DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Tetrahydrocannabinol

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000002	Mitochondrial genome maintenance	Decreases phenotype	PMID:27366949
GO:0000084	Mitotic s phase	Decreases phenotype	PMID:31730886
GO:0000086	G2/m transition of mitotic cell cycle	Increases phenotype	PMID:31730886
GO:0000122	Negative regulation of transcription by rna polymerase ii	Increases phenotype	PMID:30077641
GO:0001544	Initiation of primordial ovarian follicle growth	Increases phenotype	PMID:36912754
GO:0001586	Gi/o-coupled serotonin receptor activity	Increases phenotype	PMID:29748632
GO:0001654	Eye development	Affects phenotype	PMID:31690747
GO:0001659	Temperature homeostasis	Decreases phenotype	PMID:26361728; PMID:26361728; PMID:26799708; PMID:26799708; PMID:28087785
GO:0001661	Conditioned taste aversion	Increases phenotype	PMID:27385208; PMID:30115766
GO:0001662	Behavioral fear response	Increases phenotype	PMID:27065006; PMID:29101333; PMID:34573260
GO:0001774	Microglial cell activation	Increases phenotype	PMID:26499171
GO:0001825	Blastocyst formation	Increases phenotype	PMID:31436397
GO:0001890	Placenta development	Affects phenotype	PMID:28578322; PMID:31953475
GO:0002027	Regulation of heart rate	Increases phenotype	PMID:10812285; PMID:19949319; PMID:484957; PMID:2829241; PMID:484957
GO:0002032	Desensitization of g protein-coupled receptor signaling pathway by arrestin	Increases phenotype	PMID:27429655
GO:0002296	T-helper 1 cell lineage commitment	Increases phenotype	PMID:27038180
GO:0002507	Tolerance induction	Affects phenotype	PMID:29461336
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:32612530; PMID:32872332
GO:0002863	Positive regulation of inflammatory response to antigenic stimulus	Increases phenotype	PMID:27038180
GO:0003990	Acetylcholinesterase activity	Increases phenotype	PMID:28212939
GO:0004016	Adenylate cyclase activity	Decreases phenotype	PMID:30319418
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:30130528
GO:0004197	Cysteine-type endopeptidase activity	Increases phenotype	PMID:31730886
GO:0004392	Heme oxygenase (decyclizing) activity	Decreases phenotype	PMID:32033040
GO:0004565	Beta-galactosidase activity	Decreases phenotype	PMID:32553926
GO:0004707	Map kinase activity	Increases phenotype	PMID:24184660
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:31680560
GO:0005222	Intracellular camp-activated cation channel activity	Affects phenotype	PMID:32329240
GO:0005262	Calcium channel activity	Increases phenotype	PMID:32733202
GO:0006171	Camp biosynthetic process	Increases phenotype	PMID:29549157
GO:0006306	Dna methylation	Affects phenotype	PMID:32272438
GO:0006355	Regulation of dna-templated transcription	Increases phenotype	PMID:29691375
GO:0006497	Protein lipidation	Increases phenotype	PMID:24910342
GO:0006536	Glutamate metabolic process	Affects phenotype	PMID:30219209
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:32244040
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:29408467
GO:0006665	Sphingolipid metabolic process	Affects phenotype	PMID:27635674
GO:0006692	Prostanoid metabolic process	Affects phenotype	PMID:35588954
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:26070387; PMID:28212939; PMID:31680560
GO:0006805	Xenobiotic metabolic process	Affects phenotype	PMID:39299374
GO:0006915	Apoptotic process	Increases phenotype	PMID:24910342; PMID:31383729; PMID:31680560; PMID:32272438; PMID:32872332
GO:0006936	Muscle contraction	Increases phenotype	PMID:30460515
GO:0006954	Inflammatory response	Increases phenotype	PMID:26499171; PMID:30225659; PMID:32385136; PMID:32942172
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:31081965
GO:0007015	Actin filament organization	Affects phenotype	PMID:33477303
GO:0007190	Activation of adenylate cyclase activity	Increases phenotype	PMID:27194477
GO:0007197	Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway	Increases phenotype	PMID:27194477
GO:0007268	Chemical synaptic transmission	Decreases phenotype	PMID:12895676; PMID:32329240
GO:0007605	Sensory perception of sound	Decreases phenotype	PMID:27527584; PMID:31610187
GO:0007610	Behavior	Affects phenotype	PMID:30071445
GO:0007613	Memory	Decreases phenotype	PMID:27422357; PMID:28093016; PMID:33285233; PMID:28642081; PMID:28648819; PMID:28648819; PMID:30610611; PMID:30219209; PMID:30610611; PMID:31982904; PMID:33285233
GO:0007616	Long-term memory	Increases phenotype	PMID:28481360
GO:0007625	Grooming behavior	Affects phenotype	PMID:27126842; PMID:30071445
GO:0007626	Locomotory behavior	Decreases phenotype	PMID:27058925; PMID:32385136; PMID:27149200; PMID:27149200; PMID:28087785; PMID:31877572; PMID:31877572
GO:0007632	Visual behavior	Affects phenotype	PMID:31610187
GO:0007635	Chemosensory behavior	Increases phenotype	PMID:26388146; PMID:26397760; PMID:26875756
GO:0008211	Glucocorticoid metabolic process	Affects phenotype	PMID:36283465
GO:0008219	Cell death	Affects phenotype	PMID:24184660; PMID:31104297
GO:0008283	Cell population proliferation	Affects phenotype	PMID:32049991; PMID:32752303; PMID:32872332; PMID:35588954
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:30026298
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:26824325; PMID:27635674; PMID:27769052; PMID:29805589
GO:0008306	Associative learning	Increases phenotype	PMID:26397760; PMID:27149200; PMID:30694374; PMID:30965351
GO:0008344	Adult locomotory behavior	Decreases phenotype	PMID:30439379
GO:0008360	Regulation of cell shape	Affects phenotype	PMID:32049991
GO:0008542	Visual learning	Affects phenotype	PMID:28481360
GO:0008559	Abc-type xenobiotic transporter activity	Increases phenotype	PMID:28272498
GO:0008653	Lipopolysaccharide metabolic process	Affects phenotype	PMID:32754917
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:31054322
GO:0009408	Response to heat	Decreases phenotype	PMID:28087785; PMID:28592614; PMID:31891265; PMID:32688070; PMID:32923660
GO:0009410	Response to xenobiotic stimulus	Increases phenotype	PMID:26460022; PMID:30378732
GO:0009437	Carnitine metabolic process	Affects phenotype	PMID:32872332
GO:0010001	Glial cell differentiation	Increases phenotype	PMID:32733202; PMID:36529297
GO:0010033	Response to organic substance	Affects phenotype	PMID:26361728; PMID:27149200
GO:0010424	Dna methylation on cytosine within a cg sequence	Decreases phenotype	PMID:26044905; PMID:32272438; PMID:32704063; PMID:32704063; PMID:32994467; PMID:32994467
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:25674907; PMID:27635674
GO:0010628	Positive regulation of gene expression	Increases phenotype	PMID:28272498
GO:0010719	Negative regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:29805589
GO:0010823	Negative regulation of mitochondrion organization	Increases phenotype	PMID:27366949
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:27769052
GO:0010942	Positive regulation of cell death	Affects phenotype	PMID:26070387; PMID:27366949
GO:0010977	Negative regulation of neuron projection development	Increases phenotype	PMID:26460022
GO:0014049	Positive regulation of glutamate secretion	Increases phenotype	PMID:30151725
GO:0014055	Acetylcholine secretion, neurotransmission	Decreases phenotype	PMID:32077955
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28212939; PMID:29181404; PMID:31081965; PMID:31680560
GO:0016477	Cell migration	Affects phenotype	PMID:28578322; PMID:29285308; PMID:31471547
GO:0016525	Negative regulation of angiogenesis	Increases phenotype	PMID:29307655; PMID:37567336
GO:0018158	Protein oxidation	Increases phenotype	PMID:31081965
GO:0019226	Transmission of nerve impulse	Decreases phenotype	PMID:32077955
GO:0019233	Sensory perception of pain	Decreases phenotype	PMID:29311110
GO:0019369	Arachidonic acid metabolic process	Affects phenotype	PMID:33285233
GO:0019432	Triglyceride biosynthetic process	Decreases phenotype	PMID:30130528
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:32752303
GO:0021872	Forebrain generation of neurons	Decreases phenotype	PMID:29982505
GO:0021895	Cerebral cortex neuron differentiation	Decreases phenotype	PMID:26460022
GO:0022848	Acetylcholine-gated monoatomic cation-selective channel activity	Decreases phenotype	PMID:32077955
GO:0023041	Neuronal signal transduction	Increases phenotype	PMID:32095523; PMID:32353393; PMID:32725198
GO:0023061	Signal release	Increases phenotype	PMID:26824325
GO:0030182	Neuron differentiation	Increases phenotype	PMID:33168583
GO:0030223	Neutrophil differentiation	Increases phenotype	PMID:32272438
GO:0030224	Monocyte differentiation	Increases phenotype	PMID:32272438
GO:0030317	Flagellated sperm motility	Decreases phenotype	PMID:29454037
GO:0030336	Negative regulation of cell migration	Increases phenotype	PMID:29805589; PMID:33477303; PMID:37567336; PMID:37625625
GO:0030431	Sleep	Increases phenotype	PMID:30636988
GO:0030851	Granulocyte differentiation	Increases phenotype	PMID:32272438
GO:0031175	Neuron projection development	Decreases phenotype	PMID:27654887
GO:0031223	Auditory behavior	Decreases phenotype	PMID:28597570
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:26824325
GO:0031653	Heat dissipation	Increases phenotype	PMID:27527584; PMID:28442584; PMID:31524960; PMID:31877572; PMID:32860777; PMID:28442584; PMID:28597570; PMID:28846955; PMID:31877572; PMID:31877572; PMID:32860777
GO:0031987	Locomotion involved in locomotory behavior	Increases phenotype	PMID:26499171; PMID:28093016; PMID:31311288; PMID:32353393; PMID:26984820; PMID:29750976; PMID:30610611; PMID:31029878; PMID:31110286; PMID:32095523; PMID:27065006; PMID:28272498; PMID:28648819; PMID:30610611; PMID:30965351; PMID:31029878; PMID:31524960; PMID:31524960; PMID:32209479; PMID:32345621; PMID:32860777; PMID:32095523; PMID:32209479; PMID:32353393; PMID:32860777
GO:0032103	Positive regulation of response to external stimulus	Decreases phenotype	PMID:27449567
GO:0032148	Activation of protein kinase b activity	Affects phenotype	PMID:26824325; PMID:27038180; PMID:29748632
GO:0032967	Positive regulation of collagen biosynthetic process	Increases phenotype	PMID:33352148
GO:0032973	Amino acid export across plasma membrane	Increases phenotype	PMID:27422357
GO:0033555	Multicellular organismal response to stress	Increases phenotype	PMID:27449567
GO:0033603	Positive regulation of dopamine secretion	Increases phenotype	PMID:30115766
GO:0034067	Protein localization to golgi apparatus	Decreases phenotype	PMID:27635674
GO:0034109	Homotypic cell-cell adhesion	Decreases phenotype	PMID:32049991
GO:0034113	Heterotypic cell-cell adhesion	Decreases phenotype	PMID:31154070
GO:0034275	Kynurenic acid metabolic process	Increases phenotype	PMID:30151725
GO:0034394	Protein localization to cell surface	Affects phenotype	PMID:33205494
GO:0034505	Tooth mineralization	Increases phenotype	PMID:33352148
GO:0035176	Social behavior	Decreases phenotype	PMID:26499171; PMID:28093016; PMID:29022873; PMID:33285233; PMID:27126842; PMID:28220044; PMID:29022873; PMID:29481316; PMID:31583843; PMID:29750976; PMID:31583843; PMID:33285233; PMID:33582152
GO:0035249	Synaptic transmission, glutamatergic	Affects phenotype	PMID:32329240
GO:0035621	Er to golgi ceramide transport	Decreases phenotype	PMID:27635674
GO:0035640	Exploration behavior	Increases phenotype	PMID:27065006; PMID:27126842; PMID:27449567; PMID:28402427; PMID:30538288; PMID:30538288; PMID:31311288; PMID:30610611; PMID:32773031
GO:0035641	Locomotory exploration behavior	Affects phenotype	PMID:31583843
GO:0035810	Positive regulation of urine volume	Increases phenotype	PMID:27231154
GO:0035938	Estradiol secretion	Increases phenotype	PMID:32647869
GO:0036123	Histone h3-k9 dimethylation	Increases phenotype	PMID:28976920; PMID:29022873; PMID:29481316
GO:0036124	Histone h3-k9 trimethylation	Increases phenotype	PMID:28481360; PMID:28976920; PMID:29022873; PMID:29481316; PMID:29481316
GO:0036269	Swimming behavior	Decreases phenotype	PMID:26499171; PMID:29982505
GO:0036343	Psychomotor behavior	Decreases phenotype	PMID:32923660
GO:0040011	Locomotion	Decreases phenotype	PMID:28905207
GO:0042098	T cell proliferation	Decreases phenotype	PMID:32942172
GO:0042102	Positive regulation of t cell proliferation	Increases phenotype	PMID:27268054
GO:0042127	Regulation of cell population proliferation	Affects phenotype	PMID:33352148
GO:0042310	Vasoconstriction	Increases phenotype	PMID:29181404
GO:0042311	Vasodilation	Increases phenotype	PMID:29181404
GO:0042415	Norepinephrine metabolic process	Affects phenotype	PMID:28212939
GO:0042552	Myelination	Increases phenotype	PMID:32956517
GO:0042756	Drinking behavior	Affects phenotype	PMID:29181404
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:25674907; PMID:27635674; PMID:33477303
GO:0043149	Stress fiber assembly	Affects phenotype	PMID:32049991
GO:0043195	Terminal bouton	Affects phenotype	PMID:30219209
GO:0043197	Dendritic spine	Increases phenotype	PMID:28481360
GO:0043537	Negative regulation of blood vessel endothelial cell migration	Increases phenotype	PMID:29307655
GO:0043627	Response to estrogen	Decreases phenotype	PMID:23494106
GO:0043970	Histone h3-k9 acetylation	Increases phenotype	PMID:28481360; PMID:28976920; PMID:29022873; PMID:29481316
GO:0043977	Histone h2a-k5 acetylation	Affects phenotype	PMID:28481360
GO:0043983	Histone h4-k12 acetylation	Affects phenotype	PMID:28481360
GO:0044154	Histone h3-k14 acetylation	Increases phenotype	PMID:28976920; PMID:29022873; PMID:29481316
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:27654887; PMID:28721267; PMID:28853159; PMID:29360751; PMID:29940172; PMID:29940172; PMID:30733293; PMID:30339727; PMID:30733293; PMID:31104297; PMID:32033040; PMID:32244040; PMID:32272438; PMID:32553926; PMID:32752303; PMID:36529297
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:31461164; PMID:32049991
GO:0045333	Cellular respiration	Affects phenotype	PMID:32872332
GO:0045807	Positive regulation of endocytosis	Increases phenotype	PMID:26733986
GO:0045930	Negative regulation of mitotic cell cycle	Affects phenotype	PMID:31730886
GO:0046034	Atp metabolic process	Affects phenotype	PMID:31104297; PMID:32872332
GO:0046058	Camp metabolic process	Affects phenotype	PMID:16157695; PMID:27527584
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:29181404; PMID:31680560
GO:0046323	Glucose import	Affects phenotype	PMID:28219717
GO:0046459	Short-chain fatty acid metabolic process	Affects phenotype	PMID:32754917
GO:0046697	Decidualization	Increases phenotype	PMID:31154070
GO:0046960	Sensitization	Increases phenotype	PMID:28722246; PMID:29084627
GO:0048041	Focal adhesion assembly	Increases phenotype	PMID:31461164
GO:0048143	Astrocyte activation	Increases phenotype	PMID:31383729
GO:0048148	Behavioral response to cocaine	Increases phenotype	PMID:34436576
GO:0048265	Response to pain	Decreases phenotype	PMID:28722246; PMID:30965351
GO:0048266	Behavioral response to pain	Affects phenotype	PMID:26799708; PMID:27149200; PMID:27149200; PMID:27231154; PMID:27535976; PMID:28442584; PMID:28597570; PMID:32688070; PMID:32923660; PMID:27149200; PMID:28442584; PMID:27231154; PMID:27535976; PMID:30225659; PMID:31311288; PMID:31877572; PMID:32688070; PMID:32923660; PMID:32717503; PMID:32860777
GO:0048469	Cell maturation	Increases phenotype	PMID:32272438
GO:0048666	Neuron development	Decreases phenotype	PMID:36529297
GO:0048709	Oligodendrocyte differentiation	Increases phenotype	PMID:32956517
GO:0048871	Multicellular organismal homeostasis	Affects phenotype	PMID:27449567
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Increases phenotype	PMID:26633823
GO:0050671	Positive regulation of lymphocyte proliferation	Affects phenotype	PMID:27038180
GO:0050795	Regulation of behavior	Affects phenotype	PMID:29787777
GO:0050870	Positive regulation of t cell activation	Increases phenotype	PMID:27038180
GO:0050879	Multicellular organismal movement	Decreases phenotype	PMID:27449567
GO:0050890	Cognition	Increases phenotype	PMID:27422357; PMID:28402427; PMID:28481360; PMID:30538288; PMID:32329240
GO:0050892	Intestinal absorption	Increases phenotype	PMID:27648135
GO:0050893	Sensory processing	Decreases phenotype	PMID:28220044
GO:0050894	Determination of affect	Affects phenotype	PMID:26647971
GO:0050975	Sensory perception of touch	Affects phenotype	PMID:31610187
GO:0051447	Negative regulation of meiotic cell cycle	Decreases phenotype	PMID:28087314
GO:0051490	Negative regulation of filopodium assembly	Increases phenotype	PMID:37625625
GO:0051726	Regulation of cell cycle	Increases phenotype	PMID:27769052; PMID:33477303
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:32872332
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:27654887; PMID:31730886
GO:0051932	Synaptic transmission, gabaergic	Affects phenotype	PMID:32329240
GO:0051971	Positive regulation of transmission of nerve impulse	Increases phenotype	PMID:26388146
GO:0060004	Reflex	Decreases phenotype	PMID:28597570
GO:0060021	Roof of mouth development	Affects phenotype	PMID:31690747
GO:0060081	Membrane hyperpolarization	Increases phenotype	PMID:27421060
GO:0060082	Eye blink reflex	Decreases phenotype	PMID:27527584
GO:0060134	Prepulse inhibition	Affects phenotype	PMID:24776491; PMID:28272498; PMID:29748632
GO:0060292	Long-term synaptic depression	Increases phenotype	PMID:29038246
GO:0060326	Cell chemotaxis	Affects phenotype	PMID:27769052; PMID:28578322
GO:0060715	Syncytiotrophoblast cell differentiation involved in labyrinthine layer development	Decreases phenotype	PMID:26070387
GO:0060719	Chorionic trophoblast cell development	Decreases phenotype	PMID:26070387
GO:0060997	Dendritic spine morphogenesis	Affects phenotype	PMID:30283037
GO:0061045	Negative regulation of wound healing	Increases phenotype	PMID:37567336
GO:0061366	Behavioral response to chemical pain	Increases phenotype	PMID:29111112
GO:0061367	Behavioral response to acetic acid induced pain	Increases phenotype	PMID:19679411
GO:0061368	Behavioral response to formalin induced pain	Decreases phenotype	PMID:29461336; PMID:31891265
GO:0061450	Trophoblast cell migration	Decreases phenotype	PMID:31154070
GO:0061527	Dopamine secretion, neurotransmission	Increases phenotype	PMID:30151725
GO:0061739	Protein lipidation involved in autophagosome assembly	Increases phenotype	PMID:27769052
GO:0061744	Motor behavior	Affects phenotype	PMID:33068620
GO:0061886	Negative regulation of mini excitatory postsynaptic potential	Increases phenotype	PMID:27027565
GO:0062072	H3k9me3 modified histone binding	Increases phenotype	PMID:29481316
GO:0070075	Tear secretion	Decreases phenotype	PMID:32852544
GO:0070265	Necrotic cell death	Increases phenotype	PMID:32752303; PMID:36529297
GO:0070633	Transepithelial transport	Increases phenotype	PMID:27641813; PMID:27648135
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:28212939
GO:0070997	Neuron death	Decreases phenotype	PMID:27654887
GO:0071625	Vocalization behavior	Affects phenotype	PMID:31653479
GO:0071674	Mononuclear cell migration	Increases phenotype	PMID:32612530
GO:0071926	Endocannabinoid signaling pathway	Increases phenotype	PMID:36912754
GO:0072518	Rho-dependent protein serine/threonine kinase activity	Increases phenotype	PMID:29158718
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:26504004; PMID:32553926
GO:0086001	Cardiac muscle cell action potential	Affects phenotype	PMID:29181404
GO:0090200	Positive regulation of release of cytochrome c from mitochondria	Increases phenotype	PMID:27635674
GO:0090327	Negative regulation of locomotion involved in locomotory behavior	Increases phenotype	PMID:26361728; PMID:26799708; PMID:26875756
GO:0090461	Cellular glutamate homeostasis	Decreases phenotype	PMID:30151725
GO:0090559	Regulation of membrane permeability	Affects phenotype	PMID:27641813
GO:0090648	Response to environmental enrichment	Decreases phenotype	PMID:26499171; PMID:26499171; PMID:29022873; PMID:29481316; PMID:33285233; PMID:28648819; PMID:29022873; PMID:29481316; PMID:33285233
GO:0090659	Walking behavior	Decreases phenotype	PMID:27449567; PMID:35201352
GO:0097202	Activation of cysteine-type endopeptidase activity	Increases phenotype	PMID:35588954
GO:0097214	Positive regulation of lysosomal membrane permeability	Increases phenotype	PMID:27635674
GO:0097237	Cellular response to toxic substance	Affects phenotype	PMID:23494106
GO:0097336	Response to risperidone	Decreases phenotype	PMID:28272498
GO:0097410	Hippocampal interneuron differentiation	Decreases phenotype	PMID:26976041
GO:0097498	Endothelial tube lumen extension	Decreases phenotype	PMID:29307655
GO:0098532	Histone h3-k27 trimethylation	Decreases phenotype	PMID:28976920
GO:0098817	Evoked excitatory postsynaptic potential	Decreases phenotype	PMID:26732435
GO:0098908	Regulation of neuronal action potential	Affects phenotype	PMID:33168583
GO:0140059	Dendrite arborization	Affects phenotype	PMID:30283037
GO:0140131	Positive regulation of lymphocyte chemotaxis	Increases phenotype	PMID:27038180
GO:0150033	Negative regulation of protein localization to lysosome	Increases phenotype	PMID:27635674
GO:1900272	Negative regulation of long-term synaptic potentiation	Increases phenotype	PMID:26732435; PMID:29982505
GO:1900273	Positive regulation of long-term synaptic potentiation	Increases phenotype	PMID:29982505
GO:1900453	Negative regulation of long-term synaptic depression	Increases phenotype	PMID:29982505
GO:1901318	Negative regulation of flagellated sperm motility	Increases phenotype	PMID:29454037
GO:1901380	Negative regulation of potassium ion transmembrane transport	Increases phenotype	PMID:27027565
GO:1901856	Negative regulation of cellular respiration	Decreases phenotype	PMID:27826249
GO:1902306	Negative regulation of sodium ion transmembrane transport	Increases phenotype	PMID:27027565
GO:1903295	Negative regulation of glutamate secretion, neurotransmission	Increases phenotype	PMID:26732435
GO:1903296	Positive regulation of glutamate secretion, neurotransmission	Increases phenotype	PMID:30151725
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:26070387; PMID:27366949
GO:1903626	Positive regulation of dna catabolic process	Increases phenotype	PMID:27769052
GO:1903860	Negative regulation of dendrite extension	Increases phenotype	PMID:29982505
GO:1903980	Positive regulation of microglial cell activation	Increases phenotype	PMID:26819091
GO:1904000	Positive regulation of eating behavior	Increases phenotype	PMID:23072421
GO:1904053	Positive regulation of protein targeting to vacuole involved in autophagy	Increases phenotype	PMID:27635674
GO:1904057	Negative regulation of sensory perception of pain	Increases phenotype	PMID:26824325
GO:1904094	Positive regulation of autophagic cell death	Increases phenotype	PMID:27635674
GO:1904426	Positive regulation of gtp binding	Increases phenotype	PMID:26361728; PMID:27535976
GO:1904439	Negative regulation of iron ion import across plasma membrane	Increases phenotype	PMID:27681840
GO:1904456	Negative regulation of neuronal action potential	Increases phenotype	PMID:27027565
GO:1904457	Positive regulation of neuronal action potential	Increases phenotype	PMID:30151725
GO:1904646	Cellular response to amyloid-beta	Decreases phenotype	PMID:31104297
GO:1904972	Negative regulation of viral translation	Increases phenotype	PMID:26733986
GO:1905447	Negative regulation of mitochondrial atp synthesis coupled electron transport	Increases phenotype	PMID:31054322
GO:1905563	Negative regulation of vascular endothelial cell proliferation	Increases phenotype	PMID:29307655
GO:1905665	Positive regulation of calcium ion import across plasma membrane	Increases phenotype	PMID:29658714
GO:1905790	Regulation of mechanosensory behavior	Affects phenotype	PMID:27449567
GO:1905955	Negative regulation of endothelial tube morphogenesis	Increases phenotype	PMID:29307655
GO:1990138	Neuron projection extension	Decreases phenotype	PMID:31917333
GO:1990349	Gap junction-mediated intercellular transport	Increases phenotype	PMID:28087314
GO:1990708	Conditioned place preference	Decreases phenotype	PMID:28951549; PMID:30115766; PMID:32095523
GO:1990926	Short-term synaptic potentiation	Decreases phenotype	PMID:28402427
GO:1990962	Xenobiotic transport across blood-brain barrier	Increases phenotype	PMID:28272498
GO:2000252	Negative regulation of feeding behavior	Increases phenotype	PMID:26633823; PMID:27126842
GO:2000330	Positive regulation of t-helper 17 cell lineage commitment	Increases phenotype	PMID:27038180
GO:2000355	Negative regulation of ovarian follicle development	Increases phenotype	PMID:36912754
GO:2000854	Positive regulation of corticosterone secretion	Increases phenotype	PMID:30071445; PMID:30115766
GO:2000986	Negative regulation of behavioral fear response	Increases phenotype	PMID:26799708
GO:2000987	Positive regulation of behavioral fear response	Affects phenotype	PMID:26799708; PMID:30115766
GO:2001023	Regulation of response to drug	Affects phenotype	PMID:27449567
GO:2001024	Negative regulation of response to drug	Affects phenotype	PMID:27231154
GO:2001025	Positive regulation of response to drug	Increases phenotype	PMID:24776491; PMID:27065006; PMID:27635674
GO:2001171	Positive regulation of atp biosynthetic process	Increases phenotype	PMID:26070387

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.