Letrozole


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Affects phenotype PMID:33359182
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:33359182; PMID:33491863
GO:0004679 Amp-activated protein kinase activity Decreases phenotype PMID:32298659
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:37030623
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:33359182
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:33359182; PMID:33491863; PMID:37030623
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:28619389
GO:0006701 Progesterone biosynthetic process Increases phenotype PMID:28619389
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:28619389
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33359182; PMID:37328115
GO:0006805 Xenobiotic metabolic process Decreases phenotype PMID:19845430
GO:0006915 Apoptotic process Increases phenotype PMID:20160726
GO:0007049 Cell cycle Decreases phenotype PMID:20054642
GO:0007283 Spermatogenesis Decreases phenotype PMID:35236366
GO:0007613 Memory Decreases phenotype PMID:24902786
GO:0007614 Short-term memory Decreases phenotype PMID:24902786
GO:0007616 Long-term memory Decreases phenotype PMID:24902786
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:33359182; PMID:33491863; PMID:37030623
GO:0008210 Estrogen metabolic process Affects phenotype PMID:33491863; PMID:33491863; PMID:39032681; PMID:35236366; PMID:37030623; PMID:39032681
GO:0008219 Cell death Increases phenotype PMID:20054642
GO:0008283 Cell population proliferation Affects phenotype PMID:16263272; PMID:20054642; PMID:20054642; PMID:30817981; PMID:20160726; PMID:24068038; PMID:30817981
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:32197950
GO:0016042 Lipid catabolic process Increases phenotype PMID:28619389; PMID:33359182; PMID:33491863
GO:0016477 Cell migration Increases phenotype PMID:28619389
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:28619389
GO:0022602 Ovulation cycle process Affects phenotype PMID:37030623; PMID:39032681
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:39032681
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:32197950
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:31295448
GO:0032868 Response to insulin Decreases phenotype PMID:31295448
GO:0035938 Estradiol secretion Decreases phenotype PMID:30817981
GO:0040018 Positive regulation of multicellular organism growth Increases phenotype PMID:32298659
GO:0042448 Progesterone metabolic process Affects phenotype PMID:33491863; PMID:33491863; PMID:39032681; PMID:37254606; PMID:39032681
GO:0042593 Glucose homeostasis Decreases phenotype PMID:32298659
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:31295448
GO:0042701 Progesterone secretion Affects phenotype PMID:37254606
GO:0044849 Estrous cycle Decreases phenotype PMID:32298659
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:31295448
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:37328115
GO:0046058 Camp metabolic process Affects phenotype PMID:39032681
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:32298659
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:37328115
GO:0060016 Granulosa cell development Affects phenotype PMID:33359182
GO:0060207 Diestrus Affects phenotype PMID:37030623; PMID:39032681
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28619389; PMID:33359182; PMID:33491863; PMID:33491863; PMID:39032681; PMID:35236366; PMID:37030623; PMID:37254606; PMID:39032681
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:31295448
GO:0071901 Negative regulation of protein serine/threonine kinase activity Affects phenotype PMID:32298659
GO:0072520 Seminiferous tubule development Affects phenotype PMID:35236366
GO:0097189 Apoptotic body Increases phenotype PMID:39032681
GO:0097722 Sperm motility Decreases phenotype PMID:35236366
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:37328115
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:31295448
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:31295448; PMID:32298659; PMID:37328115
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:32298659
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.