| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000165 | Mapk cascade | Increases phenotype | PMID:18349187 |
| GO:0002027 | Regulation of heart rate | Increases phenotype | PMID:10051936; PMID:10051936; PMID:11125686; PMID:3605747; PMID:3661938; PMID:3994880; PMID:6391530; PMID:7743570; PMID:1308378; PMID:3284271; PMID:7511357; PMID:7717564; PMID:7743570; PMID:8614295 |
| GO:0002420 | Natural killer cell mediated cytotoxicity directed against tumor cell target | Decreases phenotype | PMID:27940100 |
| GO:0002433 | Immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | Decreases phenotype | PMID:28003439 |
| GO:0004197 | Cysteine-type endopeptidase activity | Increases phenotype | PMID:32663520 |
| GO:0004457 | Lactate dehydrogenase activity | Increases phenotype | PMID:33508982; PMID:35164634 |
| GO:0004602 | Glutathione peroxidase activity | Decreases phenotype | PMID:28084090 |
| GO:0004784 | Superoxide dismutase activity | Decreases phenotype | PMID:28084090; PMID:28084090; PMID:35164634; PMID:32663520; PMID:32663520; PMID:35164634; PMID:33508982; PMID:35164634 |
| GO:0006915 | Apoptotic process | Affects phenotype | PMID:11748407; PMID:14980940; PMID:15915027; PMID:16249675; PMID:16827187; PMID:17234824; PMID:17287498; PMID:18349187; PMID:20003127; PMID:25597859; PMID:32663520; PMID:32663520; PMID:35164634; PMID:33508982; PMID:33586613; PMID:35164634; PMID:35187972 |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | Affects phenotype | PMID:23922164 |
| GO:0007009 | Plasma membrane organization | Decreases phenotype | PMID:29289695 |
| GO:0007268 | Chemical synaptic transmission | Affects phenotype | PMID:1317634 |
| GO:0007613 | Memory | Affects phenotype | PMID:33878909 |
| GO:0007614 | Short-term memory | Decreases phenotype | PMID:20966663; PMID:30762015 |
| GO:0007615 | Anesthesia-resistant memory | Decreases phenotype | PMID:20966663 |
| GO:0008217 | Regulation of blood pressure | Increases phenotype | PMID:11230718; PMID:12651645; PMID:1308378; PMID:15297469; PMID:18339214; PMID:1974748; PMID:3284271; PMID:3605747; PMID:6391530; PMID:7486177; PMID:7717564; PMID:8363068; PMID:3284271; PMID:7511357; PMID:7743570; PMID:8614295 |
| GO:0008219 | Cell death | Increases phenotype | PMID:11753020 |
| GO:0008283 | Cell population proliferation | Affects phenotype | PMID:27562558; PMID:27940100 |
| GO:0008284 | Positive regulation of cell population proliferation | Decreases phenotype | PMID:34553399 |
| GO:0008285 | Negative regulation of cell population proliferation | Affects phenotype | PMID:23922164 |
| GO:0008291 | Acetylcholine metabolic process | Affects phenotype | PMID:28084090 |
| GO:0008542 | Visual learning | Decreases phenotype | PMID:33878909 |
| GO:0010508 | Positive regulation of autophagy | Increases phenotype | PMID:34553399 |
| GO:0016042 | Lipid catabolic process | Affects phenotype | PMID:28084090; PMID:32663520 |
| GO:0030593 | Neutrophil chemotaxis | Decreases phenotype | PMID:28003439 |
| GO:0036343 | Psychomotor behavior | Decreases phenotype | PMID:32062618 |
| GO:0042307 | Positive regulation of protein import into nucleus | Increases phenotype | PMID:29289695 |
| GO:0042310 | Vasoconstriction | Increases phenotype | PMID:1319121; PMID:2751124; PMID:7762854; PMID:8001219; PMID:8694307; PMID:8712443; PMID:8712451; PMID:8741470 |
| GO:0042311 | Vasodilation | Increases phenotype | PMID:11230718; PMID:1319121; PMID:2751124; PMID:15297469; PMID:15675976; PMID:1599087; PMID:18339214; PMID:7586449; PMID:7880215; PMID:8624010; PMID:9024015; PMID:9366472 |
| GO:0042391 | Regulation of membrane potential | Affects phenotype | PMID:8614295 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:34553399; PMID:36027947 |
| GO:0043525 | Positive regulation of neuron apoptotic process | Increases phenotype | PMID:23922164; PMID:29289695 |
| GO:0044237 | Cellular metabolic process | Decreases phenotype | PMID:32663520; PMID:32663520; PMID:35164634; PMID:33508982; PMID:33586613; PMID:35164634 |
| GO:0046467 | Membrane lipid biosynthetic process | Increases phenotype | PMID:36027947 |
| GO:0048666 | Neuron development | Decreases phenotype | PMID:27562558 |
| GO:0050890 | Cognition | Decreases phenotype | PMID:28084090; PMID:28084090; PMID:31672664; PMID:31672664; PMID:33586613; PMID:33586613; PMID:35164634; PMID:36000339; PMID:36263453; PMID:35164634; PMID:35187972; PMID:36000339; PMID:36027947; PMID:36263453 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Decreases phenotype | PMID:15915027 |
| GO:0051898 | Negative regulation of protein kinase b signaling | Affects phenotype | PMID:23922164 |
| GO:0051964 | Negative regulation of synapse assembly | Increases phenotype | PMID:35249202 |
| GO:0060079 | Excitatory postsynaptic potential | Affects phenotype | PMID:1317634; PMID:17898380; PMID:15108983; PMID:18362600 |
| GO:0060080 | Inhibitory postsynaptic potential | Affects phenotype | PMID:18362600 |
| GO:0070050 | Neuron cellular homeostasis | Affects phenotype | PMID:35187972 |
| GO:0070269 | Pyroptosis | Increases phenotype | PMID:35187972 |
| GO:0070585 | Protein localization to mitochondrion | Affects phenotype | PMID:29289695 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:33508982; PMID:36000339 |
| GO:0072593 | Reactive oxygen species metabolic process | Affects phenotype | PMID:23922164; PMID:32663520; PMID:35164634 |
| GO:0072672 | Neutrophil extravasation | Affects phenotype | PMID:16508399; PMID:18382663; PMID:28003439 |
| GO:0080009 | Mrna methylation | Affects phenotype | PMID:35249202 |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | Increases phenotype | PMID:29289695 |
| GO:0098609 | Cell-cell adhesion | Decreases phenotype | PMID:27940100 |
| GO:1900424 | Regulation of defense response to bacterium | Decreases phenotype | PMID:28003439 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Affects phenotype | PMID:23922164 |
| GO:1902110 | Positive regulation of mitochondrial membrane permeability involved in apoptotic process | Affects phenotype | PMID:23922164 |
| GO:1902552 | Negative regulation of catalase activity | Affects phenotype | PMID:23922164 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Affects phenotype | PMID:36027947 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:34553399 |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | Affects phenotype | PMID:23922164 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.