DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Ethinylestradiol

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
LTEA_HepaRG_CYP2B6	Liver	Human	1555	CYP2B6	Inhibitory	4.05 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
ATG_ERE_CIS	Liver	Human	2099	ESR1	Activatory	0.08 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.08 μM
CCTE_Deisenroth_AIME_384WELL_LUC_Active	Mammary gland/breast	Human	2099	ESR1	Gain	0.0 μM
CCTE_Deisenroth_AIME_384WELL_LUC_Inactive	Mammary gland/breast	Human	2099	ESR1	Gain	0.0 μM
CCTE_Deisenroth_AIME_384WELL_LUC_Shift	Mammary gland/breast	Human	2099	ESR1	Inhibitory	0.0 μM
CCTE_GLTED_hTTR_0.125uM		Human	7276	TTR	Loss	2.73 μM
CCTE_Deisenroth_AIME_96WELL_LUC_Active	Mammary gland/breast	Human	2099	ESR1	Gain	0.0 μM
CCTE_Deisenroth_AIME_96WELL_LUC_Inactive	Mammary gland/breast	Human	2099	ESR1	Gain	0.0 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	1.08 μM
NVS_ADME_hCYP2C9		Human	1559	CYP2C9	Loss	4.71 μM
NVS_ADME_hCYP3A4		Human	1576	CYP3A4	Loss	3.73 μM
NVS_GPCR_g5HT4	Brain	Guinea pig	100135548	Htr4	Loss	2.62 μM
NVS_NR_hAR		Human	367	AR	Loss	0.02 μM
NVS_NR_hER		Human	2099	ESR1	Loss	0.0 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	1.43 μM
NVS_NR_hPR		Human	5241	PGR	Loss	0.05 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	0.01 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	3.82 μM
NVS_NR_rMR	Brain	Rat	25672	Nr3c2	Loss	3.63 μM
NVS_TR_gDAT	Brain	Guinea pig	100714898	Slc6a3	Loss	1.32 μM
NVS_TR_hDAT		Human	6531	SLC6A3	Loss	0.46 μM
NVS_TR_hNET		Human	6530	SLC6A2	Loss	0.61 μM
NVS_TR_hSERT	Vascular	Human	6532	SLC6A4	Loss	0.27 μM
NVS_TR_rSERT	Brain	Rat	25553	Slc6a4	Loss	2.37 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Inhibitory	0.01 μM
ATG_Ets_CIS	Liver	Human	2113	ETS1	Activatory	100.0 μM
ATG_GLI_CIS	Liver	Human	2735	GLI1	Inhibitory	62.45 μM
ATG_HSE_CIS	Liver	Human	3297	HSF1	Inhibitory	58.15 μM
ATG_Myc_CIS	Liver	Human	4609	MYC	Activatory	61.58 μM
ATG_Sox_CIS	Liver	Human	6656	SOX1	Activatory	54.91 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.01 μM
BSK_4H_uPAR	Vascular	Human	5329	PLAUR	Inhibitory	3.92 μM
BSK_CASM3C_IL6	Vascular	Human	3569	IL6	Inhibitory	0.6 μM
BSK_CASM3C_MCP1	Vascular	Human	6347	CCL2	Inhibitory	2.14 μM
BSK_CASM3C_SAA	Vascular	Human	6288	SAA1	Inhibitory	0.93 μM
BSK_LPS_TNFa	Vascular	Human	7124	TNF	Inhibitory	0.47 μM
ATG_Ahr_CIS	Liver	Human	196	AHR	Inhibitory	3.02 μM
ATG_C_EBP_CIS	Liver	Human	1051	CEBPB	Activatory	158.5 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Activatory	100.0 μM
ATG_E2F_CIS	Liver	Human	1869	E2F1	Inhibitory	60.44 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Inhibitory	0.02 μM
ATG_GATA_CIS	Liver	Human	2623	GATA1	Inhibitory	142.27 μM
ATG_HNF6_CIS	Liver	Human	3175	ONECUT1	Inhibitory	100.0 μM
ATG_Myb_CIS	Liver	Human	4602	MYB	Inhibitory	171.78 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Inhibitory	2.12 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.0 μM
ATG_CRE_CIS	Liver	Human	10488	CREB3	Inhibitory	65.79 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Inhibitory	100.0 μM
ATG_DR5_RAR_CIS	Liver	Human	5914\|5915\|5916	RARA\|RARB\|RARG	Activatory	61.87 μM
ATG_EGR_CIS	Liver	Human	1958	EGR1	Activatory	100.0 μM
ATG_FoxO_CIS	Liver	Human	2308\|2309	FOXO1\|FOXO3	Inhibitory	72.51 μM
ATG_GATA_CIS	Liver	Human	2623	GATA1	Activatory	138.54 μM
ATG_GLI_CIS	Liver	Human	2735	GLI1	Inhibitory	72.22 μM
ATG_GRE_CIS	Liver	Human	2908	NR3C1	Inhibitory	158.84 μM
ATG_HIF1a_CIS	Liver	Human	3091	HIF1A	Activatory	66.25 μM
ATG_HSE_CIS	Liver	Human	3297	HSF1	Inhibitory	69.81 μM
ATG_IR1_CIS	Liver	Human	9971	NR1H4	Activatory	146.54 μM
ATG_MRE_CIS	Liver	Human	4520	MTF1	Activatory	92.71 μM
ATG_NF_kB_CIS	Liver	Human	4790	NFKB1	Inhibitory	161.76 μM
ATG_NFI_CIS	Liver	Human	4774	NFIA	Inhibitory	72.27 μM
ATG_NRF1_CIS	Liver	Human	4899	NRF1	Activatory	138.11 μM
ATG_NRF2_ARE_CIS	Liver	Human	4780	NFE2L2	Activatory	187.48 μM
ATG_Pax6_CIS	Liver	Human	5080	PAX6	Inhibitory	100.0 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Activatory	2.95 μM
ATG_SREBP_CIS	Liver	Human	6720	SREBF1	Inhibitory	65.94 μM
ATG_STAT3_CIS	Liver	Human	6774	STAT3	Activatory	154.8 μM
ATG_TGFb_CIS	Liver	Human	7040	TGFB1	Activatory	100.0 μM
ATG_Xbp1_CIS	Liver	Human	7494	XBP1	Activatory	67.33 μM
ATG_PXR_TRANS	Liver	Human	8856	NR1I2	Gain	4.39 μM
ATG_AP_2_CIS	Liver	Human	7020\|7021\|83741	TFAP2A\|TFAP2B\|TFAP2D	Activatory	167.46 μM
ATG_BRE_CIS	Liver	Human	4086	SMAD1	Inhibitory	75.61 μM
ATG_DR5_RAR_CIS	Liver	Human	5914\|5915\|5916	RARA\|RARB\|RARG	Activatory	61.04 μM
ATG_FoxO_CIS	Liver	Human	2308\|2309	FOXO1\|FOXO3	Activatory	179.75 μM
ATG_GLI_CIS	Liver	Human	2735	GLI1	Activatory	91.43 μM
ATG_HNF6_CIS	Liver	Human	3175	ONECUT1	Inhibitory	58.12 μM
ATG_HSE_CIS	Liver	Human	3297	HSF1	Inhibitory	59.24 μM
ATG_IR1_CIS	Liver	Human	9971	NR1H4	Inhibitory	58.15 μM
ATG_Myb_CIS	Liver	Human	4602	MYB	Inhibitory	155.91 μM
ATG_Myc_CIS	Liver	Human	4609	MYC	Activatory	146.36 μM
ATG_NRF1_CIS	Liver	Human	4899	NRF1	Inhibitory	152.29 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Activatory	3.19 μM
ATG_RORE_CIS	Liver	Human	6095\|6096\|6097	RORA\|RORB\|RORC	Inhibitory	67.35 μM
ATG_Sox_CIS	Liver	Human	6656	SOX1	Inhibitory	130.25 μM
ATG_Sp1_CIS	Liver	Human	6667	SP1	Inhibitory	169.06 μM
ATG_STAT3_CIS	Liver	Human	6774	STAT3	Activatory	68.03 μM
ATG_VDRE_CIS	Liver	Human	7421	VDR	Inhibitory	3.5 μM
ATG_Xbp1_CIS	Liver	Human	7494	XBP1	Inhibitory	58.87 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.03 μM
ATG_PXR_TRANS	Liver	Human	8856	NR1I2	Gain	2.63 μM
NVS_ADME_hCYP2J2		Human	1573	CYP2J2	Loss	0.67 μM
NVS_ADME_hCYP3A5		Human	1577	CYP3A5	Loss	1.45 μM
NVS_ADME_rCYP2A2		Rat	24895	Cyp2a2	Loss	0.68 μM
NVS_ADME_rCYP2B1		Rat	24300	Cyp2b1	Loss	1.75 μM
NVS_ADME_rCYP2C11		Rat	29277	Cyp2c11	Loss	1.61 μM
NVS_ADME_rCYP2C6		Rat	293989	Cyp2c6	Loss	1.55 μM
NVS_ADME_rCYP3A1		Rat	25642	Cyp3a23-3a1	Loss	1.38 μM
NVS_ADME_rCYP3A2		Rat	266682	Cyp3a2	Loss	1.12 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	0.0 μM
NVS_ADME_hCYP2C18		Human	1562	CYP2C18	Loss	1.72 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	1.88 μM
NVS_ADME_hCYP2J2		Human	1573	CYP2J2	Loss	2.68 μM
NVS_ADME_hCYP3A5		Human	1577	CYP3A5	Loss	3.53 μM
NVS_ADME_rCYP2A2		Rat	24895	Cyp2a2	Loss	1.44 μM
NVS_ADME_rCYP2B1		Rat	24300	Cyp2b1	Loss	4.16 μM
NVS_ADME_rCYP2C11		Rat	29277	Cyp2c11	Loss	2.81 μM
NVS_ADME_rCYP2C6		Rat	293989	Cyp2c6	Loss	2.55 μM
NVS_ADME_rCYP3A1		Rat	25642	Cyp3a23-3a1	Loss	4.34 μM
NVS_ADME_rCYP3A2		Rat	266682	Cyp3a2	Loss	2.59 μM
NVS_MP_rPBR	Kidney	Rat	24230	Tspo	Loss	4.59 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.3 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	2.72 μM
NVS_TR_hNET		Human	6530	SLC6A2	Loss	0.5 μM
NVS_ADME_hCYP2C18		Human	1562	CYP2C18	Loss	1.46 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	1.0 μM
NVS_ADME_hCYP2J2		Human	1573	CYP2J2	Loss	0.88 μM
NVS_ADME_hCYP3A4		Human	1576	CYP3A4	Loss	4.13 μM
NVS_ADME_hCYP3A5		Human	1577	CYP3A5	Loss	1.83 μM
NVS_ADME_rCYP2A2		Rat	24895	Cyp2a2	Loss	0.76 μM
NVS_ADME_rCYP2B1		Rat	24300	Cyp2b1	Loss	2.47 μM
NVS_ADME_rCYP2C11		Rat	29277	Cyp2c11	Loss	2.27 μM
NVS_ADME_rCYP2C6		Rat	293989	Cyp2c6	Loss	1.4 μM
NVS_ADME_rCYP3A1		Rat	25642	Cyp3a23-3a1	Loss	2.48 μM
NVS_ADME_rCYP3A2		Rat	266682	Cyp3a2	Loss	1.2 μM
NVS_MP_hPBR	Intestinal	Human	706	TSPO	Loss	2.45 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.23 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	2.49 μM
NVS_TR_hNET		Human	6530	SLC6A2	Loss	0.51 μM
NVS_NR_hAR		Human	367	AR	Loss	0.01 μM
ATG_hERa_XSP1	Liver	Human	2099	ESR1	Gain	0.0 μM
ATG_hERb_XSP1	Liver	Human	2100	ESR2	Gain	0.0 μM
ATG_hERb_XSP2	Liver	Human	2100	ESR2	Gain	0.0 μM
ATG_hERa_XSP2	Liver	Human	2099	ESR1	Gain	0.0 μM
ATG_hTRb_XSP2	Liver	Human	7068	THRB	Gain	0.03 μM
TOX21_AR_BLA_Antagonist_ratio	Kidney	Human	367	AR	Loss	1.66 μM
TOX21_ERa_BLA_Agonist_ratio	Kidney	Human	2099	ESR1	Gain	0.0 μM
TOX21_ERa_LUC_VM7_Agonist	Breast	Human	2099	ESR1	Gain	0.0 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	2.68 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	0.63 μM
TOX21_ERb_BLA_Agonist_ratio	Kidney	Human	2100	ESR2	Gain	0.0 μM
TOX21_PR_BLA_Agonist_ratio	Kidney	Human	5241	PGR	Gain	0.33 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	0.01 μM
TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780	Breast	Human	2099	ESR1	Gain	0.0 μM
TOX21_GNRHR_HEK293_Agonist	Kidney	Human	2798	GNRHR	Gain	0.0 μM
TOX21_AR_BLA_Antagonist_ratio	Kidney	Human	367	AR	Loss	1.76 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	1.06 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	0.26 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	73.12 μM
TOX21_ERb_BLA_Agonist_ratio	Kidney	Human	2100	ESR2	Gain	0.01 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	74.5 μM
TOX21_PR_BLA_Agonist_ratio	Kidney	Human	5241	PGR	Gain	0.31 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	65.42 μM
TOX21_AR_BLA_Agonist_ratio	Kidney	Human	367	AR	Gain	2.22 μM
TOX21_AR_BLA_Antagonist_ratio	Kidney	Human	367	AR	Loss	0.6 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	1.27 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	0.52 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	80.49 μM
TOX21_PR_BLA_Agonist_ratio	Kidney	Human	5241	PGR	Gain	0.53 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	66.83 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	58.63 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	55.06 μM

ToxCast endpoints for intended target type: Molecular messenger

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CEETOX_H295R_11DCORT	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.34 μM
CEETOX_H295R_OHPREG	Adrenal gland	Human	5241	PGR	Inhibitory	0.37 μM
CEETOX_H295R_CORTIC	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.2 μM
CEETOX_H295R_PROG	Adrenal gland	Human	5241	PGR	Inhibitory	0.37 μM

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.0 μM
APR_HepG2_P-H2AX_24hr	Liver	Human	3014	H2AX	Inhibitory	83.39 μM
APR_HepG2_p53Act_24hr	Liver	Human	7157	TP53	Activatory	87.53 μM
APR_HepG2_P-H2AX_72hr	Liver	Human	3014	H2AX	Activatory	70.63 μM
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.01 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	2.9 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	4.42 μM
OT_ER_ERaERa_0480	Kidney	Human	2099	ESR1	Gain	0.16 μM
OT_ER_ERaERa_1440	Kidney	Human	2099	ESR1	Gain	0.17 μM
OT_ER_ERaERb_0480	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.03 μM
OT_ER_ERaERb_1440	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.29 μM
OT_ER_ERbERb_0480	Kidney	Human	2100	ESR2	Gain	0.03 μM
OT_ER_ERbERb_1440	Kidney	Human	2100	ESR2	Gain	0.04 μM
OT_ERa_GFPERaERE_0120	Cervix	Human	2099	ESR1	Gain	0.06 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	0.06 μM
OT_AR_ARELUC_AG_1440	Ovary	Chinese hamster	367	AR	Gain	0.57 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	1.77 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	2.94 μM
OT_ER_ERaERa_0480	Kidney	Human	2099	ESR1	Gain	0.11 μM
OT_ER_ERaERa_1440	Kidney	Human	2099	ESR1	Gain	0.28 μM
OT_ER_ERaERb_0480	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.04 μM
OT_ER_ERaERb_1440	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.03 μM
OT_ER_ERbERb_0480	Kidney	Human	2100	ESR2	Gain	0.11 μM
OT_ER_ERbERb_1440	Kidney	Human	2100	ESR2	Gain	0.03 μM
OT_ERa_GFPERaERE_0120	Cervix	Human	2099	ESR1	Gain	0.04 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	0.04 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	1.59 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	3.01 μM
OT_ER_ERaERa_0480	Kidney	Human	2099	ESR1	Gain	0.17 μM
OT_ER_ERaERa_1440	Kidney	Human	2099	ESR1	Gain	0.29 μM
OT_ER_ERaERb_0480	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.08 μM
OT_ER_ERaERb_1440	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.1 μM
OT_ER_ERbERb_1440	Kidney	Human	2100	ESR2	Gain	0.09 μM
OT_ERa_GFPERaERE_0120	Cervix	Human	2099	ESR1	Gain	0.03 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	0.03 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.24 μM
OT_ER_ERaERa_0480	Kidney	Human	2099	ESR1	Gain	0.02 μM
OT_ER_ERaERa_1440	Kidney	Human	2099	ESR1	Gain	0.04 μM
OT_ER_ERaERb_0480	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.01 μM
OT_ER_ERbERb_0480	Kidney	Human	2100	ESR2	Gain	0.04 μM
OT_ERa_GFPERaERE_0120	Cervix	Human	2099	ESR1	Gain	0.0 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	0.0 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	0.15 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.19 μM
OT_ER_ERaERb_0480	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.02 μM
OT_ER_ERaERb_1440	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.02 μM
OT_ER_ERbERb_0480	Kidney	Human	2100	ESR2	Gain	0.02 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.16 μM
OT_ER_ERaERa_0480	Kidney	Human	2099	ESR1	Gain	0.04 μM
ACEA_AR_agonist_80hr	Prostate	Human	367	AR	Gain	0.0 μM
ACEA_AR_agonist_80hr	Prostate	Human	367	AR	Gain	0.09 μM
TOX21_HSE_BLA_Agonist_ratio	Cervix	Human	3297	HSF1	Gain	72.06 μM
TOX21_PPARd_BLA_Antagonist_ratio	Kidney	Human	5467	PPARD	Loss	64.15 μM
TOX21_PPARg_BLA_Antagonist_ratio	Kidney	Human	5468	PPARG	Loss	55.5 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	4.71 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.