DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Cyclosporin A

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:20404319
GO:0000266	Mitochondrial fission	Increases phenotype	PMID:34023961
GO:0000422	Autophagy of mitochondrion	Increases phenotype	PMID:25464205
GO:0000423	Mitophagy	Decreases phenotype	PMID:33689844
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:28703385
GO:0001516	Prostaglandin biosynthetic process	Decreases phenotype	PMID:28886988
GO:0001774	Microglial cell activation	Increases phenotype	PMID:37308051
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:27588890; PMID:35964836
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:10385269
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:17927767
GO:0002693	Positive regulation of cellular extravasation	Increases phenotype	PMID:26276312
GO:0003084	Positive regulation of systemic arterial blood pressure	Increases phenotype	PMID:28899749
GO:0003085	Negative regulation of systemic arterial blood pressure	Increases phenotype	PMID:28899749
GO:0003093	Regulation of glomerular filtration	Affects phenotype	PMID:12695417
GO:0003094	Glomerular filtration	Decreases phenotype	PMID:2778718; PMID:3458551; PMID:7543625
GO:0003097	Renal water transport	Decreases phenotype	PMID:24907557
GO:0003810	Protein-glutamine gamma-glutamyltransferase activity	Increases phenotype	PMID:33710703
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:19391111
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:17927767; PMID:17927767; PMID:19391111; PMID:19391111
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:17461432; PMID:17461432; PMID:17927767; PMID:33710703; PMID:17927767; PMID:19391111; PMID:33710703
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:33710703
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:27596067; PMID:40024757
GO:0004563	Beta-n-acetylhexosaminidase activity	Increases phenotype	PMID:16858688
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:17927767; PMID:33710703; PMID:19391111; PMID:33710703
GO:0004722	Protein serine/threonine phosphatase activity	Affects phenotype	PMID:34023961
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:17461432; PMID:17461432; PMID:33710703; PMID:19391111; PMID:33710703
GO:0006119	Oxidative phosphorylation	Decreases phenotype	PMID:15339861
GO:0006120	Mitochondrial electron transport, nadh to ubiquinone	Decreases phenotype	PMID:17265451
GO:0006121	Mitochondrial electron transport, succinate to ubiquinone	Decreases phenotype	PMID:17265451
GO:0006260	Dna replication	Decreases phenotype	PMID:29309803
GO:0006304	Dna modification	Increases phenotype	PMID:29975447
GO:0006309	Apoptotic dna fragmentation	Affects phenotype	PMID:10617104; PMID:10760090; PMID:15345483; PMID:15548389; PMID:1705513; PMID:17166486; PMID:25299210
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:25114106; PMID:29650965
GO:0006626	Protein targeting to mitochondrion	Affects phenotype	PMID:34023961
GO:0006688	Glycosphingolipid biosynthetic process	Decreases phenotype	PMID:14662772
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:27596067; PMID:33710703
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:17927767; PMID:19391111; PMID:25418342
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:35708773
GO:0006778	Porphyrin-containing compound metabolic process	Affects phenotype	PMID:23830897
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:17461432
GO:0006855	Xenobiotic transmembrane transport	Decreases phenotype	PMID:23976943; PMID:24502637; PMID:26593909
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:34023961
GO:0006914	Autophagy	Increases phenotype	PMID:20136702
GO:0006915	Apoptotic process	Affects phenotype	PMID:10205001; PMID:10604926; PMID:10617104; PMID:10760090; PMID:10774788; PMID:11692113; PMID:12006578; PMID:12377949; PMID:12871656; PMID:14550768; PMID:15207740; PMID:15365088; PMID:15486922; PMID:15548389; PMID:15754004; PMID:1705513; PMID:17166486; PMID:17369605; PMID:17385075; PMID:18058236; PMID:18766458; PMID:18984060; PMID:20594614; PMID:22343435; PMID:22843330; PMID:23283937; PMID:23315796; PMID:24036456; PMID:25299210; PMID:26388407; PMID:31157505; PMID:32569592; PMID:33689844; PMID:39109785; PMID:7514101; PMID:7871569; PMID:8630077; PMID:8891335; PMID:9247148; PMID:9425011; PMID:9430427; PMID:9580328; PMID:9667420
GO:0006954	Inflammatory response	Increases phenotype	PMID:24462674; PMID:33710703
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:32569592
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:12227681; PMID:12352326; PMID:12377949; PMID:15001429; PMID:15339861
GO:0006986	Response to unfolded protein	Increases phenotype	PMID:24907557
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:26318285; PMID:34105389
GO:0007033	Vacuole organization	Increases phenotype	PMID:35033536
GO:0007049	Cell cycle	Decreases phenotype	PMID:7579561; PMID:8844128
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:21381053
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:2128298
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:25370934
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:23830897
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:23830897; PMID:28161596; PMID:32152650
GO:0008217	Regulation of blood pressure	Increases phenotype	PMID:10385269; PMID:12394605; PMID:32298299; PMID:8743522; PMID:9794569
GO:0008219	Cell death	Increases phenotype	PMID:11527970; PMID:11738103; PMID:16796720; PMID:18191430; PMID:23313729; PMID:25656643; PMID:27718046; PMID:28181380; PMID:40024757; PMID:7579561
GO:0008283	Cell population proliferation	Affects phenotype	PMID:10486581; PMID:10528133; PMID:12296857; PMID:15001429; PMID:1705513; PMID:17962511; PMID:21704098; PMID:21711903; PMID:25299210; PMID:25370934; PMID:26055650; PMID:26318285; PMID:27113412; PMID:27718046; PMID:3097147; PMID:3341550; PMID:38729283; PMID:7554381; PMID:7682200; PMID:8586487; PMID:8844128; PMID:9112343
GO:0008284	Positive regulation of cell population proliferation	Decreases phenotype	PMID:24675465; PMID:24990931; PMID:27318970
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:21381053; PMID:24420784; PMID:25809564
GO:0008361	Regulation of cell size	Affects phenotype	PMID:39109785
GO:0008610	Lipid biosynthetic process	Increases phenotype	PMID:27089845
GO:0008654	Phospholipid biosynthetic process	Increases phenotype	PMID:28903485
GO:0010189	Vitamin e biosynthetic process	Decreases phenotype	PMID:19391111
GO:0010460	Positive regulation of heart rate	Increases phenotype	PMID:28899749
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:36100036
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:25947082; PMID:38653026
GO:0010759	Positive regulation of macrophage chemotaxis	Increases phenotype	PMID:27585667
GO:0010820	Positive regulation of t cell chemotaxis	Increases phenotype	PMID:27585667
GO:0010833	Telomere maintenance via telomere lengthening	Decreases phenotype	PMID:29309803
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:25809564; PMID:32135237; PMID:36100036
GO:0010918	Positive regulation of mitochondrial membrane potential	Affects phenotype	PMID:20865757; PMID:24675465; PMID:25947082; PMID:26884717; PMID:35505273
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:14662772; PMID:24502637; PMID:25562108; PMID:25947082; PMID:29427785; PMID:35671903; PMID:36100036
GO:0014829	Vascular associated smooth muscle contraction	Increases phenotype	PMID:25772258
GO:0014832	Urinary bladder smooth muscle contraction	Affects phenotype	PMID:27596067
GO:0015711	Organic anion transport	Affects phenotype	PMID:28552774
GO:0015721	Bile acid and bile salt transport	Affects phenotype	PMID:35708773
GO:0015727	Lactate transport	Affects phenotype	PMID:33631201
GO:0015747	Urate transport	Increases phenotype	PMID:19391111
GO:0015840	Urea transport	Increases phenotype	PMID:19391111
GO:0015908	Fatty acid transport	Increases phenotype	PMID:28903485
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:16858688; PMID:16858688; PMID:19391111; PMID:17461432; PMID:17461432; PMID:17927767; PMID:17927767; PMID:19391111; PMID:25370934; PMID:27588890; PMID:33710703
GO:0016049	Cell growth	Decreases phenotype	PMID:29309803
GO:0018158	Protein oxidation	Increases phenotype	PMID:29975447
GO:0019373	Epoxygenase p450 pathway	Increases phenotype	PMID:28899749
GO:0019646	Aerobic electron transport chain	Decreases phenotype	PMID:28013001
GO:0019722	Calcium-mediated signaling	Decreases phenotype	PMID:10528133
GO:0019853	L-ascorbic acid biosynthetic process	Decreases phenotype	PMID:19391111
GO:0030199	Collagen fibril organization	Increases phenotype	PMID:33710703
GO:0030212	Hyaluronan metabolic process	Affects phenotype	PMID:38729283
GO:0030262	Apoptotic nuclear changes	Increases phenotype	PMID:35964836
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:28886988
GO:0030282	Bone mineralization	Decreases phenotype	PMID:32220932
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:30294794
GO:0032205	Negative regulation of telomere maintenance	Increases phenotype	PMID:29975447
GO:0032516	Positive regulation of phosphoprotein phosphatase activity	Increases phenotype	PMID:25451590; PMID:27481217; PMID:29650965
GO:0032743	Positive regulation of interleukin-2 production	Affects phenotype	PMID:24462674
GO:0032914	Positive regulation of transforming growth factor beta1 production	Affects phenotype	PMID:24462674
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:25947082; PMID:28899749
GO:0033344	Cholesterol efflux	Affects phenotype	PMID:32253466
GO:0034440	Lipid oxidation	Increases phenotype	PMID:26276312; PMID:29975447; PMID:32135237
GO:0035377	Transepithelial water transport	Decreases phenotype	PMID:31076804
GO:0035633	Maintenance of blood-brain barrier	Decreases phenotype	PMID:33631201
GO:0035695	Mitophagy by induced vacuole formation	Increases phenotype	PMID:33689844
GO:0035704	Helper t cell chemotaxis	Increases phenotype	PMID:27869817
GO:0035794	Positive regulation of mitochondrial membrane permeability	Increases phenotype	PMID:22095756; PMID:22226756; PMID:22236255; PMID:24675465; PMID:25947082; PMID:28703385; PMID:31708537; PMID:31813902; PMID:34358556
GO:0035795	Negative regulation of mitochondrial membrane permeability	Increases phenotype	PMID:28703385
GO:0035861	Site of double-strand break	Increases phenotype	PMID:32569592
GO:0036211	Protein modification process	Increases phenotype	PMID:20106845
GO:0042104	Positive regulation of activated t cell proliferation	Decreases phenotype	PMID:17475810
GO:0042310	Vasoconstriction	Increases phenotype	PMID:10484530; PMID:2301595; PMID:2778718; PMID:7543625; PMID:9509456; PMID:9794569
GO:0042311	Vasodilation	Increases phenotype	PMID:26276312; PMID:28899749
GO:0042391	Regulation of membrane potential	Decreases phenotype	PMID:28774209
GO:0042908	Xenobiotic transport	Affects phenotype	PMID:31076804
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:11032765; PMID:23765110; PMID:24675465; PMID:25947082; PMID:28013001; PMID:29567065
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:30804470; PMID:33631201; PMID:33689844; PMID:34681664; PMID:34762139; PMID:34808100; PMID:34856211; PMID:35033536; PMID:35964836; PMID:37429421; PMID:38729283; PMID:39956257
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:26276312
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:38653026
GO:0045821	Positive regulation of glycolytic process	Increases phenotype	PMID:30008028
GO:0045907	Positive regulation of vasoconstriction	Increases phenotype	PMID:28899749
GO:0045987	Positive regulation of smooth muscle contraction	Increases phenotype	PMID:27869817
GO:0046034	Atp metabolic process	Increases phenotype	PMID:28703385; PMID:33689844; PMID:34023961; PMID:34762139
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:27596067
GO:0046323	Glucose import	Affects phenotype	PMID:29380240
GO:0046330	Positive regulation of jnk cascade	Increases phenotype	PMID:27585667
GO:0046415	Urate metabolic process	Decreases phenotype	PMID:16858688; PMID:24462674; PMID:27585667
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:16858688; PMID:19391111; PMID:19391111; PMID:24462674; PMID:24462674; PMID:27596067
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:15001429; PMID:17954157; PMID:18766458; PMID:2018556; PMID:27596067
GO:0046620	Regulation of organ growth	Decreases phenotype	PMID:15001429; PMID:2128298
GO:0046649	Lymphocyte activation	Affects phenotype	PMID:1705513; PMID:9112343
GO:0046827	Positive regulation of protein export from nucleus	Increases phenotype	PMID:27585667
GO:0046902	Regulation of mitochondrial membrane permeability	Affects phenotype	PMID:18022205; PMID:34105389; PMID:36725022
GO:0048146	Positive regulation of fibroblast proliferation	Increases phenotype	PMID:28726637
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:29309803
GO:0050862	Positive regulation of t cell receptor signaling pathway	Decreases phenotype	PMID:17475810
GO:0051560	Mitochondrial calcium ion homeostasis	Affects phenotype	PMID:17912452; PMID:31629068
GO:0051881	Regulation of mitochondrial membrane potential	Decreases phenotype	PMID:15486922; PMID:15754004; PMID:15985439; PMID:18679777; PMID:25656643; PMID:25845326; PMID:26388407; PMID:27089845; PMID:27544635; PMID:28012895; PMID:31157505; PMID:31629068; PMID:34668290; PMID:35964836; PMID:9580328
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:23315796
GO:0051897	Positive regulation of protein kinase b signaling	Increases phenotype	PMID:23765110
GO:0051901	Positive regulation of mitochondrial depolarization	Increases phenotype	PMID:22095756; PMID:22226756; PMID:29427785
GO:0060612	Adipose tissue development	Increases phenotype	PMID:30792690
GO:0061739	Protein lipidation involved in autophagosome assembly	Increases phenotype	PMID:27318970; PMID:29567065
GO:0070265	Necrotic cell death	Increases phenotype	PMID:33710703
GO:0070633	Transepithelial transport	Decreases phenotype	PMID:10751037; PMID:18063342
GO:0070842	Aggresome assembly	Increases phenotype	PMID:40023272
GO:0070858	Negative regulation of bile acid biosynthetic process	Increases phenotype	PMID:35708773
GO:0070886	Positive regulation of calcineurin-nfat signaling cascade	Increases phenotype	PMID:17475810
GO:0070997	Neuron death	Increases phenotype	PMID:37308051
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:33689844; PMID:36117518; PMID:40023272
GO:0090200	Positive regulation of release of cytochrome c from mitochondria	Increases phenotype	PMID:18634816; PMID:25947082; PMID:26884717; PMID:28703385
GO:0090205	Positive regulation of cholesterol metabolic process	Decreases phenotype	PMID:25562108
GO:0097280	Histamine secretion mediated by immunoglobulin	Affects phenotype	PMID:8844128; PMID:9082935; PMID:9303333
GO:0098657	Import into cell	Affects phenotype	PMID:33307820
GO:0099093	Calcium export from the mitochondrion	Increases phenotype	PMID:31708537
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:28903485; PMID:29650965
GO:1901526	Positive regulation of mitophagy	Affects phenotype	PMID:27318970; PMID:29567065
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:27596067; PMID:32135237
GO:1901671	Positive regulation of superoxide dismutase activity	Decreases phenotype	PMID:26276312
GO:1902007	Regulation of toxin transport	Affects phenotype	PMID:23200901
GO:1902008	Negative regulation of toxin transport	Affects phenotype	PMID:23562926
GO:1902110	Positive regulation of mitochondrial membrane permeability involved in apoptotic process	Increases phenotype	PMID:26884717; PMID:32135237
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:25809564
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:32135237
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:20404319; PMID:26388407; PMID:27089845; PMID:29037868
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:11861326; PMID:25418342; PMID:25947082; PMID:26975474; PMID:28013001; PMID:32135237; PMID:36100036
GO:1903955	Positive regulation of protein targeting to mitochondrion	Increases phenotype	PMID:26884717; PMID:27318970
GO:1904028	Positive regulation of collagen fibril organization	Increases phenotype	PMID:26276312
GO:1904094	Positive regulation of autophagic cell death	Increases phenotype	PMID:24675465
GO:1904251	Regulation of bile acid metabolic process	Affects phenotype	PMID:25562108; PMID:26198044
GO:1905448	Positive regulation of mitochondrial atp synthesis coupled electron transport	Decreases phenotype	PMID:28013001
GO:1990961	Xenobiotic detoxification by transmembrane export across the plasma membrane	Decreases phenotype	PMID:14675146
GO:2000277	Positive regulation of oxidative phosphorylation uncoupler activity	Decreases phenotype	PMID:28013001
GO:2000562	Negative regulation of cd4-positive, alpha-beta t cell proliferation	Increases phenotype	PMID:34051231
GO:2000565	Negative regulation of cd8-positive, alpha-beta t cell proliferation	Increases phenotype	PMID:34051231
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:36100036
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:28942281; PMID:29427785
GO:2001171	Positive regulation of atp biosynthetic process	Decreases phenotype	PMID:26884717

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.