DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Manganese

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000080	Mitotic g1 phase	Affects phenotype	PMID:28035397
GO:0000084	Mitotic s phase	Affects phenotype	PMID:28035397; PMID:34822792; PMID:38503349; PMID:38563506
GO:0000085	Mitotic g2 phase	Affects phenotype	PMID:28035397
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:34822792; PMID:38503349
GO:0000423	Mitophagy	Decreases phenotype	PMID:31690173
GO:0001774	Microglial cell activation	Affects phenotype	PMID:34018660
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:29115570
GO:0001889	Liver development	Increases phenotype	PMID:26660635
GO:0002381	Immunoglobulin production involved in immunoglobulin-mediated immune response	Affects phenotype	PMID:30643099
GO:0002534	Cytokine production involved in inflammatory response	Increases phenotype	PMID:34014775
GO:0004104	Cholinesterase activity	Increases phenotype	PMID:34058180
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:30844427; PMID:32445656; PMID:33314588; PMID:34058180
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:30738988
GO:0004602	Glutathione peroxidase activity	Affects phenotype	PMID:23339144; PMID:30844427; PMID:32445656; PMID:33314588; PMID:37415728
GO:0004784	Superoxide dismutase activity	Increases phenotype	PMID:23339144; PMID:30844427; PMID:30844427; PMID:38129942; PMID:32445656; PMID:33314588; PMID:37415728; PMID:38129942
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:37598760
GO:0005764	Lysosome	Decreases phenotype	PMID:31690173
GO:0006007	Glucose catabolic process	Increases phenotype	PMID:2204694
GO:0006171	Camp biosynthetic process	Affects phenotype	PMID:31161640
GO:0006468	Protein phosphorylation	Increases phenotype	PMID:23628791
GO:0006497	Protein lipidation	Decreases phenotype	PMID:31690173
GO:0006521	Regulation of cellular amino acid metabolic process	Affects phenotype	PMID:30715528
GO:0006576	Biogenic amine metabolic process	Decreases phenotype	PMID:31560393
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:31690173
GO:0006631	Fatty acid metabolic process	Affects phenotype	PMID:30715528
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:33314588
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:23339144; PMID:30844427
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:24777576; PMID:30844427
GO:0006812	Monoatomic cation transport	Affects phenotype	PMID:32080757
GO:0006825	Copper ion transport	Affects phenotype	PMID:24614235
GO:0006875	Cellular metal ion homeostasis	Affects phenotype	PMID:35212737
GO:0006878	Cellular copper ion homeostasis	Affects phenotype	PMID:24614235
GO:0006884	Cell volume homeostasis	Affects phenotype	PMID:38563506
GO:0006914	Autophagy	Decreases phenotype	PMID:31690173
GO:0006915	Apoptotic process	Increases phenotype	PMID:10721100; PMID:11392499; PMID:24777576; PMID:25027559; PMID:25791630; PMID:26419736; PMID:28035397; PMID:29115570; PMID:30951808; PMID:30991096; PMID:31161640; PMID:31676349; PMID:32659473; PMID:35690225; PMID:38503349
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	Increases phenotype	PMID:16168523
GO:0006929	Substrate-dependent cell migration	Increases phenotype	PMID:30592962
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:23339144; PMID:32574669
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:23628791
GO:0007042	Lysosomal lumen acidification	Decreases phenotype	PMID:31690173
GO:0007190	Activation of adenylate cyclase activity	Increases phenotype	PMID:2986305
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:32445656; PMID:34822792
GO:0007608	Sensory perception of smell	Decreases phenotype	PMID:26765332
GO:0007610	Behavior	Affects phenotype	PMID:26209874; PMID:33154986
GO:0007612	Learning	Decreases phenotype	PMID:20855239; PMID:20936744; PMID:20943219; PMID:37598760; PMID:38129942
GO:0007613	Memory	Increases phenotype	PMID:24972623; PMID:24972623; PMID:30844427; PMID:26209874; PMID:30090589; PMID:30844427; PMID:32659473; PMID:34058180; PMID:37415728; PMID:38129942
GO:0007625	Grooming behavior	Increases phenotype	PMID:34058180
GO:0007626	Locomotory behavior	Affects phenotype	PMID:32692843
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:30090589
GO:0008217	Regulation of blood pressure	Affects phenotype	PMID:21878420
GO:0008219	Cell death	Increases phenotype	PMID:1417959; PMID:21985864; PMID:23313730; PMID:32659473
GO:0008283	Cell population proliferation	Increases phenotype	PMID:22249857; PMID:22542671; PMID:22982731; PMID:24845367; PMID:25791630; PMID:29579278; PMID:32659473; PMID:34058180; PMID:38563506
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:26794142
GO:0008361	Regulation of cell size	Affects phenotype	PMID:25817889; PMID:32659473
GO:0008542	Visual learning	Decreases phenotype	PMID:24972623; PMID:24972623; PMID:30844427; PMID:30844427
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:1324726
GO:0008635	Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Increases phenotype	PMID:25416158
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:27701121
GO:0010918	Positive regulation of mitochondrial membrane potential	Decreases phenotype	PMID:25981801
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:23499988; PMID:25981801; PMID:30715528
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:23339144; PMID:30738988; PMID:30844427; PMID:32445656; PMID:33314588
GO:0018158	Protein oxidation	Increases phenotype	PMID:23339144; PMID:30738988
GO:0021759	Globus pallidus development	Affects phenotype	PMID:27466214
GO:0021772	Olfactory bulb development	Decreases phenotype	PMID:26765332
GO:0022008	Neurogenesis	Decreases phenotype	PMID:25539664; PMID:25575534; PMID:29579278
GO:0030168	Platelet activation	Increases phenotype	PMID:30537864
GO:0030182	Neuron differentiation	Decreases phenotype	PMID:29579278
GO:0030220	Platelet formation	Decreases phenotype	PMID:31991237
GO:0031143	Pseudopodium	Increases phenotype	PMID:30537864
GO:0031325	Positive regulation of cellular metabolic process	Increases phenotype	PMID:23499988
GO:0031987	Locomotion involved in locomotory behavior	Decreases phenotype	PMID:34018660; PMID:37598760
GO:0035176	Social behavior	Decreases phenotype	PMID:28569757; PMID:29847083
GO:0040018	Positive regulation of multicellular organism growth	Decreases phenotype	PMID:29020610
GO:0042133	Neurotransmitter metabolic process	Affects phenotype	PMID:30715528
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:30090589
GO:0042417	Dopamine metabolic process	Affects phenotype	PMID:34590183
GO:0042428	Serotonin metabolic process	Affects phenotype	PMID:37598760
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:31690173
GO:0042632	Cholesterol homeostasis	Affects phenotype	PMID:25867198
GO:0042743	Hydrogen peroxide metabolic process	Affects phenotype	PMID:33314588
GO:0043525	Positive regulation of neuron apoptotic process	Increases phenotype	PMID:16168523; PMID:25416158
GO:0043971	Histone h3-k18 acetylation	Increases phenotype	PMID:38129942
GO:0044114	Development of symbiont in host	Affects phenotype	PMID:28610994
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:28035397; PMID:29115570; PMID:29957541; PMID:31161640; PMID:31676349; PMID:32574669; PMID:34822792; PMID:35690225; PMID:38503349; PMID:38563506; PMID:38857675
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:38503349; PMID:38563506
GO:0045333	Cellular respiration	Decreases phenotype	PMID:31690173
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:28962525
GO:0045664	Regulation of neuron differentiation	Affects phenotype	PMID:26794142
GO:0045860	Positive regulation of protein kinase activity	Increases phenotype	PMID:3527812
GO:0046034	Atp metabolic process	Affects phenotype	PMID:31690173
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:33314588
GO:0046466	Membrane lipid catabolic process	Affects phenotype	PMID:12525082; PMID:1417959
GO:0046847	Filopodium assembly	Increases phenotype	PMID:30592962
GO:0048873	Homeostasis of number of cells within a tissue	Affects phenotype	PMID:30991096
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Affects phenotype	PMID:35037767
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:23339144; PMID:30738988; PMID:30844427
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:32692843
GO:0050769	Positive regulation of neurogenesis	Increases phenotype	PMID:26794142
GO:0050801	Monoatomic ion homeostasis	Affects phenotype	PMID:30090589
GO:0050890	Cognition	Increases phenotype	PMID:16393669; PMID:20549838; PMID:20936744; PMID:20943219; PMID:26381693; PMID:29847083; PMID:26209874; PMID:27448389
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:32692843
GO:0051402	Neuron apoptotic process	Increases phenotype	PMID:32692843; PMID:34018660
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:31676349; PMID:31690173; PMID:38503349
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:29115570
GO:0055065	Metal ion homeostasis	Decreases phenotype	PMID:29452138
GO:0055070	Copper ion homeostasis	Affects phenotype	PMID:25575534
GO:0055071	Manganese ion homeostasis	Decreases phenotype	PMID:24804307; PMID:25575534; PMID:26660635; PMID:26967026; PMID:27592743; PMID:28860195; PMID:29020610; PMID:34590183; PMID:36152728; PMID:37022104
GO:0060096	Serotonin secretion, neurotransmission	Increases phenotype	PMID:31560393
GO:0061526	Acetylcholine secretion	Decreases phenotype	PMID:30738988
GO:0061527	Dopamine secretion, neurotransmission	Increases phenotype	PMID:31560393
GO:0061533	Norepinephrine secretion, neurotransmission	Increases phenotype	PMID:31560393
GO:0061744	Motor behavior	Increases phenotype	PMID:26209874; PMID:26381693; PMID:26968381; PMID:31560393; PMID:34896555
GO:0061900	Glial cell activation	Increases phenotype	PMID:32692843
GO:0070265	Necrotic cell death	Increases phenotype	PMID:32659473; PMID:38129942
GO:0070509	Calcium ion import	Increases phenotype	PMID:30951808
GO:0070527	Platelet aggregation	Increases phenotype	PMID:30537864
GO:0070534	Protein k63-linked ubiquitination	Increases phenotype	PMID:31690173
GO:0070577	Lysine-acetylated histone binding	Decreases phenotype	PMID:38129942
GO:0070994	Detection of oxidative stress	Affects phenotype	PMID:37415728; PMID:38129942; PMID:38857675
GO:0070997	Neuron death	Increases phenotype	PMID:25461191
GO:0071421	Manganese ion transmembrane transport	Affects phenotype	PMID:27681840; PMID:28860195; PMID:8549643
GO:0071743	Ige immunoglobulin complex, circulating	Affects phenotype	PMID:30643099
GO:0071965	Multicellular organismal locomotion	Decreases phenotype	PMID:29020610
GO:0072378	Blood coagulation, fibrin clot formation	Increases phenotype	PMID:30537864
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:23339144; PMID:25817889; PMID:28035397; PMID:34310962; PMID:38503349
GO:0072673	Lamellipodium morphogenesis	Increases phenotype	PMID:30592962
GO:0090326	Positive regulation of locomotion involved in locomotory behavior	Decreases phenotype	PMID:28610743
GO:0097202	Activation of cysteine-type endopeptidase activity	Increases phenotype	PMID:25841707; PMID:30738988
GO:0097237	Cellular response to toxic substance	Increases phenotype	PMID:23628791
GO:0097722	Sperm motility	Decreases phenotype	PMID:32445656
GO:0098711	Iron ion import across plasma membrane	Increases phenotype	PMID:22898811
GO:0098989	Nmda selective glutamate receptor signaling pathway	Decreases phenotype	PMID:29205667
GO:0140048	Manganese ion export across plasma membrane	Increases phenotype	PMID:28860195
GO:1901142	Insulin metabolic process	Affects phenotype	PMID:25867198
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:28035397; PMID:34822792; PMID:38503349; PMID:38563506
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:30991096
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:28962525; PMID:32007923
GO:1990834	Response to odorant	Decreases phenotype	PMID:26765332
GO:2000403	Positive regulation of lymphocyte migration	Increases phenotype	PMID:36220500
GO:2000872	Positive regulation of progesterone secretion	Decreases phenotype	PMID:25981801
GO:2001057	Reactive nitrogen species metabolic process	Increases phenotype	PMID:25817889

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.