| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000165 | Mapk cascade | Increases phenotype | PMID:15717263; PMID:16102899; PMID:19292871; PMID:20600172; PMID:21197294 |
| GO:0000278 | Mitotic cell cycle | Affects phenotype | PMID:15160390 |
| GO:0001659 | Temperature homeostasis | Decreases phenotype | PMID:35449307; PMID:35477798 |
| GO:0001774 | Microglial cell activation | Affects phenotype | PMID:24756886; PMID:33607128; PMID:37394652 |
| GO:0002027 | Regulation of heart rate | Increases phenotype | PMID:10096766; PMID:6745320; PMID:2322896; PMID:3365320; PMID:544111; PMID:7669374; PMID:6131355; PMID:9806696 |
| GO:0002209 | Behavioral defense response | Increases phenotype | PMID:27126842 |
| GO:0003094 | Glomerular filtration | Increases phenotype | PMID:3346840 |
| GO:0004602 | Glutathione peroxidase activity | Decreases phenotype | PMID:32129083 |
| GO:0004784 | Superoxide dismutase activity | Decreases phenotype | PMID:32129083 |
| GO:0006171 | Camp biosynthetic process | Increases phenotype | PMID:23292329; PMID:23300227; PMID:23608241 |
| GO:0006309 | Apoptotic dna fragmentation | Affects phenotype | PMID:10534122; PMID:12015209; PMID:12812915; PMID:12927789; PMID:15345483; PMID:15717263; PMID:7848904; PMID:8392561; PMID:8474033; PMID:9429908; PMID:9469450 |
| GO:0006914 | Autophagy | Increases phenotype | PMID:20190558 |
| GO:0006915 | Apoptotic process | Affects phenotype | PMID:10534122; PMID:10534122; PMID:16529824; PMID:10809959; PMID:10809959; PMID:15039469; PMID:11590188; PMID:12015209; PMID:12470470; PMID:12702572; PMID:12812915; PMID:12927789; PMID:14871405; PMID:15039469; PMID:15345483; PMID:15717263; PMID:16102899; PMID:16192531; PMID:16529824; PMID:17465212; PMID:19070643; PMID:19071087; PMID:19292871; PMID:19477204; PMID:20600172; PMID:20711699; PMID:20711699; PMID:20885006; PMID:20885006; PMID:7848904; PMID:8392561; PMID:8392561; PMID:8474033; PMID:9429908; PMID:9469450 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:37394652 |
| GO:0006979 | Response to oxidative stress | Increases phenotype | PMID:10395028; PMID:12812915; PMID:14871405; PMID:15039469; PMID:15379780; PMID:17542780; PMID:19070643; PMID:19292871; PMID:20564181 |
| GO:0007049 | Cell cycle | Decreases phenotype | PMID:12702572; PMID:18832014 |
| GO:0007190 | Activation of adenylate cyclase activity | Affects phenotype | PMID:23296104 |
| GO:0007268 | Chemical synaptic transmission | Increases phenotype | PMID:14519453; PMID:15813995; PMID:15829634; PMID:16522322; PMID:20203187; PMID:6258392 |
| GO:0007613 | Memory | Affects phenotype | PMID:32129083 |
| GO:0007617 | Mating behavior | Decreases phenotype | PMID:12605406 |
| GO:0007625 | Grooming behavior | Increases phenotype | PMID:27126842; PMID:37981055 |
| GO:0008088 | Axo-dendritic transport | Decreases phenotype | PMID:7506589 |
| GO:0008217 | Regulation of blood pressure | Increases phenotype | PMID:10096766; PMID:3814921; PMID:6360061; PMID:10096766; PMID:6265238; PMID:6274577; PMID:6745320; PMID:11373431; PMID:6131355; PMID:6274577; PMID:9806696 |
| GO:0008219 | Cell death | Increases phenotype | PMID:10395028; PMID:16210602; PMID:17542780; PMID:18832014; PMID:1953803; PMID:20190558 |
| GO:0008283 | Cell population proliferation | Affects phenotype | PMID:11590188; PMID:12702572; PMID:12812915; PMID:14644156; PMID:15673448; PMID:17542780; PMID:18385270; PMID:18385270; PMID:8770954; PMID:18832014; PMID:19292871; PMID:21197294; PMID:8384517; PMID:9045750; PMID:99848 |
| GO:0009408 | Response to heat | Decreases phenotype | PMID:23624290; PMID:23624290; PMID:31400342; PMID:28962077; PMID:31400342 |
| GO:0009410 | Response to xenobiotic stimulus | Affects phenotype | PMID:23296104 |
| GO:0010033 | Response to organic substance | Increases phenotype | PMID:26791602 |
| GO:0010286 | Heat acclimation | Increases phenotype | PMID:29499192 |
| GO:0010940 | Positive regulation of necrotic cell death | Increases phenotype | PMID:26386147 |
| GO:0019226 | Transmission of nerve impulse | Decreases phenotype | PMID:6745320 |
| GO:0019233 | Sensory perception of pain | Decreases phenotype | PMID:30504240 |
| GO:0019369 | Arachidonic acid metabolic process | Increases phenotype | PMID:26791602 |
| GO:0019722 | Calcium-mediated signaling | Increases phenotype | PMID:15345483 |
| GO:0022900 | Electron transport chain | Affects phenotype | PMID:21178816 |
| GO:0030154 | Cell differentiation | Affects phenotype | PMID:15673448; PMID:16210602; PMID:18832014; PMID:8384517 |
| GO:0030182 | Neuron differentiation | Affects phenotype | PMID:26877219 |
| GO:0030595 | Leukocyte chemotaxis | Affects phenotype | PMID:19058542; PMID:2968671; PMID:9629232 |
| GO:0031623 | Receptor internalization | Increases phenotype | PMID:23300227 |
| GO:0031914 | Negative regulation of synaptic plasticity | Increases phenotype | PMID:35461814 |
| GO:0031987 | Locomotion involved in locomotory behavior | Affects phenotype | PMID:23624290 |
| GO:0032792 | Negative regulation of creb transcription factor activity | Affects phenotype | PMID:22454534 |
| GO:0032793 | Positive regulation of creb transcription factor activity | Affects phenotype | PMID:22454534 |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | Affects phenotype | PMID:24398105 |
| GO:0035176 | Social behavior | Affects phenotype | PMID:27126842; PMID:37981055 |
| GO:0035640 | Exploration behavior | Increases phenotype | PMID:27126842 |
| GO:0035810 | Positive regulation of urine volume | Affects phenotype | PMID:1356599; PMID:8968362 |
| GO:0035812 | Renal sodium excretion | Decreases phenotype | PMID:3346840 |
| GO:0035882 | Defecation rhythm | Decreases phenotype | PMID:22783044 |
| GO:0036123 | Histone h3-k9 dimethylation | Increases phenotype | PMID:33891991 |
| GO:0042116 | Macrophage activation | Increases phenotype | PMID:8770954; PMID:9045750 |
| GO:0042119 | Neutrophil activation | Affects phenotype | PMID:10070497; PMID:2968671 |
| GO:0042310 | Vasoconstriction | Increases phenotype | PMID:14751409; PMID:16009644 |
| GO:0042311 | Vasodilation | Increases phenotype | PMID:14751409; PMID:623024; PMID:8941028 |
| GO:0042391 | Regulation of membrane potential | Affects phenotype | PMID:21645529; PMID:7052335 |
| GO:0042415 | Norepinephrine metabolic process | Affects phenotype | PMID:24398105 |
| GO:0042416 | Dopamine biosynthetic process | Decreases phenotype | PMID:24008352 |
| GO:0043278 | Response to morphine | Decreases phenotype | PMID:33607128; PMID:35461814 |
| GO:0043299 | Leukocyte degranulation | Increases phenotype | PMID:16765536; PMID:1725687 |
| GO:0043966 | Histone h3 acetylation | Decreases phenotype | PMID:25643298 |
| GO:0043967 | Histone h4 acetylation | Increases phenotype | PMID:25643298 |
| GO:0044648 | Histone h3-k4 dimethylation | Increases phenotype | PMID:33891991 |
| GO:0045793 | Positive regulation of cell size | Increases phenotype | PMID:15647486 |
| GO:0046718 | Viral entry into host cell | Decreases phenotype | PMID:23751259 |
| GO:0048167 | Regulation of synaptic plasticity | Affects phenotype | PMID:17052847 |
| GO:0048265 | Response to pain | Decreases phenotype | PMID:23624290 |
| GO:0048266 | Behavioral response to pain | Decreases phenotype | PMID:27535976; PMID:31400342; PMID:33607128; PMID:33891991; PMID:35449307; PMID:35477798 |
| GO:0050729 | Positive regulation of inflammatory response | Decreases phenotype | PMID:33607128 |
| GO:0050901 | Leukocyte tethering or rolling | Decreases phenotype | PMID:10964586 |
| GO:0050965 | Detection of temperature stimulus involved in sensory perception of pain | Decreases phenotype | PMID:26791602 |
| GO:0050966 | Detection of mechanical stimulus involved in sensory perception of pain | Decreases phenotype | PMID:26791602 |
| GO:0051461 | Positive regulation of corticotropin secretion | Affects phenotype | PMID:24398105 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Decreases phenotype | PMID:19070643 |
| GO:0051899 | Membrane depolarization | Increases phenotype | PMID:27068812 |
| GO:0060073 | Micturition | Affects phenotype | PMID:2565272 |
| GO:0060079 | Excitatory postsynaptic potential | Affects phenotype | PMID:10516325; PMID:11164562; PMID:12802411; PMID:19159664; PMID:3419591 |
| GO:0060326 | Cell chemotaxis | Affects phenotype | PMID:11106302; PMID:15647486 |
| GO:0061366 | Behavioral response to chemical pain | Increases phenotype | PMID:18164607; PMID:29499192 |
| GO:0061367 | Behavioral response to acetic acid induced pain | Decreases phenotype | PMID:29555329 |
| GO:0061368 | Behavioral response to formalin induced pain | Affects phenotype | PMID:18164607; PMID:29555329; PMID:31218677; PMID:31218677; PMID:31857126 |
| GO:0070372 | Regulation of erk1 and erk2 cascade | Affects phenotype | PMID:22454534 |
| GO:0070989 | Oxidative demethylation | Increases phenotype | PMID:16595712 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:32129083 |
| GO:0071316 | Cellular response to nicotine | Affects phenotype | PMID:27068812 |
| GO:0080182 | Histone h3-k4 trimethylation | Increases phenotype | PMID:25643298; PMID:33891991 |
| GO:0090116 | C-5 methylation of cytosine | Affects phenotype | PMID:33891991 |
| GO:0090279 | Regulation of calcium ion import | Affects phenotype | PMID:6259338 |
| GO:0090394 | Negative regulation of excitatory postsynaptic potential | Increases phenotype | PMID:6259338 |
| GO:0097280 | Histamine secretion mediated by immunoglobulin | Increases phenotype | PMID:15770054; PMID:1725687; PMID:2471936; PMID:2578752; PMID:8941028; PMID:9243332 |
| GO:0098532 | Histone h3-k27 trimethylation | Increases phenotype | PMID:25643298; PMID:33891991 |
| GO:0120054 | Intestinal motility | Decreases phenotype | PMID:27068812 |
| GO:0120059 | Negative regulation of small intestinal transit | Decreases phenotype | PMID:26791602 |
| GO:1900273 | Positive regulation of long-term synaptic potentiation | Decreases phenotype | PMID:24309294 |
| GO:1901216 | Positive regulation of neuron death | Increases phenotype | PMID:26386147 |
| GO:1901568 | Fatty acid derivative metabolic process | Increases phenotype | PMID:26791602 |
| GO:1902952 | Positive regulation of dendritic spine maintenance | Decreases phenotype | PMID:24309294 |
| GO:1905792 | Positive regulation of mechanosensory behavior | Decreases phenotype | PMID:33607128 |
| GO:1990708 | Conditioned place preference | Increases phenotype | PMID:27461790; PMID:35461814 |
| GO:1990770 | Small intestine smooth muscle contraction | Affects phenotype | PMID:24345467 |
| GO:2000252 | Negative regulation of feeding behavior | Increases phenotype | PMID:27126842 |
| GO:2000854 | Positive regulation of corticosterone secretion | Affects phenotype | PMID:24398105 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.