VCAM1_down
ZiramVCAM1BSK_CASM3C_VCAM1_down
ZiramVCAM1BSK_hDFCGF_VCAM1_down
ZiramVCAM1BSK_3C_VCAM1_down
ZiramVDRTOX21_VDR_BLA_antagonist_ratio
ZiramATAD5TOX21_ELG1_LUC_Agonist
ZiramCD38BSK_SAg_CD38_down
ZiramCD40BSK_LPS_CD40_down
ZiramCD40BSK_SAg_CD40_down
ZiramCD69BSK_SAg_CD69_down
ZiramNR1I3TOX21_CAR_Antagonist
ZiramNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.