Ethinylestradiol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:30675821
GO:0002274 Myeloid leukocyte activation Increases phenotype PMID:29427786
GO:0002639 Positive regulation of immunoglobulin production Increases phenotype PMID:29427786
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:27818225
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:27090119; PMID:27090119; PMID:27743861; PMID:27743861
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:27743861
GO:0006171 Camp biosynthetic process Increases phenotype PMID:27090119; PMID:31212720
GO:0006306 Dna methylation Increases phenotype PMID:31463084
GO:0006357 Regulation of transcription by rna polymerase ii Decreases phenotype PMID:30001178
GO:0006915 Apoptotic process Increases phenotype PMID:31931096
GO:0006954 Inflammatory response Increases phenotype PMID:34058177
GO:0007286 Spermatid development Decreases phenotype PMID:37844793
GO:0007339 Binding of sperm to zona pellucida Decreases phenotype PMID:31931096
GO:0007548 Sex differentiation Decreases phenotype PMID:30001178
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:34058177
GO:0008206 Bile acid metabolic process Affects phenotype PMID:34058177
GO:0008217 Regulation of blood pressure Affects phenotype PMID:2949757
GO:0008219 Cell death Increases phenotype PMID:24685904
GO:0008283 Cell population proliferation Increases phenotype PMID:24062438; PMID:24213142; PMID:24213142; PMID:34058177
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:29783106; PMID:29783106; PMID:35307500
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28973534
GO:0009566 Fertilization Decreases phenotype PMID:31931096
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25257666
GO:0016042 Lipid catabolic process Increases phenotype PMID:2116375
GO:0030194 Positive regulation of blood coagulation Increases phenotype PMID:2821645
GO:0030879 Mammary gland development Affects phenotype PMID:39349146
GO:0032782 Bile acid secretion Decreases phenotype PMID:34058177
GO:0032816 Positive regulation of natural killer cell activation Increases phenotype PMID:29427786
GO:0032869 Cellular response to insulin stimulus Decreases phenotype PMID:29935216
GO:0033092 Positive regulation of immature t cell proliferation in thymus Increases phenotype PMID:29428349
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:27473340
GO:0034199 Activation of protein kinase a activity Increases phenotype PMID:27743861
GO:0035847 Uterine epithelium development Increases phenotype PMID:24487097; PMID:24487097; PMID:27473340
GO:0040018 Positive regulation of multicellular organism growth Increases phenotype PMID:37844793
GO:0042102 Positive regulation of t cell proliferation Increases phenotype PMID:29428349
GO:0042130 Negative regulation of t cell proliferation Increases phenotype PMID:29428349
GO:0042178 Xenobiotic catabolic process Decreases phenotype PMID:7908050
GO:0042593 Glucose homeostasis Affects phenotype PMID:29935216
GO:0043011 Myeloid dendritic cell differentiation Decreases phenotype PMID:29428349
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:37844793
GO:0044030 Regulation of dna methylation Decreases phenotype PMID:30001178
GO:0044849 Estrous cycle Decreases phenotype PMID:30675821
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:35307500
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:31201878
GO:0046622 Positive regulation of organ growth Affects phenotype PMID:20981862; PMID:27395752; PMID:27473340; PMID:27395752; PMID:28522409; PMID:37844793
GO:0048545 Response to steroid hormone Increases phenotype PMID:30387366
GO:0048863 Stem cell differentiation Decreases phenotype PMID:32205227
GO:0050870 Positive regulation of t cell activation Increases phenotype PMID:29427786
GO:0051646 Mitochondrion localization Affects phenotype PMID:31931096
GO:0055070 Copper ion homeostasis Decreases phenotype PMID:27690074
GO:0055074 Calcium ion homeostasis Decreases phenotype PMID:27690074
GO:0060065 Uterus development Increases phenotype PMID:20981862
GO:0060179 Male mating behavior Affects phenotype PMID:24798382
GO:0060180 Female mating behavior Affects phenotype PMID:24798382; PMID:28176338
GO:0060444 Branching involved in mammary gland duct morphogenesis Increases phenotype PMID:31201878
GO:0060603 Mammary gland duct morphogenesis Increases phenotype PMID:31201878
GO:0060648 Mammary gland bud morphogenesis Increases phenotype PMID:29526645
GO:0060746 Parental behavior Decreases phenotype PMID:30003164
GO:0060763 Mammary duct terminal end bud growth Increases phenotype PMID:31201878
GO:0070665 Positive regulation of leukocyte proliferation Increases phenotype PMID:29427786; PMID:29428349
GO:0070994 Detection of oxidative stress Increases phenotype PMID:24486436
GO:0072520 Seminiferous tubule development Affects phenotype PMID:37844793
GO:0072672 Neutrophil extravasation Increases phenotype PMID:36329302
GO:0098582 Innate vocalization behavior Affects phenotype PMID:29912934
GO:0120189 Positive regulation of bile acid secretion Increases phenotype PMID:26040663
GO:1902100 Negative regulation of metaphase/anaphase transition of cell cycle Increases phenotype PMID:37247809
GO:1902531 Regulation of intracellular signal transduction Affects phenotype PMID:23135549
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:31931096
GO:1903709 Uterine gland development Increases phenotype PMID:24487097; PMID:24487097; PMID:27473340
GO:2000242 Negative regulation of reproductive process Increases phenotype PMID:37844793
GO:2000386 Positive regulation of ovarian follicle development Decreases phenotype PMID:28522409
GO:2000648 Positive regulation of stem cell proliferation Increases phenotype PMID:30387366
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:28522409
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:30675821
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.