1,4-Benzenediamine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34826398
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34826398
GO:0006915 Apoptotic process Increases phenotype PMID:26784575
GO:0006954 Inflammatory response Increases phenotype PMID:34826398
GO:0007253 Cytoplasmic sequestering of nf-kappab Decreases phenotype PMID:31226360
GO:0008219 Cell death Increases phenotype PMID:23626763
GO:0008283 Cell population proliferation Decreases phenotype PMID:26784575
GO:0016477 Cell migration Affects phenotype PMID:22683935
GO:0030214 Hyaluronan catabolic process Increases phenotype PMID:31226360
GO:0031052 Programmed dna elimination by chromosome breakage Increases phenotype PMID:30439388
GO:0032980 Keratinocyte activation Increases phenotype PMID:26796489; PMID:31226360
GO:0036091 Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress Increases phenotype PMID:26796489; PMID:32335162
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23172806; PMID:35363429
GO:0043303 Mast cell degranulation Increases phenotype PMID:34826398
GO:0045576 Mast cell activation Increases phenotype PMID:34826398
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26784575
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:23172806
GO:0048312 Intracellular distribution of mitochondria Affects phenotype PMID:35363429
GO:0051726 Regulation of cell cycle Increases phenotype PMID:23172806
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26784575
GO:0060467 Negative regulation of fertilization Increases phenotype PMID:35363429
GO:0060473 Cortical granule Affects phenotype PMID:35363429
GO:0070373 Negative regulation of erk1 and erk2 cascade Increases phenotype PMID:23172806
GO:1900127 Positive regulation of hyaluronan biosynthetic process Increases phenotype PMID:31226360
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:23172806
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26784575
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23172806; PMID:35363429
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:35363429
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.