DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Mercury

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000080	Mitotic g1 phase	Affects phenotype	PMID:28035397
GO:0000084	Mitotic s phase	Affects phenotype	PMID:28035397
GO:0000085	Mitotic g2 phase	Affects phenotype	PMID:28035397
GO:0000104	Succinate dehydrogenase activity	Increases phenotype	PMID:39947444
GO:0001541	Ovarian follicle development	Affects phenotype	PMID:31071422
GO:0001822	Kidney development	Increases phenotype	PMID:30629257
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:29115570
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:18538022
GO:0002377	Immunoglobulin production	Increases phenotype	PMID:20562055
GO:0002381	Immunoglobulin production involved in immunoglobulin-mediated immune response	Increases phenotype	PMID:30643099
GO:0002455	Humoral immune response mediated by circulating immunoglobulin	Affects phenotype	PMID:32007747
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:38945390
GO:0002639	Positive regulation of immunoglobulin production	Increases phenotype	PMID:25237059
GO:0003093	Regulation of glomerular filtration	Affects phenotype	PMID:32946573
GO:0003104	Positive regulation of glomerular filtration	Increases phenotype	PMID:31326826
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:32909846
GO:0004111	Creatine kinase activity	Decreases phenotype	PMID:21725498
GO:0004129	Cytochrome-c oxidase activity	Decreases phenotype	PMID:33038468
GO:0004197	Cysteine-type endopeptidase activity	Affects phenotype	PMID:33497711
GO:0004364	Glutathione transferase activity	Decreases phenotype	PMID:30359721
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:27837179
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:23742082; PMID:37415728; PMID:38945390
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:23742082; PMID:37415728
GO:0005977	Glycogen metabolic process	Affects phenotype	PMID:38945390
GO:0005988	Lactose metabolic process	Affects phenotype	PMID:38945390
GO:0006006	Glucose metabolic process	Affects phenotype	PMID:32909846; PMID:38945390
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:33038468
GO:0006306	Dna methylation	Affects phenotype	PMID:26339649
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:38945390
GO:0006739	Nadp metabolic process	Affects phenotype	PMID:38945390
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:33497711; PMID:37676925
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:23742082; PMID:26989453; PMID:30359721
GO:0006813	Potassium ion transport	Affects phenotype	PMID:33038468
GO:0006833	Water transport	Decreases phenotype	PMID:21259319
GO:0006915	Apoptotic process	Increases phenotype	PMID:24212999; PMID:28035397; PMID:29115570; PMID:29549816
GO:0006954	Inflammatory response	Increases phenotype	PMID:31071422; PMID:8874531
GO:0006955	Immune response	Decreases phenotype	PMID:30795575
GO:0006979	Response to oxidative stress	Affects phenotype	PMID:23578882
GO:0007006	Mitochondrial membrane organization	Affects phenotype	PMID:33038468
GO:0007283	Spermatogenesis	Affects phenotype	PMID:29549816
GO:0007613	Memory	Decreases phenotype	PMID:25404430; PMID:30090589; PMID:37415728
GO:0007631	Feeding behavior	Affects phenotype	PMID:37676925
GO:0008121	Ubiquinol-cytochrome-c reductase activity	Affects phenotype	PMID:33038468; PMID:39947444
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Affects phenotype	PMID:33038468; PMID:39947444
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:33038468
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:22421054; PMID:38945390
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:30090589; PMID:38945390
GO:0008217	Regulation of blood pressure	Affects phenotype	PMID:17032453; PMID:18538022; PMID:23824410
GO:0008219	Cell death	Increases phenotype	PMID:23578882; PMID:23792957; PMID:33497711
GO:0009749	Response to glucose	Decreases phenotype	PMID:30629257
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:39947444
GO:0015694	Mercury ion transport	Increases phenotype	PMID:25145654; PMID:28536007; PMID:34670124
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:23742082
GO:0019249	Lactate biosynthetic process	Increases phenotype	PMID:39947444
GO:0019627	Urea metabolic process	Affects phenotype	PMID:32909846; PMID:38945390
GO:0019695	Choline metabolic process	Affects phenotype	PMID:32949613
GO:0022405	Hair cycle process	Decreases phenotype	PMID:22910643
GO:0022602	Ovulation cycle process	Affects phenotype	PMID:31071422
GO:0030001	Metal ion transport	Decreases phenotype	PMID:23238610
GO:0030036	Actin cytoskeleton organization	Affects phenotype	PMID:26600472
GO:0030097	Hemopoiesis	Affects phenotype	PMID:38945390
GO:0030168	Platelet activation	Increases phenotype	PMID:30537864
GO:0031143	Pseudopodium	Increases phenotype	PMID:30537864
GO:0031507	Heterochromatin formation	Decreases phenotype	PMID:26339649
GO:0031966	Mitochondrial membrane	Affects phenotype	PMID:33038468
GO:0032125	Micronucleus organization	Affects phenotype	PMID:17456398
GO:0032609	Type ii interferon production	Decreases phenotype	PMID:32007747
GO:0032613	Interleukin-10 production	Decreases phenotype	PMID:32007747
GO:0032635	Interleukin-6 production	Decreases phenotype	PMID:32007747
GO:0032640	Tumor necrosis factor production	Decreases phenotype	PMID:32007747
GO:0034255	Regulation of urea metabolic process	Affects phenotype	PMID:32949613
GO:0034440	Lipid oxidation	Increases phenotype	PMID:37137463; PMID:37676925; PMID:38945390
GO:0035794	Positive regulation of mitochondrial membrane permeability	Decreases phenotype	PMID:39947444
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:30090589; PMID:38797200
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:31071422
GO:0042593	Glucose homeostasis	Affects phenotype	PMID:23824410; PMID:30629257
GO:0042632	Cholesterol homeostasis	Affects phenotype	PMID:23824410; PMID:27178639
GO:0042756	Drinking behavior	Affects phenotype	PMID:37676925
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:27837179
GO:0044030	Regulation of dna methylation	Increases phenotype	PMID:37914285
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:28035397; PMID:29115570; PMID:29298499
GO:0045333	Cellular respiration	Decreases phenotype	PMID:33038468
GO:0045666	Positive regulation of neuron differentiation	Increases phenotype	PMID:37914285
GO:0045792	Negative regulation of cell size	Increases phenotype	PMID:37914285
GO:0045795	Positive regulation of cell volume	Affects phenotype	PMID:24028651
GO:0046034	Atp metabolic process	Affects phenotype	PMID:33038468; PMID:33497711
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:37676925
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:38945390
GO:0046459	Short-chain fatty acid metabolic process	Affects phenotype	PMID:37137463
GO:0046466	Membrane lipid catabolic process	Affects phenotype	PMID:27837179
GO:0048511	Rhythmic process	Decreases phenotype	PMID:22910643
GO:0048640	Negative regulation of developmental growth	Increases phenotype	PMID:35490160
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Affects phenotype	PMID:35037767
GO:0050665	Hydrogen peroxide biosynthetic process	Increases phenotype	PMID:23742082
GO:0050778	Positive regulation of immune response	Affects phenotype	PMID:9931279
GO:0050801	Monoatomic ion homeostasis	Affects phenotype	PMID:30090589
GO:0050855	Regulation of b cell receptor signaling pathway	Affects phenotype	PMID:24440445
GO:0050890	Cognition	Affects phenotype	PMID:31241132; PMID:31421448
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:33038468
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:29115570; PMID:33497711
GO:0060208	Proestrus	Affects phenotype	PMID:31071422
GO:0060322	Head development	Decreases phenotype	PMID:35490160
GO:0060612	Adipose tissue development	Increases phenotype	PMID:28029015; PMID:30629257
GO:0061007	Hepaticobiliary system process	Affects phenotype	PMID:25424620
GO:0061178	Regulation of insulin secretion involved in cellular response to glucose stimulus	Affects phenotype	PMID:23423697
GO:0070527	Platelet aggregation	Increases phenotype	PMID:30537864
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:26600472; PMID:37137463; PMID:37415728
GO:0071288	Cellular response to mercury ion	Affects phenotype	PMID:37258240; PMID:8108390
GO:0071743	Ige immunoglobulin complex, circulating	Increases phenotype	PMID:30643099
GO:0072378	Blood coagulation, fibrin clot formation	Increases phenotype	PMID:30537864
GO:0072593	Reactive oxygen species metabolic process	Affects phenotype	PMID:28035397; PMID:33497711
GO:0097281	Immune complex formation	Affects phenotype	PMID:8513597; PMID:9693280
GO:0097722	Sperm motility	Decreases phenotype	PMID:29549816
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:31071422
GO:0150104	Transport across blood-brain barrier	Affects phenotype	PMID:36641952
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:25237059
GO:1900535	Palmitic acid biosynthetic process	Decreases phenotype	PMID:39947444
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:27837179
GO:1902600	Proton transmembrane transport	Affects phenotype	PMID:33038468
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:28035397
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:27837179
GO:1903284	Positive regulation of glutathione peroxidase activity	Increases phenotype	PMID:16451871
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:25701957; PMID:30359721
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:27837179
GO:1903715	Regulation of aerobic respiration	Decreases phenotype	PMID:39947444
GO:1903786	Regulation of glutathione biosynthetic process	Affects phenotype	PMID:32949613
GO:1904480	Positive regulation of intestinal absorption	Increases phenotype	PMID:31175882
GO:1990266	Neutrophil migration	Increases phenotype	PMID:37137463
GO:2000403	Positive regulation of lymphocyte migration	Increases phenotype	PMID:36220500
GO:2000516	Positive regulation of cd4-positive, alpha-beta t cell activation	Increases phenotype	PMID:25237059
GO:2000842	Positive regulation of dehydroepiandrosterone secretion	Increases phenotype	PMID:36973528
GO:2001170	Negative regulation of atp biosynthetic process	Increases phenotype	PMID:39947444
GO:2001280	Positive regulation of unsaturated fatty acid biosynthetic process	Increases phenotype	PMID:39947444

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.