Hexabromocyclododecane


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001541 Ovarian follicle development Decreases phenotype PMID:32207525
GO:0001547 Antral ovarian follicle growth Increases phenotype PMID:26607716
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24291159
GO:0002420 Natural killer cell mediated cytotoxicity directed against tumor cell target Decreases phenotype PMID:19938002
GO:0003006 Developmental process involved in reproduction Affects phenotype PMID:32207525; PMID:33252648
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28011154
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:27717803
GO:0006171 Camp biosynthetic process Decreases phenotype PMID:25447410
GO:0006629 Lipid metabolic process Affects phenotype PMID:39037918
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:27717803
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:25447410
GO:0006882 Cellular zinc ion homeostasis Decreases phenotype PMID:29177809
GO:0006915 Apoptotic process Increases phenotype PMID:24291159
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:24960055
GO:0007015 Actin filament organization Decreases phenotype PMID:31200309
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:29177809; PMID:31200309
GO:0008219 Cell death Increases phenotype PMID:26073293
GO:0008283 Cell population proliferation Decreases phenotype PMID:24189551; PMID:26073293; PMID:24291159; PMID:24960055; PMID:26073293
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:26804032; PMID:26979758
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28849447; PMID:29177809; PMID:31200309; PMID:37880562; PMID:37923287
GO:0008361 Regulation of cell size Affects phenotype PMID:32679240
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:27717803
GO:0009636 Response to toxic substance Increases phenotype PMID:30090431
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:38995820
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26718265
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:27717803
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:26804032
GO:0031589 Cell-substrate adhesion Decreases phenotype PMID:32466334
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:31200309
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:26979758
GO:0042065 Glial cell growth Affects phenotype PMID:23914054
GO:0042445 Hormone metabolic process Affects phenotype PMID:23333513
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28849447; PMID:31200309; PMID:37923287
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:31200309
GO:0046034 Atp metabolic process Increases phenotype PMID:31200309
GO:0046676 Negative regulation of insulin secretion Increases phenotype PMID:30090431
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:39037918
GO:0051402 Neuron apoptotic process Increases phenotype PMID:38995820
GO:0051480 Regulation of cytosolic calcium ion concentration Affects phenotype PMID:24291159
GO:0051497 Negative regulation of stress fiber assembly Increases phenotype PMID:31200309
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:24291159; PMID:25447410
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:26476318
GO:0060068 Vagina development Decreases phenotype PMID:32207525
GO:0060209 Estrus Decreases phenotype PMID:32207525
GO:0060326 Cell chemotaxis Increases phenotype PMID:32466334
GO:0060545 Positive regulation of necroptotic process Increases phenotype PMID:37923287
GO:0060750 Epithelial cell proliferation involved in mammary gland duct elongation Increases phenotype PMID:33252648
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:25447410; PMID:26607716
GO:0061744 Motor behavior Decreases phenotype PMID:37923287
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24291159
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:37923287
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:32466334
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:31200309; PMID:35950316
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:30090431
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:38995820
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.