Carbon tetrachloride


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000050 Urea cycle Decreases phenotype PMID:26639393
GO:0000162 Tryptophan biosynthetic process Increases phenotype PMID:26639393
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:30578595; PMID:30578595; PMID:38500399; PMID:38500399
GO:0001525 Angiogenesis Increases phenotype PMID:28693887
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:29522708
GO:0002118 Aggressive behavior Increases phenotype PMID:39736447
GO:0002232 Leukocyte chemotaxis involved in inflammatory response Increases phenotype PMID:27477297
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:18989868; PMID:18989868; PMID:26929000; PMID:31150632; PMID:32633567; PMID:39736447; PMID:26929000; PMID:29974145; PMID:31150632; PMID:32633567; PMID:36310519; PMID:38500399; PMID:39736447
GO:0002675 Positive regulation of acute inflammatory response Increases phenotype PMID:25432964
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:27590029; PMID:27590029; PMID:30578595; PMID:30538632; PMID:30538632; PMID:33069761; PMID:30578595; PMID:33069761
GO:0003331 Positive regulation of extracellular matrix constituent secretion Increases phenotype PMID:27818223; PMID:32659284
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:18989868; PMID:23108452; PMID:26929000; PMID:29923357; PMID:32956689; PMID:33549628; PMID:36310519; PMID:33549628; PMID:36310519; PMID:38348705
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:18989868; PMID:23108452; PMID:26882442; PMID:26882442; PMID:31150632; PMID:31168027; PMID:32633567; PMID:27268753; PMID:27623180; PMID:28286204; PMID:31830547; PMID:32956689; PMID:32996673; PMID:33549628; PMID:35202708; PMID:36310519; PMID:38348705; PMID:28693887; PMID:28693887; PMID:29923357; PMID:29923357; PMID:31150632; PMID:31168027; PMID:31830547; PMID:32633567; PMID:32956689; PMID:33549628; PMID:35202708; PMID:36310519; PMID:36555680; PMID:37003405; PMID:38348705
GO:0004096 Catalase activity Decreases phenotype PMID:39736447
GO:0004352 Glutamate dehydrogenase (nad+) activity Increases phenotype PMID:26882442
GO:0004364 Glutathione transferase activity Affects phenotype PMID:24293383; PMID:25899501; PMID:25899501; PMID:30825423; PMID:27758841; PMID:28935427; PMID:29923357; PMID:30825423
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:23108452; PMID:27758841; PMID:33549628; PMID:33549628; PMID:38348705
GO:0004585 Ornithine carbamoyltransferase activity Increases phenotype PMID:1711115
GO:0004601 Peroxidase activity Decreases phenotype PMID:30825423
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:24717679; PMID:24717679; PMID:24973642; PMID:24975834; PMID:24973642; PMID:24975834; PMID:25899501; PMID:25899501; PMID:30825423; PMID:27623180; PMID:27623180; PMID:31150632; PMID:28935427; PMID:29923357; PMID:30825423; PMID:31150632; PMID:34029542
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:22989100; PMID:22989100; PMID:24144775; PMID:24293383; PMID:26929000; PMID:31150632; PMID:38500399; PMID:39736447; PMID:24144775; PMID:24293383; PMID:24717679; PMID:24717679; PMID:24973642; PMID:24975834; PMID:26218279; PMID:29964319; PMID:30368983; PMID:30502394; PMID:38348705; PMID:24973642; PMID:24975834; PMID:25899501; PMID:25899501; PMID:30825423; PMID:26218279; PMID:26929000; PMID:27241356; PMID:28935427; PMID:29923357; PMID:29964319; PMID:30368983; PMID:30502394; PMID:30825423; PMID:31150632; PMID:34029542; PMID:38348705; PMID:38500399; PMID:39736447
GO:0006094 Gluconeogenesis Decreases phenotype PMID:26639393
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:27318789; PMID:30056145
GO:0006259 Dna metabolic process Increases phenotype PMID:24975872
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:26882442; PMID:35405287
GO:0006304 Dna modification Increases phenotype PMID:29129047
GO:0006308 Dna catabolic process Increases phenotype PMID:23994094
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:23279844
GO:0006325 Chromatin organization Affects phenotype PMID:33779329
GO:0006497 Protein lipidation Increases phenotype PMID:31919559
GO:0006523 Alanine biosynthetic process Increases phenotype PMID:26639393
GO:0006526 Arginine biosynthetic process Decreases phenotype PMID:26639393
GO:0006529 Asparagine biosynthetic process Increases phenotype PMID:26639393
GO:0006532 Aspartate biosynthetic process Increases phenotype PMID:26639393
GO:0006533 Aspartate catabolic process Increases phenotype PMID:23279844; PMID:23500774
GO:0006537 Glutamate biosynthetic process Affects phenotype PMID:26639393
GO:0006542 Glutamine biosynthetic process Increases phenotype PMID:26639393
GO:0006561 Proline biosynthetic process Increases phenotype PMID:26639393
GO:0006564 L-serine biosynthetic process Increases phenotype PMID:26639393
GO:0006571 Tyrosine biosynthetic process Increases phenotype PMID:26639393
GO:0006592 Ornithine biosynthetic process Increases phenotype PMID:26639393
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:23374533; PMID:23374533; PMID:37009719; PMID:37009719
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:26929000
GO:0006749 Glutathione metabolic process Increases phenotype PMID:21360558; PMID:21360558; PMID:29129047; PMID:30578595; PMID:30703375; PMID:21725986; PMID:21725986; PMID:29250925; PMID:23279844; PMID:23279844; PMID:25471833; PMID:27477297; PMID:32956689; PMID:39367970; PMID:23374533; PMID:23374533; PMID:25410024; PMID:27590029; PMID:29251412; PMID:32380060; PMID:24975872; PMID:25410024; PMID:25471833; PMID:27477297; PMID:27477297; PMID:32956689; PMID:39367970; PMID:27590029; PMID:29129047; PMID:29129047; PMID:30578595; PMID:30703375; PMID:29250925; PMID:29251412; PMID:30578595; PMID:30703375; PMID:32956689; PMID:34029542; PMID:35236242; PMID:38798245; PMID:39367970
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:22902988; PMID:22902988; PMID:24973641; PMID:25656916; PMID:27151496; PMID:29964319; PMID:30502394; PMID:37573684; PMID:24144775; PMID:24144775; PMID:26882442; PMID:26929000; PMID:31150632; PMID:24293383; PMID:24973641; PMID:25656916; PMID:25899501; PMID:25899501; PMID:30825423; PMID:26882442; PMID:26929000; PMID:27151496; PMID:28693887; PMID:28693887; PMID:29923357; PMID:28935427; PMID:29923357; PMID:30502394; PMID:30551460; PMID:31150632; PMID:31168027; PMID:35745142; PMID:37573684
GO:0006751 Glutathione catabolic process Increases phenotype PMID:35745142
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:29873576
GO:0006805 Xenobiotic metabolic process Decreases phenotype PMID:3105541
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:23262250; PMID:24973641; PMID:24973641; PMID:24975834; PMID:25871905; PMID:26218279; PMID:24975834; PMID:25871905; PMID:26218279; PMID:26929000
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:39367970
GO:0006915 Apoptotic process Increases phenotype PMID:22989100; PMID:27865854; PMID:29522708; PMID:31513885; PMID:31513885; PMID:32063085; PMID:35202708; PMID:32063085; PMID:35202708
GO:0006954 Inflammatory response Increases phenotype PMID:22354081; PMID:22363424; PMID:23279844; PMID:27396813; PMID:30301768; PMID:31513885; PMID:32033504; PMID:32344006; PMID:32956689; PMID:32996673; PMID:33640489; PMID:35101388; PMID:35405287; PMID:36555680; PMID:37003405; PMID:38042390; PMID:40024562; PMID:28689299; PMID:29522708; PMID:34029542; PMID:30301768; PMID:31918260; PMID:31918260; PMID:32380060; PMID:32033504; PMID:32344006; PMID:32956689; PMID:33640489; PMID:34029542; PMID:35101388; PMID:35405287; PMID:36555680; PMID:37003405; PMID:38042390; PMID:40024562
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:29777724
GO:0006979 Response to oxidative stress Increases phenotype PMID:22354081; PMID:23279844; PMID:23994094
GO:0006997 Nucleus organization Affects phenotype PMID:23994094
GO:0007005 Mitochondrion organization Decreases phenotype PMID:33779329; PMID:35202708; PMID:35405287
GO:0007029 Endoplasmic reticulum organization Decreases phenotype PMID:33779329
GO:0007033 Vacuole organization Increases phenotype PMID:32633567; PMID:33779329
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:23374533; PMID:23374533; PMID:37009719; PMID:37009719
GO:0008219 Cell death Increases phenotype PMID:25881548; PMID:2840217; PMID:39367970
GO:0008234 Cysteine-type peptidase activity Increases phenotype PMID:32633567
GO:0008283 Cell population proliferation Affects phenotype PMID:20100483; PMID:20100483; PMID:38936533; PMID:24530446; PMID:25871905; PMID:29964319; PMID:31816328; PMID:38936533
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:25747392
GO:0009086 Methionine biosynthetic process Affects phenotype PMID:29974145
GO:0009094 L-phenylalanine biosynthetic process Increases phenotype PMID:26639393
GO:0009636 Response to toxic substance Increases phenotype PMID:23279844; PMID:23500774; PMID:23994094
GO:0010712 Regulation of collagen metabolic process Affects phenotype PMID:22223197
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:32659284
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:32659284
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:35745142
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25445725
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:17383642; PMID:22363424; PMID:30578595; PMID:30578595; PMID:30703375; PMID:30703375; PMID:33069761
GO:0015020 Glucuronosyltransferase activity Decreases phenotype PMID:32380060
GO:0015723 Bilirubin transport Increases phenotype PMID:1711115; PMID:27318789; PMID:29250925; PMID:29251412; PMID:31697926; PMID:37573684
GO:0016042 Lipid catabolic process Increases phenotype PMID:18989868; PMID:18989868; PMID:24293383; PMID:25303780; PMID:25478064; PMID:26882442; PMID:26929000; PMID:27241356; PMID:28347707; PMID:30676168; PMID:31150632; PMID:18989868; PMID:30676168; PMID:30825423; PMID:23374533; PMID:23374533; PMID:29233029; PMID:32380060; PMID:23374533; PMID:32380060; PMID:24293383; PMID:24975834; PMID:24975834; PMID:25656916; PMID:25871905; PMID:26218279; PMID:27151496; PMID:29964319; PMID:30368983; PMID:25303780; PMID:25478064; PMID:25656916; PMID:25871905; PMID:26218279; PMID:26882442; PMID:26929000; PMID:27151496; PMID:27241356; PMID:27268753; PMID:28347707; PMID:28693887; PMID:28693887; PMID:29923357; PMID:28935427; PMID:29233029; PMID:29522708; PMID:29923357; PMID:29964319; PMID:30368983; PMID:30676168; PMID:30825423; PMID:31150632; PMID:32956689; PMID:32956689; PMID:35411647; PMID:34029542; PMID:35411647
GO:0016049 Cell growth Decreases phenotype PMID:29964319
GO:0016209 Antioxidant activity Decreases phenotype PMID:37573684
GO:0016477 Cell migration Increases phenotype PMID:24639359; PMID:24973641; PMID:38936533
GO:0016567 Protein ubiquitination Increases phenotype PMID:31919559
GO:0017148 Negative regulation of translation Decreases phenotype PMID:9657110
GO:0018158 Protein oxidation Increases phenotype PMID:25451574; PMID:26102008; PMID:26102008; PMID:30056145; PMID:30056145; PMID:30719803
GO:0018212 Peptidyl-tyrosine modification Increases phenotype PMID:30538632
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:26639393
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:26929000; PMID:26929000; PMID:27623180; PMID:27042213; PMID:27623180
GO:0019471 4-hydroxyproline metabolic process Affects phenotype PMID:23500774
GO:0019481 L-alanine catabolic process, by transamination Increases phenotype PMID:23279844; PMID:23500774
GO:0019511 Peptidyl-proline hydroxylation Increases phenotype PMID:36555680
GO:0019530 Taurine metabolic process Affects phenotype PMID:36310519
GO:0019627 Urea metabolic process Affects phenotype PMID:23374533; PMID:29522708; PMID:29522708; PMID:34029542; PMID:34029542
GO:0019674 Nad metabolic process Affects phenotype PMID:34752167
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:18989868
GO:0022617 Extracellular matrix disassembly Increases phenotype PMID:27042213
GO:0030154 Cell differentiation Decreases phenotype PMID:29044176
GO:0030198 Extracellular matrix organization Affects phenotype PMID:23500774
GO:0030199 Collagen fibril organization Increases phenotype PMID:25852135; PMID:25852135; PMID:29233029; PMID:32633567; PMID:39736447; PMID:29233029; PMID:31816328; PMID:31816328; PMID:33309619; PMID:34752167; PMID:35101388; PMID:35405287; PMID:35483553; PMID:36555680; PMID:37003405; PMID:38042390; PMID:38348705; PMID:38925513; PMID:38992766; PMID:39500482; PMID:32633567; PMID:33309619; PMID:34752167; PMID:35101388; PMID:35405287; PMID:35483553; PMID:36555680; PMID:37003405; PMID:38042390; PMID:38042390; PMID:38348705; PMID:38348705; PMID:38925513; PMID:38925513; PMID:38992766; PMID:39500482; PMID:39736447
GO:0030203 Glycosaminoglycan metabolic process Increases phenotype PMID:27477297; PMID:30543783
GO:0030212 Hyaluronan metabolic process Affects phenotype PMID:33549628
GO:0030500 Regulation of bone mineralization Affects phenotype PMID:24381012
GO:0032043 Mitochondrial dna catabolic process Increases phenotype PMID:27318789
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:27818223
GO:0032731 Positive regulation of interleukin-1 beta production Affects phenotype PMID:22354081
GO:0032760 Positive regulation of tumor necrosis factor production Affects phenotype PMID:24381012
GO:0032963 Collagen metabolic process Increases phenotype PMID:23500774; PMID:23500774; PMID:25852135; PMID:25852135; PMID:32344006; PMID:32956689; PMID:32956689; PMID:35483553; PMID:34224798; PMID:35483553
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:26882442; PMID:27151496; PMID:27151496; PMID:31830547; PMID:38936533; PMID:39800144; PMID:31830547; PMID:38936533; PMID:39800144
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:21360558; PMID:21360558; PMID:29251412; PMID:30703375; PMID:27865848; PMID:27865848; PMID:30538632; PMID:37573684; PMID:29251412; PMID:30538632; PMID:30543783; PMID:30703375; PMID:33069761; PMID:35745142; PMID:37573684
GO:0034380 High-density lipoprotein particle assembly Decreases phenotype PMID:27623180
GO:0034418 Urate biosynthetic process Increases phenotype PMID:29522708; PMID:30825423
GO:0034440 Lipid oxidation Increases phenotype PMID:20589743; PMID:21360558; PMID:21360558; PMID:25410024; PMID:25450236; PMID:25852135; PMID:27590029; PMID:29129047; PMID:29251412; PMID:30578595; PMID:30703375; PMID:21360558; PMID:25410024; PMID:25852135; PMID:27590029; PMID:29129047; PMID:29251412; PMID:30578595; PMID:30703375; PMID:21725986; PMID:21725986; PMID:25445725; PMID:25471833; PMID:26102008; PMID:27318789; PMID:29250925; PMID:30056145; PMID:30538632; PMID:3105541; PMID:32659284; PMID:39367970; PMID:39800144; PMID:21725986; PMID:25445725; PMID:25471833; PMID:29250925; PMID:30056145; PMID:30538632; PMID:32659284; PMID:39367970; PMID:22354081; PMID:24975872; PMID:24975872; PMID:30825423; PMID:25410024; PMID:25410024; PMID:29129047; PMID:25445725; PMID:25450236; PMID:25451574; PMID:25471833; PMID:25471833; PMID:26102008; PMID:27318789; PMID:25852135; PMID:26102008; PMID:27318789; PMID:27590029; PMID:29129047; PMID:29250925; PMID:29250925; PMID:39800144; PMID:29251412; PMID:30056145; PMID:30578595; PMID:30703375; PMID:30825423; PMID:3105541; PMID:33840231; PMID:35236242; PMID:38798245; PMID:39367970; PMID:39800144
GO:0034589 Hydroxyproline transport Increases phenotype PMID:37573684
GO:0034773 Histone h4-k20 trimethylation Increases phenotype PMID:28285099
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:25827057
GO:0035505 Positive regulation of myosin light chain kinase activity Increases phenotype PMID:30783172
GO:0035696 Monocyte extravasation Increases phenotype PMID:33341026
GO:0036124 Histone h3-k9 trimethylation Increases phenotype PMID:28285099
GO:0036211 Protein modification process Increases phenotype PMID:3105541
GO:0036333 Hepatocyte homeostasis Increases phenotype PMID:38925513
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:29129047; PMID:29129047; PMID:34990082
GO:0042116 Macrophage activation Increases phenotype PMID:24639359; PMID:29033935
GO:0042119 Neutrophil activation Increases phenotype PMID:32033504
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:21360558
GO:0042311 Vasodilation Affects phenotype PMID:23262250
GO:0042359 Vitamin d metabolic process Affects phenotype PMID:24381012
GO:0042428 Serotonin metabolic process Affects phenotype PMID:35202708
GO:0042554 Superoxide anion generation Affects phenotype PMID:23262250
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:27185181; PMID:27590029; PMID:27590029; PMID:29129047; PMID:29251412; PMID:27590029; PMID:29251412; PMID:29129047; PMID:29250925; PMID:29251412
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:35202708
GO:0042756 Drinking behavior Affects phenotype PMID:31870920
GO:0042866 Pyruvate biosynthetic process Increases phenotype PMID:26639393
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:12706302; PMID:25432964; PMID:25432964; PMID:25445725; PMID:25566828; PMID:25747392; PMID:27865848; PMID:36526012; PMID:25445725; PMID:25566828; PMID:25747392; PMID:27865848; PMID:36526012
GO:0043123 Positive regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:30703375
GO:0043388 Positive regulation of dna binding Increases phenotype PMID:9657110
GO:0043551 Regulation of phosphatidylinositol 3-kinase activity Affects phenotype PMID:23500774
GO:0043966 Histone h3 acetylation Decreases phenotype PMID:27396813
GO:0043974 Histone h3-k27 acetylation Increases phenotype PMID:28285099
GO:0043984 Histone h4-k16 acetylation Increases phenotype PMID:28285099
GO:0044237 Cellular metabolic process Decreases phenotype PMID:32234387; PMID:35202708; PMID:32956689; PMID:35202708
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:24717679
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:30703375
GO:0045454 Cell redox homeostasis Affects phenotype PMID:29873576
GO:0045649 Regulation of macrophage differentiation Affects phenotype PMID:30056145
GO:0045766 Positive regulation of angiogenesis Affects phenotype PMID:23845850
GO:0046034 Atp metabolic process Affects phenotype PMID:35202708
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:22354081; PMID:29233029
GO:0046415 Urate metabolic process Affects phenotype PMID:30825423; PMID:34029542
GO:0046449 Creatinine metabolic process Affects phenotype PMID:29522708; PMID:29522708; PMID:34029542; PMID:29923357; PMID:30825423; PMID:34029542
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:11315500; PMID:11315500; PMID:12923366; PMID:15900909; PMID:3135123; PMID:3251335; PMID:7532385; PMID:8609590; PMID:8878782; PMID:11315500; PMID:15900909; PMID:12923366; PMID:15900909; PMID:2116696; PMID:3509882; PMID:27758841; PMID:2840217; PMID:2840217; PMID:3508441; PMID:32063085; PMID:32063085; PMID:36526012; PMID:3251335; PMID:3508441; PMID:3509882; PMID:36526012; PMID:6318726; PMID:7532385; PMID:8609590; PMID:8878782
GO:0046513 Ceramide biosynthetic process Increases phenotype PMID:29522708
GO:0046827 Positive regulation of protein export from nucleus Increases phenotype PMID:27601294; PMID:34990082
GO:0047810 D-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:26062544
GO:0047823 D-glutamyltransferase activity Increases phenotype PMID:18989868
GO:0048149 Behavioral response to ethanol Affects phenotype PMID:31870920
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:23374533; PMID:24717679; PMID:25478064; PMID:30825423
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:26862777; PMID:35745142; PMID:37573684
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:24975872
GO:0051452 Intracellular ph reduction Affects phenotype PMID:35202708
GO:0051453 Regulation of intracellular ph Affects phenotype PMID:35202708
GO:0051454 Intracellular ph elevation Affects phenotype PMID:35202708
GO:0051726 Regulation of cell cycle Increases phenotype PMID:25445725
GO:0051767 Nitric-oxide synthase biosynthetic process Increases phenotype PMID:23994094
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:23279844; PMID:37009719
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:35202708
GO:0055072 Iron ion homeostasis Affects phenotype PMID:39367970
GO:0061519 Macrophage homeostasis Affects phenotype PMID:30301768
GO:0061754 Negative regulation of circulating fibrinogen levels Decreases phenotype PMID:26921287
GO:0070265 Necrotic cell death Increases phenotype PMID:18989868; PMID:18989868; PMID:32633567; PMID:39736447; PMID:23994094; PMID:23994094; PMID:27042213; PMID:29777724; PMID:29974145; PMID:31513885; PMID:34224798; PMID:35202708; PMID:36310519; PMID:27042213; PMID:28428136; PMID:28689299; PMID:29923357; PMID:29974145; PMID:31150632; PMID:31150632; PMID:32380060; PMID:32633567; PMID:32996673; PMID:38925513; PMID:34029542; PMID:34224798; PMID:38925513; PMID:39736447
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:27185181; PMID:27590029; PMID:29129047; PMID:29250925
GO:0070365 Hepatocyte differentiation Increases phenotype PMID:23108452
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:24975872
GO:0070994 Detection of oxidative stress Affects phenotype PMID:25656916; PMID:27916511; PMID:38348705; PMID:25852135; PMID:25852135; PMID:38500399; PMID:39736447; PMID:25852135; PMID:39736447; PMID:27916511; PMID:37009719; PMID:38348705; PMID:38500399; PMID:39736447
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24530446; PMID:35202708
GO:0072683 T cell extravasation Increases phenotype PMID:33341026
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:28285099
GO:0085029 Extracellular matrix assembly Increases phenotype PMID:38500399
GO:0090181 Regulation of cholesterol metabolic process Affects phenotype PMID:31918260
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:25445725; PMID:27318789
GO:0090207 Regulation of triglyceride metabolic process Affects phenotype PMID:31918260
GO:0090358 Positive regulation of tryptophan metabolic process Increases phenotype PMID:32289347
GO:0097043 Histone h3-k56 acetylation Increases phenotype PMID:28285099
GO:0097421 Liver regeneration Affects phenotype PMID:9657110
GO:0097707 Ferroptosis Increases phenotype PMID:30551460
GO:0120189 Positive regulation of bile acid secretion Increases phenotype PMID:25747392
GO:0140042 Lipid droplet formation Increases phenotype PMID:31918260; PMID:31918260; PMID:39736447; PMID:32380060; PMID:38500399; PMID:39736447
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:39164375
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:32289347
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:27601294
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:23279844; PMID:29129047; PMID:29129047; PMID:29251412; PMID:30578595; PMID:30703375; PMID:29251412; PMID:30578595; PMID:30703375; PMID:32659284
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:24975872; PMID:25410024; PMID:25410024; PMID:25448286; PMID:25450236; PMID:25445725; PMID:25448286; PMID:25450236
GO:1901687 Glutathione derivative biosynthetic process Increases phenotype PMID:31168027
GO:1902552 Negative regulation of catalase activity Affects phenotype PMID:23279844
GO:1902957 Negative regulation of mitochondrial electron transport, nadh to ubiquinone Increases phenotype PMID:27318789; PMID:30056145
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:31816328
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:27758841; PMID:27758841; PMID:29129047; PMID:29251412; PMID:29129047; PMID:29251412
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:24975872; PMID:25445725; PMID:25448286; PMID:25448286; PMID:27590029; PMID:27590029
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26218279; PMID:26218279; PMID:30368983; PMID:29522708; PMID:30368983; PMID:30551460; PMID:36526012
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24975872; PMID:25445725; PMID:25445725; PMID:37573684; PMID:26862777; PMID:37573684
GO:1903510 Mucopolysaccharide metabolic process Affects phenotype PMID:32344006
GO:1903523 Negative regulation of blood circulation Affects phenotype PMID:30783172
GO:1903988 Iron ion export across plasma membrane Increases phenotype PMID:30551460
GO:1904028 Positive regulation of collagen fibril organization Increases phenotype PMID:28527913; PMID:33069761
GO:1905037 Autophagosome organization Increases phenotype PMID:33779329
GO:1905517 Macrophage migration Increases phenotype PMID:38042390
GO:1905698 Positive regulation of polysome binding Increases phenotype PMID:9657110
GO:2000296 Negative regulation of hydrogen peroxide catabolic process Increases phenotype PMID:30578595
GO:2000491 Positive regulation of hepatic stellate cell activation Increases phenotype PMID:23845850; PMID:27477297; PMID:27477297; PMID:27865848; PMID:28527913; PMID:27601294; PMID:27693115; PMID:27865848; PMID:28527913; PMID:30543783; PMID:30703375; PMID:33069761; PMID:34990082
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.