| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000045 | Autophagosome assembly | Increases phenotype | PMID:34560126 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:18056701 |
| GO:0004407 | Histone deacetylase activity | Decreases phenotype | PMID:39580082 |
| GO:0006094 | Gluconeogenesis | Increases phenotype | PMID:3876337 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:10554762; PMID:10799313; PMID:1696946; PMID:20108032; PMID:2543382; PMID:7686540; PMID:8135827; PMID:9326359 |
| GO:0006355 | Regulation of dna-templated transcription | Affects phenotype | PMID:35483669 |
| GO:0006412 | Translation | Decreases phenotype | PMID:15611226; PMID:25624349; PMID:30821613; PMID:37315771 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:24437944 |
| GO:0006810 | Transport | Affects phenotype | PMID:37315771 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:10203695; PMID:10222263; PMID:10222263; PMID:17724027; PMID:10506188; PMID:10554762; PMID:10556781; PMID:10760090; PMID:10799313; PMID:10801904; PMID:10963052; PMID:11010806; PMID:11392499; PMID:11726273; PMID:11839765; PMID:11943151; PMID:12095650; PMID:12395097; PMID:12646627; PMID:1282508; PMID:1282508; PMID:7686540; PMID:12925536; PMID:12933658; PMID:1349631; PMID:14502240; PMID:14982947; PMID:15258469; PMID:15924153; PMID:16807353; PMID:16951203; PMID:17166486; PMID:17724027; PMID:17912641; PMID:18034189; PMID:18056701; PMID:18641367; PMID:19151764; PMID:20108032; PMID:20561156; PMID:21569845; PMID:24657799; PMID:25576094; PMID:27853917; PMID:7517174; PMID:7540953; PMID:7686540; PMID:7688510; PMID:7811993; PMID:7969078; PMID:8048048; PMID:8069862; PMID:8132215; PMID:8376790; PMID:8485807; PMID:8570169; PMID:8806462; PMID:9166738; PMID:9326359; PMID:9395239; PMID:9443068; PMID:9647221; PMID:9790906; PMID:9876872 |
| GO:0006936 | Muscle contraction | Increases phenotype | PMID:28138957 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:22343715 |
| GO:0007029 | Endoplasmic reticulum organization | Decreases phenotype | PMID:33550458 |
| GO:0007033 | Vacuole organization | Increases phenotype | PMID:31276663 |
| GO:0007049 | Cell cycle | Increases phenotype | PMID:9094091 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | Increases phenotype | PMID:29347925 |
| GO:0007224 | Smoothened signaling pathway | Decreases phenotype | PMID:31652400 |
| GO:0008217 | Regulation of blood pressure | Affects phenotype | PMID:15545831 |
| GO:0008219 | Cell death | Affects phenotype | PMID:10486196; PMID:11535817; PMID:12930891; PMID:17912641; PMID:18056701; PMID:18355723; PMID:19932975; PMID:2153551; PMID:22343715; PMID:22560901; PMID:31276663; PMID:34390821; PMID:7830938; PMID:7867088; PMID:9178660 |
| GO:0008283 | Cell population proliferation | Decreases phenotype | PMID:22343715; PMID:22560901 |
| GO:0008284 | Positive regulation of cell population proliferation | Affects phenotype | PMID:17966066; PMID:30022450 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:32949572; PMID:39949800 |
| GO:0009060 | Aerobic respiration | Affects phenotype | PMID:26187750 |
| GO:0010575 | Positive regulation of vascular endothelial growth factor production | Affects phenotype | PMID:8537383 |
| GO:0010765 | Positive regulation of sodium ion transport | Increases phenotype | PMID:1328298 |
| GO:0010918 | Positive regulation of mitochondrial membrane potential | Decreases phenotype | PMID:26187750 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:26187750; PMID:26409479; PMID:27796870 |
| GO:0016043 | Cellular component organization | Affects phenotype | PMID:35483669 |
| GO:0016049 | Cell growth | Decreases phenotype | PMID:18355723; PMID:27867098 |
| GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity | Decreases phenotype | PMID:9381980 |
| GO:0016567 | Protein ubiquitination | Increases phenotype | PMID:17912641; PMID:26409479; PMID:33550458 |
| GO:0016925 | Protein sumoylation | Increases phenotype | PMID:31285264 |
| GO:0017148 | Negative regulation of translation | Increases phenotype | PMID:26861016; PMID:28743738 |
| GO:0030595 | Leukocyte chemotaxis | Decreases phenotype | PMID:279007 |
| GO:0032125 | Micronucleus organization | Increases phenotype | PMID:32910239 |
| GO:0032688 | Negative regulation of interferon-beta production | Increases phenotype | PMID:26861016 |
| GO:0032930 | Positive regulation of superoxide anion generation | Affects phenotype | PMID:26187750 |
| GO:0033554 | Cellular response to stress | Affects phenotype | PMID:24036268 |
| GO:0034063 | Stress granule assembly | Increases phenotype | PMID:29576526; PMID:33431410; PMID:33431410; PMID:39387926; PMID:34244458 |
| GO:0034620 | Cellular response to unfolded protein | Increases phenotype | PMID:17912641 |
| GO:0035617 | Stress granule disassembly | Affects phenotype | PMID:25409157; PMID:28241074 |
| GO:0043068 | Positive regulation of programmed cell death | Increases phenotype | PMID:29723631 |
| GO:0044237 | Cellular metabolic process | Decreases phenotype | PMID:15287886; PMID:27853917; PMID:28211448; PMID:34303041 |
| GO:0045727 | Positive regulation of translation | Decreases phenotype | PMID:27629431 |
| GO:0046034 | Atp metabolic process | Affects phenotype | PMID:27853917 |
| GO:0046323 | Glucose import | Increases phenotype | PMID:29380240; PMID:32692981 |
| GO:0046325 | Negative regulation of glucose import | Affects phenotype | PMID:24221993 |
| GO:0046483 | Heterocycle metabolic process | Affects phenotype | PMID:38734222 |
| GO:0048384 | Retinoic acid receptor signaling pathway | Decreases phenotype | PMID:31652400 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Affects phenotype | PMID:18056701 |
| GO:0060070 | Canonical wnt signaling pathway | Decreases phenotype | PMID:31652400 |
| GO:0061951 | Establishment of protein localization to plasma membrane | Increases phenotype | PMID:30591588 |
| GO:0062029 | Positive regulation of stress granule assembly | Increases phenotype | PMID:27030674 |
| GO:0071494 | Cellular response to uv-c | Decreases phenotype | PMID:25409157 |
| GO:0080135 | Regulation of cellular response to stress | Affects phenotype | PMID:9113384 |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | Increases phenotype | PMID:15317942 |
| GO:1900035 | Negative regulation of cellular response to heat | Affects phenotype | PMID:9113384 |
| GO:1901857 | Positive regulation of cellular respiration | Affects phenotype | PMID:26187750 |
| GO:1902512 | Positive regulation of apoptotic dna fragmentation | Increases phenotype | PMID:9751194 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:26187750 |
| GO:1903608 | Protein localization to cytoplasmic stress granule | Increases phenotype | PMID:25237887 |
| GO:1904662 | Positive regulation of sensory perception of bitter taste | Increases phenotype | PMID:29347925 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.