Fluoxetine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:26746107
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34669537
GO:0003006 Developmental process involved in reproduction Decreases phenotype PMID:26746107
GO:0006120 Mitochondrial electron transport, nadh to ubiquinone Decreases phenotype PMID:28482088
GO:0006122 Mitochondrial electron transport, ubiquinol to cytochrome c Decreases phenotype PMID:28482088
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:19135049
GO:0006629 Lipid metabolic process Affects phenotype PMID:37386098
GO:0006749 Glutathione metabolic process Affects phenotype PMID:26348076; PMID:30529211; PMID:33279466; PMID:34669537
GO:0006801 Superoxide metabolic process Decreases phenotype PMID:34669537
GO:0006805 Xenobiotic metabolic process Decreases phenotype PMID:30545405
GO:0006855 Xenobiotic transmembrane transport Decreases phenotype PMID:34610281
GO:0006914 Autophagy Increases phenotype PMID:20503272
GO:0006915 Apoptotic process Increases phenotype PMID:20503272; PMID:31332895
GO:0006950 Response to stress Affects phenotype PMID:24867331; PMID:24952232
GO:0006979 Response to oxidative stress Increases phenotype PMID:19135049
GO:0007200 Phospholipase c-activating g protein-coupled receptor signaling pathway Decreases phenotype PMID:21712787
GO:0007283 Spermatogenesis Decreases phenotype PMID:26348076
GO:0007610 Behavior Affects phenotype PMID:24867331; PMID:29291430
GO:0008217 Regulation of blood pressure Increases phenotype PMID:9950882
GO:0008219 Cell death Increases phenotype PMID:16753142; PMID:19135049; PMID:23770692
GO:0008283 Cell population proliferation Decreases phenotype PMID:14567288; PMID:19914299; PMID:24952232
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:26116029
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29893963
GO:0008343 Adult feeding behavior Increases phenotype PMID:26348076
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:33179799
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26162595
GO:0016042 Lipid catabolic process Affects phenotype PMID:33279466
GO:0022008 Neurogenesis Increases phenotype PMID:23770692
GO:0030073 Insulin secretion Decreases phenotype PMID:28482088
GO:0030182 Neuron differentiation Decreases phenotype PMID:24952232
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:33279466
GO:0033555 Multicellular organismal response to stress Decreases phenotype PMID:29291430
GO:0034440 Lipid oxidation Increases phenotype PMID:26348076
GO:0035176 Social behavior Decreases phenotype PMID:29291430
GO:0035482 Gastric motility Decreases phenotype PMID:31614129
GO:0036269 Swimming behavior Increases phenotype PMID:26348076; PMID:31614129; PMID:32707044
GO:0036276 Response to antidepressant Increases phenotype PMID:29107002
GO:0036343 Psychomotor behavior Decreases phenotype PMID:26454213
GO:0040018 Positive regulation of multicellular organism growth Affects phenotype PMID:26348076; PMID:26454213
GO:0042310 Vasoconstriction Increases phenotype PMID:27079619
GO:0042391 Regulation of membrane potential Affects phenotype PMID:9950882
GO:0042415 Norepinephrine metabolic process Affects phenotype PMID:33279466
GO:0042417 Dopamine metabolic process Affects phenotype PMID:33279466
GO:0042428 Serotonin metabolic process Affects phenotype PMID:26348076; PMID:26746107; PMID:33279466
GO:0042551 Neuron maturation Increases phenotype PMID:23770692
GO:0043124 Negative regulation of i-kappab kinase/nf-kappab signaling Decreases phenotype PMID:26454213
GO:0043966 Histone h3 acetylation Increases phenotype PMID:28677866
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30529211
GO:0045595 Regulation of cell differentiation Affects phenotype PMID:29893963
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29679653
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:30529211
GO:0046622 Positive regulation of organ growth Decreases phenotype PMID:29291430
GO:0048598 Embryonic morphogenesis Decreases phenotype PMID:29893963
GO:0051610 Serotonin uptake Decreases phenotype PMID:26746107
GO:0051613 Positive regulation of serotonin uptake Increases phenotype PMID:26116029
GO:0055088 Lipid homeostasis Affects phenotype PMID:34897744
GO:0060080 Inhibitory postsynaptic potential Decreases phenotype PMID:19014464
GO:0060279 Positive regulation of ovulation Decreases phenotype PMID:26746107
GO:0060281 Regulation of oocyte development Decreases phenotype PMID:26746107
GO:0070372 Regulation of erk1 and erk2 cascade Affects phenotype PMID:24125781
GO:0070633 Transepithelial transport Decreases phenotype PMID:34610281
GO:0070989 Oxidative demethylation Increases phenotype PMID:16595712
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34669537
GO:0070997 Neuron death Affects phenotype PMID:23770692
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:30529211
GO:0090090 Negative regulation of canonical wnt signaling pathway Increases phenotype PMID:29893963
GO:0099610 Action potential initiation Decreases phenotype PMID:36375636
GO:0120054 Intestinal motility Decreases phenotype PMID:31614129
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:26348076
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:26348076
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:26921665
GO:1904078 Positive regulation of estrogen biosynthetic process Increases phenotype PMID:29151792
GO:1990911 Response to psychosocial stress Decreases phenotype PMID:26454213
GO:2000386 Positive regulation of ovarian follicle development Increases phenotype PMID:26746107
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:26162595; PMID:26348076
GO:2000853 Negative regulation of corticosterone secretion Decreases phenotype PMID:24125781; PMID:29291430
GO:2000854 Positive regulation of corticosterone secretion Decreases phenotype PMID:26348076
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:26162595; PMID:26746107
GO:2000872 Positive regulation of progesterone secretion Decreases phenotype PMID:26162595
GO:2001025 Positive regulation of response to drug Increases phenotype PMID:29291430
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:26921665
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.