| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000084 | Mitotic s phase | Increases phenotype | PMID:30248417; PMID:36065135 |
| GO:0000086 | G2/m transition of mitotic cell cycle | Increases phenotype | PMID:36065135 |
| GO:0000278 | Mitotic cell cycle | Increases phenotype | PMID:25559859 |
| GO:0004115 | 3',5'-cyclic-amp phosphodiesterase activity | Decreases phenotype | PMID:26377646 |
| GO:0005980 | Glycogen catabolic process | Increases phenotype | PMID:14577594 |
| GO:0006071 | Glycerol metabolic process | Affects phenotype | PMID:33476690 |
| GO:0006094 | Gluconeogenesis | Increases phenotype | PMID:7693125 |
| GO:0006096 | Glycolytic process | Decreases phenotype | PMID:26670611 |
| GO:0006171 | Camp biosynthetic process | Increases phenotype | PMID:18187619; PMID:25980585; PMID:26377646 |
| GO:0006182 | Cgmp biosynthetic process | Increases phenotype | PMID:16943225; PMID:17561940 |
| GO:0006264 | Mitochondrial dna replication | Increases phenotype | PMID:32417366 |
| GO:0006629 | Lipid metabolic process | Increases phenotype | PMID:18586010; PMID:31596606 |
| GO:0006635 | Fatty acid beta-oxidation | Increases phenotype | PMID:26670611 |
| GO:0006641 | Triglyceride metabolic process | Affects phenotype | PMID:30446312; PMID:34302803; PMID:36708982; PMID:36764644 |
| GO:0006754 | Atp biosynthetic process | Decreases phenotype | PMID:29127035 |
| GO:0006914 | Autophagy | Affects phenotype | PMID:36708982 |
| GO:0006915 | Apoptotic process | Affects phenotype | PMID:15459114; PMID:20131233; PMID:9312165 |
| GO:0007005 | Mitochondrion organization | Affects phenotype | PMID:34323617 |
| GO:0008283 | Cell population proliferation | Affects phenotype | PMID:18769122; PMID:20131233; PMID:24576443; PMID:24646949; PMID:29127035; PMID:34323617; PMID:36065135 |
| GO:0008284 | Positive regulation of cell population proliferation | Increases phenotype | PMID:28031460; PMID:29288687 |
| GO:0008361 | Regulation of cell size | Decreases phenotype | PMID:6270161 |
| GO:0008610 | Lipid biosynthetic process | Increases phenotype | PMID:24576443; PMID:27475717; PMID:27475717; PMID:30248417; PMID:30248417; PMID:30408883; PMID:31154084 |
| GO:0010455 | Positive regulation of cell fate commitment | Increases phenotype | PMID:30133442 |
| GO:0010867 | Positive regulation of triglyceride biosynthetic process | Increases phenotype | PMID:26164185 |
| GO:0010884 | Positive regulation of lipid storage | Increases phenotype | PMID:15273253; PMID:17290005; PMID:30133442; PMID:27273607; PMID:27273607; PMID:28031460; PMID:28285642; PMID:27605626; PMID:28031460; PMID:28285642; PMID:29782964; PMID:30133442; PMID:30382123; PMID:30611848; PMID:34560244 |
| GO:0010890 | Positive regulation of sequestering of triglyceride | Increases phenotype | PMID:25761413; PMID:26200599; PMID:26820058; PMID:26820058; PMID:30721698; PMID:29288687; PMID:30721698 |
| GO:0010906 | Regulation of glucose metabolic process | Affects phenotype | PMID:26164185 |
| GO:0015884 | Folic acid transport | Affects phenotype | PMID:18207340 |
| GO:0015908 | Fatty acid transport | Affects phenotype | PMID:34323617 |
| GO:0015980 | Energy derivation by oxidation of organic compounds | Affects phenotype | PMID:26670611 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:27085773; PMID:27475863; PMID:34302803; PMID:7910434 |
| GO:0019216 | Regulation of lipid metabolic process | Affects phenotype | PMID:26164185 |
| GO:0019432 | Triglyceride biosynthetic process | Increases phenotype | PMID:24576443; PMID:27163856; PMID:29094436; PMID:29127035; PMID:30055130; PMID:30665118 |
| GO:0019915 | Lipid storage | Increases phenotype | PMID:28291828; PMID:30382123 |
| GO:0030154 | Cell differentiation | Increases phenotype | PMID:11416043; PMID:14984747; PMID:14984747; PMID:15748605; PMID:16997883; PMID:21350315 |
| GO:0030321 | Transepithelial chloride transport | Increases phenotype | PMID:18187619 |
| GO:0030595 | Leukocyte chemotaxis | Increases phenotype | PMID:1701793 |
| GO:0031323 | Regulation of cellular metabolic process | Affects phenotype | PMID:26820058 |
| GO:0032088 | Negative regulation of nf-kappab transcription factor activity | Increases phenotype | PMID:23872422 |
| GO:0032148 | Activation of protein kinase b activity | Increases phenotype | PMID:28285642 |
| GO:0032773 | Positive regulation of tyrosinase activity | Increases phenotype | PMID:21972008 |
| GO:0033148 | Positive regulation of intracellular estrogen receptor signaling pathway | Increases phenotype | PMID:26944108; PMID:28711546 |
| GO:0034199 | Activation of protein kinase a activity | Affects phenotype | PMID:29288687 |
| GO:0034389 | Lipid droplet organization | Increases phenotype | PMID:26820058 |
| GO:0042310 | Vasoconstriction | Increases phenotype | PMID:37442289 |
| GO:0042391 | Regulation of membrane potential | Decreases phenotype | PMID:21615388 |
| GO:0042438 | Melanin biosynthetic process | Increases phenotype | PMID:26748310 |
| GO:0043315 | Positive regulation of neutrophil degranulation | Increases phenotype | PMID:8549643 |
| GO:0044028 | Dna hypomethylation | Increases phenotype | PMID:29094436 |
| GO:0044237 | Cellular metabolic process | Increases phenotype | PMID:33091441 |
| GO:0044242 | Cellular lipid catabolic process | Increases phenotype | PMID:29288687 |
| GO:0044255 | Cellular lipid metabolic process | Affects phenotype | PMID:34323617 |
| GO:0045023 | G0 to g1 transition | Decreases phenotype | PMID:32023857; PMID:36065135 |
| GO:0045333 | Cellular respiration | Affects phenotype | PMID:31596606; PMID:32417366; PMID:34323617 |
| GO:0045444 | Fat cell differentiation | Affects phenotype | PMID:12496288; PMID:12496288; PMID:18586010; PMID:25338179; PMID:27384973; PMID:30959087; PMID:31078726; PMID:31154084; PMID:32017950; PMID:32220626; PMID:34302803; PMID:34323617; PMID:36152787; PMID:12496288; PMID:32017950; PMID:18591783; PMID:22732655; PMID:23503329; PMID:25559859; PMID:27475717; PMID:27507602; PMID:30248417; PMID:30409764; PMID:31199990; PMID:31470850; PMID:33945810; PMID:34968464; PMID:39842701; PMID:24576443; PMID:24646949; PMID:24646949; PMID:33026256; PMID:33203037; PMID:33689779; PMID:35504408; PMID:24911977; PMID:34800597; PMID:2523799; PMID:26996129; PMID:27085773; PMID:30446312; PMID:25338179; PMID:26117538; PMID:26504594; PMID:26972250; PMID:27085773; PMID:27507602; PMID:28291828; PMID:28298639; PMID:28437481; PMID:28528971; PMID:28528971; PMID:30408883; PMID:28628672; PMID:28849599; PMID:32473317; PMID:32522588; PMID:28921615; PMID:29094436; PMID:29127035; PMID:29704545; PMID:30055130; PMID:30248417; PMID:30408883; PMID:30446312; PMID:30665118; PMID:30665118; PMID:30920877; PMID:36708982; PMID:30738844; PMID:30920877; PMID:31154084; PMID:31596606; PMID:32017950; PMID:32407875; PMID:32473317; PMID:33395283; PMID:33476690; PMID:33836827; PMID:33865937; PMID:35736896; PMID:33945810; PMID:34323617; PMID:34800597; PMID:34864131; PMID:36065135; PMID:36706894; PMID:36708982; PMID:36764644; PMID:38048832; PMID:39842701 |
| GO:0045599 | Negative regulation of fat cell differentiation | Increases phenotype | PMID:29782964 |
| GO:0045600 | Positive regulation of fat cell differentiation | Increases phenotype | PMID:10777552; PMID:17290005; PMID:25617244; PMID:15273253; PMID:23917077; PMID:26820058; PMID:30031040; PMID:30721698; PMID:25617244; PMID:25851902; PMID:25851902; PMID:26408789; PMID:27273607; PMID:28031460; PMID:28285642; PMID:30577593; PMID:30903904; PMID:26200599; PMID:26408789; PMID:26492236; PMID:26820058; PMID:26824325; PMID:26944108; PMID:26944108; PMID:32171850; PMID:27145005; PMID:27273607; PMID:27605626; PMID:27714895; PMID:28031460; PMID:28163246; PMID:28242765; PMID:28595985; PMID:29410257; PMID:30611848; PMID:31319077; PMID:28285642; PMID:28527915; PMID:28595985; PMID:29782964; PMID:30031040; PMID:30382123; PMID:30577593; PMID:30721698; PMID:30903904; PMID:32044341; PMID:32171850; PMID:32553695; PMID:34560244 |
| GO:0045666 | Positive regulation of neuron differentiation | Increases phenotype | PMID:29698629 |
| GO:0045834 | Positive regulation of lipid metabolic process | Increases phenotype | PMID:32171850 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Increases phenotype | PMID:30409764 |
| GO:0045931 | Positive regulation of mitotic cell cycle | Increases phenotype | PMID:30903904 |
| GO:0046058 | Camp metabolic process | Increases phenotype | PMID:29179997; PMID:8549643 |
| GO:0046483 | Heterocycle metabolic process | Affects phenotype | PMID:38734222 |
| GO:0046982 | Protein heterodimerization activity | Decreases phenotype | PMID:29669941 |
| GO:0048023 | Positive regulation of melanin biosynthetic process | Increases phenotype | PMID:21972008; PMID:28051915; PMID:38164184 |
| GO:0048812 | Neuron projection morphogenesis | Increases phenotype | PMID:29698629 |
| GO:0050872 | White fat cell differentiation | Increases phenotype | PMID:26972250; PMID:27605626; PMID:30133442; PMID:33412187 |
| GO:0050873 | Brown fat cell differentiation | Increases phenotype | PMID:25761413; PMID:26972250; PMID:32417366 |
| GO:0050996 | Positive regulation of lipid catabolic process | Increases phenotype | PMID:30971429 |
| GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | Increases phenotype | PMID:2125206 |
| GO:0051343 | Positive regulation of cyclic-nucleotide phosphodiesterase activity | Decreases phenotype | PMID:21457779 |
| GO:0051344 | Negative regulation of cyclic-nucleotide phosphodiesterase activity | Increases phenotype | PMID:8549643 |
| GO:0060612 | Adipose tissue development | Increases phenotype | PMID:10496339; PMID:11101056; PMID:19594306; PMID:20206132; PMID:33091441; PMID:9543393; PMID:9564879 |
| GO:0061951 | Establishment of protein localization to plasma membrane | Increases phenotype | PMID:30591588 |
| GO:0070346 | Positive regulation of fat cell proliferation | Increases phenotype | PMID:27605626; PMID:30382123; PMID:30903904 |
| GO:0070352 | Positive regulation of white fat cell proliferation | Increases phenotype | PMID:27605626 |
| GO:0070633 | Transepithelial transport | Increases phenotype | PMID:10880878; PMID:21852683 |
| GO:0070730 | Camp transport | Increases phenotype | PMID:12153439; PMID:37442289 |
| GO:0071421 | Manganese ion transmembrane transport | Increases phenotype | PMID:2125206 |
| GO:0090297 | Positive regulation of mitochondrial dna replication | Increases phenotype | PMID:29288687 |
| GO:0090336 | Positive regulation of brown fat cell differentiation | Increases phenotype | PMID:25761413; PMID:29288687 |
| GO:0097280 | Histamine secretion mediated by immunoglobulin | Affects phenotype | PMID:1715365; PMID:70945; PMID:8689388 |
| GO:0140042 | Lipid droplet formation | Increases phenotype | PMID:26164185; PMID:28242765; PMID:28242765; PMID:28595985; PMID:30611848; PMID:28298639; PMID:28437481; PMID:28595985; PMID:28628672; PMID:28921615; PMID:29094436; PMID:30055130; PMID:30409764; PMID:30409764; PMID:31470850; PMID:33945810; PMID:30446312; PMID:30738844; PMID:30920877; PMID:30920877; PMID:36708982; PMID:31016361; PMID:31016361; PMID:34864131; PMID:31470850; PMID:32017950; PMID:32017950; PMID:32220626; PMID:36152787; PMID:32023857; PMID:32220626; PMID:32407875; PMID:32553695; PMID:33091441; PMID:33203037; PMID:33476690; PMID:33836827; PMID:33865937; PMID:33945810; PMID:34302803; PMID:34864131; PMID:36708982; PMID:36764644 |
| GO:0140354 | Lipid import into cell | Increases phenotype | PMID:37511356 |
| GO:1900745 | Positive regulation of p38mapk cascade | Increases phenotype | PMID:30721698 |
| GO:1901992 | Positive regulation of mitotic cell cycle phase transition | Increases phenotype | PMID:28285642 |
| GO:1902117 | Positive regulation of organelle assembly | Increases phenotype | PMID:29288687 |
| GO:1902608 | Positive regulation of large conductance calcium-activated potassium channel activity | Increases phenotype | PMID:27605626 |
| GO:1903047 | Mitotic cell cycle process | Affects phenotype | PMID:36065135 |
| GO:1903766 | Positive regulation of potassium ion export across plasma membrane | Increases phenotype | PMID:18187619 |
| GO:1904860 | Dna synthesis involved in mitotic dna replication | Increases phenotype | PMID:24646949 |
| GO:1990138 | Neuron projection extension | Decreases phenotype | PMID:26582457 |
| GO:2000490 | Negative regulation of hepatic stellate cell activation | Increases phenotype | PMID:26806094 |
| GO:2000491 | Positive regulation of hepatic stellate cell activation | Increases phenotype | PMID:26435214; PMID:26435214; PMID:26806094; PMID:26739621; PMID:26739621; PMID:29535048 |
| GO:2000738 | Positive regulation of stem cell differentiation | Increases phenotype | PMID:34575692 |
| GO:2000845 | Positive regulation of testosterone secretion | Increases phenotype | PMID:26377646 |
| GO:2000872 | Positive regulation of progesterone secretion | Increases phenotype | PMID:25253736 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.