Fulvestrant


Curated chemical-gene interactions from CTD
Entrez gene IDGene symbolInteraction typeReference
1000 CDH2 Affects expression PMID:36931579
100133941 CD24 Increases expression PMID:16514628
10057 ABCC5 Decreases expression PMID:15072547
10112 KIF20A Decreases expression PMID:16514628; PMID:31646340
1017 CDK2 Increases expression PMID:20215421
10171 RCL1 Decreases expression PMID:26865669
1021 CDK6 Increases expression PMID:24169358
10213 PSMD14 Decreases expression PMID:16514628
1026 CDKN1A Increases expression PMID:12154049; PMID:20696891
1027 CDKN1B Increases expression PMID:21367843
10370 CITED2 Increases expression PMID:31646340
10376 TUBA1B Increases expression PMID:12154049
10403 NDC80 Decreases expression PMID:19016759
10439 OLFM1 Decreases expression PMID:26865669
10468 FST Increases expression PMID:16298037; PMID:31646340
10498 CARM1 Increases expression PMID:31646340
10499 NCOA2 Increases expression PMID:31646340
1052 CEBPD Increases expression PMID:21980073
1058 CENPA Decreases expression PMID:16514628; PMID:31646340
10951 CBX1 Decreases expression PMID:16514628
11009 IL24 Increases expression PMID:16298037
11057 ABHD2 Decreases expression PMID:26865669
11067 DEPP1 Decreases expression PMID:16298037
11098 PRSS23 Decreases expression PMID:26865669
11130 ZWINT Decreases expression PMID:19016759
11331 PHB2 Decreases expression PMID:31646340
1152 CKB Increases expression PMID:31646340
116150 NUS1 Decreases expression PMID:16514628
1195 CLK1 Increases expression PMID:12154049
1244 ABCC2 Increases expression PMID:24685904
1312 COMT Increases expression PMID:31646340
134 ADORA1 Decreases expression PMID:31646340
1435 CSF1 Increases expression PMID:12154049
1440 CSF3 Decreases expression PMID:16298037
1475 CSTA Decreases expression PMID:15072547
1487 CTBP1 Decreases expression PMID:31646340
1490 CCN2 Increases expression PMID:31646340
1509 CTSD Affects expression PMID:14750165; PMID:15072547
1512 CTSH Increases expression PMID:16514628
1519 CTSO Increases expression PMID:31646340
1543 CYP1A1 Increases activity PMID:19901195
1543 CYP1A1 Increases expression PMID:19901195; PMID:19901195; PMID:28985473; PMID:31646340
1545 CYP1B1 Increases expression PMID:28985473
1586 CYP17A1 Increases expression PMID:17158782
1588 CYP19A1 Decreases activity PMID:11850205; PMID:15976552
1588 CYP19A1 Increases expression PMID:31646340
1660 DHX9 Decreases expression PMID:16514628
1755 DMBT1 Increases expression PMID:15564322
1786 DNMT1 Decreases expression PMID:19016759; PMID:31601247
1836 SLC26A2 Decreases expression PMID:16514628
1869 E2F1 Decreases expression PMID:20215421
190 NR0B1 Increases expression PMID:31646340
1942 EFNA1 Increases expression PMID:15072547; PMID:26865669; PMID:31646340
1946 EFNA5 Increases expression PMID:31646340
1950 EGF Affects activity PMID:19395996
196 AHR Increases activity PMID:19901195; PMID:28985473
196 AHR Increases expression PMID:19901195; PMID:31646340
1960 EGR3 Decreases expression PMID:26865669; PMID:31646340
1965 EIF2S1 Decreases expression PMID:16514628
1983 EIF5 Decreases expression PMID:16514628
200558 APLF Increases expression PMID:31646340
2041 EPHA1 Increases expression PMID:12154049
2043 EPHA4 Increases expression PMID:26865669
2063 NR2F6 Increases expression PMID:31646340
2064 ERBB2 Increases expression PMID:15072547; PMID:31646340
2065 ERBB3 Decreases expression PMID:31646340
2099 ESR1 Increases activity PMID:11174852; PMID:15537743; PMID:18976723; PMID:20211987; PMID:20362049; PMID:20435135; PMID:23562765; PMID:25012808; PMID:25752796; PMID:26865669; PMID:15950373; PMID:18635651; PMID:19339991; PMID:16010691; PMID:17299137; PMID:18417718; PMID:19570671; PMID:20419096; PMID:24782323; PMID:20208560; PMID:21873215; PMID:23213263; PMID:35803362
2099 ESR1 Increases expression PMID:11174852; PMID:11867264; PMID:15950373; PMID:16202921; PMID:19264808; PMID:19270784; PMID:19435893; PMID:19815064; PMID:20219890; PMID:23183181; PMID:23208499; PMID:25136773; PMID:26988655; PMID:27163517; PMID:32986415; PMID:38381479; PMID:12927369; PMID:18634860; PMID:20206645; PMID:27163517; PMID:20208560; PMID:20543978; PMID:26877835; PMID:28882636; PMID:31646340; PMID:30061528
210 ALAD Increases expression PMID:26865669
2100 ESR2 Decreases activity PMID:15537743; PMID:25752796; PMID:19570671; PMID:24782323
2100 ESR2 Increases expression PMID:15950373; PMID:16202921; PMID:26988655; PMID:19270784; PMID:28356238; PMID:28882636; PMID:31646340
2101 ESRRA Increases expression PMID:20211987
2149 F2R Increases expression PMID:12154049
2254 FGF9 Decreases expression PMID:14602803
2274 FHL2 Decreases expression PMID:26865669
22883 CLSTN1 Decreases expression PMID:16514628
2296 FOXC1 Decreases expression PMID:26865669
2305 FOXM1 Decreases expression PMID:19016759; PMID:20208560; PMID:31646340; PMID:20208560
2318 FLNC Decreases expression PMID:16514628
23198 PSME4 Decreases expression PMID:16514628
23286 WWC1 Decreases expression PMID:26865669
23397 NCAPH Decreases expression PMID:16514628
2353 FOS Affects expression PMID:15072547; PMID:31646340
23635 SSBP2 Increases expression PMID:26865669
23678 SGK3 Decreases expression PMID:26865669
23764 MAFF Increases expression PMID:31646340
2494 NR5A2 Increases expression PMID:31646340
2537 IFI6 Increases expression PMID:16202921
2539 G6PD Increases expression PMID:31646340
2551 GABPA Increases expression PMID:12154049
25800 SLC39A6 Decreases expression PMID:16514628
26271 FBXO5 Decreases expression PMID:19016759
266682 CYP3A2 Increases expression PMID:16837770
2697 GJA1 Affects expression PMID:29180066; PMID:36931579
27043 PELP1 Decreases expression PMID:31646340
2735 GLI1 Increases expression PMID:20232216
2796 GNRH1 Decreases expression PMID:19362103
2852 GPER1 Increases expression PMID:25969534; PMID:28882636; PMID:31646340; PMID:28882636
286204 CRB2 Increases expression PMID:31646340
2908 NR3C1 Increases expression PMID:31646340
29127 RACGAP1 Decreases expression PMID:16514628
2921 CXCL3 Increases expression PMID:16298037
29277 CYP2C11 Increases expression PMID:16837770
3002 GZMB Affects expression PMID:20145137
3015 H2AZ1 Decreases expression PMID:20543978
3146 HMGB1 Decreases expression PMID:16514628
3162 HMOX1 Decreases expression PMID:16298037
3164 NR4A1 Increases expression PMID:16514628
3169 FOXA1 Increases expression PMID:31646340
3181 HNRNPA2B1 Decreases expression PMID:16514628
3187 HNRNPH1 Decreases expression PMID:16514628
3192 HNRNPU Decreases expression PMID:16514628
3206 HOXA10 Increases expression PMID:30061528
3301 DNAJA1 Decreases expression PMID:16514628
3308 HSPA4 Decreases expression PMID:16514628
3312 HSPA8 Decreases expression PMID:16514628
3315 HSPB1 Increases activity PMID:11174852
3315 HSPB1 Increases expression PMID:11174852
332 BIRC5 Decreases expression PMID:19016759; PMID:21980073
3320 HSP90AA1 Increases expression PMID:31646340
3326 HSP90AB1 Decreases expression PMID:16514628
3329 HSPD1 Decreases expression PMID:16514628
3399 ID3 Increases expression PMID:26865669
347 APOD Affects expression PMID:16514628; PMID:27163517
3475 IFRD1 Decreases expression PMID:16514628
3484 IGFBP1 Increases expression PMID:31646340
3487 IGFBP4 Decreases expression PMID:15072547; PMID:31646340
3488 IGFBP5 Increases expression PMID:31646340
354 KLK3 Decreases expression PMID:31646340
3549 IHH Decreases expression PMID:20232216
3553 IL1B Increases expression PMID:16298037
356 FASLG Affects expression PMID:20145137
3569 IL6 Increases expression PMID:16298037
3576 CXCL8 Increases expression PMID:16298037
3667 IRS1 Decreases expression PMID:15072547
367 AR Affects expression PMID:11867264; PMID:15026081; PMID:27163517
367 AR Decreases activity PMID:15316697
3684 ITGAM Decreases expression PMID:28811679
3687 ITGAX Decreases expression PMID:28811679
3688 ITGB1 Increases expression PMID:12154049
3717 JAK2 Decreases expression PMID:26865669
3725 JUN Increases expression PMID:12154049
3726 JUNB Increases expression PMID:31646340
374 AREG Affects expression PMID:15072547; PMID:16202921; PMID:16514628; PMID:26865669; PMID:31646340
3752 KCND3 Decreases activity PMID:25231973
3756 KCNH1 Decreases expression PMID:19351862
3837 KPNB1 Decreases expression PMID:16514628
3838 KPNA2 Decreases expression PMID:16514628
3842 TNPO1 Decreases expression PMID:16514628
3897 L1CAM Increases expression PMID:31646340
3925 STMN1 Decreases expression PMID:16514628
3956 LGALS1 Increases expression PMID:31646340
3976 LIF Decreases expression PMID:30061528
4023 LPL Decreases expression PMID:17974624; PMID:31646340
4052 LTBP1 Decreases expression PMID:31646340
4057 LTF Increases expression PMID:31646340
406991 MIR21 Increases expression PMID:25969534
407033 MIR30D Decreases expression PMID:27481218
4071 TM4SF1 Increases expression PMID:31646340
4085 MAD2L1 Decreases expression PMID:19016759
4137 MAPT Decreases expression PMID:20579400
4256 MGP Decreases expression PMID:16514628
4296 MAP3K11 Increases expression PMID:12154049
4311 MME Increases expression PMID:16202921
4318 MMP9 Increases expression PMID:31646340
4324 MMP15 Increases expression PMID:15072547
440 ASNS Decreases expression PMID:16514628
4582 MUC1 Increases expression PMID:30061528
4602 MYB Decreases expression PMID:26865669
4603 MYBL1 Decreases expression PMID:26865669; PMID:33405908
4609 MYC Decreases expression PMID:15072547; PMID:20219890; PMID:31646340; PMID:21980073; PMID:24169358
4665 NAB2 Increases expression PMID:31646340
4677 NARS1 Decreases expression PMID:16514628
4691 NCL Decreases expression PMID:16514628
4751 NEK2 Decreases expression PMID:19016759
4792 NFKBIA Decreases expression PMID:16298037
4830 NME1 Decreases expression PMID:19016759
4846 NOS3 Decreases expression PMID:19962728
4856 CCN3 Increases expression PMID:15072547; PMID:18984771; PMID:18984771
4869 NPM1 Decreases expression PMID:16514628
4953 ODC1 Affects expression PMID:15925091
4982 TNFRSF11B Increases expression PMID:31646340
5055 SERPINB2 Increases expression PMID:16298037
506 ATP5F1B Increases expression PMID:20211987
5079 PAX5 Increases expression PMID:12154049
50943 FOXP3 Increases expression PMID:20145137
5111 PCNA Decreases expression PMID:15072547; PMID:16202921; PMID:19016759
51195 RAPGEFL1 Decreases expression PMID:26865669
5174 PDZK1 Decreases expression PMID:26865669; PMID:31646340
51765 STK26 Decreases expression PMID:16514628
5241 PGR Decreases activity PMID:25752796
5241 PGR Decreases expression PMID:11867264; PMID:15072547; PMID:20206645; PMID:20543978; PMID:26865669; PMID:31646340; PMID:20179196; PMID:30061528
5243 ABCB1 Increases expression PMID:24685904
5292 PIM1 Increases expression PMID:16298037
5329 PLAUR Decreases expression PMID:26865669
54106 TLR9 Decreases expression PMID:28811679
54205 CYCS Increases expression PMID:20211987
5431 POLR2B Decreases expression PMID:16514628
54361 WNT4 Decreases expression PMID:31646340
54498 SMOX Decreases expression PMID:26865669
54658 UGT1A1 Increases expression PMID:15072547
5469 MED1 Decreases expression PMID:31646340
54981 NMRK1 Decreases expression PMID:26865669
55503 TRPV6 Increases expression PMID:30061528
5551 PRF1 Affects expression PMID:20145137
55540 IL17RB Decreases expression PMID:19016759
5591 PRKDC Decreases expression PMID:16514628
5617 PRL Decreases expression PMID:20419096
56892 TCIM Increases expression PMID:31646340
5727 PTCH1 Increases expression PMID:31646340
5743 PTGS2 Increases expression PMID:31646340
5862 RAB2A Increases expression PMID:12154049
5888 RAD51 Decreases expression PMID:19016759
5898 RALA Increases expression PMID:31646340
5906 RAP1A Decreases expression PMID:16514628
5914 RARA Decreases expression PMID:31646340
5931 RBBP7 Decreases expression PMID:16514628
5932 RBBP8 Decreases expression PMID:26865669
595 CCND1 Decreases expression PMID:20206645; PMID:20215421; PMID:20219890; PMID:20543978; PMID:26865669; PMID:26877835; PMID:31646340; PMID:21367843; PMID:21980073
596 BCL2 Increases expression PMID:16951259
5979 RET Decreases expression PMID:26865669
599 BCL2L2 Increases expression PMID:31646340
60481 ELOVL5 Decreases expression PMID:16514628
6128 RPL6 Decreases expression PMID:16514628
6240 RRM1 Decreases expression PMID:16514628
627 BDNF Increases expression PMID:31646340
6276 S100A5 Increases expression PMID:31646340
6294 SAFB Increases expression PMID:31646340
6347 CCL2 Increases expression PMID:31646340
6352 CCL5 Increases expression PMID:12154049
6364 CCL20 Increases expression PMID:16298037
6387 CXCL12 Decreases expression PMID:26865669
6421 SFPQ Decreases expression PMID:16514628
6426 SRSF1 Decreases expression PMID:16514628
64285 RHBDF1 Increases expression PMID:26865669
6446 SGK1 Decreases expression PMID:26865669; PMID:33405908
64771 ILRUN Decreases expression PMID:16514628
6478 SIAH2 Decreases expression PMID:26865669
6506 SLC1A2 Increases expression PMID:24782323
652 BMP4 Increases expression PMID:31646340
655 BMP7 Increases expression PMID:31646340
6597 SMARCA4 Decreases expression PMID:24169358
6598 SMARCB1 Increases expression PMID:24169358
6599 SMARCC1 Increases expression PMID:24169358
66008 TRAK2 Decreases expression PMID:16514628
6601 SMARCC2 Decreases expression PMID:24169358
6615 SNAI1 Increases expression PMID:31646340
6647 SOD1 Increases expression PMID:12154049
6651 SON Decreases expression PMID:16514628
667 DST Increases expression PMID:16202921
6696 SPP1 Increases expression PMID:31646340
672 BRCA1 Decreases expression PMID:20206645; PMID:31646340
6772 STAT1 Decreases expression PMID:16514628
6790 AURKA Decreases expression PMID:16514628
6840 SVIL Decreases expression PMID:26865669
6867 TACC1 Increases expression PMID:15072547; PMID:18984771; PMID:18984771
6880 TAF9 Affects expression PMID:12154049; PMID:16514628
6897 TARS1 Decreases expression PMID:16514628
6923 ELOB Decreases expression PMID:16514628
6928 HNF1B Decreases expression PMID:32623698
6941 TCF19 Decreases expression PMID:19016759
699 BUB1 Decreases expression PMID:19016759
701 BUB1B Decreases expression PMID:19016759
7015 TERT Decreases expression PMID:19501078
7020 TFAP2A Increases expression PMID:26865669
7022 TFAP2C Decreases expression PMID:26865669
7031 TFF1 Affects expression PMID:14750165; PMID:15072547; PMID:16202921; PMID:16514628; PMID:20206645; PMID:27163517; PMID:9276643; PMID:27163517; PMID:31646340
7032 TFF2 Decreases expression PMID:20696891
7033 TFF3 Decreases expression PMID:16202921
7035 TFPI Increases expression PMID:26865669
7037 TFRC Increases expression PMID:12154049
7038 TG Increases expression PMID:23238275
7039 TGFA Increases expression PMID:31646340
7040 TGFB1 Increases expression PMID:20145137
7043 TGFB3 Decreases expression PMID:31646340
7057 THBS1 Increases expression PMID:31646340
7058 THBS2 Decreases expression PMID:16514628
7112 TMPO Decreases expression PMID:16514628
7150 TOP1 Decreases expression PMID:16514628
7153 TOP2A Increases expression PMID:12154049
7155 TOP2B Decreases expression PMID:16514628
7157 TP53 Decreases expression PMID:24169358
718 C3 Affects expression PMID:11086226; PMID:31646340
7184 HSP90B1 Decreases expression PMID:16514628
7272 TTK Decreases expression PMID:19016759
7296 TXNRD1 Decreases expression PMID:16514628
7374 UNG Decreases expression PMID:16514628
7421 VDR Decreases expression PMID:15930183; PMID:31646340
7422 VEGFA Decreases expression PMID:31646340
7472 WNT2 Decreases expression PMID:15072547
7474 WNT5A Increases expression PMID:31646340
7514 XPO1 Decreases expression PMID:16514628
7520 XRCC5 Decreases expression PMID:16514628
7543 ZFX Increases expression PMID:12154049
7555 CNBP Increases expression PMID:12154049
771 CA12 Decreases expression PMID:26865669
7764 ZNF217 Increases expression PMID:15072547
79026 AHNAK Decreases expression PMID:16514628
79666 PLEKHF2 Increases expression PMID:26865669
79789 CLMN Increases expression PMID:26865669
79923 NANOG Increases expression PMID:27581495
8140 SLC7A5 Decreases expression PMID:26865669
8165 AKAP1 Increases expression PMID:31646340
8202 NCOA3 Increases expression PMID:31646340
8204 NRIP1 Decreases expression PMID:31646340
8289 ARID1A Increases expression PMID:24169358
837 CASP4 Increases expression PMID:12154049
84248 FYTTD1 Decreases expression PMID:16514628
8431 NR0B2 Decreases expression PMID:31646340
8445 DYRK2 Increases expression PMID:26865669
84669 USP32 Decreases expression PMID:16514628
8493 PPM1D Decreases expression PMID:16514628
8503 PIK3R3 Increases expression PMID:26865669
8546 AP3B1 Decreases expression PMID:31646340
857 CAV1 Decreases expression PMID:31646340
8648 NCOA1 Increases expression PMID:31646340
8653 DDX3Y Decreases expression PMID:16514628
8655 DYNLL1 Increases expression PMID:12154049
8714 ABCC3 Increases expression PMID:15072547
8826 IQGAP1 Decreases expression PMID:16514628
8829 NRP1 Decreases expression PMID:31646340
8839 CCN5 Increases expression PMID:31646340
8847 DLEU2 Increases expression PMID:15072547
8856 NR1I2 Increases activity PMID:15885729
890 CCNA2 Decreases expression PMID:15072547; PMID:19016759; PMID:31646340; PMID:21367843
891 CCNB1 Affects expression PMID:12154049; PMID:21980073
8914 TIMELESS Decreases expression PMID:19016759
8942 KYNU Increases expression PMID:26865669
898 CCNE1 Decreases expression PMID:20215421
901 CCNG2 Increases expression PMID:26865669
9021 SOCS3 Decreases expression PMID:31646340; PMID:32044397
9055 PRC1 Decreases expression PMID:31646340
9112 MTA1 Decreases expression PMID:31646340
9133 CCNB2 Decreases expression PMID:19016759; PMID:31646340; PMID:21980073
9134 CCNE2 Decreases expression PMID:19016759; PMID:31646340
9166 EBAG9 Decreases expression PMID:31646340
9188 DDX21 Decreases expression PMID:16514628
9212 AURKB Decreases expression PMID:19016759; PMID:31646340
9232 PTTG1 Decreases expression PMID:18984771; PMID:18984771; PMID:19016759
9276 COPB2 Decreases expression PMID:16514628
948 CD36 Increases expression PMID:27358406
9536 PTGES Decreases expression PMID:26865669
9564 BCAR1 Increases expression PMID:31646340
960 CD44 Decreases expression PMID:26865669
9611 NCOR1 Increases expression PMID:31646340
9612 NCOR2 Increases expression PMID:31646340
9645 MICAL2 Decreases expression PMID:26865669
9687 GREB1 Decreases expression PMID:31646340; PMID:33405908
9700 ESPL1 Decreases expression PMID:19016759
9768 PCLAF Decreases expression PMID:16514628
9782 MATR3 Decreases expression PMID:16514628
983 CDK1 Decreases expression PMID:19016759; PMID:31646340
9861 PSMD6 Decreases expression PMID:16514628
991 CDC20 Decreases expression PMID:19016759
9915 ARNT2 Increases expression PMID:16514628
9950 GOLGA5 Decreases expression PMID:16514628

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.