Fluoxetine


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
100188971 CPG21 Decreases expression PMID:17033635
10117 ENAM Decreases expression PMID:21083617
102 ADAM10 Increases expression PMID:17033635
1020 CDK5 Decreases expression PMID:17105902
10215 OLIG2 Increases expression PMID:20857517
10253 SPRY2 Affects expression PMID:29893963
10257 ABCC4 Decreases activity PMID:39023798
1026 CDKN1A Increases expression PMID:18371935; PMID:18836303
1027 CDKN1B Increases expression PMID:18371935; PMID:21497159
1029 CDKN2A Increases expression PMID:21497159
10294 DNAJA2 Decreases expression PMID:21852994
1030 CDKN2B Increases expression PMID:21497159
10311 VPS26C Increases expression PMID:37386098
10381 TUBB3 Decreases expression PMID:20857517
104 ADARB1 Increases expression PMID:21320410
1044 CDX1 Affects expression PMID:29893963
10458 BAIAP2 Decreases expression PMID:17033635
10599 SLCO1B1 Decreases activity PMID:39023798
10682 EBP Increases expression PMID:37386098
10998 SLC27A5 Increases expression PMID:34897744
11067 DEPP1 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
11098 PRSS23 Decreases expression PMID:17033635
11161 ERG28 Increases expression PMID:37386098
1138 CHRNA5 Decreases expression PMID:21820738
114 ADCY8 Decreases expression PMID:17033635
1143 CHRNB4 Decreases expression PMID:21820738
1163 CKS1B Decreases activity PMID:18371935
1163 CKS1B Decreases expression PMID:18371935
116844 LRG1 Increases expression PMID:17033635
1174 AP1S1 Decreases expression PMID:15342952
12 SERPINA3 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
121278 TPH2 Increases expression PMID:11901216; PMID:16982082; PMID:21740920; PMID:17321503; PMID:17950541; PMID:20374287
1244 ABCC2 Increases expression PMID:37386098
1268 CNR1 Decreases expression PMID:15936043; PMID:18722357
134429 STARD4 Increases expression PMID:37386098
1385 CREB1 Affects activity PMID:18573488; PMID:20122921
1385 CREB1 Affects expression PMID:19477151; PMID:21753012; PMID:8601816
1392 CRH Affects expression PMID:1351783; PMID:20374287; PMID:9740405
1394 CRHR1 Increases expression PMID:9740405
140679 SLC32A1 Decreases expression PMID:20707986
1407 CRY1 Affects expression PMID:15994025
1408 CRY2 Decreases expression PMID:15994025
1431 CS Increases activity PMID:20971158
147798 TMC4 Decreases expression PMID:17033635
15 AANAT Increases expression PMID:22291481; PMID:9951564
1545 CYP1B1 Decreases activity PMID:33814510
1557 CYP2C19 Decreases activity PMID:21915887; PMID:22652334
1558 CYP2C8 Decreases activity PMID:15304522
1565 CYP2D6 Decreases activity PMID:12173784; PMID:16595712; PMID:26599973
1576 CYP3A4 Decreases activity PMID:39023798
1583 CYP11A1 Decreases expression PMID:26348076
1588 CYP19A1 Decreases activity PMID:26162595
1600 DAB1 Increases expression PMID:19359144
1611 DAP Increases expression PMID:21852994
1621 DBH Increases expression PMID:20626387
1717 DHCR7 Increases expression PMID:37386098
1718 DHCR24 Increases expression PMID:37386098
17224 MCPT1 Decreases expression PMID:19058337
1735 DIO3 Increases activity PMID:15456934
1735 DIO3 Increases expression PMID:15456934
1813 DRD2 Decreases expression PMID:11981225
182 JAG1 Increases expression PMID:19801843
1850 DUSP8 Increases expression PMID:9813294
19 ABCA1 Decreases expression PMID:37386098
1956 EGFR Increases activity PMID:19662385
1958 EGR1 Increases expression PMID:21753012
1960 EGR3 Decreases expression PMID:17033635
1961 EGR4 Decreases expression PMID:17033635
201163 FLCN Increases expression PMID:37386098
20997 T Affects expression PMID:29893963
2123 EVI2A Increases expression PMID:24356939
2168 FABP1 Increases expression PMID:15342952; PMID:17567588
2170 FABP3 Increases expression PMID:37386098
2181 ACSL3 Increases expression PMID:37386098
2182 ACSL4 Increases expression PMID:37386098
2185 PTK2B Decreases expression PMID:17033635
22059 TRP53 Increases expression PMID:21497159
2222 FDFT1 Increases expression PMID:37386098
2246 FGF1 Increases expression PMID:17033635
2274 FHL2 Decreases expression PMID:21852994
22848 AAK1 Decreases expression PMID:17033635
22866 CNKSR2 Decreases expression PMID:17033635
230 ALDOC Increases expression PMID:37386098
23034 SAMD4A Decreases expression PMID:17033635
23109 DDN Decreases expression PMID:17033635
23175 LPIN1 Increases expression PMID:37386098
23236 PLCB1 Decreases expression PMID:12527476
23237 ARC Affects expression PMID:15381288; PMID:18301726; PMID:17033635
2331 FMOD Decreases expression PMID:17033635
2353 FOS Increases expression PMID:12527473; PMID:15609068; PMID:15953686; PMID:16521035; PMID:17987061; PMID:19429152; PMID:17033635; PMID:18758753; PMID:18836303; PMID:9740405
2354 FOSB Increases expression PMID:18758753
23617 TSSK2 Decreases expression PMID:17033635
23657 SLC7A11 Increases expression PMID:24356939
253152 EPHX4 Decreases expression PMID:17033635
2538 G6PC1 Decreases expression PMID:33179799
2563 GABRD Decreases expression PMID:17033635
2571 GAD1 Increases expression PMID:17033635
2572 GAD2 Affects expression PMID:19359144; PMID:9526047
25798 BRI3 Increases expression PMID:37386098
2580 GAK Decreases expression PMID:21852994
2596 GAP43 Decreases expression PMID:17950272
26266 SLC13A4 Decreases expression PMID:17033635
26353 HSPB8 Increases expression PMID:20924750
26471 NUPR1 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
265 AMELX Decreases expression PMID:21083617
2668 GDNF Increases expression PMID:15456934
2670 GFAP Increases expression PMID:20857517
2697 GJA1 Increases expression PMID:18585900
27012 KCNV1 Decreases expression PMID:17033635
27044 SND1 Increases expression PMID:21852994
271 AMPD2 Increases expression PMID:20924750
2767 GNA11 Decreases expression PMID:21712787
2768 GNA12 Increases expression PMID:1426031
2771 GNAI2 Decreases expression PMID:21852994
2776 GNAQ Affects expression PMID:1426031; PMID:21712787
2778 GNAS Affects expression PMID:1426031; PMID:21852994
2783 GNB2 Decreases expression PMID:17105902
2819 GPD1 Increases expression PMID:17033635
28234 SLCO1B3 Decreases activity PMID:39023798
2875 GPT Increases expression PMID:34669537
2878 GPX3 Increases expression PMID:20924750
2890 GRIA1 Affects expression PMID:20417256
2891 GRIA2 Increases expression PMID:20417256
28962 OSTM1 Increases expression PMID:37386098
2898 GRIK2 Increases expression PMID:21320410
2903 GRIN2A Increases expression PMID:20417256
2908 NR3C1 Increases expression PMID:10929085; PMID:12393271; PMID:15469896; PMID:11406320; PMID:20374287; PMID:21281618; PMID:24952232
2932 GSK3B Increases expression PMID:19359144
301 ANXA1 Decreases expression PMID:21852994
3066 HDAC2 Increases expression PMID:16670375
308 ANXA5 Affects expression PMID:21852994
3091 HIF1A Increases expression PMID:37386098
31 ACACA Increases expression PMID:28677866
3113 HLA-DPA1 Affects expression PMID:25811541
3156 HMGCR Increases expression PMID:37386098
3157 HMGCS1 Increases expression PMID:16324787; PMID:37386098
3162 HMOX1 Increases expression PMID:34669537
3223 HOXC6 Affects expression PMID:29893963
3241 HPCAL1 Increases expression PMID:20924750
3249 HPN Increases expression PMID:15342952
3263 HPX Decreases expression PMID:21852994
3280 HES1 Increases expression PMID:19801843
331 XIAP Increases expression PMID:17033635
3350 HTR1A Affects expression PMID:10665824; PMID:21083617
3351 HTR1B Increases expression PMID:10665824; PMID:10861803; PMID:8914125; PMID:20525077
3356 HTR2A Decreases activity PMID:19445393; PMID:20464512
3356 HTR2A Increases expression PMID:21083617
3357 HTR2B Increases activity PMID:11930908; PMID:18758753; PMID:19662385
3357 HTR2B Increases expression PMID:11930908; PMID:19662385; PMID:21083617
3358 HTR2C Affects activity PMID:19662385; PMID:9050900
3358 HTR2C Increases expression PMID:15659601; PMID:21083617
3422 IDI1 Increases expression PMID:37386098
3458 IFNG Affects expression PMID:21497159; PMID:32588356
3481 IGF2 Decreases expression PMID:17033635
3485 IGFBP2 Decreases expression PMID:17033635
3553 IL1B Decreases expression PMID:21966942
3569 IL6 Increases expression PMID:16413968; PMID:34669537
3586 IL10 Decreases expression PMID:32588356
3638 INSIG1 Increases expression PMID:21852994; PMID:37386098
3706 ITPKA Decreases expression PMID:17033635
3725 JUN Decreases expression PMID:17105902; PMID:18836303
3738 KCNA3 Decreases activity PMID:17638537
3741 KCNA5 Increases expression PMID:19298536
3742 KCNA6 Decreases expression PMID:17033635
3752 KCND3 Decreases activity PMID:35550413
3757 KCNH2 Decreases activity PMID:15272206; PMID:16967046; PMID:24052561
3757 KCNH2 Decreases expression PMID:35680041
37657 FATP2 Increases expression PMID:34897744
3776 KCNK2 Decreases activity PMID:23022515
3776 KCNK2 Decreases expression PMID:21069514; PMID:23022515
378938 MALAT1 Increases expression PMID:17033635
379 ARL4D Increases expression PMID:18301726
388394 RPRML Decreases expression PMID:17033635
388585 HES5 Increases expression PMID:17033635; PMID:19801843; PMID:19801843
389058 SP5 Affects expression PMID:29893963
3897 L1CAM Increases expression PMID:16900104
389941 C1QL3 Decreases expression PMID:17033635
4000 LMNA Decreases expression PMID:21852994
4047 LSS Increases expression PMID:15342952; PMID:17567588; PMID:37386098
406 BMAL1 Increases expression PMID:15994025
4131 MAP1B Increases expression PMID:17033635
4152 MBD1 Increases expression PMID:16670375
4160 MC4R Decreases expression PMID:18359080
4189 DNAJB9 Increases expression PMID:21852994
4204 MECP2 Increases expression PMID:16670375
4222 MEOX1 Affects expression PMID:29893963
427 ASAH1 Increases expression PMID:15342952; PMID:17567588
4306 NR3C2 Affects expression PMID:10929085; PMID:10929085; PMID:12393271; PMID:1351783; PMID:11406320
4318 MMP9 Decreases activity PMID:21966942
440 ASNS Increases expression PMID:15342952; PMID:17175557; PMID:17567588
4598 MVK Increases expression PMID:37386098
4684 NCAM1 Increases expression PMID:21852994
4758 NEU1 Increases expression PMID:37386098
4761 NEUROD2 Decreases expression PMID:17033635
4763 NF1 Decreases expression PMID:17105902
4780 NFE2L2 Increases expression PMID:34669537
4792 NFKBIA Increases expression PMID:17033635
4804 NGFR Decreases expression PMID:32588356
4838 NODAL Affects expression PMID:29893963
4843 NOS2 Increases expression PMID:16413968
4851 NOTCH1 Increases expression PMID:19801843
4852 NPY Increases expression PMID:16042082; PMID:20816900; PMID:9729278
4856 CCN3 Decreases expression PMID:17033635
4862 NPAS2 Affects expression PMID:15994025
488 ATP2A2 Increases expression PMID:21852994
4885 NPTX2 Increases expression PMID:18301726
4886 NPY1R Affects expression PMID:9729278
4900 NRGN Decreases expression PMID:17033635
4915 NTRK2 Increases activity PMID:21666748
4915 NTRK2 Increases expression PMID:15456934; PMID:15456934; PMID:8601816
4924 NUCB1 Affects expression PMID:21852994
4929 NR4A2 Decreases expression PMID:20857517
4988 OPRM1 Increases expression PMID:16484055
5015 OTX2 Affects expression PMID:29893963
5020 OXT Decreases expression PMID:17033635
5021 OXTR Increases expression PMID:15380831
5034 P4HB Increases expression PMID:21852994
5077 PAX3 Affects expression PMID:29893963
50814 NSDHL Increases expression PMID:37386098
51083 GAL Increases expression PMID:20816900
51171 HSD17B14 Increases expression PMID:37386098
51272 BET1L Increases expression PMID:20924750
51299 NRN1 Increases expression PMID:18301726
51324 SPG21 Increases expression PMID:37386098
5141 PDE4A Increases expression PMID:12504921
5142 PDE4B Increases expression PMID:12504921; PMID:20222156; PMID:22291481
5144 PDE4D Affects expression PMID:12504921
51478 HSD17B7 Increases expression PMID:37386098
5173 PDYN Decreases expression PMID:14997015; PMID:15936043
5179 PENK Decreases expression PMID:15936043; PMID:9526047
5187 PER1 Decreases expression PMID:15994025
5274 SERPINI1 Increases expression PMID:16637596
5321 PLA2G4A Increases activity PMID:19662385
5321 PLA2G4A Increases expression PMID:19662385
5334 PLCL1 Increases expression PMID:24356939
5339 PLEC Decreases expression PMID:21852994
5367 PMCH Decreases expression PMID:17033635
54207 KCNK10 Decreases activity PMID:23022515
54207 KCNK10 Increases expression PMID:23022515
54407 SLC38A2 Increases expression PMID:37386098
5443 POMC Affects expression PMID:15936043; PMID:16042082; PMID:18359080
5460 POU5F1 Affects expression PMID:29893963
5468 PPARG Affects expression PMID:34669537; PMID:34897744
54800 KLHL24 Increases expression PMID:24356939
54865 GPATCH4 Increases expression PMID:17033635
55062 WIPI1 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
551 AVP Decreases expression PMID:17033635
55213 RCBTB1 Increases expression PMID:37386098
5582 PRKCG Decreases expression PMID:17033635
55902 ACSS2 Increases expression PMID:37386098
5594 MAPK1 Affects expression PMID:15138445; PMID:19662385; PMID:21753012
5594 MAPK1 Increases activity PMID:15456934; PMID:18573488; PMID:18758753; PMID:19662385
5595 MAPK3 Increases activity PMID:15456934; PMID:18573488; PMID:18758753; PMID:19662385
5595 MAPK3 Increases expression PMID:15138445; PMID:19477151; PMID:19662385
5599 MAPK8 Decreases expression PMID:20924750
5617 PRL Increases expression PMID:16848655; PMID:313977; PMID:9098464
5649 RELN Increases expression PMID:19359144
56603 CYP26B1 Decreases expression PMID:17033635
5684 PSMA3 Affects expression PMID:21852994
5692 PSMB4 Decreases expression PMID:21852994
57030 SLC17A7 Affects expression PMID:16111724; PMID:17033635
572 BAD Increases expression PMID:21497159
5730 PTGDS Affects expression PMID:17105902; PMID:34897744
5742 PTGS1 Increases expression PMID:34897744
5743 PTGS2 Affects expression PMID:17033635; PMID:21966942; PMID:21554931; PMID:34897744
581 BAX Increases expression PMID:34669537
5833 PCYT2 Increases expression PMID:37386098
595 CCND1 Affects expression PMID:18573488; PMID:18836303
596 BCL2 Decreases expression PMID:19298536; PMID:21497159; PMID:34669537
5970 RELA Increases activity PMID:16413968
598 BCL2L1 Increases expression PMID:19298536; PMID:21740920; PMID:21852994
5998 RGS3 Increases expression PMID:21852994
60484 HAPLN2 Decreases expression PMID:17033635
627 BDNF Increases expression PMID:12504921; PMID:15381288; PMID:15456934; PMID:16035958; PMID:16887358; PMID:19211973; PMID:21048974; PMID:8601816; PMID:15555640; PMID:18973993; PMID:19775499; PMID:21301813; PMID:21945287; PMID:24125781; PMID:17328894; PMID:18301726; PMID:21301813; PMID:22218094; PMID:24125781; PMID:32588356
6285 S100B Increases expression PMID:12960766; PMID:20857517
6307 MSMO1 Increases expression PMID:37386098
6309 SC5D Increases expression PMID:37386098
6319 SCD Increases expression PMID:16324787; PMID:37386098
63917 GALNT11 Increases expression PMID:37386098
63982 ANO3 Decreases expression PMID:17033635
6430 SRSF5 Affects expression PMID:21852994
6446 SGK1 Increases expression PMID:17033635
64838 FNDC4 Increases expression PMID:15342952; PMID:17175557; PMID:17567588
6490 PMEL Increases expression PMID:37386098
64919 BCL11B Decreases expression PMID:17033635
6515 SLC2A3 Decreases expression PMID:15342952; PMID:17567588
6532 SLC6A4 Decreases activity PMID:16272152; PMID:18561912; PMID:19616025
6532 SLC6A4 Increases expression PMID:15936043; PMID:16982082; PMID:17950541; PMID:21554931; PMID:21740920; PMID:8914125; PMID:16951736; PMID:18496518; PMID:21083617
65983 GRAMD2B Increases expression PMID:17033635
6609 SMPD1 Decreases activity PMID:23770692
6609 SMPD1 Decreases expression PMID:23770692
6647 SOD1 Increases expression PMID:17328894
6657 SOX2 Affects expression PMID:29893963
6713 SQLE Affects expression PMID:21852994; PMID:37386098
6770 STAR Decreases expression PMID:26348076
6781 STC1 Increases expression PMID:17033635
680 BRS3 Decreases expression PMID:21820738
6812 STXBP1 Increases expression PMID:21852994
6853 SYN1 Increases expression PMID:16887358
6855 SYP Affects expression PMID:17950272; PMID:20857517
6876 TAGLN Decreases expression PMID:15342952; PMID:17175557; PMID:17567588
6911 TBX6 Affects expression PMID:29893963
6948 TCN2 Increases expression PMID:37386098
7054 TH Affects expression PMID:1351783; PMID:20626387; PMID:15936043; PMID:20374287; PMID:20857517
7071 KLF10 Increases expression PMID:18301726
7087 ICAM5 Decreases expression PMID:17033635
7124 TNF Decreases activity PMID:17477857
7124 TNF Increases expression PMID:16413968; PMID:21497159; PMID:34669537
7157 TP53 Increases expression PMID:18836303
7166 TPH1 Increases expression PMID:15631896; PMID:21083617
7168 TPM1 Decreases expression PMID:21852994
7252 TSHB Increases expression PMID:17033635
7276 TTR Increases expression PMID:17105902
7422 VEGFA Increases expression PMID:21301813
7425 VGF Increases expression PMID:21301813
7436 VLDLR Increases expression PMID:19359144; PMID:24356939
7466 WFS1 Decreases expression PMID:17033635
7514 XPO1 Affects expression PMID:21852994
7531 YWHAE Affects expression PMID:21852994
7533 YWHAH Affects expression PMID:21852994
7534 YWHAZ Increases expression PMID:15631896
7781 SLC30A3 Decreases expression PMID:17033635
79071 ELOVL6 Increases expression PMID:28677866
79153 GDPD3 Increases expression PMID:17175557; PMID:17567588
79646 PANK3 Increases expression PMID:37386098
79923 NANOG Affects expression PMID:29893963
8013 NR4A3 Decreases expression PMID:17033635
80339 PNPLA3 Increases expression PMID:37386098
8125 ANP32A Decreases expression PMID:17033635
814 CAMK4 Decreases expression PMID:17033635
814 CAMK4 Increases activity PMID:15138445
834 CASP1 Increases expression PMID:28677866
836 CASP3 Increases activity PMID:19135049; PMID:34669537; PMID:22700542; PMID:28482088
83729 INHBE Increases expression PMID:15342952; PMID:17175557; PMID:17567588
83881 MIXL1 Affects expression PMID:29893963
840 CASP7 Increases activity PMID:22700542
841 CASP8 Increases activity PMID:28482088
84109 QRFPR Decreases expression PMID:21820738
84152 PPP1R1B Increases expression PMID:11880651
842 CASP9 Increases activity PMID:28482088
8431 NR0B2 Increases expression PMID:15342952; PMID:17175557
84667 HES7 Affects expression PMID:29893963
847 CAT Decreases activity PMID:26348076; PMID:34669537
847 CAT Increases expression PMID:17328894
85315 PAQR8 Increases expression PMID:17033635
85465 SELENOI Increases expression PMID:37386098
8622 PDE8B Increases expression PMID:22291481
8678 BECN1 Increases expression PMID:20503272
8694 DGAT1 Increases expression PMID:28677866
8714 ABCC3 Decreases activity PMID:39023798
885 CCK Decreases expression PMID:17033635; PMID:17105902
8864 PER2 Affects expression PMID:15994025
8878 SQSTM1 Decreases expression PMID:17105902
890 CCNA2 Decreases expression PMID:18371935
891 CCNB1 Decreases expression PMID:21497159
8912 CACNA1H Decreases expression PMID:17033635
8913 CACNA1G Affects expression PMID:21852994
8934 RAB29 Increases expression PMID:37386098
896 CCND3 Decreases expression PMID:21497159
89780 WNT3A Affects expression PMID:29893963
898 CCNE1 Decreases expression PMID:18371935; PMID:21497159
901 CCNG2 Increases expression PMID:24356939
90809 PIP4P1 Increases expression PMID:37386098
91373 UAP1L1 Increases expression PMID:37386098
91694 LONRF1 Increases expression PMID:37386098
9201 DCLK1 Increases expression PMID:18301726
925 CD8A Increases expression PMID:21497159
9313 MMP20 Decreases expression PMID:21083617
9317 PTER Decreases expression PMID:17033635
9415 FADS2 Increases expression PMID:37386098
9456 HOMER1 Decreases expression PMID:17033635
948 CD36 Increases expression PMID:34897744
9575 CLOCK Increases expression PMID:15994025
9607 CARTPT Decreases expression PMID:21167239
96459 FNIP1 Increases expression PMID:37386098
9650 MTFR1 Increases expression PMID:37386098

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.