Isoniazid


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
10 NAT2 Decreases expression PMID:28619387
10063 COX17 Affects expression PMID:24848797
10130 PDIA6 Increases expression PMID:40015660
10134 BCAP31 Increases expression PMID:40015660
10162 LPCAT3 Increases expression PMID:40015660
10165 SLC25A13 Decreases expression PMID:40015660
10257 ABCC4 Decreases expression PMID:32673658
10314 LANCL1 Decreases expression PMID:40015660
10327 AKR1A1 Increases expression PMID:40015660
10427 SEC24B Decreases expression PMID:40015660
10449 ACAA2 Increases expression PMID:40015660
10476 ATP5PD Increases expression PMID:40015660
1050 CEBPA Decreases expression PMID:24128855
1051 CEBPB Decreases expression PMID:24128855
1052 CEBPD Decreases expression PMID:24128855
10525 HYOU1 Increases expression PMID:40015660
10587 TXNRD2 Affects expression PMID:24848797
10599 SLCO1B1 Decreases expression PMID:32673658
10632 ATP5MG Increases expression PMID:40015660
10728 PTGES3 Decreases expression PMID:40015660
10808 HSPH1 Increases expression PMID:40015660
10841 FTCD Decreases expression PMID:40015660
10857 PGRMC1 Increases expression PMID:40015660
10891 PPARGC1A Decreases expression PMID:28556920
10960 LMAN2 Increases expression PMID:40015660
10961 ERP29 Increases expression PMID:40015660
10963 STIP1 Increases expression PMID:40015660
10970 CKAP4 Increases expression PMID:40015660
11009 IL24 Increases expression PMID:32816093
11067 DEPP1 Increases expression PMID:17175557
1109 AKR1C4 Decreases expression PMID:40015660
11231 SEC63 Decreases expression PMID:40015660
11315 PARK7 Affects expression PMID:24848797
116519 APOA5 Decreases expression PMID:28619387
122867 COX4I1P1 Decreases expression PMID:40015660
1244 ABCC2 Decreases expression PMID:32673658
127 ADH4 Decreases expression PMID:40015660
128 ADH5 Decreases expression PMID:40015660
130 ADH6 Decreases expression PMID:40015660
1329 COX5B Decreases expression PMID:24848797; PMID:40015660
1337 COX6A1 Affects expression PMID:24848797
1340 COX6B1 Decreases expression PMID:24848797; PMID:40015660
1347 COX7A2 Decreases expression PMID:24848797; PMID:40015660
1350 COX7C Decreases expression PMID:40015660
1353 COX11 Affects expression PMID:24848797
1356 CP Increases expression PMID:40015660
1374 CPT1A Increases expression PMID:24848797; PMID:40015660
1376 CPT2 Affects expression PMID:40015660
140809 SRXN1 Increases expression PMID:28444390
1431 CS Increases expression PMID:40015660
1491 CTH Decreases expression PMID:40015660
1528 CYB5A Decreases expression PMID:28619387
1558 CYP2C8 Decreases activity PMID:15304522
1571 CYP2E1 Affects activity PMID:12458634; PMID:15132840; PMID:15205388; PMID:19683030; PMID:23211455; PMID:25683034; PMID:26880746; PMID:9051121; PMID:9129171; PMID:18754103; PMID:39047805
1571 CYP2E1 Increases expression PMID:11752103; PMID:25683034; PMID:15205388; PMID:15763544; PMID:24929095; PMID:3113478; PMID:9065729; PMID:18754103; PMID:22342832; PMID:8074729
1576 CYP3A4 Decreases activity PMID:15005856; PMID:15304522
1581 CYP7A1 Increases expression PMID:25331106; PMID:32673658
1593 CYP27A1 Increases expression PMID:32673658
1646 AKR1C2 Affects expression PMID:40015660
1647 GADD45A Decreases expression PMID:20623750
1649 DDIT3 Affects expression PMID:12883083; PMID:30008028
1728 NQO1 Affects expression PMID:24128855; PMID:28444390; PMID:40015660; PMID:33121995; PMID:33771660; PMID:40015660
1737 DLAT Increases expression PMID:40015660
1738 DLD Affects expression PMID:40015660
174 AFP Decreases expression PMID:30008028
1743 DLST Increases expression PMID:40015660
1786 DNMT1 Decreases expression PMID:40015660
17992 NDUFA4 Affects expression PMID:24848797
1892 ECHS1 Increases expression PMID:40015660
191 AHCY Decreases expression PMID:40015660
1962 EHHADH Decreases expression PMID:40015660
197322 ACSF3 Increases expression PMID:40015660
2 A2M Increases expression PMID:12883083
201595 STT3B Increases expression PMID:40015660
2052 EPHX1 Increases expression PMID:40015660
2053 EPHX2 Increases expression PMID:40015660
211 ALAS1 Increases expression PMID:27438535; PMID:30517741
217 ALDH2 Decreases expression PMID:40015660
2180 ACSL1 Affects expression PMID:40015660
2181 ACSL3 Increases expression PMID:40015660
2182 ACSL4 Decreases expression PMID:40015660
219 ALDH1B1 Increases expression PMID:40015660
2194 FASN Decreases expression PMID:40015660
223 ALDH9A1 Increases expression PMID:40015660
2235 FECH Decreases expression PMID:27438535; PMID:30517741
22824 HSPA4L Increases expression PMID:40015660
22872 SEC31A Decreases expression PMID:40015660
22906 TRAK1 Affects expression PMID:24848797
23193 GANAB Increases expression PMID:40015660
23204 ARL6IP1 Decreases expression PMID:40015660
23234 DNAJC9 Decreases expression PMID:40015660
23411 SIRT1 Decreases expression PMID:28556920; PMID:31332904
23471 TRAM1 Decreases expression PMID:40015660
23480 SEC61G Decreases expression PMID:40015660
23516 SLC39A14 Decreases expression PMID:40015660
23640 HSPBP1 Decreases expression PMID:40015660
23657 SLC7A11 Increases expression PMID:40015660
249 ALPL Increases activity PMID:25886055
2539 G6PD Decreases activity PMID:20433247
2539 G6PD Increases expression PMID:40015660
25642 CYP3A23-3A1 Increases activity PMID:26880746
25642 CYP3A23-3A1 Increases expression PMID:12883083
25828 TXN2 Affects expression PMID:24848797
2597 GAPDH Increases expression PMID:12883083
26227 PHGDH Decreases expression PMID:40015660
26232 FBXO2 Decreases expression PMID:40015660
26471 NUPR1 Increases expression PMID:17175557
2670 GFAP Increases expression PMID:33121995
26762 HAVCR1 Affects expression PMID:20623750
2686 GGT7 Increases expression PMID:40015660
26873 OPLAH Decreases expression PMID:40015660
27109 DMAC2L Increases expression PMID:40015660
27248 ERLEC1 Increases expression PMID:40015660
2729 GCLC Affects expression PMID:24128855; PMID:33121995; PMID:33771660; PMID:40015660
2730 GCLM Affects expression PMID:30008028; PMID:33121995; PMID:33771660
2739 GLO1 Increases expression PMID:40015660
27430 MAT2B Decreases expression PMID:40015660
2805 GOT1 Increases activity PMID:25886055
2805 GOT1 Increases expression PMID:40015660
2806 GOT2 Increases expression PMID:40015660
2810 SFN Decreases expression PMID:30008028
2875 GPT Increases activity PMID:25886055; PMID:28619387
2875 GPT Increases expression PMID:31332904
2876 GPX1 Affects expression PMID:40015660
2885 GRB2 Increases expression PMID:40015660
290 ANPEP Decreases expression PMID:40015660
291 SLC25A4 Increases expression PMID:40015660
292 SLC25A5 Increases expression PMID:40015660
2923 PDIA3 Increases expression PMID:40015660
293 SLC25A6 Decreases expression PMID:40015660
2936 GSR Increases expression PMID:40015660
2937 GSS Decreases expression PMID:40015660
2938 GSTA1 Decreases expression PMID:40015660
2939 GSTA2 Increases expression PMID:12883083
2947 GSTM3 Increases expression PMID:40015660
2950 GSTP1 Decreases expression PMID:20623750
29957 SLC25A24 Increases expression PMID:40015660
29968 PSAT1 Decreases expression PMID:40015660
29979 UBQLN1 Increases expression PMID:40015660
30 ACAA1 Decreases expression PMID:40015660
30001 ERO1A Increases expression PMID:40015660
3030 HADHA Affects expression PMID:40015660
3032 HADHB Affects expression PMID:40015660
3033 HADH Increases expression PMID:40015660
31 ACACA Decreases expression PMID:40015660
3162 HMOX1 Affects expression PMID:24128855; PMID:33121995; PMID:33771660; PMID:40015660
3163 HMOX2 Increases expression PMID:12883083
3251 HPRT1 Increases expression PMID:12883083
3295 HSD17B4 Increases expression PMID:40015660
3301 DNAJA1 Decreases expression PMID:40015660
3304 HSPA1B Increases expression PMID:40015660
3309 HSPA5 Decreases expression PMID:40015660
3312 HSPA8 Decreases expression PMID:40015660
3320 HSP90AA1 Decreases expression PMID:40015660
3326 HSP90AB1 Decreases expression PMID:40015660
338 APOB Decreases expression PMID:40015660
34 ACADM Decreases expression PMID:40015660
3418 IDH2 Increases expression PMID:40015660
3419 IDH3A Increases expression PMID:40015660
3421 IDH3G Affects expression PMID:40015660
35 ACADS Affects expression PMID:40015660
351 APP Increases expression PMID:30008028
35279 COX4 Decreases expression PMID:28556920
3552 IL1A Increases expression PMID:32816093
3553 IL1B Increases expression PMID:32816093; PMID:33121995
3569 IL6 Increases expression PMID:19575532; PMID:33121995
36 ACADSB Decreases expression PMID:40015660
368 ABCC6 Decreases expression PMID:16260000
37 ACADVL Affects expression PMID:40015660
3703 STT3A Increases expression PMID:40015660
3710 ITPR3 Increases expression PMID:40015660
373156 GSTK1 Affects expression PMID:40015660
374291 NDUFS7 Decreases expression PMID:40015660
374383 NCR3LG1 Increases expression PMID:32060585
39 ACAT2 Decreases expression PMID:40015660
390243 IZUMO1R Decreases expression PMID:33771660
3934 LCN2 Increases expression PMID:20623750
3939 LDHA Decreases expression PMID:40015660
3998 LMAN1 Increases expression PMID:40015660
4043 LRPAP1 Increases expression PMID:40015660
4121 MAN1A1 Decreases expression PMID:40015660
4133 MAP2 Affects expression PMID:22131109
4143 MAT1A Decreases expression PMID:40015660
4144 MAT2A Decreases expression PMID:40015660
4190 MDH1 Increases expression PMID:40015660
4191 MDH2 Increases expression PMID:40015660
4257 MGST1 Increases expression PMID:33771660; PMID:40015660
4258 MGST2 Increases expression PMID:40015660
435 ASL Increases activity PMID:28619387
4363 ABCC1 Increases expression PMID:11752103
4507 MTAP Increases expression PMID:40015660
4508 ATP6 Increases expression PMID:40015660
4513 COX2 Affects expression PMID:40015660
4514 COX3 Increases expression PMID:12883083
4519 CYTB Increases expression PMID:40015660
4537 ND3 Affects expression PMID:40015660
4582 MUC1 Increases expression PMID:30008028
4642 MYO1D Increases expression PMID:40015660
468 ATF4 Decreases expression PMID:40015660
4694 NDUFA1 Affects expression PMID:24848797
4695 NDUFA2 Decreases expression PMID:40015660
4697 COXFA4 Decreases expression PMID:40015660
4698 NDUFA5 Decreases expression PMID:24848797; PMID:40015660
47 ACLY Decreases expression PMID:40015660
4702 NDUFA8 Affects expression PMID:24848797
4704 NDUFA9 Decreases expression PMID:24848797; PMID:40015660
4705 NDUFA10 Affects expression PMID:24848797
4706 NDUFAB1 Increases expression PMID:24848797; PMID:40015660
4707 NDUFB1 Decreases expression PMID:40015660
4708 NDUFB2 Affects expression PMID:24848797
4709 NDUFB3 Decreases expression PMID:24848797; PMID:40015660
4711 NDUFB5 Affects expression PMID:24848797
4712 NDUFB6 Affects expression PMID:24848797
4713 NDUFB7 Decreases expression PMID:24848797; PMID:40015660
4715 NDUFB9 Decreases expression PMID:40015660
4716 NDUFB10 Affects expression PMID:24848797
4719 NDUFS1 Decreases expression PMID:24848797; PMID:40015660
4720 NDUFS2 Decreases expression PMID:24848797; PMID:40015660
4722 NDUFS3 Decreases expression PMID:24848797; PMID:40015660
4723 NDUFV1 Decreases expression PMID:24848797; PMID:40015660
4724 NDUFS4 Decreases expression PMID:24848797; PMID:40015660
4725 NDUFS5 Decreases expression PMID:40015660
4726 NDUFS6 Decreases expression PMID:40015660
4728 NDUFS8 Decreases expression PMID:24848797; PMID:40015660
4729 NDUFV2 Decreases expression PMID:24848797; PMID:40015660
4780 NFE2L2 Increases activity PMID:30203046
4780 NFE2L2 Increases expression PMID:33121995; PMID:33771660; PMID:40015660
4790 NFKB1 Increases expression PMID:33121995
48 ACO1 Affects expression PMID:40015660
481 ATP1B1 Increases expression PMID:30008028
4891 SLC11A2 Increases expression PMID:40015660
4893 NRAS Increases expression PMID:40015660
4899 NRF1 Decreases expression PMID:28556920
4967 OGDH Increases expression PMID:24848797; PMID:40015660
498 ATP5F1A Affects expression PMID:40015660
501 ALDH7A1 Increases expression PMID:40015660
5034 P4HB Increases expression PMID:40015660
50484 RRM2B Increases expression PMID:40015660
506 ATP5F1B Increases expression PMID:24848797; PMID:40015660
509 ATP5F1C Increases expression PMID:40015660
5091 PC Increases expression PMID:40015660
5093 PCBP1 Decreases expression PMID:40015660
5094 PCBP2 Decreases expression PMID:40015660
51 ACOX1 Decreases expression PMID:40015660
51035 UBXN1 Decreases expression PMID:40015660
51056 LAP3 Increases expression PMID:40015660
5106 PCK2 Decreases expression PMID:40015660
51060 TXNDC12 Increases expression PMID:40015660
51079 NDUFA13 Decreases expression PMID:24848797; PMID:40015660
51102 MECR Increases expression PMID:40015660
51144 HSD17B12 Increases expression PMID:40015660
51382 ATP6V1D Increases expression PMID:40015660
51495 HACD3 Increases expression PMID:40015660
515 ATP5PB Increases expression PMID:24848797; PMID:40015660
51552 RAB14 Increases expression PMID:40015660
516 ATP5MC1 Affects expression PMID:24848797
5160 PDHA1 Increases expression PMID:40015660
51606 ATP6V1H Affects expression PMID:40015660
5162 PDHB Increases expression PMID:40015660
51703 ACSL5 Increases expression PMID:40015660
51726 DNAJB11 Increases expression PMID:40015660
518 ATP5MC3 Affects expression PMID:24848797
52 ACP1 Increases expression PMID:40015660
522 ATP5PF Increases expression PMID:24848797; PMID:40015660
523 ATP6V1A Affects expression PMID:40015660
526 ATP6V1B2 Affects expression PMID:40015660
529 ATP6V1E1 Increases expression PMID:40015660
5313 PKLR Decreases expression PMID:40015660
5315 PKM Increases expression PMID:40015660
5337 PLD1 Increases expression PMID:40015660
535 ATP6V0A1 Increases expression PMID:40015660
5351 PLOD1 Decreases expression PMID:40015660
5352 PLOD2 Increases expression PMID:15997088; PMID:40015660
537 ATP6AP1 Increases expression PMID:40015660
539 ATP5PO Increases expression PMID:40015660
54205 CYCS Decreases expression PMID:40015660
54431 DNAJC10 Increases expression PMID:40015660
5447 POR Decreases expression PMID:28619387
5464 PPA1 Decreases expression PMID:40015660
5465 PPARA Increases activity PMID:30203046
54658 UGT1A1 Increases expression PMID:40015660
5468 PPARG Decreases expression PMID:24128855
5479 PPIB Increases expression PMID:40015660
54898 ELOVL2 Decreases expression PMID:40015660
55022 PID1 Increases expression PMID:32816093
55240 STEAP3 Decreases expression PMID:40015660
55256 ADI1 Decreases expression PMID:40015660
5536 PPP5C Increases expression PMID:40015660
5538 PPT1 Increases expression PMID:40015660
55666 NPLOC4 Decreases expression PMID:40015660
55757 UGGT2 Increases expression PMID:40015660
5589 PRKCSH Increases expression PMID:40015660
5595 MAPK3 Decreases expression PMID:40015660
55967 NDUFA12 Decreases expression PMID:24848797; PMID:40015660
5601 MAPK9 Increases expression PMID:40015660
5605 MAP2K2 Decreases expression PMID:40015660
5609 MAP2K7 Decreases expression PMID:40015660
5611 DNAJC3 Increases expression PMID:40015660
5663 PSEN1 Affects expression PMID:24848797
56681 SAR1A Increases expression PMID:40015660
56886 UGGT1 Increases expression PMID:40015660
56894 AGPAT3 Increases expression PMID:28619387
56984 PSMG2 Increases expression PMID:40015660
57003 CCDC47 Decreases expression PMID:40015660
57016 AKR1B10 Increases expression PMID:28444390
5743 PTGS2 Increases expression PMID:32816093
5770 PTPN1 Increases expression PMID:40015660
57761 TRIB3 Increases expression PMID:30008028
5781 PTPN11 Increases expression PMID:40015660
581 BAX Increases expression PMID:20433247; PMID:31332904; PMID:40015660; PMID:33121995; PMID:33771660; PMID:40015660
58478 ENOPH1 Increases expression PMID:40015660
5887 RAD23B Decreases expression PMID:40015660
59272 ACE2 Decreases expression PMID:32808185
596 BCL2 Decreases expression PMID:20433247; PMID:31332904; PMID:40015660; PMID:33771660
6124 RPL4 Decreases expression PMID:40015660
6128 RPL6 Decreases expression PMID:40015660
6134 RPL10 Decreases expression PMID:40015660
6141 RPL18 Decreases expression PMID:40015660
6155 RPL27 Decreases expression PMID:40015660
6184 RPN1 Increases expression PMID:40015660
6227 RPS21 Decreases expression PMID:40015660
6228 RPS23 Decreases expression PMID:40015660
6231 RPS26 Decreases expression PMID:40015660
6234 RPS28 Decreases expression PMID:40015660
6235 RPS29 Decreases expression PMID:40015660
6238 RRBP1 Decreases expression PMID:40015660
6240 RRM1 Decreases expression PMID:40015660
6241 RRM2 Decreases expression PMID:40015660
6319 SCD Decreases expression PMID:40015660
6342 SCP2 Increases expression PMID:40015660
635 BHMT Increases expression PMID:40015660
6388 SDF2 Increases expression PMID:40015660
6389 SDHA Increases expression PMID:24848797; PMID:40015660
6390 SDHB Decreases expression PMID:24848797; PMID:40015660
6391 SDHC Affects expression PMID:40015660
6392 SDHD Affects expression PMID:24848797
6400 SEL1L Increases expression PMID:40015660
64374 SIL1 Decreases expression PMID:40015660
64834 ELOVL1 Increases expression PMID:40015660
6500 SKP1 Decreases expression PMID:40015660
6520 SLC3A2 Decreases expression PMID:40015660
6554 SLC10A1 Decreases expression PMID:25886055; PMID:32673658
6556 SLC11A1 Affects expression PMID:20623750
6576 SLC25A1 Affects expression PMID:40015660
6590 SLPI Increases expression PMID:32816093
6611 SMS Increases expression PMID:40015660
6647 SOD1 Increases expression PMID:33771660
6648 SOD2 Increases expression PMID:24848797; PMID:40015660
6652 SORD Increases expression PMID:7401618
6696 SPP1 Decreases expression PMID:20623750; PMID:30008028
6714 SRC Increases expression PMID:40015660
6723 SRM Decreases expression PMID:40015660
6734 SRPRA Decreases expression PMID:40015660
6748 SSR4 Increases expression PMID:40015660
6780 STAU1 Decreases expression PMID:40015660
6834 SURF1 Affects expression PMID:24848797
7018 TF Affects expression PMID:12883083; PMID:40015660
7037 TFRC Increases expression PMID:40015660
7113 TMPRSS2 Affects expression PMID:32808185
7124 TNF Increases expression PMID:28619387; PMID:33121995
7173 TPO Decreases activity PMID:26884060
7184 HSP90B1 Increases expression PMID:40015660
7263 TST Increases expression PMID:40015660
729230 CCR2 Decreases expression PMID:20623750
7296 TXNRD1 Increases expression PMID:28444390
7317 UBA1 Increases expression PMID:40015660
7381 UQCRB Affects expression PMID:24848797
7385 UQCRC2 Affects expression PMID:24848797
7386 UQCRFS1 Decreases expression PMID:40015660
7388 UQCRH Increases expression PMID:40015660
7415 VCP Increases expression PMID:40015660
7416 VDAC1 Increases expression PMID:40015660
7417 VDAC2 Increases expression PMID:40015660
7419 VDAC3 Increases expression PMID:40015660
7448 VTN Increases expression PMID:40015660
746 TMEM258 Increases expression PMID:40015660
7466 WFS1 Increases expression PMID:40015660
7841 MOGS Increases expression PMID:40015660
79139 DERL1 Increases expression PMID:40015660
811 CALR Affects expression PMID:40015660
8140 SLC7A5 Decreases expression PMID:30008028
81502 HM13 Decreases expression PMID:40015660
81567 TXNDC5 Increases expression PMID:40015660
821 CANX Affects expression PMID:40015660
824 CAPN2 Increases expression PMID:40015660
836 CASP3 Increases activity PMID:20433247
836 CASP3 Increases expression PMID:33771660
83729 INHBE Increases expression PMID:17175557
842 CASP9 Increases activity PMID:20433247
8424 BBOX1 Increases expression PMID:30008028
84245 MRI1 Decreases expression PMID:40015660
8431 NR0B2 Decreases expression PMID:32673658
84447 SYVN1 Increases expression PMID:40015660
84532 ACSS1 Increases expression PMID:40015660
846 CASR Affects expression PMID:20623750
847 CAT Decreases activity PMID:20433247; PMID:33121995; PMID:33771660
847 CAT Decreases expression PMID:40015660
8607 RUVBL1 Increases expression PMID:40015660
8624 PSMG1 Decreases expression PMID:40015660
8644 AKR1C3 Increases expression PMID:40015660
8647 ABCB11 Decreases expression PMID:25886055; PMID:32673658
8714 ABCC3 Decreases expression PMID:32673658
873 CBR1 Increases expression PMID:40015660
8801 SUCLG2 Increases expression PMID:40015660
8802 SUCLG1 Increases expression PMID:40015660
8803 SUCLA2 Increases expression PMID:40015660
8985 PLOD3 Increases expression PMID:40015660
9075 CLDN2 Increases expression PMID:30008028
9114 ATP6V0D1 Increases expression PMID:40015660
9296 ATP6V1F Increases expression PMID:40015660
9380 GRHPR Increases expression PMID:40015660
9446 GSTO1 Increases expression PMID:40015660
9532 BAG2 Increases expression PMID:40015660
9550 ATP6V1G1 Increases expression PMID:40015660
9551 ATP5MF Increases expression PMID:40015660
9588 PRDX6 Decreases expression PMID:40015660
9601 PDIA4 Affects expression PMID:40015660
9817 KEAP1 Decreases expression PMID:33771660
9970 NR1I3 Increases activity PMID:30203046
9971 NR1H4 Decreases expression PMID:32673658
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.