Isoniazid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000212 Meiotic spindle organization Decreases phenotype PMID:33771660
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:20433247
GO:0001824 Blastocyst development Decreases phenotype PMID:33771660
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:20433247
GO:0002253 Activation of immune response Increases phenotype PMID:27933861
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28619387
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:25331106; PMID:28619387
GO:0004364 Glutathione transferase activity Increases phenotype PMID:25683034; PMID:33771660
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:33121995; PMID:33771660
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:20433247; PMID:27919644; PMID:33121995; PMID:33771660; PMID:36878459
GO:0005739 Mitochondrion Increases phenotype PMID:40015660
GO:0006101 Citrate metabolic process Affects phenotype PMID:40015660
GO:0006163 Purine nucleotide metabolic process Affects phenotype PMID:40015660
GO:0006213 Pyrimidine nucleoside metabolic process Affects phenotype PMID:40015660
GO:0006259 Dna metabolic process Increases phenotype PMID:24929095
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:17519118
GO:0006518 Peptide metabolic process Affects phenotype PMID:40015660
GO:0006520 Amino acid metabolic process Affects phenotype PMID:40015660
GO:0006600 Creatine metabolic process Affects phenotype PMID:40015660
GO:0006629 Lipid metabolic process Affects phenotype PMID:35156134
GO:0006695 Cholesterol biosynthetic process Affects phenotype PMID:25331106; PMID:28619387
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33121995; PMID:33771660; PMID:36878459; PMID:40015660
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:27919644; PMID:30426164; PMID:31332904
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:28556920; PMID:29407385
GO:0006769 Nicotinamide metabolic process Affects phenotype PMID:40015660
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:40015660
GO:0006915 Apoptotic process Increases phenotype PMID:17519118; PMID:31332904; PMID:31332904; PMID:33771660
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25683034; PMID:27919644; PMID:33771660
GO:0006979 Response to oxidative stress Increases phenotype PMID:17519118
GO:0007005 Mitochondrion organization Decreases phenotype PMID:33771660; PMID:40015660
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:28762043
GO:0007283 Spermatogenesis Decreases phenotype PMID:27919644
GO:0008206 Bile acid metabolic process Increases phenotype PMID:32673658; PMID:35835356
GO:0008219 Cell death Increases phenotype PMID:24519941
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:32673658
GO:0008610 Lipid biosynthetic process Affects phenotype PMID:28619387
GO:0008654 Phospholipid biosynthetic process Affects phenotype PMID:28619387
GO:0009308 Amine metabolic process Affects phenotype PMID:40015660
GO:0009437 Carnitine metabolic process Affects phenotype PMID:40015660
GO:0009566 Fertilization Decreases phenotype PMID:33771660
GO:0010694 Positive regulation of alkaline phosphatase activity Increases phenotype PMID:25886055
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:27461009
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28762043
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:25886055
GO:0010942 Positive regulation of cell death Increases phenotype PMID:22354161; PMID:24929095; PMID:26708503; PMID:28762043
GO:0015723 Bilirubin transport Increases phenotype PMID:25886055
GO:0016042 Lipid catabolic process Increases phenotype PMID:27919644; PMID:33121995; PMID:33771660
GO:0016049 Cell growth Affects phenotype PMID:30426164
GO:0016999 Antibiotic metabolic process Increases phenotype PMID:32673658
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:27461009
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:28619387
GO:0019530 Taurine metabolic process Affects phenotype PMID:40015660
GO:0019674 Nad metabolic process Affects phenotype PMID:27461009
GO:0019695 Choline metabolic process Affects phenotype PMID:40015660
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:40015660
GO:0019858 Cytosine metabolic process Affects phenotype PMID:40015660
GO:0019860 Uracil metabolic process Affects phenotype PMID:40015660
GO:0030258 Lipid modification Affects phenotype PMID:40015660
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:28762043
GO:0034440 Lipid oxidation Increases phenotype PMID:36878459
GO:0042104 Positive regulation of activated t cell proliferation Increases phenotype PMID:27933861
GO:0042178 Xenobiotic catabolic process Increases phenotype PMID:9929512
GO:0042267 Natural killer cell mediated cytotoxicity Increases phenotype PMID:32060585
GO:0042278 Purine nucleoside metabolic process Affects phenotype PMID:40015660
GO:0042554 Superoxide anion generation Affects phenotype PMID:20433247; PMID:30426164
GO:0042816 Vitamin b6 metabolic process Increases phenotype PMID:32673658
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28762043; PMID:32673658
GO:0043372 Positive regulation of cd4-positive, alpha-beta t cell differentiation Increases phenotype PMID:27933861
GO:0043378 Positive regulation of cd8-positive, alpha-beta t cell differentiation Increases phenotype PMID:27933861
GO:0044237 Cellular metabolic process Decreases phenotype PMID:20433247; PMID:31332904; PMID:40015660; PMID:31332904; PMID:35156134; PMID:35835356; PMID:36878459; PMID:40015660
GO:0045333 Cellular respiration Decreases phenotype PMID:40015660
GO:0045444 Fat cell differentiation Decreases phenotype PMID:24128855
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:32673658
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:27919644
GO:0046034 Atp metabolic process Affects phenotype PMID:40015660
GO:0046083 Adenine metabolic process Affects phenotype PMID:40015660
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:19471772; PMID:21189914
GO:0046501 Protoporphyrinogen ix metabolic process Affects phenotype PMID:27438535
GO:0047810 D-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:25886055
GO:0051693 Actin filament capping Decreases phenotype PMID:33771660
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:28556920; PMID:28556920; PMID:35156134; PMID:40015660; PMID:31332904; PMID:36878459; PMID:40015660
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:40015660
GO:0051899 Membrane depolarization Affects phenotype PMID:40015660
GO:0055072 Iron ion homeostasis Affects phenotype PMID:36878459
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30426164
GO:0070265 Necrotic cell death Increases phenotype PMID:25331106; PMID:36878459
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:32673658
GO:0070453 Regulation of heme biosynthetic process Affects phenotype PMID:30517741
GO:0070859 Positive regulation of bile acid biosynthetic process Increases phenotype PMID:25886055
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24486436; PMID:34494278; PMID:32633153; PMID:40015660
GO:0071236 Cellular response to antibiotic Increases phenotype PMID:32673658
GO:0071486 Cellular response to high light intensity Increases phenotype PMID:24519941
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:20433247; PMID:33771660; PMID:35156134; PMID:36878459; PMID:40015660
GO:0098739 Import across plasma membrane Increases phenotype PMID:32673658
GO:0140042 Lipid droplet formation Increases phenotype PMID:25331106; PMID:32633153; PMID:35835356; PMID:36878459; PMID:40015660
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:27461009
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:30426164
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24929095; PMID:25886055; PMID:28762043
GO:1903537 Meiotic cell cycle process involved in oocyte maturation Decreases phenotype PMID:33771660
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.