DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Cycloheximide

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
LTEA_HepaRG_ABCB1	Liver	Human	5243	ABCB1	Activatory	83.55 μM
LTEA_HepaRG_ABCB11	Liver	Human	8647	ABCB11	Activatory	4.26 μM
LTEA_HepaRG_ABCC2	Liver	Human	1244	ABCC2	Activatory	27.46 μM
LTEA_HepaRG_ABCG2	Liver	Human	9429	ABCG2	Activatory	10.36 μM
LTEA_HepaRG_ACLY	Liver	Human	47	ACLY	Inhibitory	8.63 μM
LTEA_HepaRG_ACOX1	Liver	Human	51	ACOX1	Inhibitory	50.0 μM
LTEA_HepaRG_ADK	Liver	Human	132	ADK	Inhibitory	81.18 μM
LTEA_HepaRG_AFP	Liver	Human	174	AFP	Activatory	15.49 μM
LTEA_HepaRG_ALPP	Liver	Human	250	ALPP	Activatory	73.79 μM
LTEA_HepaRG_APOA5	Liver	Human	116519	APOA5	Inhibitory	25.99 μM
LTEA_HepaRG_BAX	Liver	Human	581	BAX	Inhibitory	9.92 μM
LTEA_HepaRG_BCL2L11	Liver	Human	10018	BCL2L11	Activatory	16.86 μM
LTEA_HepaRG_BID	Liver	Human	637	BID	Activatory	50.0 μM
LTEA_HepaRG_CASP8	Liver	Human	841	CASP8	Inhibitory	79.95 μM
LTEA_HepaRG_CAT	Liver	Human	847	CAT	Inhibitory	11.62 μM
LTEA_HepaRG_CCND1	Liver	Human	595	CCND1	Activatory	3.34 μM
LTEA_HepaRG_CDKN1A	Liver	Human	1026	CDKN1A	Inhibitory	13.19 μM
LTEA_HepaRG_CFLAR	Liver	Human	8837	CFLAR	Inhibitory	13.3 μM
LTEA_HepaRG_CYP1A1	Liver	Human	1543	CYP1A1	Activatory	4.41 μM
LTEA_HepaRG_CYP1A2	Liver	Human	1544	CYP1A2	Activatory	10.3 μM
LTEA_HepaRG_CYP2B6	Liver	Human	1555	CYP2B6	Activatory	11.08 μM
LTEA_HepaRG_CYP2C19	Liver	Human	1557	CYP2C19	Inhibitory	22.62 μM
LTEA_HepaRG_CYP2C8	Liver	Human	1558	CYP2C8	Activatory	26.66 μM
LTEA_HepaRG_CYP2C9	Liver	Human	1559	CYP2C9	Activatory	17.06 μM
LTEA_HepaRG_CYP2E1	Liver	Human	1571	CYP2E1	Activatory	21.9 μM
LTEA_HepaRG_CYP3A4	Liver	Human	1576	CYP3A4	Activatory	11.71 μM
LTEA_HepaRG_CYP3A5	Liver	Human	1577	CYP3A5	Activatory	11.44 μM
LTEA_HepaRG_CYP3A7	Liver	Human	1551	CYP3A7	Activatory	8.63 μM
LTEA_HepaRG_CYP4A11	Liver	Human	1579	CYP4A11	Activatory	8.46 μM
LTEA_HepaRG_CYP4A22	Liver	Human	284541	CYP4A22	Inhibitory	9.16 μM
LTEA_HepaRG_CYP7A1	Liver	Human	1581	CYP7A1	Inhibitory	18.43 μM
LTEA_HepaRG_DDIT3	Liver	Human	1649	DDIT3	Inhibitory	9.92 μM
LTEA_HepaRG_EGF	Liver	Human	1950	EGF	Inhibitory	2.36 μM
LTEA_HepaRG_EGR1	Liver	Human	1958	EGR1	Inhibitory	91.78 μM
LTEA_HepaRG_EZR	Liver	Human	7430	EZR	Inhibitory	10.79 μM
LTEA_HepaRG_FABP1	Liver	Human	2168	FABP1	Activatory	18.32 μM
LTEA_HepaRG_FASN	Liver	Human	2194	FASN	Inhibitory	4.28 μM
LTEA_HepaRG_FMO3	Liver	Human	2328	FMO3	Inhibitory	19.59 μM
LTEA_HepaRG_FOXO3	Liver	Human	2309	FOXO3	Inhibitory	33.44 μM
LTEA_HepaRG_GADD45A	Liver	Human	1647	GADD45A	Activatory	50.0 μM
LTEA_HepaRG_GADD45B	Liver	Human	4616	GADD45B	Activatory	21.56 μM
LTEA_HepaRG_GADD45G	Liver	Human	10912	GADD45G	Inhibitory	2.24 μM
LTEA_HepaRG_GCLC	Liver	Human	2729	GCLC	Inhibitory	33.27 μM
LTEA_HepaRG_GCLM	Liver	Human	2730	GCLM	Inhibitory	21.36 μM
LTEA_HepaRG_GSTA2	Liver	Human	2939	GSTA2	Activatory	23.87 μM
LTEA_HepaRG_GSTM3	Liver	Human	2947	GSTM3	Activatory	5.85 μM
LTEA_HepaRG_HGF	Liver	Human	3082	HGF	Inhibitory	71.75 μM
LTEA_HepaRG_HIF1A	Liver	Human	3091	HIF1A	Activatory	9.18 μM
LTEA_HepaRG_HMGCS2	Liver	Human	3158	HMGCS2	Activatory	27.17 μM
LTEA_HepaRG_HSPA1A	Liver	Human	3303	HSPA1A	Activatory	28.01 μM
LTEA_HepaRG_ICAM1	Liver	Human	3383	ICAM1	Inhibitory	11.86 μM
LTEA_HepaRG_IGF1	Liver	Human	3479	IGF1	Inhibitory	9.09 μM
LTEA_HepaRG_IGFBP1	Liver	Human	3484	IGFBP1	Inhibitory	22.32 μM
LTEA_HepaRG_IL6	Liver	Human	3569	IL6	Inhibitory	13.13 μM
LTEA_HepaRG_JUN	Liver	Human	3725	JUN	Inhibitory	30.04 μM
LTEA_HepaRG_KCNK1	Liver	Human	3775	KCNK1	Inhibitory	12.24 μM
LTEA_HepaRG_KRT19	Liver	Human	3880	KRT19	Activatory	12.36 μM
LTEA_HepaRG_LIPC	Liver	Human	3990	LIPC	Activatory	15.43 μM
LTEA_HepaRG_LPL	Liver	Human	4023	LPL	Inhibitory	12.15 μM
LTEA_HepaRG_MIR122	Liver	Human	406906	MIR122	Activatory	10.55 μM
LTEA_HepaRG_MMP3	Liver	Human	4314	MMP3	Activatory	83.29 μM
LTEA_HepaRG_MYC	Liver	Human	4609	MYC	Activatory	19.49 μM
LTEA_HepaRG_NFE2L2	Liver	Human	4780	NFE2L2	Activatory	30.3 μM
LTEA_HepaRG_NFKB1	Liver	Human	4790	NFKB1	Inhibitory	17.6 μM
LTEA_HepaRG_NQO1	Liver	Human	1728	NQO1	Inhibitory	29.25 μM
LTEA_HepaRG_PDK4	Liver	Human	5166	PDK4	Inhibitory	31.93 μM
LTEA_HepaRG_PTEN	Liver	Human	5728	PTEN	Activatory	87.59 μM
LTEA_HepaRG_SDHB	Liver	Human	6390	SDHB	Activatory	50.0 μM
LTEA_HepaRG_SLC22A1	Liver	Human	6580	SLC22A1	Inhibitory	8.29 μM
LTEA_HepaRG_SLCO1B1	Liver	Human	10599	SLCO1B1	Activatory	15.19 μM
LTEA_HepaRG_STAT3	Liver	Human	6774	STAT3	Activatory	20.2 μM
LTEA_HepaRG_SULT2A1	Liver	Human	6822	SULT2A1	Activatory	40.39 μM
LTEA_HepaRG_TGFA	Liver	Human	7039	TGFA	Activatory	31.13 μM
LTEA_HepaRG_THRSP	Liver	Human	7069	THRSP	Inhibitory	7.46 μM
LTEA_HepaRG_TIMP1	Liver	Human	7076	TIMP1	Activatory	50.0 μM
LTEA_HepaRG_TNFRSF1A	Liver	Human	7132	TNFRSF1A	Inhibitory	80.55 μM
LTEA_HepaRG_TP53	Liver	Human	7157	TP53	Inhibitory	13.62 μM
LTEA_HepaRG_UGT1A1	Liver	Human	54658	UGT1A1	Activatory	27.62 μM
LTEA_HepaRG_UGT1A6	Liver	Human	54578	UGT1A6	Activatory	39.56 μM
LTEA_HepaRG_XBP1	Liver	Human	7494	XBP1	Inhibitory	16.27 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CCTE_Deisenroth_5AR_NBTE_ratio	Kidney	Human	6716	SRD5A2	Activatory	0.09 μM
ATG_AP_1_CIS	Liver	Human	2353\|3725	FOS\|JUN	Inhibitory	11.93 μM
ATG_BRE_CIS	Liver	Human	4086	SMAD1	Inhibitory	17.26 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Activatory	18.92 μM
ATG_E_Box_CIS	Liver	Human	7391	USF1	Activatory	3.69 μM
ATG_Ets_CIS	Liver	Human	2113	ETS1	Activatory	4.06 μM
ATG_FoxO_CIS	Liver	Human	2308\|2309	FOXO1\|FOXO3	Activatory	4.19 μM
ATG_HIF1a_CIS	Liver	Human	3091	HIF1A	Inhibitory	26.59 μM
ATG_ISRE_CIS	Liver	Human	3659	IRF1	Activatory	2.3 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Inhibitory	16.22 μM
ATG_Oct_MLP_CIS	Liver	Human	5451	POU2F1	Inhibitory	16.04 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Inhibitory	12.9 μM
ATG_TCF_b_cat_CIS	Liver	Human	6932\|6934\|51176\|83439	TCF7\|TCF7L2\|LEF1\|TCF7L1	Inhibitory	8.07 μM
ATG_TGFb_CIS	Liver	Human	7040	TGFB1	Activatory	6.35 μM
ATG_GR_TRANS	Liver	Human	2908	NR3C1	Gain	8.38 μM
ATG_AP_1_CIS	Liver	Human	2353\|3725	FOS\|JUN	Inhibitory	30.54 μM
ATG_BRE_CIS	Liver	Human	4086	SMAD1	Activatory	5.79 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Activatory	30.96 μM
ATG_E_Box_CIS	Liver	Human	7391	USF1	Inhibitory	2.58 μM
ATG_Ets_CIS	Liver	Human	2113	ETS1	Activatory	5.57 μM
ATG_FoxO_CIS	Liver	Human	2308\|2309	FOXO1\|FOXO3	Inhibitory	4.75 μM
ATG_GRE_CIS	Liver	Human	2908	NR3C1	Activatory	3.06 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Activatory	12.04 μM
ATG_PBREM_CIS	Liver	Human	9970	NR1I3	Activatory	3.79 μM
ATG_PPRE_CIS	Liver	Human	5465\|5467\|5468	PPARA\|PPARD\|PPARG	Activatory	27.45 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Activatory	3.24 μM
ATG_TCF_b_cat_CIS	Liver	Human	6932\|6934\|51176\|83439	TCF7\|TCF7L2\|LEF1\|TCF7L1	Inhibitory	8.48 μM
ATG_TGFb_CIS	Liver	Human	7040	TGFB1	Inhibitory	5.52 μM
ATG_GR_TRANS	Liver	Human	2908	NR3C1	Gain	11.4 μM
ATG_AP_2_CIS	Liver	Human	7020\|7021\|83741	TFAP2A\|TFAP2B\|TFAP2D	Inhibitory	2.86 μM
ATG_Ets_CIS	Liver	Human	2113	ETS1	Activatory	4.57 μM
ATG_GRE_CIS	Liver	Human	2908	NR3C1	Inhibitory	2.38 μM
ATG_HIF1a_CIS	Liver	Human	3091	HIF1A	Activatory	0.12 μM
ATG_HSE_CIS	Liver	Human	3297	HSF1	Inhibitory	2.68 μM
ATG_ISRE_CIS	Liver	Human	3659	IRF1	Activatory	5.03 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Inhibitory	17.76 μM
ATG_NRF2_ARE_CIS	Liver	Human	4780	NFE2L2	Inhibitory	17.76 μM
ATG_p53_CIS	Liver	Human	7157	TP53	Activatory	2.34 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Inhibitory	23.24 μM
ATG_TCF_b_cat_CIS	Liver	Human	6932\|6934\|51176\|83439	TCF7\|TCF7L2\|LEF1\|TCF7L1	Activatory	6.33 μM
ATG_TGFb_CIS	Liver	Human	7040	TGFB1	Activatory	22.33 μM
ATG_PPARg_TRANS	Liver	Human	5468	PPARG	Gain	28.1 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	5.25 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	22.35 μM
NVS_MP_rPBR	Kidney	Rat	24230	Tspo	Loss	33.32 μM
NVS_NR_hER		Human	2099	ESR1	Loss	13.63 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	12.03 μM
ATG_BRE_CIS	Liver	Human	4086	SMAD1	Activatory	16.62 μM
ATG_CRE_CIS	Liver	Human	10488	CREB3	Activatory	8.91 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Activatory	38.34 μM
ATG_DR5_RAR_CIS	Liver	Human	5914\|5915\|5916	RARA\|RARB\|RARG	Activatory	2.83 μM
ATG_E_Box_CIS	Liver	Human	7391	USF1	Inhibitory	2.39 μM
ATG_Ets_CIS	Liver	Human	2113	ETS1	Activatory	5.51 μM
ATG_FoxA2_CIS	Liver	Human	3170	FOXA2	Inhibitory	10.09 μM
ATG_FoxO_CIS	Liver	Human	2308\|2309	FOXO1\|FOXO3	Activatory	13.6 μM
ATG_GRE_CIS	Liver	Human	2908	NR3C1	Activatory	4.09 μM
ATG_ISRE_CIS	Liver	Human	3659	IRF1	Activatory	2.87 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Inhibitory	17.9 μM
ATG_Oct_MLP_CIS	Liver	Human	5451	POU2F1	Inhibitory	24.14 μM
ATG_PBREM_CIS	Liver	Human	9970	NR1I3	Inhibitory	4.3 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Activatory	6.53 μM
ATG_TCF_b_cat_CIS	Liver	Human	6932\|6934\|51176\|83439	TCF7\|TCF7L2\|LEF1\|TCF7L1	Inhibitory	6.1 μM
ATG_TGFb_CIS	Liver	Human	7040	TGFB1	Activatory	31.16 μM
ATG_Xbp1_CIS	Liver	Human	7494	XBP1	Activatory	89.5 μM
BSK_3C_Eselectin	Vascular	Human	6401	SELE	Inhibitory	2.4 μM
BSK_3C_HLADR	Vascular	Human	3122	HLA-DRA	Inhibitory	3.82 μM
BSK_3C_ICAM1	Vascular	Human	3383	ICAM1	Inhibitory	12.49 μM
BSK_3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	4.35 μM
BSK_3C_MCP1	Vascular	Human	6347	CCL2	Inhibitory	7.79 μM
BSK_3C_MIG	Vascular	Human	4283	CXCL9	Inhibitory	20.11 μM
BSK_3C_uPAR	Vascular	Human	5329	PLAUR	Inhibitory	4.13 μM
BSK_3C_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	9.56 μM
BSK_4H_Eotaxin3	Vascular	Human	10344	CCL26	Inhibitory	9.11 μM
BSK_4H_MCP1	Vascular	Human	6347	CCL2	Inhibitory	4.05 μM
BSK_4H_Pselectin	Vascular	Human	6403	SELP	Inhibitory	3.29 μM
BSK_4H_uPAR	Vascular	Human	5329	PLAUR	Inhibitory	4.28 μM
BSK_4H_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	17.73 μM
BSK_4H_VEGFRII	Vascular	Human	3791	KDR	Inhibitory	9.02 μM
BSK_BE3C_HLADR	Lung	Human	3122	HLA-DRA	Inhibitory	4.93 μM
BSK_BE3C_IL1a	Lung	Human	3552	IL1A	Inhibitory	10.72 μM
BSK_BE3C_IP10	Lung	Human	3627	CXCL10	Inhibitory	8.4 μM
BSK_BE3C_MIG	Lung	Human	4283	CXCL9	Inhibitory	11.75 μM
BSK_BE3C_MMP1	Lung	Human	4312	MMP1	Inhibitory	2.36 μM
BSK_BE3C_TGFb1	Lung	Human	7040	TGFB1	Inhibitory	2.83 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	2.9 μM
BSK_BE3C_uPA	Lung	Human	5328	PLAU	Inhibitory	4.95 μM
BSK_BE3C_uPAR	Lung	Human	5329	PLAUR	Inhibitory	4.02 μM
BSK_CASM3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	6.03 μM
BSK_CASM3C_MCP1	Vascular	Human	6347	CCL2	Inhibitory	9.46 μM
BSK_CASM3C_MCSF	Vascular	Human	1435	CSF1	Inhibitory	4.28 μM
BSK_CASM3C_Thrombomodulin	Vascular	Human	7056	THBD	Inhibitory	8.07 μM
BSK_CASM3C_uPAR	Vascular	Human	5329	PLAUR	Inhibitory	3.79 μM
BSK_hDFCGF_IL8	Skin	Human	3576	CXCL8	Inhibitory	7.53 μM
BSK_hDFCGF_IP10	Skin	Human	3627	CXCL10	Inhibitory	2.14 μM
BSK_hDFCGF_MCSF	Skin	Human	1435	CSF1	Inhibitory	4.09 μM
BSK_hDFCGF_MIG	Skin	Human	4283	CXCL9	Inhibitory	4.38 μM
BSK_hDFCGF_MMP1	Skin	Human	4312	MMP1	Inhibitory	3.29 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	2.9 μM
BSK_hDFCGF_TIMP1	Skin	Human	7076	TIMP1	Inhibitory	2.49 μM
BSK_KF3CT_ICAM1	Skin	Human	3383	ICAM1	Inhibitory	7.24 μM
BSK_KF3CT_IL1a	Skin	Human	3552	IL1A	Inhibitory	31.19 μM
BSK_KF3CT_IP10	Skin	Human	3627	CXCL10	Inhibitory	12.93 μM
BSK_KF3CT_MMP9	Skin	Human	4318	MMP9	Inhibitory	4.29 μM
BSK_KF3CT_TGFb1	Skin	Human	7040	TGFB1	Inhibitory	2.79 μM
BSK_KF3CT_TIMP2	Skin	Human	7077	TIMP2	Inhibitory	5.84 μM
BSK_KF3CT_uPA	Skin	Human	5328	PLAU	Inhibitory	10.43 μM
BSK_LPS_CD40	Vascular	Human	958	CD40	Inhibitory	2.88 μM
BSK_LPS_IL1a	Vascular	Human	3552	IL1A	Inhibitory	5.63 μM
BSK_LPS_IL8	Vascular	Human	3576	CXCL8	Inhibitory	4.6 μM
BSK_LPS_MCP1	Vascular	Human	6347	CCL2	Inhibitory	5.7 μM
BSK_LPS_MCSF	Vascular	Human	1435	CSF1	Inhibitory	4.48 μM
BSK_LPS_PGE2	Vascular	Human	5732	PTGER2	Inhibitory	5.67 μM
BSK_LPS_TissueFactor	Vascular	Human	2152	F3	Inhibitory	17.9 μM
BSK_LPS_TNFa	Vascular	Human	7124	TNF	Inhibitory	7.65 μM
BSK_LPS_VCAM1	Vascular	Human	7412	VCAM1	Inhibitory	6.31 μM
BSK_SAg_CD38	Vascular	Human	952	CD38	Inhibitory	5.66 μM
BSK_SAg_CD40	Vascular	Human	958	CD40	Inhibitory	2.6 μM
BSK_SAg_CD69	Vascular	Human	969	CD69	Inhibitory	6.41 μM
BSK_SAg_MCP1	Vascular	Human	6347	CCL2	Inhibitory	5.47 μM
BSK_SAg_MIG	Vascular	Human	4283	CXCL9	Inhibitory	11.72 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	3.48 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.06 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	2.66 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	0.0 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	6.45 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.04 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	4.44 μM
TOX21_SBE_BLA_Antagonist_ratio	Kidney	Human	4086	SMAD1	Loss	0.14 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	7.22 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	108.0 μM

ToxCast endpoints for intended target type: Molecular messenger

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CEETOX_H295R_11DCORT	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.08 μM

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist	Bone	Human	367	AR	Loss	0.11 μM
APR_HepG2_p53Act_24hr	Liver	Human	7157	TP53	Activatory	21.67 μM
APR_HepG2_p53Act_72hr	Liver	Human	7157	TP53	Activatory	4.79 μM
ACEA_AR_agonist_80hr	Prostate	Human	367	AR	Gain	0.01 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.07 μM
TOX21_FXR_BLA_Antagonist_ratio	Kidney	Human	9971	NR1H4	Loss	11.19 μM
TOX21_PPARd_BLA_Antagonist_ratio	Kidney	Human	5467	PPARD	Loss	12.11 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	13.78 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.02 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.1 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.