| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18634860 | IVR | 50 mg/kg/day | 50 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Ovarian carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| PMID:21737371 | IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg/kg/day | - | No significant effects observed | - | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg/day | 0.01 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:22960446 | IVR | 5 mg/kg/day | - | No significant effects observed | - |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:23037998 | IVR | 10 mg/kg/day | 10 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Uterotrophic effect | Reproductive endocrine-mediated perturbations | |
| PMID:23059060 | IVR | 75 mg/L | - | No significant effects observed | - |
| IVR | 50 mg/L | - | No significant effects observed | - | |
| IVR | 100 mg/L | 100 mg/L | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:23280776 | IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg | 0.1 mg/kg | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| PMID:24769007 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| PMID:27221463 | IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased progestagens levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:28043741 | IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg | 20 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:28263535 | IVR | 0 | - | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| PMID:29649501 | IVR | 150 mg/kg | 150 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| PMID:30443902 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 M | 0.00001 M | Induce apoptosis of endometrial cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Compromised endometrial receptivity | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000005 M | 0.000005 M | Induce apoptosis of endometrial cells | Reproductive endocrine-mediated perturbations | |
| PMID:31085209 | IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| PMID:32023792 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects ovarian angiogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Increased estrogen levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased estrogen levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| PMID:32670863 | IVTH | 0.0000000001 M | 0.0000000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:33254415 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Induce apoptosis in ovary | Reproductive endocrine-mediated perturbations | |
| PMID:33297042 | IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 mg/kg/day | 0.1 - 1 mg/kg/day | Decreased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| PMID:33433340 | IVTH | 0.00000005 M | 0.00000005 M | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000005 M | 0.00000005 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:33513405 | IVR | 0.001 - 0.01 mg/kg/day | 0.001 - 0.01 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg/kg/day | 0.001 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in preputial separation in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg/day | 0.001 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg/day | 0.001 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Affects placental function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased body weights in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Abnormal estrous cycles | Reproductive | |
| IVR | 0.0001 - 0.001 mg/kg/day | 0.0001 - 0.001 mg/kg/day | Changes in morphology of seminiferous tubules | ||
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Alterations in leydig cell morphology | ||
| IVR | 0.0001 - 0.01 mg/kg/day | 0.0001 - 0.01 mg/kg/day | Alterations in number of leydig cells | ||
| PMID:34050522 | IVR | 0.05 - 0.2 mg/kg | 0.05 - 0.2 mg/kg | Affects placental function | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 - 2 mg/kg | 0.2 - 2 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| PMID:34459573 | IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:35912572 | IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| PMID:36460192 | IVTH | 0.00001 M | 0.00001 M | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| IVTH | 0.00001 M | 0.00001 M | Increased oxidative stress in neurons | Neurological endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:37167865 | IVR | 0.05 - 0.2 mg/kg | 0.05 - 0.2 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.05 - 0.2 mg/kg | 0.05 - 0.2 mg/kg | Induce apoptosis in uterus | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 - 0.2 mg/kg | 0.05 - 0.2 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| PMID:37369342 | IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Increased placental weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| PMID:37783996 | IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Increased placental weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| PMID:37802009 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Induced ferroptosis in placenta | Reproductive endocrine-mediated perturbations | |
| PMID:38583661 | IVR | 0.2 mg/kg | 0.2 mg/kg | Affects mitochondrial function in the ovaries | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Decreased estrogen levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Induce apoptosis in ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 mg/kg | 0.2 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| PMID:38701656 | IVR | 0.05 - 0.2 mg/kg/day | 0.05 - 0.2 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations |
| IVR | 0.05 - 0.2 mg/kg/day | 0.05 - 0.2 mg/kg/day | Affects placental function | Reproductive endocrine-mediated perturbations | |
| PMID:38763096 | IVTH | 0.00001 M | 0.00001 M | Affects lipid metabolism | Metabolic endocrine-mediated perturbations |
| IVTH | 0.00001 M | 0.00001 M | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Alters thyroglobulin levels | Metabolic endocrine-mediated perturbations | |
| PMID:39108652 | IVR | 5 mg/kg/week | 5 mg/kg/week | Increased LDL levels | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/week | 5 mg/kg/week | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/week | 1 - 5 mg/kg/week | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| PMID:39226951 | IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Decreased mitochondrial membrane potential in sperm | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Epigenomic alterations in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| PMID:39454710 | IVR | 0.2 mg/kg/day | 0.2 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.