Methylmercuric chloride


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:34089799
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:34089799
GO:0000280 Nuclear division Decreases phenotype PMID:38308452
GO:0001662 Behavioral fear response Increases phenotype PMID:27814245
GO:0001732 Formation of cytoplasmic translation initiation complex Increases phenotype PMID:3845956
GO:0001822 Kidney development Increases phenotype PMID:30629257
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:28027877; PMID:35678294
GO:0002376 Immune system process Affects phenotype PMID:31918252
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:38308452
GO:0002830 Positive regulation of type 2 immune response Affects phenotype PMID:9931279
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Decreases phenotype PMID:38308452
GO:0004198 Calcium-dependent cysteine-type endopeptidase activity Increases phenotype PMID:32061141
GO:0004357 Glutamate-cysteine ligase activity Decreases phenotype PMID:32061141
GO:0004364 Glutathione transferase activity Affects phenotype PMID:32061141; PMID:38308452
GO:0004457 Lactate dehydrogenase activity Decreases phenotype PMID:38308452
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:22269903; PMID:27298056; PMID:28027877; PMID:32061141; PMID:27298056; PMID:32061141; PMID:28027877; PMID:38308452
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:22269903; PMID:27298056; PMID:38308452
GO:0004791 Thioredoxin-disulfide reductase activity Decreases phenotype PMID:28027877
GO:0005388 P-type calcium transporter activity Decreases phenotype PMID:27298056
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:27298056
GO:0005757 Mitochondrial permeability transition pore complex Increases phenotype PMID:35678294
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:31918252
GO:0006096 Glycolytic process Affects phenotype PMID:33831500
GO:0006163 Purine nucleotide metabolic process Affects phenotype PMID:31918252
GO:0006220 Pyrimidine nucleotide metabolic process Affects phenotype PMID:31918252
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:9694217
GO:0006325 Chromatin organization Decreases phenotype PMID:38308452
GO:0006534 Cysteine metabolic process Affects phenotype PMID:32061141
GO:0006536 Glutamate metabolic process Affects phenotype PMID:31918252; PMID:32061141
GO:0006541 Glutamine metabolic process Affects phenotype PMID:32061141
GO:0006554 Lysine catabolic process Affects phenotype PMID:31918252
GO:0006568 Tryptophan metabolic process Affects phenotype PMID:31918252
GO:0006629 Lipid metabolic process Affects phenotype PMID:31918252
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:39921560
GO:0006749 Glutathione metabolic process Increases phenotype PMID:27456245; PMID:31330227; PMID:32061141; PMID:34062221; PMID:38308452
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:18627028; PMID:22269903; PMID:22966415; PMID:22966415; PMID:28027877; PMID:27180086; PMID:28027877
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24024199
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:27298056; PMID:32061141; PMID:32991939; PMID:35678294
GO:0006915 Apoptotic process Increases phenotype PMID:27298056; PMID:28027877; PMID:28027877; PMID:32061141; PMID:32061141; PMID:32179164; PMID:34062221; PMID:34328791; PMID:35678294; PMID:9694217
GO:0006955 Immune response Affects phenotype PMID:3262595
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:34062221
GO:0006979 Response to oxidative stress Increases phenotype PMID:22966415; PMID:9694217
GO:0006997 Nucleus organization Decreases phenotype PMID:18627028
GO:0007005 Mitochondrion organization Decreases phenotype PMID:27298056
GO:0007033 Vacuole organization Increases phenotype PMID:38308452
GO:0007214 Gamma-aminobutyric acid signaling pathway Increases phenotype PMID:27720918
GO:0007409 Axonogenesis Decreases phenotype PMID:20869980
GO:0007605 Sensory perception of sound Decreases phenotype PMID:34062221
GO:0007612 Learning Affects phenotype PMID:23903816
GO:0007613 Memory Affects phenotype PMID:23903816
GO:0007625 Grooming behavior Affects phenotype PMID:34062221
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:39921560
GO:0008219 Cell death Increases phenotype PMID:26865462; PMID:28526320; PMID:28736149; PMID:30075218; PMID:30769081; PMID:32991939
GO:0008283 Cell population proliferation Decreases phenotype PMID:26159257; PMID:28736149
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:23872426; PMID:29581082; PMID:31330227; PMID:31330229; PMID:32949729; PMID:35527009; PMID:37210002
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:31918252
GO:0009636 Response to toxic substance Affects phenotype PMID:23179753; PMID:23872426
GO:0009749 Response to glucose Decreases phenotype PMID:30629257
GO:0009966 Regulation of signal transduction Affects phenotype PMID:23903816
GO:0010470 Regulation of gastrulation Affects phenotype PMID:28184906
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:37967789
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23203475; PMID:23872426; PMID:24816296; PMID:25841707; PMID:27667695; PMID:27720909; PMID:28001369; PMID:29581082
GO:0010977 Negative regulation of neuron projection development Increases phenotype PMID:29261810
GO:0014005 Microglia development Decreases phenotype PMID:31270303
GO:0014902 Myotube differentiation Decreases phenotype PMID:29104120
GO:0015694 Mercury ion transport Increases phenotype PMID:28536007
GO:0016042 Lipid catabolic process Increases phenotype PMID:22269903; PMID:24024199; PMID:27178136; PMID:28027877; PMID:29258870; PMID:30769081; PMID:34062221
GO:0016049 Cell growth Decreases phenotype PMID:30503815
GO:0017148 Negative regulation of translation Affects phenotype PMID:3845956
GO:0018158 Protein oxidation Increases phenotype PMID:29258870; PMID:34062221
GO:0019227 Neuronal action potential propagation Increases phenotype PMID:36565944
GO:0019627 Urea metabolic process Affects phenotype PMID:38308452
GO:0019646 Aerobic electron transport chain Decreases phenotype PMID:25601988
GO:0023041 Neuronal signal transduction Affects phenotype PMID:38065418
GO:0030041 Actin filament polymerization Decreases phenotype PMID:28526320
GO:0030073 Insulin secretion Affects phenotype PMID:23202902
GO:0030182 Neuron differentiation Decreases phenotype PMID:33831500
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Affects phenotype PMID:9144456
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:37210002
GO:0030335 Positive regulation of cell migration Affects phenotype PMID:29581082
GO:0030399 Autophagosome membrane disassembly Decreases phenotype PMID:27667695
GO:0031175 Neuron projection development Affects phenotype PMID:30075218; PMID:33454822; PMID:36565944
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:28821999; PMID:31330229
GO:0032310 Prostaglandin secretion Increases phenotype PMID:28958600
GO:0032469 Endoplasmic reticulum calcium ion homeostasis Affects phenotype PMID:35678294
GO:0032774 Rna biosynthetic process Decreases phenotype PMID:28027877
GO:0032776 Dna methylation on cytosine Increases phenotype PMID:33454822
GO:0033138 Positive regulation of peptidyl-serine phosphorylation Decreases phenotype PMID:28821999
GO:0034440 Lipid oxidation Affects phenotype PMID:38308452
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:33454823
GO:0035640 Exploration behavior Affects phenotype PMID:34062221
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:28821999
GO:0036164 Cell-abiotic substrate adhesion Decreases phenotype PMID:34328791; PMID:37258240
GO:0036269 Swimming behavior Affects phenotype PMID:34062221
GO:0036445 Neuronal stem cell division Affects phenotype PMID:34089799
GO:0042116 Macrophage activation Increases phenotype PMID:38308452
GO:0042133 Neurotransmitter metabolic process Affects phenotype PMID:31918252
GO:0042417 Dopamine metabolic process Affects phenotype PMID:25601988
GO:0042593 Glucose homeostasis Decreases phenotype PMID:23202902; PMID:27814245; PMID:30629257
GO:0043005 Neuron projection Decreases phenotype PMID:37210002
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:22966415; PMID:23202902; PMID:31330229; PMID:37967789; PMID:9144456
GO:0043408 Regulation of mapk cascade Increases phenotype PMID:28958600
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:20869980; PMID:31330229
GO:0043966 Histone h3 acetylation Decreases phenotype PMID:33454822; PMID:39187442
GO:0043970 Histone h3-k9 acetylation Affects phenotype PMID:36565944
GO:0044154 Histone h3-k14 acetylation Decreases phenotype PMID:33454822; PMID:36565944
GO:0044237 Cellular metabolic process Decreases phenotype PMID:18627028; PMID:31706035; PMID:31850806; PMID:31878059; PMID:32870474; PMID:32991939; PMID:34328791; PMID:35678294; PMID:36813253; PMID:38323385; PMID:38692911
GO:0045333 Cellular respiration Affects phenotype PMID:33831500
GO:0045665 Negative regulation of neuron differentiation Increases phenotype PMID:29261810
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:31330227
GO:0046034 Atp metabolic process Affects phenotype PMID:32949729
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:34062221
GO:0046415 Urate metabolic process Affects phenotype PMID:31918252
GO:0046449 Creatinine metabolic process Affects phenotype PMID:38308452
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:8295846
GO:0047823 D-glutamyltransferase activity Decreases phenotype PMID:32061141
GO:0048874 Host-mediated regulation of intestinal microbiota composition Increases phenotype PMID:31175882; PMID:39921560
GO:0050893 Sensory processing Affects phenotype PMID:31918252
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:35678294
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:35678294
GO:0060612 Adipose tissue development Affects phenotype PMID:29850906; PMID:30629257
GO:0070265 Necrotic cell death Increases phenotype PMID:34062221; PMID:38308452
GO:0070994 Detection of oxidative stress Increases phenotype PMID:39921560
GO:0071763 Nuclear membrane organization Decreases phenotype PMID:27298056
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:28027877
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:32061141; PMID:34328791; PMID:36813253
GO:0090559 Regulation of membrane permeability Affects phenotype PMID:28027877
GO:0097202 Activation of cysteine-type endopeptidase activity Increases phenotype PMID:25841707
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:33454822; PMID:36565944; PMID:39187442
GO:0098743 Cell aggregation Increases phenotype PMID:37258240
GO:1900103 Positive regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:37967789
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:27667695; PMID:28821999
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:29522201
GO:1901670 Negative regulation of superoxide dismutase activity Affects phenotype PMID:21781743
GO:1902512 Positive regulation of apoptotic dna fragmentation Affects phenotype PMID:9144456
GO:1902667 Regulation of axon guidance Affects phenotype PMID:23903816
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:34089799
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:27456245
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27178136; PMID:27298056; PMID:28526320; PMID:28736149; PMID:31850806
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:31330227; PMID:31330229
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:27814245
GO:1904456 Negative regulation of neuronal action potential Increases phenotype PMID:39187442
GO:1904480 Positive regulation of intestinal absorption Increases phenotype PMID:31175882
GO:1905146 Lysosomal protein catabolic process Decreases phenotype PMID:27667695
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:31330229
GO:2000379 Positive regulation of reactive oxygen species metabolic process Increases phenotype PMID:23202902
GO:2000786 Positive regulation of autophagosome assembly Affects phenotype PMID:27667695
GO:2001272 Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Increases phenotype PMID:31330229
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.