| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:29627606 | IVR | 2 mg/kg/day | - | No significant effects observed | - |
| IVR | 4 mg/kg/day | - | No significant effects observed | - | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg/day | 8 mg/kg/day | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg/day | 8 mg/kg/day | Affects sertoli cells function in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg/day | 8 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:30422632 | IVR | 4 mg/kg | 4 mg/kg | Affects sertoli cells function | Reproductive endocrine-mediated perturbations |
| IVR | 4 mg/kg | 4 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg | 4 mg/kg | Affects leydig cells function | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects sertoli cells function | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Affects leydig cells function | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| PMID:6230523 | IVR | 0.001 mg | 0.001 mg | Affects fertility | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg | 0.001 mg | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 0.002 mg | 0.002 mg | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 0.002 mg | 0.002 mg | Affects fertility | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.