Morphine


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
10014 HDAC5 Increases expression PMID:35461814
10018 BCL2L11 Increases expression PMID:19292871
10128 LRPPRC Increases expression PMID:20144693
10207 PATJ Decreases expression PMID:21955143
10268 RAMP3 Decreases expression PMID:21955143
10382 TUBB4A Decreases expression PMID:21955143
10487 CAP1 Decreases expression PMID:21955143
10550 ARL6IP5 Increases expression PMID:21600884
10763 NES Decreases expression PMID:26877219
10777 ARPP21 Affects expression PMID:21955143; PMID:27126842
10846 PDE10A Decreases expression PMID:21955143; PMID:27126842
10873 ME3 Increases expression PMID:21178816
10919 EHMT2 Affects expression PMID:33891991
10938 EHD1 Decreases expression PMID:23056601
11170 FAM107A Increases expression PMID:21955143
112 ADCY6 Affects expression PMID:15829634
114 ADCY8 Affects expression PMID:15829634
114548 NLRP3 Increases expression PMID:37394652
1153 CIRBP Increases expression PMID:21955143
116173 CMTM5 Increases expression PMID:21955143
121551 ABTB3 Decreases expression PMID:21955143
12349 CAR2 Increases expression PMID:20144693
1268 CNR1 Affects expression PMID:21955143; PMID:27126842; PMID:9351646
128218 TMEM125 Decreases expression PMID:21955143
134 ADORA1 Increases expression PMID:26478469
134147 CMBL Decreases expression PMID:23056601
134548 SOWAHA Increases expression PMID:21955143
135 ADORA2A Increases expression PMID:21955143
1363 CPE Increases expression PMID:20144693
1385 CREB1 Affects expression PMID:15183518; PMID:23292329; PMID:33609567
1390 CREM Increases expression PMID:22454534
1392 CRH Increases expression PMID:21955143; PMID:27126842
1401 CRP Increases expression PMID:18980684
140809 SRXN1 Increases expression PMID:20144693
1410 CRYAB Affects expression PMID:21955143; PMID:23056601
14103 FASL Increases expression PMID:16210602
1432 MAPK14 Increases expression PMID:23056601
143425 SYT9 Decreases expression PMID:21955143
14599 GH Decreases expression PMID:21178816
1476 CSTB Decreases expression PMID:23056601
1508 CTSB Increases expression PMID:9429908
1536 CYBB Increases expression PMID:14871405
1544 CYP1A2 Decreases activity PMID:35914676
1555 CYP2B6 Increases activity PMID:35914676
1557 CYP2C19 Increases activity PMID:35914676
1565 CYP2D6 Increases activity PMID:35914676
158135 TTLL11 Increases expression PMID:21178816
1593 CYP27A1 Increases expression PMID:20144693
161253 REM2 Increases expression PMID:21955143
1643 DDB2 Increases expression PMID:19397953
1649 DDIT3 Increases expression PMID:37394652
1718 DHCR24 Decreases expression PMID:21955143
1742 DLG4 Affects expression PMID:15183518; PMID:16598705; PMID:21955143; PMID:22713680
1749 DLX5 Increases expression PMID:21178816
1778 DYNC1H1 Decreases expression PMID:21178816
1786 DNMT1 Increases expression PMID:33891991
1787 TRDMT1 Affects expression PMID:33891991
1788 DNMT3A Affects expression PMID:33891991
1789 DNMT3B Affects expression PMID:33891991
1808 DPYSL2 Decreases expression PMID:23056601
1809 DPYSL3 Decreases expression PMID:23056601
181 AGRP Increases expression PMID:20144693
1812 DRD1 Affects expression PMID:21955143; PMID:27126842
1813 DRD2 Affects expression PMID:15183518; PMID:17063042; PMID:27126842
1815 DRD4 Increases expression PMID:15183518
1848 DUSP6 Increases expression PMID:21955143; PMID:27126842
1891 ECH1 Decreases expression PMID:23056601
1958 EGR1 Increases expression PMID:21955143; PMID:27126842
1959 EGR2 Increases expression PMID:22454534
1960 EGR3 Increases expression PMID:21955143
1961 EGR4 Increases activity PMID:22454534
1961 EGR4 Increases expression PMID:22454534
1984 EIF5A Increases expression PMID:19397953
199 AIF1 Increases expression PMID:37394652
2002 ELK1 Increases activity PMID:22454534
2002 ELK1 Increases expression PMID:22454534
200424 TET3 Affects expression PMID:33891991
2053 EPHX2 Increases expression PMID:21178816
207 AKT1 Affects expression PMID:19239323; PMID:20600172
213 ALB Decreases expression PMID:23056601
2146 EZH2 Affects expression PMID:33891991
2147 F2 Increases expression PMID:23056601
2155 F7 Increases expression PMID:18980684
219972 MPEG1 Increases expression PMID:21178816
2200 FBN1 Decreases expression PMID:21178816
2260 FGFR1 Increases expression PMID:15183518
22685 ZFP239 Increases expression PMID:21178816
2271 FH Increases expression PMID:23056601
2274 FHL2 Decreases expression PMID:23056601
22854 NTNG1 Decreases expression PMID:21955143
22895 RPH3A Decreases expression PMID:21955143
22914 KLRK1 Decreases expression PMID:20144693
23067 SETD1B Affects expression PMID:33891991
23071 ERP44 Increases expression PMID:21178816
231 AKR1B1 Decreases expression PMID:23056601
23176 SEPTIN8 Decreases expression PMID:21955143
23187 PHLDB1 Decreases expression PMID:21955143
23316 CUX2 Increases expression PMID:21178816
23345 SYNE1 Increases expression PMID:21955143
2335 FN1 Increases expression PMID:20144693
23512 SUZ12 Increases expression PMID:33891991
2353 FOS Increases expression PMID:10521585; PMID:12821175; PMID:15183518; PMID:12934646; PMID:22258905; PMID:22258905; PMID:32319158; PMID:27126842
2354 FOSB Increases expression PMID:15899480; PMID:23185589; PMID:18293355; PMID:22454534; PMID:23185589
23564 DDAH2 Increases expression PMID:23056601
23589 CARHSP1 Increases expression PMID:21178816
23673 STX12 Increases expression PMID:15183518
23676 SMPX Increases expression PMID:23056601
24139 EML2 Increases expression PMID:23056601
2554 GABRA1 Affects expression PMID:15183518
2557 GABRA4 Increases expression PMID:21178816
2563 GABRD Increases expression PMID:15183518
2566 GABRG2 Increases expression PMID:21955143
2571 GAD1 Increases expression PMID:15673448; PMID:18312583
2572 GAD2 Increases expression PMID:21178816
2597 GAPDH Decreases expression PMID:23056601
25979 DHRS7B Increases expression PMID:21178816
26289 AK5 Decreases expression PMID:21955143
2651 GCNT2 Affects expression PMID:21955143; PMID:27126842
2670 GFAP Decreases expression PMID:21955143
27086 FOXP1 Affects expression PMID:21955143; PMID:27126842
27113 BBC3 Increases expression PMID:19397953
27254 CSDC2 Decreases expression PMID:21955143
27344 PCSK1N Increases expression PMID:20144693
2742 GLRA2 Increases expression PMID:21178816
2771 GNAI2 Affects expression PMID:15183518
2778 GNAS Increases expression PMID:17893922
2791 GNG11 Decreases expression PMID:21955143
28185 TOMM70A Decreases expression PMID:21955143
2830 GPR6 Decreases expression PMID:21955143
285800 PRR18 Decreases expression PMID:21955143
2869 GRK5 Increases expression PMID:15183518
2890 GRIA1 Affects expression PMID:15183518; PMID:23711322
2891 GRIA2 Decreases expression PMID:23711322
2892 GRIA3 Decreases expression PMID:15183518
2893 GRIA4 Decreases expression PMID:15183518
2902 GRIN1 Increases activity PMID:17996026
2902 GRIN1 Increases expression PMID:20950603; PMID:22713680; PMID:22713680
2903 GRIN2A Increases expression PMID:12878694; PMID:33609567
2904 GRIN2B Increases expression PMID:22713680
2905 GRIN2C Increases expression PMID:15183518
29108 PYCARD Affects expression PMID:20144693; PMID:37394652
2911 GRM1 Increases expression PMID:15183518
2915 GRM5 Affects expression PMID:21955143; PMID:27126842
2932 GSK3B Increases expression PMID:20600172
3061 HCRTR1 Increases expression PMID:32319158
30827 CXXC1 Affects expression PMID:33891991
309 ANXA6 Decreases expression PMID:23056601
3157 HMGCS1 Decreases expression PMID:21955143
3158 HMGCS2 Increases expression PMID:20144693
3162 HMOX1 Increases expression PMID:14871405
3163 HMOX2 Affects activity PMID:12812915
3164 NR4A1 Increases expression PMID:21955143
3191 HNRNPL Increases expression PMID:21955143; PMID:27126842
3208 HPCA Affects expression PMID:21955143; PMID:27126842
3240 HP Decreases expression PMID:23056601
3290 HSD11B1 Decreases expression PMID:21955143
3303 HSPA1A Increases expression PMID:15497504; PMID:15497504; PMID:23056601
3309 HSPA5 Increases expression PMID:37394652
3312 HSPA8 Increases expression PMID:15497504
3315 HSPB1 Increases expression PMID:15497504; PMID:23056601
3326 HSP90AB1 Increases expression PMID:15497504
3336 HSPE1 Increases expression PMID:23056601
335 APOA1 Increases expression PMID:23056601
3359 HTR3A Increases expression PMID:21178816
338 APOB Increases expression PMID:18980684
3383 ICAM1 Decreases expression PMID:10070497
3420 IDH3B Decreases expression PMID:23056601
348 APOE Increases expression PMID:23056601
348932 SLC6A18 Increases expression PMID:20144693
352944 CXCL12A Decreases expression PMID:20144693
3547 IGSF1 Decreases expression PMID:21955143
355 FAS Increases expression PMID:16210602
3552 IL1A Decreases expression PMID:12182845
3553 IL1B Increases expression PMID:12427855; PMID:21081778; PMID:12427855; PMID:21081778; PMID:22713680; PMID:24756886; PMID:37394652
3558 IL2 Decreases expression PMID:23965172
3565 IL4 Increases expression PMID:16210602; PMID:23965172
3569 IL6 Increases expression PMID:12427855; PMID:15317861; PMID:21081778; PMID:22713680; PMID:12427855; PMID:21081778; PMID:24756886; PMID:37394652
358 AQP1 Increases expression PMID:21178816
3592 IL12A Affects expression PMID:16299287
3593 IL12B Affects expression PMID:16299287
3596 IL13 Increases expression PMID:16210602
360 AQP3 Increases expression PMID:25766885
361 AQP4 Decreases expression PMID:21955143
3684 ITGAM Increases expression PMID:37981055
3725 JUN Increases activity PMID:19292871
3726 JUNB Increases expression PMID:21955143
379 ARL4D Increases expression PMID:20144693
38 ACAT1 Decreases expression PMID:23056601
3848 KRT1 Decreases expression PMID:23056601
3849 KRT2 Decreases expression PMID:23056601
3852 KRT5 Decreases expression PMID:23056601
3856 KRT8 Decreases expression PMID:23056601
3858 KRT10 Decreases expression PMID:23056601
3883 KRT33A Increases expression PMID:23056601
389941 C1QL3 Increases expression PMID:21178816
3934 LCN2 Increases expression PMID:20144693
3953 LEPR Increases expression PMID:20144693
3972 LHB Decreases expression PMID:7022252
4008 LMO7 Increases expression PMID:21955143
4010 LMX1B Increases expression PMID:19397953
4023 LPL Increases expression PMID:21955143
4035 LRP1 Decreases expression PMID:21178816
4082 MARCKS Decreases expression PMID:23056601
409 ARRB2 Increases activity PMID:35477798
4133 MAP2 Decreases expression PMID:15183518
4137 MAPT Increases expression PMID:15183518
4152 MBD1 Affects expression PMID:33891991
4170 MCL1 Increases expression PMID:20144693
419 ART3 Increases expression PMID:23056601
4297 KMT2A Affects expression PMID:33891991
4311 MME Increases activity PMID:10070497
4318 MMP9 Increases activity PMID:20519536
4671 NAIP Increases expression PMID:15183518
468 ATF4 Increases expression PMID:37394652
4684 NCAM1 Decreases expression PMID:15673448
4706 NDUFAB1 Affects expression PMID:20144693
471 ATIC Decreases expression PMID:23056601
4729 NDUFV2 Increases expression PMID:23056601
4744 NEFH Increases expression PMID:15183518
4790 NFKB1 Increases expression PMID:15183518
4792 NFKBIA Increases expression PMID:22258905
4814 NINJ1 Increases expression PMID:19397953
4842 NOS1 Affects expression PMID:16598705; PMID:20568289
4843 NOS2 Increases expression PMID:11590188; PMID:15220775; PMID:24756886; PMID:37394652
4852 NPY Increases expression PMID:20144693; PMID:21178816
4886 NPY1R Decreases expression PMID:20144693
4897 NRCAM Increases expression PMID:16123759
4929 NR4A2 Decreases expression PMID:25643298
4985 OPRD1 Increases expression PMID:21600884
4986 OPRK1 Increases activity PMID:18385270; PMID:26476280
4986 OPRK1 Increases expression PMID:22661197
4988 OPRM1 Affects expression PMID:21957251; PMID:26877219
4988 OPRM1 Increases activity PMID:11106302; PMID:11272841; PMID:12605406; PMID:17656655; PMID:17996026; PMID:19800397; PMID:26476280; PMID:35477798
5019 OXCT1 Decreases expression PMID:23056601
50484 RRM2B Increases expression PMID:21178816
51046 ST8SIA3 Affects expression PMID:21955143; PMID:27126842
51083 GAL Affects expression PMID:21178816; PMID:21955143
51090 PLLP Decreases expression PMID:21955143
51134 CEP83 Increases expression PMID:20144693
51181 DCXR Decreases expression PMID:23056601
51299 NRN1 Decreases expression PMID:21955143
5162 PDHB Increases expression PMID:23056601
5163 PDK1 Decreases expression PMID:23056601
5164 PDK2 Decreases expression PMID:23056601
5169 ENPP3 Increases expression PMID:23056601
51704 GPRC5B Decreases expression PMID:21955143
5173 PDYN Affects expression PMID:17401159; PMID:20359526; PMID:27126842
5176 SERPINF1 Decreases expression PMID:21955143
5179 PENK Decreases expression PMID:27126842
5187 PER1 Affects expression PMID:19383088
5277 PIGA Decreases expression PMID:21955143
5316 PKNOX1 Increases expression PMID:21178816
5333 PLCD1 Increases expression PMID:23056601
53615 MBD3 Decreases expression PMID:33891991
53822 FXYD7 Decreases expression PMID:21955143
54112 GPR88 Affects expression PMID:21955143; PMID:27126842
54331 GNG2 Increases expression PMID:15183518
5443 POMC Increases expression PMID:20144693
54579 UGT1A5 Increases expression PMID:21955143
546 ATRX Increases expression PMID:21955143
54751 FBLIM1 Increases expression PMID:23056601
5478 PPIA Increases expression PMID:23056601
54790 TET2 Affects expression PMID:33891991
552 AVPR1A Decreases expression PMID:21178816
55327 LIN7C Decreases expression PMID:21955143
5534 PPP3R1 Increases expression PMID:21955143; PMID:27126842
55515 ASIC4 Increases expression PMID:21178816
55567 DNAH3 Decreases expression PMID:21178816
55619 DOCK10 Increases expression PMID:21178816
5580 PRKCD Decreases expression PMID:21955143
5582 PRKCG Increases expression PMID:20359526; PMID:20568289
5594 MAPK1 Increases activity PMID:21483469
5594 MAPK1 Increases expression PMID:20359526
5595 MAPK3 Increases activity PMID:21483469
56256 SERTAD4 Increases expression PMID:21955143
56271 BEX4 Increases expression PMID:21178816
56389 STX5A Increases expression PMID:15183518
5649 RELN Decreases expression PMID:21178816
5686 PSMA5 Increases expression PMID:23056601
5697 PYY Increases expression PMID:20144693
57017 COQ9 Decreases expression PMID:23056601
57030 SLC17A7 Affects expression PMID:16522322
5708 PSMD2 Decreases expression PMID:23056601
57084 SLC17A6 Decreases expression PMID:21955143
57165 GJC2 Decreases expression PMID:21955143
5742 PTGS1 Affects expression PMID:15183518; PMID:18706994
5743 PTGS2 Increases expression PMID:16325209; PMID:37394652
57453 DSCAML1 Increases expression PMID:20144693
57458 TMCC3 Decreases expression PMID:21955143
57464 STRIP2 Affects expression PMID:21955143; PMID:27126842
57480 PLEKHG1 Decreases expression PMID:21955143
57506 MAVS Increases expression PMID:23056601
578 BAK1 Increases expression PMID:19070643
581 BAX Affects expression PMID:10534122; PMID:19070643; PMID:21483469; PMID:10809959; PMID:12196588; PMID:32129083; PMID:15183518; PMID:18976035
5816 PVALB Decreases expression PMID:21955143
5864 RAB3A Affects expression PMID:16522322
5929 RBBP5 Decreases expression PMID:33891991
596 BCL2 Decreases expression PMID:10534122; PMID:19292871; PMID:21483469; PMID:12196588; PMID:32129083; PMID:18976035
598 BCL2L1 Decreases expression PMID:15183518
5999 RGS4 Affects expression PMID:12270694
627 BDNF Affects expression PMID:19033880; PMID:25643298; PMID:27461790
6285 S100B Decreases expression PMID:21955143
6352 CCL5 Decreases expression PMID:11106302
6385 SDC4 Increases expression PMID:21955143; PMID:27126842
6389 SDHA Increases expression PMID:23056601
63982 ANO3 Increases expression PMID:21955143
6402 SELL Decreases expression PMID:10070497
64236 PDLIM2 Decreases expression PMID:21955143
64405 CDH22 Increases expression PMID:21178816
6446 SGK1 Increases expression PMID:21955143
6474 SHOX2 Decreases expression PMID:21955143
64753 CCDC136 Decreases expression PMID:21955143
64919 BCL11B Affects expression PMID:21955143; PMID:27126842
6534 SLC6A7 Decreases expression PMID:21955143
6609 SMPD1 Increases expression PMID:22825003
6622 SNCA Increases expression PMID:15183518
66222 SERPINB1A Decreases expression PMID:21955143
6648 SOD2 Increases expression PMID:14871405; PMID:20564181
666 BOK Decreases expression PMID:21955143
6722 SRF Increases expression PMID:22454534
6750 SST Increases expression PMID:21178816
6817 SULT1A1 Increases expression PMID:20144693
68239 KRT42 Decreases expression PMID:23056601
6861 SYT5 Increases expression PMID:21178816
6863 TAC1 Increases expression PMID:11976266; PMID:15964684; PMID:21178816; PMID:27126842
6865 TACR2 Decreases expression PMID:19428329
6869 TACR1 Affects expression PMID:15964684; PMID:17123731; PMID:19428329
7054 TH Affects expression PMID:15541421; PMID:26386147
7086 TKT Decreases expression PMID:23056601
7097 TLR2 Increases expression PMID:37394652; PMID:37394652; PMID:37981055
7099 TLR4 Increases expression PMID:20178837; PMID:24756886
710 SERPING1 Decreases expression PMID:23056601
7124 TNF Increases expression PMID:12427855; PMID:15317861; PMID:21081778; PMID:22713680; PMID:21081778; PMID:24756886; PMID:37394652
7157 TP53 Increases activity PMID:19397953
7157 TP53 Increases expression PMID:19397953
7184 HSP90B1 Decreases expression PMID:23056601
7200 TRH Increases expression PMID:21178816
7201 TRHR Increases expression PMID:21178816
7276 TTR Decreases expression PMID:23056601
7422 VEGFA Increases expression PMID:19356684
7431 VIM Increases expression PMID:23056601
7442 TRPV1 Affects activity PMID:22189556
7442 TRPV1 Increases expression PMID:18774343
7531 YWHAE Decreases expression PMID:23056601
7545 ZIC1 Increases expression PMID:21955143
7555 CNBP Decreases expression PMID:23056601
793 CALB1 Increases expression PMID:21178816
796 CALCA Increases expression PMID:16935424; PMID:20359526; PMID:20568289
79772 MCTP1 Increases expression PMID:21955143
79813 EHMT1 Affects expression PMID:33891991
80179 MYO19 Decreases expression PMID:21178816
80303 EFHD1 Decreases expression PMID:21955143
80312 TET1 Decreases expression PMID:33891991
80339 PNPLA3 Increases expression PMID:20144693
81490 PTDSS2 Increases expression PMID:20144693
815 CAMK2A Increases expression PMID:21955143
81615 TMEM163 Decreases expression PMID:21955143
834 CASP1 Decreases expression PMID:15183518
836 CASP3 Increases activity PMID:10534122; PMID:19070643; PMID:21483469; PMID:11590188; PMID:20600172; PMID:19292871; PMID:20711699
836 CASP3 Increases expression PMID:12196588; PMID:16102899; PMID:18756534; PMID:18832014; PMID:20600172
841 CASP8 Decreases expression PMID:19239323
841 CASP8 Increases activity PMID:11590188; PMID:19070643
84152 PPP1R1B Affects expression PMID:15287884
842 CASP9 Increases activity PMID:19292871
842 CASP9 Increases expression PMID:15183518
84435 ADGRA1 Decreases expression PMID:21955143
84808 PERM1 Increases expression PMID:23056601
84812 PLCD4 Decreases expression PMID:21955143
8537 BCAS1 Decreases expression PMID:21955143
85476 GFM1 Decreases expression PMID:23056601
8609 KLF7 Increases expression PMID:14644156
8678 BECN1 Increases expression PMID:20190558
869 CBLN1 Decreases expression PMID:21955143
8726 EED Increases expression PMID:33891991
8727 CTNNAL1 Increases expression PMID:21178816
8743 TNFSF10 Increases expression PMID:16210602
8802 SUCLG1 Decreases expression PMID:23056601
885 CCK Decreases expression PMID:21955143
8864 PER2 Affects expression PMID:19383088
8930 MBD4 Affects expression PMID:33891991
89796 NAV1 Decreases expression PMID:21178816
90161 HS6ST2 Increases expression PMID:21178816
9075 CLDN2 Increases expression PMID:21178816
91137 SLC25A46 Decreases expression PMID:23056601
9141 PDCD5 Increases expression PMID:23056601
9230 RAB11B Increases expression PMID:21178816
928 CD9 Increases expression PMID:23056601
93377 OPALIN Decreases expression PMID:21955143
9369 NRXN3 Increases expression PMID:21955143
9456 HOMER1 Increases expression PMID:21955143
9516 LITAF Decreases expression PMID:21955143
9531 BAG3 Increases expression PMID:23056601
9607 CARTPT Increases expression PMID:20144693
9628 RGS6 Increases expression PMID:21178816
9725 TMEM63A Decreases expression PMID:21955143
9739 SETD1A Affects expression PMID:33891991
974 CD79B Increases expression PMID:20144693
989 SEPTIN7 Decreases expression PMID:23056601
9958 USP15 Increases expression PMID:24068670
9962 SLC23A2 Decreases expression PMID:19418264
9987 HNRNPDL Increases expression PMID:20144693

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.