| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18977275 | IVR | 3 mg/kg/day | 3 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| PMID:22447239 | IVR | 0.0000034 mol/kg | 0.0000034 mol/kg | Increased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 0.0000034 mol/kg | 0.0000034 mol/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0000034 mol/kg | 0.0000034 mol/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:27074097 | IVR | 0.03 mg/kg | - | No significant effects observed | - |
| IVR | 3 mg/kg | 3 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg | 0.3 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:27166213 | IVR | 0.03 mg/kg | 0.03 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 3 mg/kg | 3 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.3 mg/kg | 0.3 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:31759041 | IVR | 0.475 mg/kg | 0.475 mg/kg | Alterations in thymocytes population | Immunological endocrine-mediated perturbations |
| IVR | 0.475 mg/kg | 0.475 mg/kg | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| IVR | 0.475 mg/kg | 0.475 mg/kg | Changes in thymus gland morphology | Immunological endocrine-mediated perturbations | |
| IVR | 0.475 mg/kg | 0.475 mg/kg | Changes in spleen morphology | Immunological endocrine-mediated perturbations | |
| IVR | 0.475 mg/kg | 0.475 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| PMID:31881178 | IVR | 3 mg/kg/day | 3 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Affects thyroid hormone metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:32751827 | IVR | 5 mg/kg/day | 5 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| PMID:34438272 | IVR | 9.7 mg/kg | 9.7 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations |
| IVR | 9.7 mg/kg | 9.7 mg/kg | Affects spleen morphology | Immunological endocrine-mediated perturbations | |
| IVR | 9.7 mg/kg | 9.7 mg/kg | Oxidative stress in thymus | Immunological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.