| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10091860 | IVR | 0.1 % | 0.1 % | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 0.5 % | 0.5 % | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.2 % | 0.2 % | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:21933222 | IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:26558472 | IVR | 0.01 mg/L | 0.01 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.1 mg/L | 0.1 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:33223335 | IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Alters hypothalamic-pituitary-thyroid axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Hypertrophy in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:37716076 | IVR | 5 mg/L | 5 mg/L | Causes inflammation | Immunological endocrine-mediated perturbations |
| IVR | 5 mg/L | 5 mg/L | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects blood-testis barrier (BTB) | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:3931714 | IVR | 0.3 % | 0.3 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 0.1 % | 0.1 % | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 % | 0.3 % | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 % | 0.3 % | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 % | 0.1 % | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 % | 0.3 % | Decreased FSH levels | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.