alpha-Naphthoflavone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Affects phenotype PMID:31712135
GO:0001544 Initiation of primordial ovarian follicle growth Decreases phenotype PMID:27163632
GO:0001545 Primary ovarian follicle growth Decreases phenotype PMID:27163632
GO:0001546 Preantral ovarian follicle growth Decreases phenotype PMID:27163632
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:27163632
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:29146461
GO:0001555 Oocyte growth Decreases phenotype PMID:31712135
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:27581038; PMID:32721735
GO:0006259 Dna metabolic process Increases phenotype PMID:25781201
GO:0006595 Polyamine metabolic process Affects phenotype PMID:38346634
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:23686521
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:27159630; PMID:27769111; PMID:30010034; PMID:32370496; PMID:33253783; PMID:34875353; PMID:35101544
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:26086121
GO:0006915 Apoptotic process Affects phenotype PMID:16213648; PMID:18334599; PMID:21534955; PMID:29274324; PMID:30508555; PMID:31712135
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27163632; PMID:28461126; PMID:29545172; PMID:31712135; PMID:33938965
GO:0007049 Cell cycle Decreases phenotype PMID:15157999
GO:0007253 Cytoplasmic sequestering of nf-kappab Decreases phenotype PMID:26221077
GO:0008219 Cell death Increases phenotype PMID:26477383; PMID:35908932
GO:0008283 Cell population proliferation Decreases phenotype PMID:15253042; PMID:23994263; PMID:29274324
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29626627
GO:0010595 Positive regulation of endothelial cell migration Increases phenotype PMID:26358519
GO:0014902 Myotube differentiation Decreases phenotype PMID:24431215
GO:0016049 Cell growth Affects phenotype PMID:30508555
GO:0016477 Cell migration Affects phenotype PMID:28923513
GO:0030728 Ovulation Decreases phenotype PMID:31712135
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:25051199
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:22646800; PMID:25781201; PMID:29146461; PMID:31368503
GO:0044237 Cellular metabolic process Affects phenotype PMID:34200499; PMID:35200000
GO:0045333 Cellular respiration Decreases phenotype PMID:23686521
GO:0045672 Positive regulation of osteoclast differentiation Decreases phenotype PMID:26221077
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29274324; PMID:30508555
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:25781201
GO:0051276 Chromosome organization Decreases phenotype PMID:31712135
GO:0051354 Negative regulation of oxidoreductase activity Increases phenotype PMID:30010034
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26086121; PMID:30508555
GO:0060278 Regulation of ovulation Affects phenotype PMID:27163632
GO:0070192 Chromosome organization involved in meiotic cell cycle Decreases phenotype PMID:31712135
GO:0070265 Necrotic cell death Increases phenotype PMID:23686521
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:26358519
GO:0070527 Platelet aggregation Increases phenotype PMID:25797602
GO:0070989 Oxidative demethylation Affects phenotype PMID:30010034; PMID:8498088
GO:0097498 Endothelial tube lumen extension Increases phenotype PMID:26358519
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:25781201; PMID:26358519
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:26221077
GO:1901661 Quinone metabolic process Affects phenotype PMID:38346634
GO:1902656 Calcium ion import into cytosol Increases phenotype PMID:30508555
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:29935983; PMID:30508555
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25781201
GO:1903543 Positive regulation of exosomal secretion Increases phenotype PMID:31368503
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:29146461
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:29146461
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.