Tetrabromobisphenol A


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000080 Mitotic g1 phase Increases phenotype PMID:31332466
GO:0000084 Mitotic s phase Decreases phenotype PMID:31332466
GO:0001655 Urogenital system development Affects phenotype PMID:32416200
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:24132472
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:29702088
GO:0006171 Camp biosynthetic process Increases phenotype PMID:25223798; PMID:28858478
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:25048947
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:27718046
GO:0006754 Atp biosynthetic process Affects phenotype PMID:28301301; PMID:35435491
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:24395120; PMID:31332466; PMID:25371527; PMID:25371527; PMID:26215658; PMID:26215658; PMID:31332466
GO:0006882 Cellular zinc ion homeostasis Decreases phenotype PMID:28919410
GO:0006915 Apoptotic process Increases phenotype PMID:24132472; PMID:25146423; PMID:27592553; PMID:28301301; PMID:31332466
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25146423; PMID:27633978
GO:0007010 Cytoskeleton organization Affects phenotype PMID:27633978; PMID:35230478
GO:0007049 Cell cycle Affects phenotype PMID:27633978
GO:0007283 Spermatogenesis Decreases phenotype PMID:35230478
GO:0007613 Memory Decreases phenotype PMID:28564613
GO:0008210 Estrogen metabolic process Affects phenotype PMID:26988606
GO:0008219 Cell death Increases phenotype PMID:24395120; PMID:26640238; PMID:27592553; PMID:27718046; PMID:28851516
GO:0008283 Cell population proliferation Increases phenotype PMID:24395120; PMID:27592553; PMID:27718046; PMID:28616630; PMID:28811233; PMID:29653259; PMID:33095664
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:26979758; PMID:26988606
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30098271; PMID:30766661; PMID:30951941; PMID:32763284; PMID:35734227; PMID:35734227
GO:0010001 Glial cell differentiation Increases phenotype PMID:28851516
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:38995820
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:27998958
GO:0010826 Negative regulation of centrosome duplication Decreases phenotype PMID:27998958
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:25777084
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:30951941; PMID:39586487
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28919410
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25223798; PMID:26718265
GO:0016042 Lipid catabolic process Affects phenotype PMID:29702088
GO:0016477 Cell migration Decreases phenotype PMID:33969458
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:25863188
GO:0022008 Neurogenesis Decreases phenotype PMID:28564613
GO:0030033 Microvillus assembly Increases phenotype PMID:32041402
GO:0030182 Neuron differentiation Decreases phenotype PMID:28851516; PMID:33969458
GO:0030954 Astral microtubule nucleation Increases phenotype PMID:27998958
GO:0031116 Positive regulation of microtubule polymerization Increases phenotype PMID:27998958
GO:0031175 Neuron projection development Decreases phenotype PMID:31332466
GO:0032048 Cardiolipin metabolic process Affects phenotype PMID:28301301
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:30766661
GO:0032308 Positive regulation of prostaglandin secretion Increases phenotype PMID:30055667
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25449125; PMID:26979758
GO:0033864 Positive regulation of nad(p)h oxidase activity Increases phenotype PMID:30766661
GO:0034389 Lipid droplet organization Increases phenotype PMID:28329833
GO:0034440 Lipid oxidation Increases phenotype PMID:30098271; PMID:30951941
GO:0034454 Microtubule anchoring at centrosome Increases phenotype PMID:27998958
GO:0042310 Vasoconstriction Increases phenotype PMID:35321852
GO:0042554 Superoxide anion generation Increases phenotype PMID:28301301
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:30951941
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:39586487
GO:0044237 Cellular metabolic process Affects phenotype PMID:26215658; PMID:27093678; PMID:32041402; PMID:33969458
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:34323617
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:38369087
GO:0045444 Fat cell differentiation Increases phenotype PMID:25863188; PMID:30496566; PMID:32473317
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:25777084
GO:0045669 Positive regulation of osteoblast differentiation Decreases phenotype PMID:25777084
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:30766661
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:31332466
GO:0046460 Neutral lipid biosynthetic process Increases phenotype PMID:35734227
GO:0048143 Astrocyte activation Increases phenotype PMID:28564613
GO:0048709 Oligodendrocyte differentiation Decreases phenotype PMID:33969458
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:33078840
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:30766661
GO:0051402 Neuron apoptotic process Increases phenotype PMID:38995820
GO:0051726 Regulation of cell cycle Increases phenotype PMID:31750923
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:27718046
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:31404653
GO:0051899 Membrane depolarization Increases phenotype PMID:28143888
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:27718046; PMID:28143888; PMID:28858478
GO:0060009 Sertoli cell development Decreases phenotype PMID:35230478
GO:0060548 Negative regulation of cell death Increases phenotype PMID:37487893
GO:0061089 Negative regulation of sequestering of zinc ion Increases phenotype PMID:28919410
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:25146423; PMID:25576683
GO:0061900 Glial cell activation Increases phenotype PMID:28564613
GO:0070509 Calcium ion import Increases phenotype PMID:26215658
GO:0071577 Zinc ion transmembrane transport Increases phenotype PMID:28919410
GO:0072520 Seminiferous tubule development Affects phenotype PMID:35230478
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:28301301
GO:0110053 Regulation of actin filament organization Affects phenotype PMID:31750923
GO:0140042 Lipid droplet formation Increases phenotype PMID:25048947
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:30766661
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:28919410
GO:1901612 Cardiolipin binding Affects phenotype PMID:28301301
GO:1903353 Regulation of nucleus organization Affects phenotype PMID:31750923
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24395120; PMID:24395120; PMID:31332466; PMID:27592553; PMID:27718046; PMID:31332466
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28919410; PMID:30098271; PMID:30766661; PMID:30951941; PMID:35950316
GO:1904181 Positive regulation of membrane depolarization Increases phenotype PMID:30769291
GO:1904251 Regulation of bile acid metabolic process Affects phenotype PMID:33078840
GO:1905665 Positive regulation of calcium ion import across plasma membrane Increases phenotype PMID:28919410
GO:1990138 Neuron projection extension Decreases phenotype PMID:31332466
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:25576683
GO:2000278 Regulation of dna biosynthetic process Affects phenotype PMID:31750923
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:24278553
GO:2000611 Positive regulation of thyroid hormone generation Decreases phenotype PMID:26988606
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:25576683; PMID:30055667
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:30055667
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:25223798
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:30055667
GO:2001025 Positive regulation of response to drug Increases phenotype PMID:35734227
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:28301301
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.