1,4-Benzenediamine


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
1026 CDKN1A Increases expression PMID:16314067
10553 HTATIP2 Increases expression PMID:16314067
10808 HSPH1 Increases expression PMID:23999411
11080 DNAJB4 Increases expression PMID:23999411; PMID:27965148
112744 IL17F Increases expression PMID:23445166
114548 NLRP3 Increases expression PMID:31276767
123 PLIN2 Increases expression PMID:16314067
1235 CCR6 Decreases expression PMID:15924226
1390 CREM Increases expression PMID:19371601
1646 AKR1C2 Increases expression PMID:20491607; PMID:25724174
1728 NQO1 Increases expression PMID:16314067; PMID:19033392; PMID:25724174; PMID:23445166
1843 DUSP1 Increases expression PMID:16314067
20309 CXCL15 Increases expression PMID:34826398
23766 GABARAPL3 Increases expression PMID:16314067
2495 FTH1 Increases expression PMID:16314067
253260 RICTOR Decreases expression PMID:26784575
2730 GCLM Increases expression PMID:16314067; PMID:23999411; PMID:27965148
29108 PYCARD Increases expression PMID:31276767
29126 CD274 Increases expression PMID:20488241
2919 CXCL1 Increases expression PMID:20713136
2920 CXCL2 Increases expression PMID:23178550
301 ANXA1 Increases expression PMID:16314067
3036 HAS1 Increases expression PMID:31226360
3037 HAS2 Increases expression PMID:31226360
3038 HAS3 Increases expression PMID:31226360
3091 HIF1A Increases expression PMID:16314067
3162 HMOX1 Increases expression PMID:16314067; PMID:19033392; PMID:20491607; PMID:20713136; PMID:25724174; PMID:26244607; PMID:31967339; PMID:23445166
3310 HSPA6 Increases expression PMID:23999411
3373 HYAL1 Increases expression PMID:31226360
3458 IFNG Increases expression PMID:11531941
3552 IL1A Increases expression PMID:23178550
3553 IL1B Increases expression PMID:15140218
3565 IL4 Increases expression PMID:11531941
3576 CXCL8 Increases expression PMID:20491607; PMID:20713136; PMID:21920952; PMID:27965148; PMID:24136171; PMID:25617811; PMID:31734321
3586 IL10 Increases expression PMID:11531941
360 AQP3 Decreases expression PMID:15140218
3606 IL18 Increases expression PMID:23063874; PMID:27585668
3627 CXCL10 Decreases expression PMID:23445166
4199 ME1 Increases expression PMID:16314067
4496 MT1H Increases expression PMID:16314067
4502 MT2A Increases expression PMID:16314067
467 ATF3 Increases expression PMID:16314067; PMID:23999411; PMID:27965148
4780 NFE2L2 Affects expression PMID:19033392; PMID:31967339
4814 NINJ1 Increases expression PMID:16314067
5226 PGD Increases expression PMID:16314067
5366 PMAIP1 Increases expression PMID:16314067; PMID:20713136
5468 PPARG Increases expression PMID:16314067
5742 PTGS1 Increases expression PMID:18571826
5743 PTGS2 Increases expression PMID:18571826; PMID:19371601; PMID:20713136
57521 RPTOR Decreases expression PMID:26784575
59082 CARD18 Increases expression PMID:27585668
5996 RGS1 Increases expression PMID:20713136
6016 RIT1 Increases expression PMID:16314067
6286 S100P Increases expression PMID:16314067
6347 CCL2 Increases expression PMID:34826398
6349 CCL3L1 Increases expression PMID:20713136
6351 CCL4 Increases expression PMID:20713136
6352 CCL5 Increases expression PMID:27585668
6354 CCL7 Increases expression PMID:27585668
639 PRDM1 Increases expression PMID:27585668; PMID:31276767; PMID:31276767
64223 MLST8 Decreases expression PMID:26784575
64499 TPSB2 Increases expression PMID:34826398
6476 SI Increases expression PMID:16314067
6504 SLAMF1 Decreases expression PMID:20713136
6515 SLC2A3 Increases expression PMID:19371601
6708 SPTA1 Increases expression PMID:16314067
7099 TLR4 Increases expression PMID:31226360
7124 TNF Increases expression PMID:34826398
7128 TNFAIP3 Increases expression PMID:20713136
7130 TNFAIP6 Increases expression PMID:20713136
729230 CCR2 Decreases expression PMID:19371601
7296 TXNRD1 Increases expression PMID:23445166
7422 VEGFA Increases expression PMID:25617811; PMID:9390328
7852 CXCR4 Decreases expression PMID:15924226
79671 NLRX1 Increases expression PMID:27585668
834 CASP1 Increases activity PMID:31276767
836 CASP3 Increases activity PMID:26784575
8544 PIR Increases expression PMID:16314067
8714 ABCC3 Increases expression PMID:16314067
9 NAT1 Decreases activity PMID:20406859
9 NAT1 Decreases expression PMID:20406859
91662 NLRP12 Affects expression PMID:27585668; PMID:27585668; PMID:31276767
942 CD86 Increases expression PMID:12423654; PMID:19033392; PMID:19665512; PMID:20488241; PMID:24136171; PMID:32006680
9547 CXCL14 Decreases expression PMID:31734321
9595 CYTIP Increases expression PMID:19371601
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.