Dichloroacetic acid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0004022 Alcohol dehydrogenase (nad+) activity Decreases phenotype PMID:33405312
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:18493934
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:18493934
GO:0006007 Glucose catabolic process Increases phenotype PMID:31629899
GO:0006085 Acetyl-coa biosynthetic process Increases phenotype PMID:31654802
GO:0006089 Lactate metabolic process Affects phenotype PMID:39922521
GO:0006611 Protein export from nucleus Affects phenotype PMID:33405312
GO:0006749 Glutathione metabolic process Affects phenotype PMID:33259821
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:18493934
GO:0006754 Atp biosynthetic process Increases phenotype PMID:31629899
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:33259821
GO:0008152 Metabolic process Affects phenotype PMID:28962523
GO:0008219 Cell death Increases phenotype PMID:26343699; PMID:33259821
GO:0008283 Cell population proliferation Decreases phenotype PMID:25630799; PMID:28962523
GO:0009060 Aerobic respiration Decreases phenotype PMID:29653124
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25482950
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25482950
GO:0016042 Lipid catabolic process Affects phenotype PMID:33259821
GO:0016049 Cell growth Decreases phenotype PMID:18493934
GO:0016477 Cell migration Decreases phenotype PMID:33405312
GO:0016570 Histone modification Affects phenotype PMID:39922521
GO:0018205 Peptidyl-lysine modification Affects phenotype PMID:39922521
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:31629899
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25482950
GO:0044237 Cellular metabolic process Affects phenotype PMID:31629899; PMID:33259821
GO:0045820 Negative regulation of glycolytic process Increases phenotype PMID:29653124
GO:0046449 Creatinine metabolic process Affects phenotype PMID:39922521
GO:0060326 Cell chemotaxis Decreases phenotype PMID:33405312
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33259821
GO:1902031 Regulation of nadp metabolic process Affects phenotype PMID:25482950
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25482950
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:29653124
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.