DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Fulvestrant

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000084	Mitotic s phase	Increases phenotype	PMID:28736785; PMID:30684532; PMID:33484789
GO:0000165	Mapk cascade	Increases phenotype	PMID:12967334
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:26397976; PMID:33484789
GO:0001503	Ossification	Increases phenotype	PMID:25014179
GO:0001821	Histamine secretion	Increases phenotype	PMID:23782309
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:24726523
GO:0001954	Positive regulation of cell-matrix adhesion	Affects phenotype	PMID:24440569
GO:0001985	Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	Increases phenotype	PMID:26597895
GO:0002281	Macrophage activation involved in immune response	Increases phenotype	PMID:32044397
GO:0003720	Telomerase activity	Increases phenotype	PMID:26397976
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:24742230; PMID:31733320
GO:0005977	Glycogen metabolic process	Affects phenotype	PMID:32623698
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:34147605
GO:0006171	Camp biosynthetic process	Increases phenotype	PMID:31126612
GO:0006561	Proline biosynthetic process	Increases phenotype	PMID:27514991
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:26470790
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:31126612
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:24437944
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:30590302
GO:0006914	Autophagy	Increases phenotype	PMID:24726523
GO:0006915	Apoptotic process	Affects phenotype	PMID:12967334; PMID:23788033; PMID:26397976; PMID:27163517; PMID:34537452; PMID:34655285; PMID:35439536; PMID:35461094; PMID:35461094; PMID:35563431; PMID:36613676
GO:0006936	Muscle contraction	Increases phenotype	PMID:28138957
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:28446726
GO:0007141	Male meiosis i	Affects phenotype	PMID:23788033
GO:0007155	Cell adhesion	Increases phenotype	PMID:25096985
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:30195206
GO:0007267	Cell-cell signaling	Decreases phenotype	PMID:28736254
GO:0007566	Embryo implantation	Decreases phenotype	PMID:30061528
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:34537452
GO:0008219	Cell death	Affects phenotype	PMID:24361291; PMID:27364615; PMID:31059536
GO:0008277	Regulation of g protein-coupled receptor signaling pathway	Affects phenotype	PMID:24440569
GO:0008283	Cell population proliferation	Increases phenotype	PMID:10079213; PMID:16700038; PMID:16951259; PMID:17075048; PMID:17458902; PMID:23982890; PMID:24213142; PMID:24684733; PMID:25004094; PMID:30817981; PMID:33484789; PMID:17572228; PMID:19654912; PMID:20219890; PMID:20962025; PMID:21367843; PMID:22965848; PMID:23302510; PMID:23596885; PMID:23982890; PMID:24213142; PMID:24213142; PMID:24684733; PMID:24213142; PMID:25004094; PMID:25130739; PMID:28808208; PMID:24361291; PMID:24495410; PMID:24684733; PMID:24726523; PMID:24758408; PMID:25004094; PMID:25014179; PMID:25728338; PMID:26006730; PMID:26397976; PMID:26435001; PMID:26593444; PMID:27025157; PMID:27163517; PMID:27260121; PMID:28446726; PMID:28500084; PMID:28808208; PMID:28808208; PMID:30684532; PMID:29063134; PMID:30677511; PMID:30682495; PMID:30817981; PMID:31016752; PMID:31689473; PMID:32926937; PMID:33484789
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:23810794; PMID:25786527; PMID:26116029; PMID:26344002; PMID:26344002; PMID:26877835; PMID:26877835; PMID:26979758; PMID:27539251; PMID:28844962; PMID:37827210; PMID:27071941; PMID:27366082; PMID:27539251; PMID:27880919; PMID:28811679; PMID:28844962; PMID:29074358; PMID:29945225; PMID:30187510; PMID:30195206; PMID:30196065; PMID:30796839; PMID:35028925; PMID:38381479
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:20981859; PMID:23526725; PMID:29180066; PMID:31381935; PMID:37827210
GO:0008361	Regulation of cell size	Affects phenotype	PMID:32415908
GO:0008610	Lipid biosynthetic process	Affects phenotype	PMID:25819109; PMID:27003841
GO:0009410	Response to xenobiotic stimulus	Decreases phenotype	PMID:18277952
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:31601247
GO:0010693	Negative regulation of alkaline phosphatase activity	Increases phenotype	PMID:20981859
GO:0010694	Positive regulation of alkaline phosphatase activity	Increases phenotype	PMID:27401186
GO:0010718	Positive regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:28284859; PMID:28844962; PMID:32956863
GO:0010825	Positive regulation of centrosome duplication	Increases phenotype	PMID:27998958
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:21215799; PMID:24437944
GO:0014064	Positive regulation of serotonin secretion	Increases phenotype	PMID:26116029
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	Affects phenotype	PMID:22982565
GO:0014902	Myotube differentiation	Decreases phenotype	PMID:24431215
GO:0015108	Chloride transmembrane transporter activity	Decreases phenotype	PMID:12527479
GO:0015908	Fatty acid transport	Affects phenotype	PMID:32623698
GO:0016049	Cell growth	Increases phenotype	PMID:26234195
GO:0016358	Dendrite development	Increases phenotype	PMID:24231043
GO:0016477	Cell migration	Affects phenotype	PMID:26407941; PMID:28808208; PMID:31230753
GO:0019058	Viral life cycle	Decreases phenotype	PMID:26684252
GO:0030030	Cell projection organization	Increases phenotype	PMID:25096985
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:25534675; PMID:25690688; PMID:25690688; PMID:26344002; PMID:26344002; PMID:26546977; PMID:27366082; PMID:27539251; PMID:27539251; PMID:28844962; PMID:28844962; PMID:28844962; PMID:35597549; PMID:32956863; PMID:39306225
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:29180066; PMID:32956863
GO:0030501	Positive regulation of bone mineralization	Increases phenotype	PMID:26362186
GO:0030520	Intracellular estrogen receptor signaling pathway	Affects phenotype	PMID:33111528; PMID:36513145
GO:0032125	Micronucleus organization	Increases phenotype	PMID:29362861
GO:0032148	Activation of protein kinase b activity	Affects phenotype	PMID:23170834; PMID:27880919; PMID:30195206
GO:0032735	Positive regulation of interleukin-12 production	Increases phenotype	PMID:28811679
GO:0032966	Negative regulation of collagen biosynthetic process	Increases phenotype	PMID:20981859
GO:0033146	Regulation of intracellular estrogen receptor signaling pathway	Affects phenotype	PMID:26865669
GO:0033148	Positive regulation of intracellular estrogen receptor signaling pathway	Increases phenotype	PMID:23756170; PMID:24437944; PMID:26018136; PMID:26139245; PMID:26979758; PMID:27366082; PMID:28711546; PMID:31388671; PMID:34831106
GO:0033313	Meiotic cell cycle checkpoint signaling	Increases phenotype	PMID:23788033
GO:0034109	Homotypic cell-cell adhesion	Increases phenotype	PMID:34049886
GO:0035021	Negative regulation of rac protein signal transduction	Increases phenotype	PMID:29180066
GO:0035774	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	Increases phenotype	PMID:28180948
GO:0035847	Uterine epithelium development	Increases phenotype	PMID:25786527
GO:0035936	Testosterone secretion	Increases phenotype	PMID:35764126; PMID:36931579; PMID:37357847
GO:0036091	Positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress	Increases phenotype	PMID:24437944
GO:0036474	Cell death in response to hydrogen peroxide	Affects phenotype	PMID:23526725
GO:0042023	Dna endoreduplication	Increases phenotype	PMID:26027920
GO:0042116	Macrophage activation	Increases phenotype	PMID:28500084
GO:0042127	Regulation of cell population proliferation	Affects phenotype	PMID:33582643
GO:0042310	Vasoconstriction	Increases phenotype	PMID:31415774
GO:0042311	Vasodilation	Increases phenotype	PMID:22982565; PMID:36310694
GO:0042552	Myelination	Decreases phenotype	PMID:27364615
GO:0042701	Progesterone secretion	Increases phenotype	PMID:31126612
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:25738436; PMID:29134746
GO:0043149	Stress fiber assembly	Increases phenotype	PMID:25096985
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:15196704; PMID:22905168; PMID:22965848; PMID:29360751; PMID:29360751; PMID:33484789; PMID:30590302; PMID:31059536; PMID:31601247; PMID:33181973; PMID:33484789; PMID:37357847
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:27145024; PMID:31601247; PMID:35181438
GO:0044381	Glucose import in response to insulin stimulus	Increases phenotype	PMID:31536778
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:33484789
GO:0045333	Cellular respiration	Decreases phenotype	PMID:37657410
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:22982565; PMID:32559890; PMID:36089060
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:25014179; PMID:25143472
GO:0045600	Positive regulation of fat cell differentiation	Increases phenotype	PMID:26018136; PMID:26408789
GO:0045668	Negative regulation of osteoblast differentiation	Increases phenotype	PMID:20981859
GO:0045862	Positive regulation of proteolysis	Increases phenotype	PMID:24440569
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:19194971; PMID:21367843
GO:0046323	Glucose import	Increases phenotype	PMID:34147605
GO:0046326	Positive regulation of glucose import	Increases phenotype	PMID:36328215
GO:0046622	Positive regulation of organ growth	Increases phenotype	PMID:25786527; PMID:27395752; PMID:30077407
GO:0048041	Focal adhesion assembly	Increases phenotype	PMID:25096985
GO:0048863	Stem cell differentiation	Decreases phenotype	PMID:31119342
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:20962025
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:25738436
GO:0051298	Centrosome duplication	Increases phenotype	PMID:36384894
GO:0051613	Positive regulation of serotonin uptake	Increases phenotype	PMID:26116029
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:23419388; PMID:33484789
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:24726523; PMID:34655285
GO:0051896	Regulation of protein kinase b signaling	Affects phenotype	PMID:23419388
GO:0051897	Positive regulation of protein kinase b signaling	Increases phenotype	PMID:22982565; PMID:24437944
GO:0051965	Positive regulation of synapse assembly	Increases phenotype	PMID:29278848
GO:0060065	Uterus development	Decreases phenotype	PMID:28248286
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:26225806; PMID:35181438
GO:0060999	Positive regulation of dendritic spine development	Increases phenotype	PMID:29278848
GO:0061370	Testosterone biosynthetic process	Increases phenotype	PMID:35810996
GO:0070168	Negative regulation of biomineral tissue development	Increases phenotype	PMID:20981859
GO:0070374	Positive regulation of erk1 and erk2 cascade	Affects phenotype	PMID:25616260; PMID:27071941; PMID:30195206
GO:0070509	Calcium ion import	Increases phenotype	PMID:28701262; PMID:30707916
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24726523
GO:0090398	Cellular senescence	Affects phenotype	PMID:17075048; PMID:21367843
GO:0097264	Self proteolysis	Increases phenotype	PMID:24440569
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:32623698; PMID:33865937; PMID:33872936; PMID:35736896
GO:1900182	Positive regulation of protein localization to nucleus	Increases phenotype	PMID:32956863
GO:1900273	Positive regulation of long-term synaptic potentiation	Increases phenotype	PMID:28255459
GO:1900745	Positive regulation of p38mapk cascade	Increases phenotype	PMID:29180066
GO:1902261	Positive regulation of delayed rectifier potassium channel activity	Increases phenotype	PMID:16985185
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:24720662
GO:1902608	Positive regulation of large conductance calcium-activated potassium channel activity	Increases phenotype	PMID:17878692
GO:1902847	Regulation of neuronal signal transduction	Affects phenotype	PMID:26934298
GO:1903077	Negative regulation of protein localization to plasma membrane	Increases phenotype	PMID:32956863
GO:1903284	Positive regulation of glutathione peroxidase activity	Increases phenotype	PMID:21215799
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:20962025; PMID:30590302
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Affects phenotype	PMID:28180948; PMID:30195206
GO:1905665	Positive regulation of calcium ion import across plasma membrane	Increases phenotype	PMID:29476780
GO:1990349	Gap junction-mediated intercellular transport	Decreases phenotype	PMID:30187510; PMID:32610363
GO:2000845	Positive regulation of testosterone secretion	Increases phenotype	PMID:35803362
GO:2000865	Negative regulation of estradiol secretion	Increases phenotype	PMID:37084542
GO:2000866	Positive regulation of estradiol secretion	Increases phenotype	PMID:31016752
GO:2001200	Positive regulation of dendritic cell differentiation	Increases phenotype	PMID:21538406; PMID:28811679

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.