Chromium hexavalent ion


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000041 Transition metal ion transport Increases phenotype PMID:21437922; PMID:30496737
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:35643323
GO:0000423 Mitophagy Increases phenotype PMID:36739042
GO:0000724 Double-strand break repair via homologous recombination Decreases phenotype PMID:27449664
GO:0000729 Dna double-strand break processing Increases phenotype PMID:26860703
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:35024197; PMID:35643323; PMID:36849043; PMID:40016168
GO:0001510 Rna methylation Affects phenotype PMID:36739042
GO:0001541 Ovarian follicle development Affects phenotype PMID:24530425
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:25568306
GO:0001678 Cellular glucose homeostasis Affects phenotype PMID:38992767
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:30974164; PMID:36880428; PMID:40016168
GO:0003993 Acid phosphatase activity Increases phenotype PMID:28988497
GO:0003994 Aconitate hydratase activity Decreases phenotype PMID:36108929
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28988497
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28988497; PMID:28988497; PMID:30974164; PMID:31756458; PMID:35024197
GO:0004096 Catalase activity Increases phenotype PMID:40016168
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:32679048
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:28988497
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:25846368; PMID:28988497; PMID:32679048
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:28988497; PMID:31756458; PMID:32679048; PMID:35024197; PMID:36108929; PMID:36849043
GO:0006084 Acetyl-coa metabolic process Increases phenotype PMID:32525551
GO:0006089 Lactate metabolic process Affects phenotype PMID:32679048
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:32679048
GO:0006302 Double-strand break repair Affects phenotype PMID:25173789
GO:0006304 Dna modification Increases phenotype PMID:38563870
GO:0006306 Dna methylation Decreases phenotype PMID:25846368
GO:0006382 Adenosine to inosine editing Decreases phenotype PMID:31433169
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:30236763
GO:0006703 Estrogen biosynthetic process Affects phenotype PMID:32679048
GO:0006749 Glutathione metabolic process Affects phenotype PMID:28988497; PMID:32679048; PMID:40016168
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25448439; PMID:30236763; PMID:31756458
GO:0006914 Autophagy Increases phenotype PMID:30416085
GO:0006915 Apoptotic process Increases phenotype PMID:14971653; PMID:22858589; PMID:24530425; PMID:24732427; PMID:30416085; PMID:30974164; PMID:35024197; PMID:35307491; PMID:35643323; PMID:36849043
GO:0006954 Inflammatory response Increases phenotype PMID:31756458; PMID:35024197
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:21481275; PMID:24374135; PMID:26860703
GO:0007005 Mitochondrion organization Decreases phenotype PMID:35024197; PMID:36108929; PMID:36849043
GO:0007033 Vacuole organization Increases phenotype PMID:30974164
GO:0007286 Spermatid development Decreases phenotype PMID:39121936
GO:0008121 Ubiquinol-cytochrome-c reductase activity Decreases phenotype PMID:24732427
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:24732427; PMID:36108929
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:36108929
GO:0008209 Androgen metabolic process Affects phenotype PMID:33675932
GO:0008210 Estrogen metabolic process Affects phenotype PMID:33675932
GO:0008283 Cell population proliferation Affects phenotype PMID:24374135; PMID:25448439; PMID:27323401; PMID:27344173; PMID:35643323; PMID:38563870
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:25820237; PMID:30715550
GO:0008584 Male gonad development Affects phenotype PMID:33675932
GO:0009451 Rna modification Affects phenotype PMID:31433169
GO:0010467 Gene expression Affects phenotype PMID:28596144
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:28077780
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:26293554
GO:0010942 Positive regulation of cell death Increases phenotype PMID:27793765
GO:0016042 Lipid catabolic process Increases phenotype PMID:25448439; PMID:28988497; PMID:30236763; PMID:32679048
GO:0016049 Cell growth Increases phenotype PMID:38992767
GO:0016174 Nad(p)h oxidase h2o2-forming activity Increases phenotype PMID:25448439; PMID:27323401
GO:0016209 Antioxidant activity Decreases phenotype PMID:28077780
GO:0016573 Histone acetylation Decreases phenotype PMID:24858232
GO:0030199 Collagen fibril organization Increases phenotype PMID:31756458
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:40016168
GO:0031589 Cell-substrate adhesion Decreases phenotype PMID:38563870
GO:0034440 Lipid oxidation Increases phenotype PMID:36108929; PMID:40016168
GO:0036124 Histone h3-k9 trimethylation Increases phenotype PMID:35643323
GO:0042554 Superoxide anion generation Increases phenotype PMID:27323401
GO:0042573 Retinoic acid metabolic process Affects phenotype PMID:32679048
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:32679048
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25568306; PMID:29069462
GO:0043966 Histone h3 acetylation Increases phenotype PMID:32525551
GO:0044237 Cellular metabolic process Decreases phenotype PMID:24732427; PMID:35643323
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:38992767
GO:0045333 Cellular respiration Decreases phenotype PMID:24732427; PMID:36108929
GO:0045833 Negative regulation of lipid metabolic process Decreases phenotype PMID:39121936
GO:0046034 Atp metabolic process Increases phenotype PMID:24732427; PMID:35643323; PMID:36849043
GO:0046449 Creatinine metabolic process Affects phenotype PMID:36108929
GO:0046601 Positive regulation of centriole replication Increases phenotype PMID:26293554
GO:0046722 Lactic acid secretion Affects phenotype PMID:38992767
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:27323401; PMID:27344173
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:30416085; PMID:30715550; PMID:35643323; PMID:36739042
GO:0055072 Iron ion homeostasis Affects phenotype PMID:24418189
GO:0060723 Regulation of cell proliferation involved in embryonic placenta development Affects phenotype PMID:28077780
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:32679048
GO:0061621 Canonical glycolysis Increases phenotype PMID:32525551
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:32866567
GO:0070265 Necrotic cell death Increases phenotype PMID:28988497; PMID:28988497; PMID:30974164; PMID:31756458; PMID:36108929; PMID:40016168
GO:0070266 Necroptotic process Increases phenotype PMID:36108929
GO:0070994 Detection of oxidative stress Affects phenotype PMID:25846368; PMID:35024197; PMID:36849043
GO:0070997 Neuron death Increases phenotype PMID:40016168
GO:0071247 Cellular response to chromate Decreases phenotype PMID:31152816
GO:0072582 17-beta-hydroxysteroid dehydrogenase (nadp+) activity Decreases phenotype PMID:33675932
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:23050433; PMID:24732427; PMID:25448439; PMID:35643323; PMID:36108929; PMID:36368423; PMID:36739042
GO:0080009 Mrna methylation Affects phenotype PMID:35201342
GO:0098658 Inorganic anion import across plasma membrane Decreases phenotype PMID:25977998
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:33675932
GO:0106292 Superoxide-generating nadph oxidase activity Increases phenotype PMID:27344173
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:28077780
GO:1901382 Regulation of chorionic trophoblast cell proliferation Affects phenotype PMID:28077780
GO:1901525 Negative regulation of mitophagy Increases phenotype PMID:30715550
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:32866567
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:35643323
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27323401; PMID:28881718; PMID:30236763
GO:1903703 Enterocyte differentiation Affects phenotype PMID:38563870
GO:1905037 Autophagosome organization Increases phenotype PMID:36739042
GO:1905168 Positive regulation of double-strand break repair via homologous recombination Increases phenotype PMID:38867691
GO:1905707 Negative regulation of mitochondrial atp synthesis coupled proton transport Increases phenotype PMID:30715550
GO:1990266 Neutrophil migration Increases phenotype PMID:36880428
GO:2000781 Positive regulation of double-strand break repair Increases phenotype PMID:25288669
GO:2001022 Positive regulation of response to dna damage stimulus Affects phenotype PMID:25173789
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.