DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Indomethacin

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000423	Mitophagy	Increases phenotype	PMID:38705399
GO:0001516	Prostaglandin biosynthetic process	Affects phenotype	PMID:27645307; PMID:31048000
GO:0001692	Histamine metabolic process	Affects phenotype	PMID:36868495
GO:0001776	Leukocyte homeostasis	Affects phenotype	PMID:34789018
GO:0001780	Neutrophil homeostasis	Affects phenotype	PMID:34789018
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:23022152
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:6963085
GO:0002232	Leukocyte chemotaxis involved in inflammatory response	Increases phenotype	PMID:27452194; PMID:29127031
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:29499192; PMID:37676835; PMID:38447874
GO:0002539	Prostaglandin production involved in inflammatory response	Increases phenotype	PMID:29523851
GO:0003006	Developmental process involved in reproduction	Decreases phenotype	PMID:34431458
GO:0003094	Glomerular filtration	Affects phenotype	PMID:2478751
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Affects phenotype	PMID:34431458
GO:0004303	Estradiol 17-beta-dehydrogenase activity	Decreases phenotype	PMID:34431458
GO:0004396	Hexokinase activity	Decreases phenotype	PMID:28266800
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:25698669; PMID:28648817; PMID:34431458; PMID:34789018
GO:0004784	Superoxide dismutase activity	Affects phenotype	PMID:25698669; PMID:25926722; PMID:25926722; PMID:30580614; PMID:27645307; PMID:27645307; PMID:28648817; PMID:28648817; PMID:30580614; PMID:34431458; PMID:38705399
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:35946054
GO:0005776	Autophagosome	Increases phenotype	PMID:38705399
GO:0006014	D-ribose metabolic process	Affects phenotype	PMID:36868495
GO:0006105	Succinate metabolic process	Affects phenotype	PMID:36868495
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:15133238
GO:0006520	Amino acid metabolic process	Affects phenotype	PMID:36868495
GO:0006568	Tryptophan metabolic process	Affects phenotype	PMID:36868495
GO:0006600	Creatine metabolic process	Affects phenotype	PMID:36868495
GO:0006631	Fatty acid metabolic process	Affects phenotype	PMID:36868495
GO:0006650	Glycerophospholipid metabolic process	Affects phenotype	PMID:36868495
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:10027849; PMID:37483153
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:30252991; PMID:30580614; PMID:34789018; PMID:35752295; PMID:38447874; PMID:38705399
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:25698669; PMID:25926722; PMID:27645307
GO:0006771	Riboflavin metabolic process	Affects phenotype	PMID:36868495
GO:0006801	Superoxide metabolic process	Decreases phenotype	PMID:34789018
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:21381754; PMID:23994084; PMID:25698669
GO:0006851	Mitochondrial calcium ion transmembrane transport	Increases phenotype	PMID:23022152
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:33276066
GO:0006914	Autophagy	Increases phenotype	PMID:38705399
GO:0006915	Apoptotic process	Affects phenotype	PMID:10554762; PMID:10828028; PMID:11470254; PMID:11532860; PMID:11879183; PMID:12897060; PMID:15133238; PMID:15482327; PMID:16187199; PMID:20190399; PMID:19148790; PMID:19153190; PMID:19220725; PMID:23022152; PMID:24312908; PMID:31916655; PMID:9192825; PMID:32128977
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	Increases phenotype	PMID:9851595
GO:0006939	Smooth muscle contraction	Increases phenotype	PMID:7257821
GO:0006954	Inflammatory response	Increases phenotype	PMID:30580614
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:19148790; PMID:19220725; PMID:19220725; PMID:20374237; PMID:20374237; PMID:23668856
GO:0007049	Cell cycle	Decreases phenotype	PMID:11504793; PMID:12535653
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:34431458
GO:0008202	Steroid metabolic process	Affects phenotype	PMID:36868495
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:34789018
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:38815664
GO:0008215	Spermine metabolic process	Affects phenotype	PMID:36868495
GO:0008216	Spermidine metabolic process	Affects phenotype	PMID:36868495
GO:0008217	Regulation of blood pressure	Increases phenotype	PMID:10892668; PMID:10892668; PMID:7635531; PMID:10988282; PMID:11159720; PMID:119300; PMID:12011663; PMID:12556654; PMID:8557971; PMID:8755685; PMID:16635112; PMID:20632668; PMID:3038419; PMID:6498036; PMID:6614039; PMID:7035040; PMID:3063971; PMID:3429061; PMID:439781; PMID:6280473; PMID:6963085; PMID:7049707; PMID:712191; PMID:7635531; PMID:8535553
GO:0008219	Cell death	Increases phenotype	PMID:12967722; PMID:16388830; PMID:2364169; PMID:24737281
GO:0008283	Cell population proliferation	Affects phenotype	PMID:11532860; PMID:12490308; PMID:12535653; PMID:15482327; PMID:17420946; PMID:1993070; PMID:23022152; PMID:24312908; PMID:3097147; PMID:6332851; PMID:8301609
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:33785417
GO:0008610	Lipid biosynthetic process	Affects phenotype	PMID:32535746
GO:0009119	Ribonucleoside metabolic process	Affects phenotype	PMID:36868495
GO:0009120	Deoxyribonucleoside metabolic process	Affects phenotype	PMID:36868495
GO:0009308	Amine metabolic process	Affects phenotype	PMID:36868495
GO:0009408	Response to heat	Affects phenotype	PMID:10701834; PMID:36736112
GO:0009410	Response to xenobiotic stimulus	Decreases phenotype	PMID:11567657
GO:0009437	Carnitine metabolic process	Affects phenotype	PMID:36868495
GO:0009636	Response to toxic substance	Decreases phenotype	PMID:21319177
GO:0010033	Response to organic substance	Decreases phenotype	PMID:32006539
GO:0010884	Positive regulation of lipid storage	Increases phenotype	PMID:15273253; PMID:27605626; PMID:30382123; PMID:34560244
GO:0010890	Positive regulation of sequestering of triglyceride	Increases phenotype	PMID:25761413
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:25446496; PMID:28754375
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:1370149; PMID:22653900; PMID:25698669; PMID:25926722; PMID:27645307; PMID:27645307; PMID:28648817; PMID:28648817; PMID:30580614; PMID:31542; PMID:32128977
GO:0016477	Cell migration	Decreases phenotype	PMID:28342779
GO:0019371	Cyclooxygenase pathway	Decreases phenotype	PMID:32738273
GO:0019372	Lipoxygenase pathway	Increases phenotype	PMID:6438153
GO:0019395	Fatty acid oxidation	Decreases phenotype	PMID:32535746
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:30055130
GO:0019467	Ornithine catabolic process, by decarboxylation	Increases phenotype	PMID:6438153
GO:0019507	Pyridine metabolic process	Affects phenotype	PMID:36868495
GO:0019695	Choline metabolic process	Affects phenotype	PMID:36868495
GO:0019752	Carboxylic acid metabolic process	Affects phenotype	PMID:36868495; PMID:38701902
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:36868495
GO:0019858	Cytosine metabolic process	Affects phenotype	PMID:36868495
GO:0019915	Lipid storage	Increases phenotype	PMID:30382123
GO:0020027	Hemoglobin metabolic process	Affects phenotype	PMID:34789018
GO:0030154	Cell differentiation	Affects phenotype	PMID:18354491; PMID:2015844
GO:0030220	Platelet formation	Affects phenotype	PMID:34789018
GO:0030321	Transepithelial chloride transport	Increases phenotype	PMID:18187619
GO:0030595	Leukocyte chemotaxis	Increases phenotype	PMID:18823975; PMID:6845886
GO:0031393	Negative regulation of prostaglandin biosynthetic process	Increases phenotype	PMID:32006539
GO:0031394	Positive regulation of prostaglandin biosynthetic process	Decreases phenotype	PMID:11567657
GO:0031987	Locomotion involved in locomotory behavior	Decreases phenotype	PMID:34789018
GO:0032088	Negative regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:23872422
GO:0033554	Cellular response to stress	Affects phenotype	PMID:8836877
GO:0034101	Erythrocyte homeostasis	Affects phenotype	PMID:34789018
GO:0034275	Kynurenic acid metabolic process	Affects phenotype	PMID:36868495
GO:0034440	Lipid oxidation	Affects phenotype	PMID:30252991; PMID:34431458; PMID:34789018; PMID:38447874; PMID:38705399; PMID:6438153
GO:0035635	Entry of bacterium into host cell	Increases phenotype	PMID:28450277
GO:0035784	Nickel cation homeostasis	Decreases phenotype	PMID:27452194
GO:0035810	Positive regulation of urine volume	Affects phenotype	PMID:28284659; PMID:3856211; PMID:6588700; PMID:6588700; PMID:6945054; PMID:8261690
GO:0035812	Renal sodium excretion	Affects phenotype	PMID:10737671; PMID:1621809; PMID:16303714; PMID:16521006; PMID:2596536; PMID:3136271; PMID:6587655; PMID:844248; PMID:9853274
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:34431458
GO:0042168	Heme metabolic process	Affects phenotype	PMID:30252991
GO:0042246	Tissue regeneration	Increases phenotype	PMID:29127031
GO:0042310	Vasoconstriction	Affects phenotype	PMID:10729242; PMID:10790511; PMID:12021577; PMID:1321188; PMID:1443750; PMID:15302685; PMID:17179254; PMID:2147865; PMID:2196965; PMID:2751124; PMID:28826906; PMID:30244120; PMID:3080585; PMID:3104084; PMID:31415774; PMID:3279819; PMID:34411564; PMID:39551421; PMID:6498036
GO:0042311	Vasodilation	Increases phenotype	PMID:10729242; PMID:10790511; PMID:10839955; PMID:12883323; PMID:1443750; PMID:15265802; PMID:16782846; PMID:18635485; PMID:20033351; PMID:2196965; PMID:3795972; PMID:9052889
GO:0042417	Dopamine metabolic process	Affects phenotype	PMID:36868495
GO:0042431	Indole metabolic process	Affects phenotype	PMID:36868495
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:22653900
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:21882223; PMID:29523851
GO:0043306	Positive regulation of mast cell degranulation	Increases phenotype	PMID:29127031
GO:0044065	Regulation of respiratory system process	Affects phenotype	PMID:23871789
GO:0044237	Cellular metabolic process	Affects phenotype	PMID:31916655; PMID:32128977; PMID:32535746; PMID:33091441; PMID:33276066
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:28342779
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:28298639; PMID:28628672; PMID:28758259; PMID:30055130; PMID:30738844
GO:0045600	Positive regulation of fat cell differentiation	Increases phenotype	PMID:26492236; PMID:26824325; PMID:27605626; PMID:27714895; PMID:30382123; PMID:34560244; PMID:39004236
GO:0045654	Positive regulation of megakaryocyte differentiation	Increases phenotype	PMID:14726416
GO:0045671	Negative regulation of osteoclast differentiation	Increases phenotype	PMID:19198759
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:21832210; PMID:27421582; PMID:28987480; PMID:32738273
GO:0045987	Positive regulation of smooth muscle contraction	Increases phenotype	PMID:27084847
GO:0046034	Atp metabolic process	Affects phenotype	PMID:32535746
GO:0046085	Adenosine metabolic process	Affects phenotype	PMID:36868495
GO:0046092	Deoxycytidine metabolic process	Affects phenotype	PMID:36868495
GO:0046100	Hypoxanthine metabolic process	Affects phenotype	PMID:36868495
GO:0046110	Xanthine metabolic process	Affects phenotype	PMID:36868495
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:38447874
GO:0046415	Urate metabolic process	Affects phenotype	PMID:36868495
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:36868495; PMID:38705399
GO:0046457	Prostanoid biosynthetic process	Affects phenotype	PMID:6438153
GO:0046460	Neutral lipid biosynthetic process	Increases phenotype	PMID:32535746
GO:0046466	Membrane lipid catabolic process	Affects phenotype	PMID:12093485; PMID:12603077; PMID:1511859; PMID:15267151; PMID:19615346; PMID:20374237; PMID:2116696; PMID:31542; PMID:39182545; PMID:8721639
GO:0046483	Heterocycle metabolic process	Affects phenotype	PMID:36868495
GO:0048266	Behavioral response to pain	Increases phenotype	PMID:30261224
GO:0048872	Homeostasis of number of cells	Affects phenotype	PMID:34789018
GO:0050872	White fat cell differentiation	Increases phenotype	PMID:27605626; PMID:33412187
GO:0050873	Brown fat cell differentiation	Increases phenotype	PMID:25761413
GO:0050901	Leukocyte tethering or rolling	Increases phenotype	PMID:11159720; PMID:7783059
GO:0050966	Detection of mechanical stimulus involved in sensory perception of pain	Increases phenotype	PMID:33259823
GO:0051281	Positive regulation of release of sequestered calcium ion into cytosol	Increases phenotype	PMID:23022152
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:19220725; PMID:22653900
GO:0060326	Cell chemotaxis	Affects phenotype	PMID:1511864; PMID:314231; PMID:6853143
GO:0060454	Positive regulation of gastric acid secretion	Increases phenotype	PMID:29523851
GO:0060612	Adipose tissue development	Increases phenotype	PMID:20206132; PMID:33091441; PMID:9564879
GO:0061024	Membrane organization	Decreases phenotype	PMID:26808022
GO:0061366	Behavioral response to chemical pain	Increases phenotype	PMID:9777656
GO:0061367	Behavioral response to acetic acid induced pain	Affects phenotype	PMID:15619576; PMID:36736112; PMID:21372527
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:34431458
GO:0061436	Establishment of skin barrier	Decreases phenotype	PMID:23668856
GO:0070165	Positive regulation of adiponectin secretion	Increases phenotype	PMID:39004236
GO:0070265	Necrotic cell death	Increases phenotype	PMID:37676835
GO:0070346	Positive regulation of fat cell proliferation	Increases phenotype	PMID:27605626; PMID:30382123
GO:0070352	Positive regulation of white fat cell proliferation	Increases phenotype	PMID:27605626
GO:0070374	Positive regulation of erk1 and erk2 cascade	Increases phenotype	PMID:29523851
GO:0070633	Transepithelial transport	Increases phenotype	PMID:33276066
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:35752295; PMID:37483153; PMID:38447874
GO:0072350	Tricarboxylic acid metabolic process	Affects phenotype	PMID:36868495
GO:0072672	Neutrophil extravasation	Increases phenotype	PMID:20374237
GO:0072719	Cellular response to cisplatin	Decreases phenotype	PMID:33785417
GO:0090336	Positive regulation of brown fat cell differentiation	Increases phenotype	PMID:25761413
GO:0090592	Dna synthesis involved in dna replication	Increases phenotype	PMID:6438153
GO:0097189	Apoptotic body	Increases phenotype	PMID:31916655
GO:0097202	Activation of cysteine-type endopeptidase activity	Increases phenotype	PMID:23022152
GO:0097280	Histamine secretion mediated by immunoglobulin	Increases phenotype	PMID:2409022; PMID:2445231; PMID:3966716
GO:0098743	Cell aggregation	Decreases phenotype	PMID:33785417
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:28298639; PMID:28628672; PMID:28758259; PMID:30055130; PMID:30738844; PMID:33091441; PMID:39004236
GO:1900227	Positive regulation of nlrp3 inflammasome complex assembly	Increases phenotype	PMID:26349656
GO:1901417	Negative regulation of response to ethanol	Increases phenotype	PMID:24337826
GO:1901418	Positive regulation of response to ethanol	Increases phenotype	PMID:24337826
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:30252991; PMID:39182545
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:9851595
GO:1902565	Positive regulation of neutrophil activation	Increases phenotype	PMID:21873894
GO:1902608	Positive regulation of large conductance calcium-activated potassium channel activity	Increases phenotype	PMID:27605626
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:31916655
GO:1903522	Regulation of blood circulation	Affects phenotype	PMID:3965332
GO:1903936	Cellular response to sodium arsenite	Affects phenotype	PMID:8836877
GO:1904345	Negative regulation of gastric mucosal blood circulation	Increases phenotype	PMID:11567657
GO:2000439	Positive regulation of monocyte extravasation	Increases phenotype	PMID:26349656
GO:2000738	Positive regulation of stem cell differentiation	Increases phenotype	PMID:34575692
GO:2001025	Positive regulation of response to drug	Increases phenotype	PMID:24337826
GO:2001171	Positive regulation of atp biosynthetic process	Decreases phenotype	PMID:28754375

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.