Fipronil


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:34352653; PMID:36916050
GO:0001675 Acrosome assembly Increases phenotype PMID:32294523
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:35850439
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:32651782; PMID:35850439
GO:0004197 Cysteine-type endopeptidase activity Decreases phenotype PMID:38040083
GO:0004364 Glutathione transferase activity Affects phenotype PMID:25721553; PMID:36916050
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:35850439
GO:0004602 Glutathione peroxidase activity Increases phenotype PMID:36916050
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:25721553; PMID:32651782; PMID:36916050
GO:0006006 Glucose metabolic process Affects phenotype PMID:38050659
GO:0006116 Nadh oxidation Decreases phenotype PMID:25943759
GO:0006600 Creatine metabolic process Affects phenotype PMID:32651782
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:32810590; PMID:38050659
GO:0006749 Glutathione metabolic process Increases phenotype PMID:30777931; PMID:32651782
GO:0006754 Atp biosynthetic process Affects phenotype PMID:32294523
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:27067106
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:19591892; PMID:32651782
GO:0008219 Cell death Increases phenotype PMID:27067106; PMID:30130558
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:27816694; PMID:28531659
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29149346
GO:0009566 Fertilization Decreases phenotype PMID:32294523
GO:0009790 Embryo development Decreases phenotype PMID:30130558; PMID:32294523
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38040083
GO:0016042 Lipid catabolic process Increases phenotype PMID:25721553; PMID:27067106; PMID:32651782
GO:0016209 Antioxidant activity Decreases phenotype PMID:36113622
GO:0018108 Peptidyl-tyrosine phosphorylation Decreases phenotype PMID:32294523
GO:0018158 Protein oxidation Increases phenotype PMID:34352653; PMID:36916050
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:27103584; PMID:30738135; PMID:31199990
GO:0019479 L-alanine oxidation to d-lactate and ammonia Increases phenotype PMID:25943759
GO:0019627 Urea metabolic process Affects phenotype PMID:32651782
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:30777931; PMID:34352653
GO:0031323 Regulation of cellular metabolic process Affects phenotype PMID:28965233
GO:0031959 Mineralocorticoid receptor signaling pathway Increases phenotype PMID:29149346
GO:0032125 Micronucleus organization Affects phenotype PMID:36113622
GO:0034440 Lipid oxidation Increases phenotype PMID:30777931; PMID:30777931; PMID:36916050; PMID:34352653; PMID:36916050
GO:0044237 Cellular metabolic process Decreases phenotype PMID:35850439
GO:0045333 Cellular respiration Decreases phenotype PMID:34044035
GO:0045444 Fat cell differentiation Increases phenotype PMID:27103584
GO:0045666 Positive regulation of neuron differentiation Decreases phenotype PMID:27816694
GO:0045687 Positive regulation of glial cell differentiation Increases phenotype PMID:27816694
GO:0045819 Positive regulation of glycogen catabolic process Increases phenotype PMID:25943759
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:25943759
GO:0046449 Creatinine metabolic process Affects phenotype PMID:32651782
GO:0048240 Sperm capacitation Decreases phenotype PMID:32294523
GO:0048589 Developmental growth Increases phenotype PMID:31708466
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:34044035
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:35850439
GO:0140042 Lipid droplet formation Increases phenotype PMID:38050659
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:30777931
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30777931
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:36113622
GO:2000376 Positive regulation of oxygen metabolic process Decreases phenotype PMID:25943759
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.