Benzo(a)pyrene


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:30726812; PMID:32619457
GO:0000080 Mitotic g1 phase Decreases phenotype PMID:32497684; PMID:33411230
GO:0000084 Mitotic s phase Affects phenotype PMID:30020114; PMID:33411230
GO:0000085 Mitotic g2 phase Affects phenotype PMID:35678645
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:30020114; PMID:32087850; PMID:32497684
GO:0000132 Establishment of mitotic spindle orientation Decreases phenotype PMID:29126329
GO:0000281 Mitotic cytokinesis Affects phenotype PMID:39454710
GO:0000729 Dna double-strand break processing Increases phenotype PMID:36399157
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34027802; PMID:37390851; PMID:37515497; PMID:38382706
GO:0001541 Ovarian follicle development Decreases phenotype PMID:35993611
GO:0001837 Epithelial to mesenchymal transition Increases phenotype PMID:31778776
GO:0002244 Hematopoietic progenitor cell differentiation Increases phenotype PMID:31059917
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34027802; PMID:34998820; PMID:35378083; PMID:37373040
GO:0003720 Telomerase activity Decreases phenotype PMID:35151814
GO:0003958 Nadph-hemoprotein reductase activity Increases phenotype PMID:34472326
GO:0003993 Acid phosphatase activity Decreases phenotype PMID:30520250
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:35437857; PMID:35777681
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:31730885; PMID:33393179
GO:0004129 Cytochrome-c oxidase activity Affects phenotype PMID:15207643; PMID:30165701
GO:0004364 Glutathione transferase activity Affects phenotype PMID:12641979; PMID:25374376; PMID:25632966; PMID:25632966; PMID:26546711; PMID:29019276; PMID:26546711; PMID:27206700; PMID:29019276; PMID:30520250; PMID:31004597; PMID:31702096; PMID:33411230; PMID:35437857
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:18057710; PMID:18057710; PMID:29019276; PMID:31702096; PMID:27206700; PMID:29019276; PMID:31702096
GO:0004497 Monooxygenase activity Increases phenotype PMID:26466350
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:16858674; PMID:18057710; PMID:18057710; PMID:26546711; PMID:29019276; PMID:22052664; PMID:26546711; PMID:29019276; PMID:31702096; PMID:33663268; PMID:35437857
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:16858674; PMID:18057710; PMID:18057710; PMID:25632966; PMID:26546711; PMID:29019276; PMID:25632966; PMID:25946486; PMID:26546711; PMID:29019276; PMID:31004597; PMID:31702096; PMID:31830554; PMID:32417428; PMID:33663268; PMID:35437857; PMID:35777681; PMID:38278498
GO:0004855 Xanthine oxidase activity Increases phenotype PMID:27206700
GO:0005243 Gap junction channel activity Decreases phenotype PMID:31568845
GO:0005776 Autophagosome Increases phenotype PMID:39454710
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:36736873
GO:0006006 Glucose metabolic process Affects phenotype PMID:36736873
GO:0006054 N-acetylneuraminate metabolic process Affects phenotype PMID:35437857
GO:0006059 Hexitol metabolic process Affects phenotype PMID:36736873
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Increases phenotype PMID:15207643
GO:0006123 Mitochondrial electron transport, cytochrome c to oxygen Decreases phenotype PMID:30165701
GO:0006259 Dna metabolic process Increases phenotype PMID:25781201
GO:0006260 Dna replication Decreases phenotype PMID:28461126
GO:0006264 Mitochondrial dna replication Affects phenotype PMID:32619457
GO:0006289 Nucleotide-excision repair Increases phenotype PMID:28238931
GO:0006304 Dna modification Increases phenotype PMID:26238291; PMID:26377693; PMID:28457874; PMID:30714215; PMID:34529316
GO:0006306 Dna methylation Affects phenotype PMID:35151814
GO:0006497 Protein lipidation Increases phenotype PMID:32619457
GO:0006506 Gpi anchor biosynthetic process Decreases phenotype PMID:27931811
GO:0006520 Amino acid metabolic process Affects phenotype PMID:36736873
GO:0006534 Cysteine metabolic process Affects phenotype PMID:36736873
GO:0006580 Ethanolamine metabolic process Affects phenotype PMID:36736873
GO:0006582 Melanin metabolic process Affects phenotype PMID:34856342
GO:0006606 Protein import into nucleus Affects phenotype PMID:32062438
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:31830554; PMID:32417428; PMID:36736873; PMID:39111554
GO:0006633 Fatty acid biosynthetic process Affects phenotype PMID:27329536
GO:0006635 Fatty acid beta-oxidation Affects phenotype PMID:24107266
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:31730885; PMID:32417428; PMID:39111554
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:36736873
GO:0006703 Estrogen biosynthetic process Affects phenotype PMID:31730885
GO:0006749 Glutathione metabolic process Increases phenotype PMID:25170436; PMID:27206700; PMID:27206700; PMID:35437857; PMID:36736873; PMID:28032951; PMID:28032951; PMID:29019276; PMID:29019276; PMID:29526570; PMID:31568845; PMID:32061149; PMID:33663268; PMID:34856342; PMID:35437857; PMID:35437857; PMID:36736873; PMID:38278498
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:18057710; PMID:18057710; PMID:26546711; PMID:22052664; PMID:26546711; PMID:28238931; PMID:28412278; PMID:31004597; PMID:31702096
GO:0006783 Heme biosynthetic process Increases phenotype PMID:31059917
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:26091049
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:24685774; PMID:26086121; PMID:31004597
GO:0006914 Autophagy Increases phenotype PMID:39454710
GO:0006915 Apoptotic process Affects phenotype PMID:23510837; PMID:23994263; PMID:24239969; PMID:24246761; PMID:24246761; PMID:26086121; PMID:24954032; PMID:26086121; PMID:26359795; PMID:26419736; PMID:28412278; PMID:28681665; PMID:30776357; PMID:32619457; PMID:32802178; PMID:34529316; PMID:35567930; PMID:35777681; PMID:36193556
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:27208085
GO:0006954 Inflammatory response Increases phenotype PMID:28681665; PMID:28681665; PMID:32061149; PMID:33393179; PMID:29019276; PMID:31059917; PMID:32061149; PMID:33393179; PMID:37364758
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:10693172; PMID:10693172; PMID:28428138; PMID:28882572; PMID:29218508; PMID:29549414; PMID:31542801; PMID:16242274; PMID:16970932; PMID:23333640; PMID:24657529; PMID:26856715; PMID:27195522; PMID:27448386; PMID:27448386; PMID:28111842; PMID:28111842; PMID:28111842; PMID:30776357; PMID:28428138; PMID:28461126; PMID:28882572; PMID:29170806; PMID:29218508; PMID:29218508; PMID:33249052; PMID:29545172; PMID:29549414; PMID:30776357; PMID:30842367; PMID:31542801; PMID:32062438; PMID:33393179; PMID:33411230; PMID:34762139; PMID:34998820
GO:0006979 Response to oxidative stress Increases phenotype PMID:15621696; PMID:15969944
GO:0007005 Mitochondrion organization Decreases phenotype PMID:32619457
GO:0007009 Plasma membrane organization Decreases phenotype PMID:30726812
GO:0007049 Cell cycle Increases phenotype PMID:16406622
GO:0007059 Chromosome segregation Increases phenotype PMID:27913846
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:25242404; PMID:26657896; PMID:31568845
GO:0007283 Spermatogenesis Decreases phenotype PMID:31568845; PMID:38278498
GO:0007346 Regulation of mitotic cell cycle Affects phenotype PMID:28681665
GO:0007566 Embryo implantation Decreases phenotype PMID:39454710
GO:0007601 Visual perception Decreases phenotype PMID:31730894
GO:0007611 Learning or memory Decreases phenotype PMID:30085273; PMID:31730894
GO:0007612 Learning Decreases phenotype PMID:26420751; PMID:32255272; PMID:32619457; PMID:32619457
GO:0007613 Memory Decreases phenotype PMID:32255272; PMID:32619457; PMID:32619457; PMID:34979192
GO:0008080 N-acetyltransferase activity Increases phenotype PMID:30439556
GO:0008152 Metabolic process Affects phenotype PMID:33939976
GO:0008202 Steroid metabolic process Affects phenotype PMID:36736873
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:30664314; PMID:31730885
GO:0008206 Bile acid metabolic process Affects phenotype PMID:32417428; PMID:39111554
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34929288
GO:0008219 Cell death Increases phenotype PMID:24664296; PMID:25946486; PMID:29502740; PMID:33411230; PMID:35777681; PMID:35993611
GO:0008253 5'-nucleotidase activity Increases phenotype PMID:31702096
GO:0008283 Cell population proliferation Increases phenotype PMID:23994263; PMID:24289642; PMID:24847786; PMID:29746904; PMID:25230394; PMID:26359795; PMID:28533128; PMID:30236600; PMID:32802178; PMID:33429317; PMID:34998820; PMID:35678645
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:24464499; PMID:25820237; PMID:26657896; PMID:27740625; PMID:27901495; PMID:35870112; PMID:37972769
GO:0008285 Negative regulation of cell population proliferation Affects phenotype PMID:28049045; PMID:29524502; PMID:29526570; PMID:30385349; PMID:30659931; PMID:34979192
GO:0008306 Associative learning Decreases phenotype PMID:34979192
GO:0008344 Adult locomotory behavior Decreases phenotype PMID:16858674
GO:0008360 Regulation of cell shape Affects phenotype PMID:33429317
GO:0008610 Lipid biosynthetic process Affects phenotype PMID:26303333; PMID:27544633
GO:0010189 Vitamin e biosynthetic process Decreases phenotype PMID:18057710; PMID:18057710; PMID:26546711; PMID:26546711
GO:0010424 Dna methylation on cytosine within a cg sequence Decreases phenotype PMID:27901495; PMID:30085273
GO:0010467 Gene expression Affects phenotype PMID:28233961
GO:0010669 Epithelial structure maintenance Decreases phenotype PMID:31255691
GO:0010719 Negative regulation of epithelial to mesenchymal transition Increases phenotype PMID:30659931
GO:0010820 Positive regulation of t cell chemotaxis Increases phenotype PMID:30453624
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:29126329
GO:0010923 Negative regulation of phosphatase activity Affects phenotype PMID:30520250
GO:0010976 Positive regulation of neuron projection development Decreases phenotype PMID:28049045
GO:0014902 Myotube differentiation Decreases phenotype PMID:24431215
GO:0014904 Myotube cell development Decreases phenotype PMID:35567930
GO:0015020 Glucuronosyltransferase activity Increases phenotype PMID:30439556
GO:0015746 Citrate transport Increases phenotype PMID:26303333
GO:0016042 Lipid catabolic process Increases phenotype PMID:16858674; PMID:18057710; PMID:18057710; PMID:25632966; PMID:26546711; PMID:30776357; PMID:25632966; PMID:26546711; PMID:29019276; PMID:30776357; PMID:31702096; PMID:32061149; PMID:35437857
GO:0016477 Cell migration Increases phenotype PMID:24847786; PMID:25724548; PMID:27003318; PMID:30236600
GO:0016712 Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Increases phenotype PMID:34999049; PMID:35437857
GO:0018158 Protein oxidation Increases phenotype PMID:25374376; PMID:30520250; PMID:30520250; PMID:30776357; PMID:30776357; PMID:35437857
GO:0019321 Pentose metabolic process Affects phenotype PMID:36736873
GO:0019530 Taurine metabolic process Affects phenotype PMID:36736873
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:36736873
GO:0019825 Oxygen binding Increases phenotype PMID:25632966
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:18057710; PMID:18057710; PMID:26546711; PMID:26546711
GO:0019857 5-methylcytosine metabolic process Affects phenotype PMID:39967322
GO:0019859 Thymine metabolic process Affects phenotype PMID:36736873
GO:0019860 Uracil metabolic process Affects phenotype PMID:36736873
GO:0022904 Respiratory electron transport chain Increases phenotype PMID:15207643
GO:0030185 Nitric oxide transport Increases phenotype PMID:30726812
GO:0030282 Bone mineralization Affects phenotype PMID:35777681
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:23333640; PMID:30294794; PMID:35870112; PMID:38602648
GO:0030513 Positive regulation of bmp signaling pathway Increases phenotype PMID:27740625
GO:0031589 Cell-substrate adhesion Decreases phenotype PMID:32670863
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:32619457
GO:0032125 Micronucleus organization Increases phenotype PMID:29502740; PMID:30842367; PMID:31051210; PMID:32087850; PMID:31515600; PMID:31733235; PMID:32497684; PMID:33961948; PMID:34762139; PMID:35882637
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:30659931; PMID:34283317
GO:0032205 Negative regulation of telomere maintenance Increases phenotype PMID:37579952
GO:0032464 Positive regulation of protein homooligomerization Increases phenotype PMID:34332006
GO:0032502 Developmental process Affects phenotype PMID:39967322
GO:0032649 Regulation of type ii interferon production Affects phenotype PMID:22562770
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:29524502; PMID:35993611
GO:0033023 Mast cell homeostasis Affects phenotype PMID:34999049
GO:0033090 Positive regulation of extrathymic t cell differentiation Increases phenotype PMID:30664314
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:26022396
GO:0033522 Histone h2a ubiquitination Increases phenotype PMID:23712474
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:35437857
GO:0034113 Heterotypic cell-cell adhesion Increases phenotype PMID:31748929
GO:0034440 Lipid oxidation Increases phenotype PMID:25242404; PMID:28032951; PMID:28032951; PMID:30520250; PMID:30520250; PMID:31004597; PMID:31568845; PMID:33663268; PMID:38278498; PMID:39111554
GO:0034660 Ncrna metabolic process Affects phenotype PMID:24084393
GO:0036065 Fucosylation Decreases phenotype PMID:33429317
GO:0036123 Histone h3-k9 dimethylation Increases phenotype PMID:32062438
GO:0036269 Swimming behavior Decreases phenotype PMID:34979192
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:34979192
GO:0042127 Regulation of cell population proliferation Affects phenotype PMID:30664314
GO:0042332 Gravitaxis Affects phenotype PMID:39967322
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:26466350
GO:0042421 Norepinephrine biosynthetic process Increases phenotype PMID:26466350
GO:0042431 Indole metabolic process Affects phenotype PMID:36736873
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34929288
GO:0042554 Superoxide anion generation Increases phenotype PMID:28533128
GO:0042593 Glucose homeostasis Affects phenotype PMID:30520250; PMID:37019984
GO:0042634 Regulation of hair cycle Affects phenotype PMID:39967322
GO:0042640 Anagen Affects phenotype PMID:39967322
GO:0043005 Neuron projection Decreases phenotype PMID:37364758
GO:0043030 Regulation of macrophage activation Affects phenotype PMID:35378083
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28032951; PMID:28032951; PMID:30520250; PMID:29524502; PMID:30385349; PMID:30520250; PMID:30659931; PMID:31368503; PMID:31568845; PMID:34979192; PMID:37579952; PMID:39423996
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:35870112
GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:31368503
GO:0043433 Negative regulation of dna-binding transcription factor activity Increases phenotype PMID:26022396
GO:0044030 Regulation of dna methylation Affects phenotype PMID:36754249
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30020114; PMID:31154059; PMID:31154059; PMID:35151814; PMID:31733235; PMID:31830554; PMID:31830554; PMID:35151814; PMID:32087850; PMID:33393179; PMID:33411230; PMID:34856342; PMID:34929288; PMID:35151814; PMID:35777681; PMID:36941454; PMID:36982514; PMID:37364758; PMID:38382706
GO:0044242 Cellular lipid catabolic process Increases phenotype PMID:24657529; PMID:25374376
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:29746904; PMID:31778776
GO:0044648 Histone h3-k4 dimethylation Decreases phenotype PMID:26149760
GO:0044691 Tooth eruption Affects phenotype PMID:39967322
GO:0045023 G0 to g1 transition Affects phenotype PMID:30020114
GO:0045026 Plasma membrane fusion Increases phenotype PMID:24361490
GO:0045540 Regulation of cholesterol biosynthetic process Affects phenotype PMID:31368503
GO:0045657 Positive regulation of monocyte differentiation Increases phenotype PMID:29524502
GO:0045662 Negative regulation of myoblast differentiation Increases phenotype PMID:35427736
GO:0045666 Positive regulation of neuron differentiation Decreases phenotype PMID:28049045
GO:0045687 Positive regulation of glial cell differentiation Decreases phenotype PMID:28049045
GO:0045732 Positive regulation of protein catabolic process Affects phenotype PMID:35427736
GO:0045793 Positive regulation of cell size Decreases phenotype PMID:28049045
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:34979192
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:23994263; PMID:26148868; PMID:26657896; PMID:27286660; PMID:32087850; PMID:33411230
GO:0045931 Positive regulation of mitotic cell cycle Decreases phenotype PMID:26091049
GO:0046034 Atp metabolic process Affects phenotype PMID:32619457
GO:0046110 Xanthine metabolic process Affects phenotype PMID:36736873
GO:0046449 Creatinine metabolic process Affects phenotype PMID:36736873
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:15621696; PMID:27206700; PMID:35920545; PMID:35920545; PMID:36193556; PMID:35993611; PMID:36193556
GO:0046483 Heterocycle metabolic process Affects phenotype PMID:36736873
GO:0046697 Decidualization Decreases phenotype PMID:39454710
GO:0047823 D-glutamyltransferase activity Increases phenotype PMID:34999049
GO:0048866 Stem cell fate specification Increases phenotype PMID:32062438
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:36592837
GO:0050847 Progesterone receptor signaling pathway Decreases phenotype PMID:26022396
GO:0050900 Leukocyte migration Decreases phenotype PMID:23539630
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:26022396
GO:0051131 Chaperone-mediated protein complex assembly Decreases phenotype PMID:35427736
GO:0051347 Positive regulation of transferase activity Increases phenotype PMID:30520250
GO:0051402 Neuron apoptotic process Increases phenotype PMID:32115946
GO:0051726 Regulation of cell cycle Increases phenotype PMID:24664296
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26086121; PMID:32619457
GO:0051985 Negative regulation of chromosome segregation Increases phenotype PMID:29126329
GO:0060013 Righting reflex Affects phenotype PMID:39967322
GO:0060291 Long-term synaptic potentiation Decreases phenotype PMID:32255272
GO:0060326 Cell chemotaxis Increases phenotype PMID:31778776
GO:0060346 Bone trabecula formation Affects phenotype PMID:35777681
GO:0060348 Bone development Affects phenotype PMID:35777681
GO:0060395 Smad protein signal transduction Increases phenotype PMID:27740625
GO:0060560 Developmental growth involved in morphogenesis Decreases phenotype PMID:30659931
GO:0060612 Adipose tissue development Increases phenotype PMID:3891103
GO:0060997 Dendritic spine morphogenesis Decreases phenotype PMID:39967322
GO:0061024 Membrane organization Decreases phenotype PMID:30248327
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:38278498
GO:0061450 Trophoblast cell migration Decreases phenotype PMID:26359795
GO:0061564 Axon development Increases phenotype PMID:37373040
GO:0061902 Negative regulation of 1-phosphatidylinositol-3-kinase activity Increases phenotype PMID:34283317
GO:0070265 Necrotic cell death Increases phenotype PMID:29019276; PMID:37364758
GO:0070266 Necroptotic process Increases phenotype PMID:35777681
GO:0070269 Pyroptosis Increases phenotype PMID:30726812
GO:0070328 Triglyceride homeostasis Affects phenotype PMID:37019984
GO:0070509 Calcium ion import Increases phenotype PMID:30248327
GO:0070633 Transepithelial transport Decreases phenotype PMID:31255691
GO:0070661 Leukocyte proliferation Decreases phenotype PMID:38278498
GO:0070994 Detection of oxidative stress Increases phenotype PMID:23720242; PMID:34027802; PMID:35777681; PMID:36736873
GO:0071407 Cellular response to organic cyclic compound Increases phenotype PMID:26022396
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24685774; PMID:25680693; PMID:25724548; PMID:32619457; PMID:33421718; PMID:33421718; PMID:37515497; PMID:34856342; PMID:35437857; PMID:35567930; PMID:35777681; PMID:37515497; PMID:39111554
GO:0080009 Mrna methylation Increases phenotype PMID:37972769
GO:0090090 Negative regulation of canonical wnt signaling pathway Increases phenotype PMID:34283317
GO:0090119 Vesicle-mediated cholesterol transport Affects phenotype PMID:31368503
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:31568845; PMID:35993611
GO:0090240 Positive regulation of histone h4 acetylation Decreases phenotype PMID:26149760
GO:0090327 Negative regulation of locomotion involved in locomotory behavior Increases phenotype PMID:34979192
GO:0090524 Cytochrome-b5 reductase activity, acting on nadh Increases phenotype PMID:35437857
GO:0097237 Cellular response to toxic substance Increases phenotype PMID:29502735
GO:0097484 Dendrite extension Decreases phenotype PMID:39967322
GO:0097722 Sperm motility Decreases phenotype PMID:37579952
GO:0098508 Endothelial to hematopoietic transition Increases phenotype PMID:31404653
GO:0098532 Histone h3-k27 trimethylation Decreases phenotype PMID:30157460
GO:0098743 Cell aggregation Increases phenotype PMID:27740625
GO:0120252 Hydrocarbon metabolic process Affects phenotype PMID:36736873
GO:0140042 Lipid droplet formation Affects phenotype PMID:31730885; PMID:35993611; PMID:39111554
GO:0140059 Dendrite arborization Decreases phenotype PMID:39967322
GO:0140454 Protein aggregate center assembly Increases phenotype PMID:36941454
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:36592837
GO:0160024 Leydig cell proliferation Affects phenotype PMID:38278498
GO:1900119 Positive regulation of execution phase of apoptosis Increases phenotype PMID:29526570
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:34283317
GO:1900225 Regulation of nlrp3 inflammasome complex assembly Affects phenotype PMID:34999049
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:35993611
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:25233930
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:34332006
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:31568845
GO:1901522 Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Increases phenotype PMID:26022396
GO:1901525 Negative regulation of mitophagy Increases phenotype PMID:39147092
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:27206700; PMID:29526570; PMID:31568845
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:25242404; PMID:28032951; PMID:30520250
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:28032951
GO:1901858 Regulation of mitochondrial dna metabolic process Affects phenotype PMID:29145655
GO:1902034 Negative regulation of hematopoietic stem cell proliferation Increases phenotype PMID:32553695
GO:1902108 Regulation of mitochondrial membrane permeability involved in apoptotic process Affects phenotype PMID:35993611
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:27206700
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:29502740; PMID:30020114; PMID:32497684; PMID:35678645; PMID:39454710
GO:1903165 Response to polycyclic arene Increases phenotype PMID:27589885
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:27206700; PMID:31568845
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:28032951; PMID:30520250
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:25242404
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:28533128; PMID:30236600; PMID:31830554
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29526570; PMID:31568845; PMID:32890658; PMID:39423996
GO:1903430 Negative regulation of cell maturation Increases phenotype PMID:34437932
GO:1903543 Positive regulation of exosomal secretion Increases phenotype PMID:31368503
GO:1903561 Extracellular vesicle Increases phenotype PMID:34044057
GO:1903612 Positive regulation of calcium-dependent atpase activity Decreases phenotype PMID:25242404
GO:1903753 Negative regulation of p38mapk cascade Decreases phenotype PMID:35427736
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:34332006
GO:1904613 Cellular response to 2,3,7,8-tetrachlorodibenzodioxine Increases phenotype PMID:26022396
GO:1905376 Negative regulation of cytochrome-c oxidase activity Increases phenotype PMID:30165701
GO:1990349 Gap junction-mediated intercellular transport Decreases phenotype PMID:34283317
GO:1990440 Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress Increases phenotype PMID:26022396
GO:2000183 Negative regulation of progesterone biosynthetic process Increases phenotype PMID:39423996
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:31568845; PMID:39423996
GO:2000379 Positive regulation of reactive oxygen species metabolic process Increases phenotype PMID:24664296
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:37267060
GO:2000409 Positive regulation of t cell extravasation Increases phenotype PMID:30453624
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:37267060
GO:2000648 Positive regulation of stem cell proliferation Increases phenotype PMID:34437932
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:37579952
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:31568845
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:39423996
GO:2000868 Negative regulation of estrone secretion Increases phenotype PMID:39423996
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.