Lead diacetate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000050 Urea cycle Increases phenotype PMID:30980911
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:27236077
GO:0000266 Mitochondrial fission Increases phenotype PMID:31874198
GO:0000422 Autophagy of mitochondrion Increases phenotype PMID:25031709
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:26078282
GO:0000902 Cell morphogenesis Affects phenotype PMID:32142724
GO:0001755 Neural crest cell migration Decreases phenotype PMID:26238599
GO:0001774 Microglial cell activation Increases phenotype PMID:36308466
GO:0001808 Negative regulation of type iv hypersensitivity Increases phenotype PMID:23058909
GO:0001836 Release of cytochrome c from mitochondria Affects phenotype PMID:31874198
GO:0001991 Regulation of systemic arterial blood pressure by circulatory renin-angiotensin Increases phenotype PMID:21494558
GO:0002441 Histamine secretion involved in inflammatory response Increases phenotype PMID:23928832
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:32116774; PMID:38180308
GO:0002575 Basophil chemotaxis Increases phenotype PMID:23088908; PMID:23928832
GO:0002639 Positive regulation of immunoglobulin production Increases phenotype PMID:23928832
GO:0002690 Positive regulation of leukocyte chemotaxis Increases phenotype PMID:22581110
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:28817314
GO:0003084 Positive regulation of systemic arterial blood pressure Increases phenotype PMID:21494558
GO:0003872 6-phosphofructokinase activity Decreases phenotype PMID:30980912; PMID:34508822
GO:0003954 Nadh dehydrogenase activity Decreases phenotype PMID:32407874
GO:0003993 Acid phosphatase activity Increases phenotype PMID:35307918
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:35307918
GO:0004129 Cytochrome-c oxidase activity Affects phenotype PMID:39547369
GO:0004303 Estradiol 17-beta-dehydrogenase activity Decreases phenotype PMID:30510688
GO:0004364 Glutathione transferase activity Affects phenotype PMID:19263481; PMID:25322819; PMID:28817314; PMID:31610155
GO:0004396 Hexokinase activity Decreases phenotype PMID:30980912
GO:0004457 Lactate dehydrogenase activity Decreases phenotype PMID:30615929; PMID:34508822
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:19263481; PMID:19263481; PMID:25322819; PMID:23906897; PMID:24184865; PMID:25322819; PMID:25800560; PMID:30510688; PMID:30510688; PMID:37471654; PMID:32116774; PMID:32407874; PMID:37471654
GO:0004697 Protein kinase c activity Decreases phenotype PMID:31843630
GO:0004722 Protein serine/threonine phosphatase activity Increases phenotype PMID:24954411
GO:0004743 Pyruvate kinase activity Decreases phenotype PMID:30980912
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:24184865; PMID:25322819; PMID:25322819; PMID:30703413; PMID:25800560; PMID:30510688; PMID:30510688; PMID:37471654; PMID:30703413; PMID:31874198; PMID:32116774; PMID:35398025; PMID:35752206; PMID:37471654; PMID:40010429
GO:0005243 Gap junction channel activity Decreases phenotype PMID:33242459
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:31874198
GO:0005757 Mitochondrial permeability transition pore complex Affects phenotype PMID:31874198; PMID:35300571
GO:0005776 Autophagosome Affects phenotype PMID:36840722
GO:0006006 Glucose metabolic process Affects phenotype PMID:34508822
GO:0006089 Lactate metabolic process Affects phenotype PMID:34508822
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:34508822
GO:0006096 Glycolytic process Decreases phenotype PMID:36096218
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:36096218; PMID:39547369
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:22534743
GO:0006264 Mitochondrial dna replication Decreases phenotype PMID:31874198
GO:0006304 Dna modification Increases phenotype PMID:28817314; PMID:34553816
GO:0006306 Dna methylation Affects phenotype PMID:25530354
GO:0006325 Chromatin organization Decreases phenotype PMID:30905827
GO:0006497 Protein lipidation Increases phenotype PMID:33242459
GO:0006602 Creatinine catabolic process Increases phenotype PMID:27599793
GO:0006606 Protein import into nucleus Increases phenotype PMID:33080273
GO:0006629 Lipid metabolic process Affects phenotype PMID:38180308
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:29908845
GO:0006749 Glutathione metabolic process Increases phenotype PMID:22197700; PMID:23274417; PMID:23274417; PMID:37471654; PMID:23292317; PMID:23292317; PMID:23428833; PMID:23428833; PMID:24970117; PMID:30251767; PMID:30623991; PMID:32208856; PMID:32407874; PMID:34051273; PMID:34508822; PMID:35307918; PMID:35527006; PMID:35752206; PMID:36088639; PMID:36642386; PMID:37471654; PMID:39032614; PMID:39276841; PMID:40010429
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:24184865; PMID:25322819; PMID:30476502; PMID:30980911; PMID:31874198
GO:0006751 Glutathione catabolic process Increases phenotype PMID:25496357
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:27236077; PMID:31874198; PMID:32407874
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:30980911
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:31843630; PMID:39153536
GO:0006878 Cellular copper ion homeostasis Affects phenotype PMID:40010429
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:39276841
GO:0006914 Autophagy Increases phenotype PMID:29660402
GO:0006915 Apoptotic process Increases phenotype PMID:24293362; PMID:24960054; PMID:25031709; PMID:25800560; PMID:26498409; PMID:26498409; PMID:26542248; PMID:26542248; PMID:26797587; PMID:27236077; PMID:27604105; PMID:28283887; PMID:30905827; PMID:31874198; PMID:33242459; PMID:40010429
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:31874198
GO:0006939 Smooth muscle contraction Increases phenotype PMID:35498220
GO:0006954 Inflammatory response Increases phenotype PMID:22728154; PMID:22728154; PMID:30980911
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:32142724; PMID:34508822
GO:0006997 Nucleus organization Decreases phenotype PMID:30905827
GO:0007005 Mitochondrion organization Decreases phenotype PMID:27236077; PMID:30905827; PMID:31874198; PMID:36642386; PMID:39276841; PMID:39547369
GO:0007029 Endoplasmic reticulum organization Decreases phenotype PMID:30905827
GO:0007033 Vacuole organization Increases phenotype PMID:38157908; PMID:38180308
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:21712424
GO:0007268 Chemical synaptic transmission Affects phenotype PMID:30121340; PMID:31785328
GO:0007283 Spermatogenesis Decreases phenotype PMID:22806249; PMID:30510688; PMID:30510688; PMID:34051273; PMID:31054310; PMID:32142724; PMID:34051273; PMID:34508822; PMID:36484981; PMID:36807407
GO:0007286 Spermatid development Decreases phenotype PMID:36088639
GO:0007409 Axonogenesis Decreases phenotype PMID:36096218
GO:0007610 Behavior Affects phenotype PMID:32073883
GO:0007611 Learning or memory Decreases phenotype PMID:27936013; PMID:27936013; PMID:29476096; PMID:30523571; PMID:32058320
GO:0007612 Learning Decreases phenotype PMID:33978298; PMID:36308466; PMID:36539177; PMID:39947421
GO:0007613 Memory Decreases phenotype PMID:28173832; PMID:33978298; PMID:33978298; PMID:35367965; PMID:36539177; PMID:36652739; PMID:39947421
GO:0007626 Locomotory behavior Increases phenotype PMID:35527006
GO:0008021 Synaptic vesicle Decreases phenotype PMID:30121340
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Affects phenotype PMID:39547369
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:33856607
GO:0008217 Regulation of blood pressure Affects phenotype PMID:32791093
GO:0008219 Cell death Increases phenotype PMID:24530660; PMID:25975991; PMID:26498409; PMID:26797587; PMID:26865462; PMID:26926986; PMID:29502740; PMID:31708536
GO:0008283 Cell population proliferation Decreases phenotype PMID:22806249; PMID:24316150; PMID:24598511; PMID:24962574; PMID:25800560
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:24200059
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:22101983; PMID:22271317; PMID:23598043; PMID:33932463; PMID:37436718; PMID:37939567
GO:0008584 Male gonad development Affects phenotype PMID:30510688
GO:0010035 Response to inorganic substance Increases phenotype PMID:34553816
GO:0010259 Multicellular organism aging Affects phenotype PMID:22613225
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:29481626
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:29457680
GO:0010468 Regulation of gene expression Affects phenotype PMID:32458983
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:32879255; PMID:36652739; PMID:38072110
GO:0010669 Epithelial structure maintenance Decreases phenotype PMID:31054310; PMID:34051273
GO:0010714 Positive regulation of collagen metabolic process Increases phenotype PMID:20643234
GO:0010757 Negative regulation of plasminogen activation Affects phenotype PMID:2143947
GO:0010863 Positive regulation of phospholipase c activity Decreases phenotype PMID:21712424
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:36088639
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25981801
GO:0010942 Positive regulation of cell death Increases phenotype PMID:22033380; PMID:25981801; PMID:34051273; PMID:37939567
GO:0010996 Response to auditory stimulus Decreases phenotype PMID:12062763
GO:0014043 Negative regulation of neuron maturation Increases phenotype PMID:28173832
GO:0014069 Postsynaptic density Decreases phenotype PMID:30121340
GO:0015692 Lead ion transport Increases phenotype PMID:34051273; PMID:34508822
GO:0015723 Bilirubin transport Increases phenotype PMID:30251767
GO:0016042 Lipid catabolic process Increases phenotype PMID:22728154; PMID:22728154; PMID:30980911; PMID:24293362; PMID:25322819; PMID:25322819; PMID:30703413; PMID:25800560; PMID:30510688; PMID:30703413; PMID:30980911; PMID:31610155; PMID:31874198; PMID:32407874; PMID:34508822; PMID:35307918; PMID:35398025; PMID:35752206
GO:0016049 Cell growth Decreases phenotype PMID:30615929
GO:0016209 Antioxidant activity Decreases phenotype PMID:37385299
GO:0016358 Dendrite development Decreases phenotype PMID:31708536
GO:0016477 Cell migration Decreases phenotype PMID:38157908
GO:0018158 Protein oxidation Increases phenotype PMID:23292317; PMID:23501611; PMID:25322819; PMID:30251767; PMID:32407874; PMID:36088639; PMID:36484981
GO:0019249 Lactate biosynthetic process Decreases phenotype PMID:30615929
GO:0019627 Urea metabolic process Affects phenotype PMID:32116774
GO:0019827 Stem cell population maintenance Decreases phenotype PMID:31715224
GO:0020027 Hemoglobin metabolic process Affects phenotype PMID:22534743
GO:0021778 Oligodendrocyte cell fate specification Increases phenotype PMID:32458983
GO:0022008 Neurogenesis Decreases phenotype PMID:33978298
GO:0022010 Central nervous system myelination Decreases phenotype PMID:39150886
GO:0030097 Hemopoiesis Decreases phenotype PMID:25800560
GO:0030182 Neuron differentiation Decreases phenotype PMID:36096218
GO:0030263 Apoptotic chromosome condensation Affects phenotype PMID:30905827; PMID:31708536; PMID:32116774; PMID:32208856; PMID:38180308
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:31054310
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:39722890
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:38281554
GO:0030500 Regulation of bone mineralization Decreases phenotype PMID:27915097
GO:0030501 Positive regulation of bone mineralization Decreases phenotype PMID:20643234
GO:0030730 Sequestering of triglyceride Increases phenotype PMID:34842334
GO:0031175 Neuron projection development Affects phenotype PMID:33080273; PMID:39947421
GO:0031987 Locomotion involved in locomotory behavior Affects phenotype PMID:25322819; PMID:35398025
GO:0032008 Positive regulation of tor signaling Decreases phenotype PMID:22811615
GO:0032125 Micronucleus organization Increases phenotype PMID:29502740
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:23501611; PMID:23501611; PMID:23855546; PMID:23855546; PMID:32879255
GO:0032286 Central nervous system myelin maintenance Decreases phenotype PMID:23680456
GO:0032430 Positive regulation of phospholipase a2 activity Increases phenotype PMID:23030477
GO:0032469 Endoplasmic reticulum calcium ion homeostasis Affects phenotype PMID:36308466
GO:0032516 Positive regulation of phosphoprotein phosphatase activity Increases phenotype PMID:21195594
GO:0032715 Negative regulation of interleukin-6 production Affects phenotype PMID:23598043
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:33445541
GO:0032790 Ribosome disassembly Increases phenotype PMID:30905827
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:22534743
GO:0034199 Activation of protein kinase a activity Decreases phenotype PMID:23855546
GO:0034440 Lipid oxidation Increases phenotype PMID:22033380; PMID:22197700; PMID:22197700; PMID:23086308; PMID:22534743; PMID:22894711; PMID:23292317; PMID:23292317; PMID:23501611; PMID:23855546; PMID:35527006; PMID:23292317; PMID:30623991; PMID:23501611; PMID:23855546; PMID:24222729; PMID:24222729; PMID:24970117; PMID:24970117; PMID:25088297; PMID:25088297; PMID:27492863; PMID:27492863; PMID:28817314; PMID:28817314; PMID:30251767; PMID:30251767; PMID:30623991; PMID:31054310; PMID:31054310; PMID:34051273; PMID:37471654; PMID:32879255; PMID:34051273; PMID:34553816; PMID:35527006; PMID:36088639; PMID:36484981; PMID:36642386; PMID:37471654; PMID:39276841; PMID:40010429
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:32058320
GO:0035633 Maintenance of blood-brain barrier Decreases phenotype PMID:24200059
GO:0035640 Exploration behavior Affects phenotype PMID:36539177
GO:0035902 Response to immobilization stress Affects phenotype PMID:32073883
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:34553816; PMID:36088639
GO:0042310 Vasoconstriction Increases phenotype PMID:32791093
GO:0042311 Vasodilation Increases phenotype PMID:23760256
GO:0042332 Gravitaxis Decreases phenotype PMID:30510688
GO:0042416 Dopamine biosynthetic process Affects phenotype PMID:25322819; PMID:2604901
GO:0042421 Norepinephrine biosynthetic process Increases phenotype PMID:2604901
GO:0042554 Superoxide anion generation Increases phenotype PMID:25800560; PMID:30510688; PMID:35398025
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:30251767
GO:0042670 Retinal cone cell differentiation Decreases phenotype PMID:28050121
GO:0042755 Eating behavior Affects phenotype PMID:33862172
GO:0042756 Drinking behavior Increases phenotype PMID:31550440; PMID:33862172
GO:0043005 Neuron projection Decreases phenotype PMID:33080273
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:21640820; PMID:21712424; PMID:22033380; PMID:22811615; PMID:23086308; PMID:24806610; PMID:22952811; PMID:23428833; PMID:23680456; PMID:27492863; PMID:29797346; PMID:37866543; PMID:38072110
GO:0043197 Dendritic spine Affects phenotype PMID:39947421
GO:0043371 Negative regulation of cd4-positive, alpha-beta t cell differentiation Increases phenotype PMID:23058909
GO:0044030 Regulation of dna methylation Affects phenotype PMID:33445541
GO:0044237 Cellular metabolic process Affects phenotype PMID:30476502; PMID:31610155; PMID:31715224; PMID:31843630; PMID:31874198; PMID:31874198; PMID:35300571; PMID:39032614; PMID:39547369; PMID:32142724; PMID:34508822; PMID:32344020; PMID:32344020; PMID:39947421; PMID:34508822; PMID:35300571; PMID:36484981; PMID:36642386; PMID:36925031; PMID:38157908; PMID:39032614; PMID:39276841; PMID:39547369; PMID:40010429
GO:0044728 Dna methylation or demethylation Affects phenotype PMID:33445541
GO:0044838 Cell quiescence Increases phenotype PMID:37436718
GO:0044861 Protein transport into plasma membrane raft Increases phenotype PMID:22033380
GO:0045216 Cell-cell junction organization Decreases phenotype PMID:36642386
GO:0045429 Positive regulation of nitric oxide biosynthetic process Affects phenotype PMID:23501611; PMID:23501611; PMID:23855546; PMID:23855546; PMID:30251767
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:22033380; PMID:34553816; PMID:36088639
GO:0045591 Positive regulation of regulatory t cell differentiation Increases phenotype PMID:23058909
GO:0045662 Negative regulation of myoblast differentiation Increases phenotype PMID:37797690
GO:0045665 Negative regulation of neuron differentiation Increases phenotype PMID:28173832
GO:0045777 Positive regulation of blood pressure Increases phenotype PMID:29457680
GO:0045792 Negative regulation of cell size Increases phenotype PMID:22033380
GO:0045852 Ph elevation Increases phenotype PMID:34842334
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:23760256
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:24782466; PMID:25800560
GO:0045987 Positive regulation of smooth muscle contraction Increases phenotype PMID:23088908; PMID:23928832
GO:0046034 Atp metabolic process Increases phenotype PMID:29797346; PMID:34508822; PMID:36088639; PMID:36484981; PMID:39547369
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:32791093; PMID:35752206
GO:0046323 Glucose import Decreases phenotype PMID:31874198
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:24200059; PMID:24481447; PMID:25088297
GO:0046415 Urate metabolic process Affects phenotype PMID:23428833
GO:0046449 Creatinine metabolic process Affects phenotype PMID:23428833; PMID:30980911; PMID:30980911; PMID:32116774; PMID:32116774
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:25496357
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:30623991; PMID:31054310; PMID:36088639
GO:0046622 Positive regulation of organ growth Affects phenotype PMID:27492863; PMID:34553816
GO:0046722 Lactic acid secretion Decreases phenotype PMID:30615929
GO:0046850 Regulation of bone remodeling Decreases phenotype PMID:27915097
GO:0046852 Positive regulation of bone remodeling Increases phenotype PMID:20643234
GO:0046933 Proton-transporting atp synthase activity, rotational mechanism Decreases phenotype PMID:39547369
GO:0048143 Astrocyte activation Increases phenotype PMID:26396915
GO:0048149 Behavioral response to ethanol Increases phenotype PMID:30385389
GO:0048642 Negative regulation of skeletal muscle tissue development Increases phenotype PMID:37797690
GO:0048714 Positive regulation of oligodendrocyte differentiation Increases phenotype PMID:32458983
GO:0048863 Stem cell differentiation Affects phenotype PMID:31715224
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:30510688
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:37385299; PMID:38530053
GO:0050768 Negative regulation of neurogenesis Increases phenotype PMID:28173832
GO:0050807 Regulation of synapse organization Decreases phenotype PMID:24806610
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:19647414; PMID:30523571; PMID:38530053
GO:0051346 Negative regulation of hydrolase activity Affects phenotype PMID:28817314
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:28817314
GO:0051354 Negative regulation of oxidoreductase activity Increases phenotype PMID:36088639
GO:0051402 Neuron apoptotic process Increases phenotype PMID:33978298
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:36308466
GO:0051611 Regulation of serotonin uptake Decreases phenotype PMID:27771255
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:25800560; PMID:26542248; PMID:29660402; PMID:31874198; PMID:32407874; PMID:35300571
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:36484981
GO:0051897 Positive regulation of protein kinase b signaling Affects phenotype PMID:22811615; PMID:23501611; PMID:24200059
GO:0051964 Negative regulation of synapse assembly Increases phenotype PMID:27771255; PMID:28050121
GO:0051965 Positive regulation of synapse assembly Decreases phenotype PMID:24999626
GO:0052689 Carboxylic ester hydrolase activity Decreases phenotype PMID:28817314
GO:0055065 Metal ion homeostasis Decreases phenotype PMID:29452138; PMID:32208856
GO:0055069 Zinc ion homeostasis Affects phenotype PMID:35398025
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:30905827
GO:0060013 Righting reflex Decreases phenotype PMID:30510688
GO:0060080 Inhibitory postsynaptic potential Affects phenotype PMID:30121340
GO:0060193 Positive regulation of lipase activity Increases phenotype PMID:30251767
GO:0060221 Retinal rod cell differentiation Decreases phenotype PMID:28050121
GO:0060587 Regulation of lipoprotein lipid oxidation Increases phenotype PMID:23428833
GO:0060588 Negative regulation of lipoprotein lipid oxidation Increases phenotype PMID:23428833
GO:0060996 Dendritic spine development Decreases phenotype PMID:27936013; PMID:39947421
GO:0061000 Negative regulation of dendritic spine development Increases phenotype PMID:29476096
GO:0061075 Positive regulation of neural retina development Decreases phenotype PMID:23680456
GO:0061351 Neural precursor cell proliferation Decreases phenotype PMID:27562236
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:22806249; PMID:30510688; PMID:36484981; PMID:36807407
GO:0061564 Axon development Decreases phenotype PMID:23680456
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:32879255; PMID:34842334
GO:0061890 Positive regulation of astrocyte activation Increases phenotype PMID:32879255
GO:0070265 Necrotic cell death Increases phenotype PMID:38180308
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:30251767
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:24200059; PMID:24481447
GO:0070444 Oligodendrocyte progenitor proliferation Decreases phenotype PMID:39150886
GO:0070814 Hydrogen sulfide biosynthetic process Decreases phenotype PMID:30980911
GO:0070977 Bone maturation Decreases phenotype PMID:24959776
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24184865; PMID:24293362; PMID:32116774; PMID:32208856; PMID:35398025; PMID:36484981; PMID:36807407; PMID:36807407; PMID:37471654; PMID:37471654; PMID:38180308; PMID:39547369
GO:0070997 Neuron death Increases phenotype PMID:36308466
GO:0071284 Cellular response to lead ion Increases phenotype PMID:22839698; PMID:32458983
GO:0071577 Zinc ion transmembrane transport Increases phenotype PMID:24311739
GO:0071763 Nuclear membrane organization Decreases phenotype PMID:30905827
GO:0071971 Extracellular exosome assembly Increases phenotype PMID:36840722
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24412756; PMID:25800560; PMID:32407874; PMID:35300571; PMID:36642386; PMID:39032614; PMID:39276841; PMID:40010429
GO:0090090 Negative regulation of canonical wnt signaling pathway Increases phenotype PMID:37436718
GO:0090263 Positive regulation of canonical wnt signaling pathway Decreases phenotype PMID:24999626
GO:0090326 Positive regulation of locomotion involved in locomotory behavior Decreases phenotype PMID:27492863
GO:0090398 Cellular senescence Increases phenotype PMID:25800560
GO:0090648 Response to environmental enrichment Decreases phenotype PMID:35398025
GO:0097062 Dendritic spine maintenance Decreases phenotype PMID:30738087
GO:0097119 Postsynaptic density protein 95 clustering Decreases phenotype PMID:26660114
GO:0097150 Neuronal stem cell population maintenance Decreases phenotype PMID:22812564
GO:0097410 Hippocampal interneuron differentiation Affects phenotype PMID:33862172
GO:0097621 Monoamine oxidase activity Decreases phenotype PMID:19647414
GO:0097707 Ferroptosis Increases phenotype PMID:36642386
GO:0097722 Sperm motility Decreases phenotype PMID:30510688; PMID:36484981; PMID:36807407
GO:0098743 Cell aggregation Decreases phenotype PMID:24260418
GO:0098816 Mini excitatory postsynaptic potential Affects phenotype PMID:30121340
GO:0099558 Maintenance of synapse structure Decreases phenotype PMID:27984133
GO:0099610 Action potential initiation Decreases phenotype PMID:12062763
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:30510688
GO:0106128 Negative regulation of store-operated calcium entry Increases phenotype PMID:38281554
GO:0140042 Lipid droplet formation Increases phenotype PMID:34842334
GO:0140657 Atp-dependent activity Decreases phenotype PMID:35307918
GO:0150195 Transport across blood-cerebrospinal fluid barrier Affects phenotype PMID:36642386
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:26396915
GO:1900154 Regulation of bone trabecula formation Decreases phenotype PMID:27915097
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:34842334; PMID:35527006
GO:1900272 Negative regulation of long-term synaptic potentiation Increases phenotype PMID:22952811; PMID:29476096
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:29797346
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:24200059; PMID:25088297; PMID:26396915; PMID:29457680
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:18353414
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:34051273; PMID:36088639
GO:1901612 Cardiolipin binding Decreases phenotype PMID:35300571
GO:1901668 Regulation of superoxide dismutase activity Affects phenotype PMID:30251767
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:19647414; PMID:23428833; PMID:29797346; PMID:31054310; PMID:31054310; PMID:34051273; PMID:34051273; PMID:35527006
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:23086308; PMID:24222729; PMID:24970117; PMID:24970117; PMID:30623991
GO:1901687 Glutathione derivative biosynthetic process Affects phenotype PMID:22033380; PMID:23274417
GO:1901740 Negative regulation of myoblast fusion Increases phenotype PMID:37797690
GO:1902043 Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Increases phenotype PMID:22033380
GO:1902046 Positive regulation of fas signaling pathway Increases phenotype PMID:22033380
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:22894711; PMID:26396915
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:19647414
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:29502740
GO:1903282 Regulation of glutathione peroxidase activity Affects phenotype PMID:30251767
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:30623991; PMID:31054310
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:22033380; PMID:22197700; PMID:22534743; PMID:24222729; PMID:24970117
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:21494558
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:22728154; PMID:25322819; PMID:26498409; PMID:26498409; PMID:26542248; PMID:26797587; PMID:27236077; PMID:30476502; PMID:30905827; PMID:31610155; PMID:31874198
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:19647414; PMID:19647414; PMID:25088297; PMID:22033380; PMID:22271317; PMID:23086308; PMID:23292317; PMID:23292317; PMID:30623991; PMID:23501611; PMID:23501611; PMID:23855546; PMID:23855546; PMID:24782466; PMID:24970117; PMID:25088297; PMID:27599793; PMID:34051273; PMID:36088639; PMID:36308466; PMID:37385299; PMID:37939567
GO:1903591 Negative regulation of lysozyme activity Increases phenotype PMID:22581110
GO:1903592 Positive regulation of lysozyme activity Increases phenotype PMID:22581110
GO:1903599 Positive regulation of autophagy of mitochondrion Increases phenotype PMID:24806610
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:38530053
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:22952811; PMID:38281554
GO:1904109 Positive regulation of cholesterol import Increases phenotype PMID:34842334
GO:1905037 Autophagosome organization Affects phenotype PMID:36840722
GO:1905075 Positive regulation of tight junction disassembly Increases phenotype PMID:39722890
GO:1905166 Negative regulation of lysosomal protein catabolic process Increases phenotype PMID:34842334
GO:1905456 Regulation of lymphoid progenitor cell differentiation Affects phenotype PMID:32428222
GO:1905672 Negative regulation of lysosome organization Increases phenotype PMID:34842334
GO:1990182 Exosomal secretion Increases phenotype PMID:36840722
GO:2000134 Negative regulation of g1/s transition of mitotic cell cycle Increases phenotype PMID:24782466; PMID:38072110
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:36088639
GO:2000252 Negative regulation of feeding behavior Increases phenotype PMID:32208856
GO:2000304 Positive regulation of ceramide biosynthetic process Increases phenotype PMID:22033380
GO:2000379 Positive regulation of reactive oxygen species metabolic process Increases phenotype PMID:36308466
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:23088908; PMID:23928832
GO:2000403 Positive regulation of lymphocyte migration Increases phenotype PMID:23088908; PMID:23928832
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:23088908; PMID:23928832
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:23928832
GO:2000481 Positive regulation of camp-dependent protein kinase activity Decreases phenotype PMID:23501611
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:34553816
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:24782466
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:22811615; PMID:32879255; PMID:34842334
GO:2000808 Negative regulation of synaptic vesicle clustering Increases phenotype PMID:35367965
GO:2000841 Negative regulation of dehydroepiandrosterone secretion Increases phenotype PMID:30523571
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:31054310; PMID:31054310; PMID:34051273; PMID:34051273; PMID:36088639
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:25981801
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:31054310
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:32407874
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.