DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Cyclosporin A

No ToxCast endpoints for intended target type: RNA

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
BSK_3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	1.3 μM
BSK_4H_MCP1	Vascular	Human	6347	CCL2	Inhibitory	0.84 μM
BSK_4H_Pselectin	Vascular	Human	6403	SELP	Inhibitory	1.93 μM
BSK_4H_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	0.52 μM
BSK_BE3C_MMP1	Lung	Human	4312	MMP1	Inhibitory	0.04 μM
BSK_BE3C_PAI1	Lung	Human	5054	SERPINE1	Inhibitory	0.32 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	0.35 μM
BSK_CASM3C_IL6	Vascular	Human	3569	IL6	Inhibitory	1.22 μM
BSK_CASM3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	0.58 μM
BSK_CASM3C_MCSF	Vascular	Human	1435	CSF1	Inhibitory	1.72 μM
BSK_CASM3C_MIG	Vascular	Human	4283	CXCL9	Inhibitory	1.55 μM
BSK_CASM3C_SAA	Vascular	Human	6288	SAA1	Inhibitory	0.51 μM
BSK_CASM3C_Thrombomodulin	Vascular	Human	7056	THBD	Inhibitory	1.23 μM
BSK_CASM3C_TissueFactor	Vascular	Human	2152	F3	Inhibitory	1.63 μM
BSK_hDFCGF_CollagenIII	Skin	Human	1281	COL3A1	Inhibitory	1.67 μM
BSK_hDFCGF_EGFR	Skin	Human	1956	EGFR	Inhibitory	0.9 μM
BSK_hDFCGF_MCSF	Skin	Human	1435	CSF1	Inhibitory	1.87 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	1.2 μM
BSK_hDFCGF_TIMP1	Skin	Human	7076	TIMP1	Inhibitory	1.31 μM
BSK_hDFCGF_VCAM1	Skin	Human	7412	VCAM1	Inhibitory	1.89 μM
BSK_KF3CT_ICAM1	Skin	Human	3383	ICAM1	Inhibitory	1.75 μM
BSK_LPS_IL8	Vascular	Human	3576	CXCL8	Inhibitory	0.01 μM
BSK_SAg_CD38	Vascular	Human	952	CD38	Inhibitory	0.01 μM
BSK_SAg_CD40	Vascular	Human	958	CD40	Inhibitory	0.03 μM
BSK_SAg_CD69	Vascular	Human	969	CD69	Inhibitory	0.01 μM
BSK_SAg_Eselectin	Vascular	Human	6401	SELE	Inhibitory	0.04 μM
BSK_SAg_IL8	Vascular	Human	3576	CXCL8	Inhibitory	0.15 μM
BSK_SAg_MCP1	Vascular	Human	6347	CCL2	Inhibitory	0.01 μM
BSK_SAg_MIG	Vascular	Human	4283	CXCL9	Inhibitory	0.02 μM
BSK_BT_sIgG	Vascular	Human	3500	IGHG1	Inhibitory	0.03 μM
BSK_BT_xIL17A	Vascular	Human	3605	IL17A	Inhibitory	0.02 μM
BSK_BT_xIL17F	Vascular	Human	112744	IL17F	Inhibitory	0.02 μM
BSK_BT_xIL2	Vascular	Human	3558	IL2	Inhibitory	0.03 μM
BSK_BT_xIL6	Vascular	Human	3569	IL6	Inhibitory	0.02 μM
BSK_BT_xTNFa	Vascular	Human	7124	TNF	Inhibitory	0.02 μM
BSK_MyoF_ACTA1	Vascular	Human	58	ACTA1	Inhibitory	1.01 μM
BSK_MyoF_CollagenIII	Vascular	Human	1281	COL3A1	Inhibitory	0.59 μM
BSK_BF4T_Eotaxin3	Vascular	Human	10344	CCL26	Inhibitory	0.82 μM
BSK_BF4T_MMP9	Vascular	Human	4318	MMP9	Inhibitory	0.94 μM
BSK_BF4T_tPA	Vascular	Human	5327	PLAT	Inhibitory	1.55 μM
BSK_BE3C_IL8	Lung	Human	3576	CXCL8	Inhibitory	0.36 μM
BSK_BE3C_MMP9	Lung	Human	4318	MMP9	Inhibitory	0.22 μM
BSK_hDFCGF_MCP1	Skin	Human	6347	CCL2	Inhibitory	1.62 μM
BSK_hDFCGF_CollagenI	Skin	Human	1277	COL1A1	Inhibitory	0.95 μM
BSK_hDFCGF_TIMP2	Skin	Human	7077	TIMP2	Inhibitory	1.54 μM
BSK_KF3CT_IL8	Skin	Human	3576	CXCL8	Inhibitory	0.63 μM
BSK_IMphg_CD69	Vascular	Human	969	CD69	Inhibitory	2.04 μM
BSK_IMphg_IL10	Vascular	Human	3586	IL10	Inhibitory	1.99 μM
BSK_LPS_CD69	Vascular	Human	969	CD69	Inhibitory	0.02 μM
BSK_3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	1.59 μM
BSK_4H_MCP1	Vascular	Human	6347	CCL2	Inhibitory	1.04 μM
BSK_4H_Pselectin	Vascular	Human	6403	SELP	Inhibitory	2.04 μM
BSK_4H_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	0.02 μM
BSK_BE3C_HLADR	Lung	Human	3122	HLA-DRA	Inhibitory	1.94 μM
BSK_BE3C_MMP1	Lung	Human	4312	MMP1	Inhibitory	0.02 μM
BSK_BE3C_PAI1	Lung	Human	5054	SERPINE1	Inhibitory	0.4 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	0.25 μM
BSK_CASM3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	0.44 μM
BSK_CASM3C_MCSF	Vascular	Human	1435	CSF1	Inhibitory	1.7 μM
BSK_CASM3C_SAA	Vascular	Human	6288	SAA1	Inhibitory	1.2 μM
BSK_CASM3C_TissueFactor	Vascular	Human	2152	F3	Inhibitory	1.44 μM
BSK_hDFCGF_CollagenIII	Skin	Human	1281	COL3A1	Inhibitory	1.62 μM
BSK_hDFCGF_IL8	Skin	Human	3576	CXCL8	Inhibitory	2.01 μM
BSK_hDFCGF_MCSF	Skin	Human	1435	CSF1	Inhibitory	1.57 μM
BSK_hDFCGF_MMP1	Skin	Human	4312	MMP1	Inhibitory	1.9 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	1.18 μM
BSK_hDFCGF_TIMP1	Skin	Human	7076	TIMP1	Inhibitory	1.54 μM
BSK_hDFCGF_VCAM1	Skin	Human	7412	VCAM1	Inhibitory	1.78 μM
BSK_LPS_Eselectin	Vascular	Human	6401	SELE	Inhibitory	0.7 μM
BSK_LPS_IL1a	Vascular	Human	3552	IL1A	Inhibitory	0.17 μM
BSK_LPS_TissueFactor	Vascular	Human	2152	F3	Inhibitory	0.52 μM
BSK_SAg_CD40	Vascular	Human	958	CD40	Inhibitory	0.05 μM
BSK_SAg_CD69	Vascular	Human	969	CD69	Inhibitory	0.02 μM
BSK_SAg_Eselectin	Vascular	Human	6401	SELE	Inhibitory	0.05 μM
BSK_SAg_IL8	Vascular	Human	3576	CXCL8	Inhibitory	0.13 μM
BSK_SAg_MCP1	Vascular	Human	6347	CCL2	Inhibitory	0.04 μM
BSK_SAg_MIG	Vascular	Human	4283	CXCL9	Inhibitory	0.04 μM
BSK_BT_sIgG	Vascular	Human	3500	IGHG1	Inhibitory	0.04 μM
BSK_BT_xIL17A	Vascular	Human	3605	IL17A	Inhibitory	0.05 μM
BSK_BT_xIL17F	Vascular	Human	112744	IL17F	Inhibitory	0.04 μM
BSK_BT_xIL6	Vascular	Human	3569	IL6	Inhibitory	0.04 μM
BSK_BT_xTNFa	Vascular	Human	7124	TNF	Inhibitory	0.05 μM
BSK_MyoF_ACTA1	Vascular	Human	58	ACTA1	Inhibitory	1.35 μM
BSK_MyoF_CollagenIII	Vascular	Human	1281	COL3A1	Inhibitory	1.97 μM
BSK_BF4T_MCP1	Vascular	Human	6347	CCL2	Inhibitory	1.89 μM
BSK_BF4T_Eotaxin3	Vascular	Human	10344	CCL26	Inhibitory	1.43 μM
BSK_BF4T_CD90	Vascular	Human	7070	THY1	Inhibitory	1.52 μM
BSK_BE3C_IL8	Lung	Human	3576	CXCL8	Inhibitory	0.84 μM
BSK_BE3C_MMP9	Lung	Human	4318	MMP9	Inhibitory	0.09 μM
BSK_hDFCGF_MCP1	Skin	Human	6347	CCL2	Inhibitory	1.6 μM
BSK_hDFCGF_CollagenI	Skin	Human	1277	COL1A1	Inhibitory	1.55 μM
BSK_KF3CT_IL8	Skin	Human	3576	CXCL8	Inhibitory	1.01 μM
BSK_KF3CT_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	1.79 μM
BSK_IMphg_IL10	Vascular	Human	3586	IL10	Inhibitory	1.9 μM
BSK_LPS_CD69	Vascular	Human	969	CD69	Inhibitory	0.81 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	1.52 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	40.91 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	31.06 μM

No ToxCast endpoints for intended target type: Molecular messenger

No ToxCast endpoints for intended target type: Pathway

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.