Tetrabromobisphenol A

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15635150	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:18255212	IVR	100 mg/kg/day	100 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
PMID:18313098	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects corticosterone metabolism	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:20399831	IVR	2100 mg/kg	2100 mg/kg	Decrease in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
PMID:25146423	IVR	0.035 mg/kg	0.035 mg/kg	Alters sperm function	Reproductive endocrine-mediated perturbations
	IVR	0.035 mg/kg	0.035 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:25223798	IVTH	0.000000001 - 0.0001 M	0.00000001 - 0.0001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.00000001 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:26253174	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Decreased hCG levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0001 M	0.000000001 - 0.0001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:26979758	IVTH	0.001 M	0.001 M	Altered estrogen levels	Reproductive endocrine-mediated perturbations
PMID:28564613	IVR	100 mg/kg	100 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	20 mg/kg	-	No significant effects observed	-
PMID:28616630	IVTH	0.000000000001 - 0.0001 M	0.0000005 - 0.000005 M	Cancer phenotype	Endocrine-mediated cancer
PMID:32416200	IVR	25 mg/kg	25 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:33099281	IVTH	0.000001 M	0.000001 M	Affects cholesterol metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:35101577	IVTH	0.00003 M	0.00003 M	Altered adipocyte morphology	Metabolic endocrine-mediated perturbations
	IVTH	0.00003 M	0.00003 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations
PMID:35321852	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Pregnancy complications	Reproductive endocrine-mediated perturbations
PMID:36499108	IVR	15 mg/kg/day	15 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	15 mg/kg/day	15 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:37487893	IVR	0.02 - 2 mg/kg/day	0.02 - 2 mg/kg/day	Affects thyroid hormone synthesis	Metabolic endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
PMID:38128231	IVTH	0.0001 M	0.0001 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:38763426	IVR	1 mg/kg	1 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased brain weights	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:38997027	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
PMID:39134236	IVR	2 mg/kg/day	2 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
PMID:39236844	IVR	2 mg/L	2 mg/L	Alters hypothalamic-pituitary-liver axis	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	No significant effects observed	-

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.