Manganese


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
10096 ACTR3 Affects expression PMID:24885898
10135 NAMPT Increases expression PMID:17175027
10152 ABI2 Increases expression PMID:17175027
1017 CDK2 Affects expression PMID:38563506
10241 CALCOCO2 Increases expression PMID:17175027
1027 CDKN1B Affects expression PMID:38563506
1028 CDKN1C Affects expression PMID:38563506
1031 CDKN2C Decreases expression PMID:17175027
1033 CDKN3 Decreases expression PMID:17175027
10350 ABCA9 Increases expression PMID:17175027
10396 ATP8A1 Decreases expression PMID:17175027
10397 NDRG1 Increases expression PMID:16386771
10408 MYCNOS Increases expression PMID:17175027
10439 OLFM1 Increases expression PMID:17175027
1052 CEBPD Increases expression PMID:17175027
10591 DNPH1 Decreases expression PMID:17175027
10745 PHTF1 Decreases expression PMID:17175027
10873 ME3 Increases expression PMID:17175027
10891 PPARGC1A Increases expression PMID:24787138
10916 MAGED2 Decreases expression PMID:23499988
10960 LMAN2 Increases expression PMID:17175027
10991 SLC38A3 Decreases expression PMID:17468184
1103 CHAT Decreases activity PMID:24885898
11081 KERA Increases expression PMID:26745496
11170 FAM107A Decreases expression PMID:26745496
11258 DCTN3 Affects expression PMID:24885898
11274 USP18 Increases expression PMID:23499988
11315 PARK7 Decreases expression PMID:20798247
114134 SLC2A13 Increases expression PMID:17175027
1164 CKS2 Decreases expression PMID:17175027
117154 DACH2 Increases expression PMID:17175027
120892 LRRK2 Increases expression PMID:38857675
121643 FOXN4 Increases expression PMID:26745496
12319 CAR8 Increases expression PMID:26745496
124565 SLC38A10 Increases expression PMID:17175027
12526 CD8B1 Increases expression PMID:17175027
127602 DNAH14 Decreases expression PMID:17175027
128553 TSHZ2 Increases expression PMID:17175027
1303 COL12A1 Decreases expression PMID:17175027
133 ADM Increases expression PMID:17175027
1368 CPM Decreases expression PMID:17175027
137075 CLDN23 Increases expression PMID:26745496
1378 CR1 Increases expression PMID:17175027
1385 CREB1 Decreases expression PMID:29205667
1428 CRYM Affects expression PMID:24885898
145508 CEP128 Decreases expression PMID:17175027
1495 CTNNA1 Decreases expression PMID:17175027
1499 CTNNB1 Decreases expression PMID:17175027
153830 RNF145 Increases expression PMID:17175027
157697 ERICH1 Increases expression PMID:17175027
1581 CYP7A1 Increases activity PMID:12700418
1583 CYP11A1 Decreases expression PMID:25981801
162514 TRPV3 Decreases expression PMID:17175027
1647 GADD45A Increases expression PMID:23499988
1649 DDIT3 Increases expression PMID:21477646; PMID:23499988
1728 NQO1 Increases activity PMID:17573173
1738 DLD Decreases expression PMID:25981801
174 AFP Decreases expression PMID:26745496
1803 DPP4 Increases expression PMID:17175027
1810 DR1 Decreases expression PMID:17175027
1813 DRD2 Decreases expression PMID:20224926; PMID:33881537
1834 DSPP Increases expression PMID:17175027
1843 DUSP1 Decreases expression PMID:20589745
18671 ABCB1A Increases expression PMID:26745496
1869 E2F1 Affects expression PMID:38563506
1997 ELF1 Decreases expression PMID:17175027
201163 FLCN Increases expression PMID:17175027
2015 ADGRE1 Increases expression PMID:20224926
201895 SMIM14 Increases expression PMID:17175027
2023 ENO1 Decreases activity PMID:22191580
2069 EREG Increases expression PMID:17175027
207 AKT1 Decreases expression PMID:17043766
2070 EYA4 Decreases expression PMID:17175027
20888 SULT1C1 Increases expression PMID:17175027
2099 ESR1 Increases expression PMID:24845367
2185 PTK2B Decreases expression PMID:17175027
2188 FANCF Decreases expression PMID:17175027
219736 STOX1 Decreases expression PMID:17175027
2209 FCGR1A Decreases expression PMID:26745496
2273 FHL1 Decreases expression PMID:17175027
22926 ATF6 Decreases expression PMID:17175027
22933 SIRT2 Increases expression PMID:17175027
23011 RAB21 Decreases expression PMID:17175027
23040 MYT1L Increases expression PMID:17175027; PMID:26745496
2309 FOXO3 Increases expression PMID:24787138
23230 VPS13A Decreases expression PMID:17175027
23461 ABCA5 Decreases expression PMID:17175027
23516 SLC39A14 Increases expression PMID:17065364
2353 FOS Decreases expression PMID:17043766
23576 DDAH1 Decreases expression PMID:21312047
23621 BACE1 Increases expression PMID:18583042
23780 APOL2 Increases expression PMID:17175027
24139 EML2 Increases expression PMID:17175027
246175 CNOT6L Increases expression PMID:17175027
2475 MTOR Increases expression PMID:23997110
2495 FTH1 Affects expression PMID:16545456; PMID:16568477; PMID:17469137; PMID:16740617
2566 GABRG2 Increases expression PMID:17175027
25928 SOSTDC1 Decreases expression PMID:26745496
26239 LCE2B Increases expression PMID:17175027
26464 VNN3 Increases expression PMID:26745496
2670 GFAP Increases expression PMID:19782702; PMID:19782702; PMID:20224926; PMID:20224926; PMID:23832297; PMID:24885898
2702 GJA5 Decreases expression PMID:26745496
27111 SDCBP2 Decreases expression PMID:17175027
27327 TNRC6A Increases expression PMID:17175027
2746 GLUD1 Decreases expression PMID:21312047
2752 GLUL Decreases expression PMID:16842851; PMID:16943606
2796 GNRH1 Increases expression PMID:23997110
2819 GPD1 Decreases activity PMID:11952153
28250 SLCO1A4 Decreases expression PMID:26745496
2841 GPR18 Decreases expression PMID:26745496
2847 MCHR1 Increases expression PMID:17175027
285 ANGPT2 Decreases expression PMID:26745496
2857 GPR34 Decreases expression PMID:26745496
286128 ZFP41 Increases expression PMID:17175027
2902 GRIN1 Decreases expression PMID:19643132; PMID:29205667
2903 GRIN2A Decreases expression PMID:19643132; PMID:29205667
2904 GRIN2B Decreases expression PMID:19643132; PMID:29205667
2920 CXCL2 Increases expression PMID:17175027; PMID:19782702; PMID:20224926
2921 CXCL3 Increases expression PMID:17175027
2936 GSR Decreases expression PMID:17175027
2956 MSH6 Decreases expression PMID:17175027
2965 GTF2H1 Decreases expression PMID:17175027
2982 GUCY1A1 Increases activity PMID:22171090
2983 GUCY1B1 Increases activity PMID:22171090
29979 UBQLN1 Decreases expression PMID:22191580
30061 SLC40A1 Decreases expression PMID:29020610
3064 HTT Increases expression PMID:25099302
30818 KCNIP3 Increases expression PMID:17175027
3091 HIF1A Increases activity PMID:16386771
3091 HIF1A Increases expression PMID:16386771; PMID:17175027
3126 HLA-DRB4 Increases expression PMID:17175027
3156 HMGCR Increases activity PMID:12700418
3158 HMGCS2 Decreases expression PMID:26745496
3162 HMOX1 Increases expression PMID:11181820; PMID:23832297; PMID:18948096
3219 HOXB9 Decreases expression PMID:17175027
3309 HSPA5 Increases expression PMID:21477646
3312 HSPA8 Increases expression PMID:16600465
3398 ID2 Increases expression PMID:17175027
342035 GLDN Decreases expression PMID:26745496
348013 TMEM255B Increases expression PMID:26745496
351 APP Increases expression PMID:18583042
3553 IL1B Increases expression PMID:19782702
3569 IL6 Increases expression PMID:17065364; PMID:20224926
3574 IL7 Increases expression PMID:17175027
3592 IL12A Increases expression PMID:17175027
3643 INSR Decreases expression PMID:2204694
3658 IREB2 Decreases activity PMID:16568477
3658 IREB2 Increases expression PMID:17469137
3675 ITGA3 Increases expression PMID:17175027
3684 ITGAM Increases expression PMID:20224926
3688 ITGB1 Increases activity PMID:10820171; PMID:16606368
3693 ITGB5 Increases expression PMID:17175027
3725 JUN Decreases expression PMID:17043766
3760 KCNJ3 Increases expression PMID:17175027
3814 KISS1 Increases expression PMID:23997110
387758 FIBIN Increases expression PMID:21615908
389558 FAM180A Decreases expression PMID:26745496
39 ACAT2 Decreases expression PMID:23499988
3945 LDHB Affects expression PMID:24885898
396 ARHGDIA Decreases expression PMID:17175027
4094 MAF Increases expression PMID:23997110
4155 MBP Increases expression PMID:17175027
4173 MCM4 Decreases expression PMID:17175027
4174 MCM5 Decreases expression PMID:17175027; PMID:38563506
4193 MDM2 Decreases expression PMID:25791630
4281 MID1 Decreases expression PMID:23976782
43 ACHE Increases activity PMID:24885898
4308 TRPM1 Increases expression PMID:17175027
4313 MMP2 Decreases expression PMID:17043766
4314 MMP3 Increases expression PMID:26745496
4322 MMP13 Increases expression PMID:26745496
4323 MMP14 Decreases expression PMID:17043766
4534 MTM1 Decreases expression PMID:17175027
4620 MYH2 Decreases expression PMID:26745496
472 ATM Decreases expression PMID:17175027
4747 NEFL Increases expression PMID:22191580
478 ATP1A3 Decreases expression PMID:23976782
4781 NFIB Increases expression PMID:17175027
4784 NFIX Decreases expression PMID:17175027
48 ACO1 Affects activity PMID:16386771; PMID:16545456; PMID:16568477; PMID:17469137
4801 NFYB Decreases expression PMID:17175027
4836 NMT1 Decreases activity PMID:16600465
4837 NNMT Increases activity PMID:22249857
4842 NOS1 Decreases expression PMID:16476481
4843 NOS2 Affects activity PMID:16488514; PMID:24777576
4843 NOS2 Increases expression PMID:16168523; PMID:16417967; PMID:16551646; PMID:19812365; PMID:16168523; PMID:16417967; PMID:18335517; PMID:23832297; PMID:20224926; PMID:24777576; PMID:20798247; PMID:24777576
4848 CNOT2 Decreases expression PMID:17175027
4855 NOTCH4 Decreases expression PMID:17175027
486 FXYD2 Increases expression PMID:17175027
4878 NPPA Decreases expression PMID:17175027
4891 SLC11A2 Increases expression PMID:16705042; PMID:16729984; PMID:25575534; PMID:16729984; PMID:18849539; PMID:19782702; PMID:20224926; PMID:23997110; PMID:25575534; PMID:17175027
4914 NTRK1 Decreases expression PMID:17029596
4929 NR4A2 Decreases expression PMID:38563506
4968 OGG1 Decreases expression PMID:22641096
50 ACO2 Decreases activity PMID:16625280; PMID:17469137; PMID:9675333
50 ACO2 Decreases expression PMID:16625280
5034 P4HB Increases activity PMID:24777576
5034 P4HB Increases expression PMID:24777576
5055 SERPINB2 Increases expression PMID:26745496
50649 ARHGEF4 Increases expression PMID:17175027
5069 PAPPA Increases expression PMID:17175027
5071 PRKN Affects expression PMID:19781568; PMID:20798247; PMID:28826884
5099 PCDH7 Increases expression PMID:17175027
51083 GAL Increases expression PMID:17175027
5111 PCNA Affects expression PMID:38563506
51129 ANGPTL4 Increases expression PMID:17175027
51194 IPO11 Decreases expression PMID:17175027
51196 PLCE1 Increases expression PMID:17175027
5142 PDE4B Increases expression PMID:31161640
5149 PDE6H Increases expression PMID:26745496
5158 PDE6B Increases expression PMID:26745496
5163 PDK1 Increases expression PMID:17175027
51715 RAB23 Decreases expression PMID:17175027
5228 PGF Increases expression PMID:17175027
5243 ABCB1 Increases activity PMID:2900677
53340 SPA17 Decreases expression PMID:17175027
53343 NUDT9 Increases activity PMID:16860484
53373 TPCN1 Increases expression PMID:17175027
5350 PLN Decreases expression PMID:17175027
538 ATP7A Decreases expression PMID:24614235
540 ATP7B Decreases expression PMID:24614235
5406 PNLIP Increases expression PMID:26745496
5449 POU1F1 Increases expression PMID:17175027
54536 EXOC6 Decreases expression PMID:17175027
54625 PARP14 Increases expression PMID:23499988
54795 TRPM4 Increases expression PMID:17175027
54821 ERCC6L Decreases expression PMID:17175027
54834 GDAP2 Increases expression PMID:17175027
55283 MCOLN3 Increases expression PMID:26745496
55356 SLC22A15 Decreases expression PMID:17175027
55532 SLC30A10 Decreases expression PMID:29020610
5557 PRIM1 Decreases expression PMID:17175027
5558 PRIM2 Decreases expression PMID:17175027
55636 CHD7 Increases expression PMID:26586927
5566 PRKACA Decreases expression PMID:25981801
55662 HIF1AN Decreases expression PMID:17175027
5578 PRKCA Decreases expression PMID:25981801
5580 PRKCD Increases activity PMID:21812036; PMID:25416158
55800 SCN3B Increases expression PMID:17175027
5587 PRKD1 Increases expression PMID:17175027
56142 PCDHA6 Increases expression PMID:17175027
5617 PRL Decreases expression PMID:19595304
56603 CYP26B1 Decreases expression PMID:26745496
56892 TCIM Increases expression PMID:17175027
57055 DAZ2 Decreases expression PMID:17175027
57282 SLC4A10 Decreases expression PMID:17175027
5743 PTGS2 Increases expression PMID:17175027
57453 DSCAML1 Increases expression PMID:26745496
57817 HAMP Decreases expression PMID:29020610
58 ACTA1 Decreases expression PMID:26745496
5806 PTX3 Increases expression PMID:17175027
581 BAX Increases expression PMID:25027559; PMID:25791630; PMID:31161640
5816 PVALB Decreases expression PMID:23976782
5817 PVR Decreases expression PMID:17175027
595 CCND1 Increases expression PMID:23997110; PMID:38563506
596 BCL2 Decreases expression PMID:31161640; PMID:32246071
598 BCL2L1 Decreases expression PMID:25791630
5985 RFC5 Decreases expression PMID:17175027
5997 RGS2 Increases expression PMID:17175027
6009 RHEB Increases expression PMID:23997110
6167 RPL37 Decreases expression PMID:27329587
627 BDNF Decreases expression PMID:25099302; PMID:25099302; PMID:29205667; PMID:31161640; PMID:29205667
6272 SORT1 Decreases expression PMID:17175027
6277 S100A6 Increases expression PMID:17175027
6288 SAA1 Increases expression PMID:17065364
6332 SCN7A Decreases expression PMID:26745496
6347 CCL2 Increases expression PMID:19782702
6354 CCL7 Increases expression PMID:17175027
6372 CXCL6 Increases expression PMID:17175027
6387 CXCL12 Decreases expression PMID:23499988
6416 MAP2K4 Increases activity PMID:20589745
64361 PRL7A3 Increases expression PMID:26745496
6439 SFTPB Increases expression PMID:17175027
64710 NUCKS1 Decreases expression PMID:17175027
6496 SIX3 Increases expression PMID:17175027
6506 SLC1A2 Decreases expression PMID:22645130; PMID:22645130; PMID:24469401; PMID:28610743
6507 SLC1A3 Decreases expression PMID:19453300; PMID:28610743
6531 SLC6A3 Decreases expression PMID:16571372
6533 SLC6A6 Increases expression PMID:20832424
6558 SLC12A2 Increases activity PMID:25817889
6558 SLC12A2 Increases expression PMID:25817889
6571 SLC18A2 Decreases expression PMID:20224926
6622 SNCA Increases expression PMID:19781568
6648 SOD2 Increases activity PMID:18317567; PMID:19093460; PMID:27701121
6648 SOD2 Increases expression PMID:17175027; PMID:21312047; PMID:24787138
6667 SP1 Increases activity PMID:22975163
6667 SP1 Increases expression PMID:38857675
6714 SRC Decreases expression PMID:16600465
6770 STAR Decreases expression PMID:25981801
6869 TACR1 Decreases expression PMID:17175027
687 KLF9 Decreases expression PMID:17175027
6936 GCFC2 Decreases expression PMID:17175027
699 BUB1 Decreases expression PMID:17175027
7020 TFAP2A Increases expression PMID:24845367
7021 TFAP2B Increases expression PMID:17175027
7025 NR2F1 Decreases expression PMID:23976782
7037 TFRC Increases expression PMID:16545456; PMID:16568477; PMID:16705042; PMID:16740617; PMID:17469137; PMID:23499988
7040 TGFB1 Decreases expression PMID:16476481; PMID:19453300
7044 LEFTY2 Decreases expression PMID:17175027
7046 TGFBR1 Decreases expression PMID:17175027
7054 TH Decreases expression PMID:16943606; PMID:19781568; PMID:20224926; PMID:20798247
7124 TNF Increases expression PMID:19782702; PMID:20224926; PMID:20798247; PMID:24469401; PMID:38857675
7157 TP53 Increases expression PMID:23997110; PMID:24845367; PMID:25027559; PMID:25448048; PMID:25791630
7306 TYRP1 Decreases expression PMID:17175027; PMID:26745496
7311 UBA52 Decreases expression PMID:27329587
7345 UCHL1 Decreases expression PMID:20798247
7416 VDAC1 Increases expression PMID:21312047
7422 VEGFA Increases expression PMID:17175027; PMID:17467022
7490 WT1 Decreases expression PMID:17175027
7528 YY1 Increases expression PMID:24469401
7767 ZNF224 Increases expression PMID:17175027
7851 MALL Decreases expression PMID:26745496
79152 FA2H Increases expression PMID:26745496
8048 CSRP3 Increases expression PMID:26745496
80705 TSGA10 Increases expression PMID:17175027
811 CALR Affects expression PMID:24885898
8120 AP3B2 Increases expression PMID:17175027
81539 SLC38A1 Decreases expression PMID:17468184
8190 MIA Increases expression PMID:17175027
823 CAPN1 Increases activity PMID:21985864
836 CASP3 Increases activity PMID:11933051; PMID:21985864; PMID:22427945; PMID:25027559; PMID:25416158; PMID:31161640; PMID:22841634
836 CASP3 Increases expression PMID:16787641; PMID:16787641; PMID:22975163; PMID:32246071; PMID:22975163
83939 EIF2A Increases expression PMID:21477646
840 CASP7 Increases activity PMID:22427945
8407 TAGLN2 Decreases expression PMID:17175027
841 CASP8 Increases activity PMID:31161640
842 CASP9 Increases activity PMID:25416158
84634 KISS1R Increases expression PMID:23997110
847 CAT Decreases activity PMID:23339144
8490 RGS5 Decreases expression PMID:17175027
84913 ATOH8 Decreases expression PMID:26745496
8493 PPM1D Decreases expression PMID:25791630
85015 USP45 Decreases expression PMID:17175027
8542 APOL1 Increases expression PMID:17175027
857 CAV1 Decreases expression PMID:23499988; PMID:23597857; PMID:23597857
8570 KHSRP Increases expression PMID:25027559
859 CAV3 Decreases expression PMID:23597857
8718 TNFRSF25 Increases expression PMID:17175027
8736 MYOM1 Increases expression PMID:17175027
8829 NRP1 Increases expression PMID:17175027
8900 CCNA1 Increases expression PMID:26745496; PMID:38563506
9096 TBX18 Increases expression PMID:17175027
9123 SLC16A3 Increases expression PMID:17175027
9133 CCNB2 Decreases expression PMID:17175027
9173 IL1RL1 Decreases expression PMID:26745496
9227 LRAT Increases expression PMID:26745496
926 CD8B Increases expression PMID:17175027
9314 KLF4 Increases expression PMID:17175027
93986 FOXP2 Increases expression PMID:17175027
94097 SFXN5 Increases expression PMID:17175027
9465 AKAP7 Decreases expression PMID:17175027
9518 GDF15 Increases expression PMID:17175027
9542 NRG2 Increases expression PMID:17175027
9545 RAB3D Decreases expression PMID:23499988
9547 CXCL14 Increases expression PMID:17175027
9588 PRDX6 Affects expression PMID:24885898
962 CD48 Increases expression PMID:17175027
9620 CELSR1 Increases expression PMID:17175027
9628 RGS6 Increases expression PMID:17175027
9805 SCRN1 Affects expression PMID:24885898
9843 HEPH Increases expression PMID:17175027
9958 USP15 Decreases expression PMID:17175027
9982 FGFBP1 Decreases expression PMID:26745496

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.