Trichloroethylene


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:25855085
GO:0002263 Cell activation involved in immune response Increases phenotype PMID:30685357
GO:0002513 Tolerance induction to self antigen Decreases phenotype PMID:33007382
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:26095957
GO:0002524 Hypersensitivity Affects phenotype PMID:35763063
GO:0002885 Positive regulation of hypersensitivity Increases phenotype PMID:30685357
GO:0003094 Glomerular filtration Decreases phenotype PMID:32763311
GO:0003870 5-aminolevulinate synthase activity Increases phenotype PMID:6710543
GO:0004364 Glutathione transferase activity Increases phenotype PMID:30468822
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:25855085
GO:0004697 Protein kinase c activity Increases phenotype PMID:25855085
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:25855085
GO:0006094 Gluconeogenesis Decreases phenotype PMID:4344008
GO:0006304 Dna modification Increases phenotype PMID:30468822
GO:0006497 Protein lipidation Increases phenotype PMID:36849104
GO:0006525 Arginine metabolic process Affects phenotype PMID:35301063
GO:0006603 Phosphocreatine metabolic process Affects phenotype PMID:35301063
GO:0006749 Glutathione metabolic process Affects phenotype PMID:25855085
GO:0006809 Nitric oxide biosynthetic process Decreases phenotype PMID:31068537
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:25855085
GO:0006915 Apoptotic process Increases phenotype PMID:25855085
GO:0006954 Inflammatory response Increases phenotype PMID:33930529
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:23559643
GO:0008152 Metabolic process Affects phenotype PMID:23575800
GO:0008219 Cell death Increases phenotype PMID:26343699; PMID:31618666
GO:0008283 Cell population proliferation Increases phenotype PMID:26095957; PMID:34896440
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:23559643; PMID:28013219
GO:0010468 Regulation of gene expression Affects phenotype PMID:38518092
GO:0016042 Lipid catabolic process Increases phenotype PMID:31068537; PMID:33636387
GO:0016064 Immunoglobulin mediated immune response Affects phenotype PMID:33007382
GO:0018158 Protein oxidation Increases phenotype PMID:33007382; PMID:33636387; PMID:33930529
GO:0019521 D-gluconate metabolic process Affects phenotype PMID:35301063
GO:0030388 Fructose 1,6-bisphosphate metabolic process Affects phenotype PMID:35301063
GO:0031345 Negative regulation of cell projection organization Increases phenotype PMID:33132242
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:33636387
GO:0032740 Positive regulation of interleukin-17 production Affects phenotype PMID:22490199
GO:0032755 Positive regulation of interleukin-6 production Affects phenotype PMID:22490199
GO:0035358 Regulation of peroxisome proliferator activated receptor signaling pathway Affects phenotype PMID:23575800
GO:0035696 Monocyte extravasation Increases phenotype PMID:38485042
GO:0035743 Cd4-positive, alpha-beta t cell cytokine production Affects phenotype PMID:28369519
GO:0036211 Protein modification process Increases phenotype PMID:33007382
GO:0044027 Hypermethylation of cpg island Increases phenotype PMID:27553676
GO:0044030 Regulation of dna methylation Affects phenotype PMID:38518092
GO:0044237 Cellular metabolic process Decreases phenotype PMID:25855085; PMID:33387578
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:34233590
GO:0045625 Regulation of t-helper 1 cell differentiation Affects phenotype PMID:38518092
GO:0045786 Negative regulation of cell cycle Increases phenotype PMID:25855085
GO:0045917 Positive regulation of complement activation Increases phenotype PMID:32763311
GO:0045922 Negative regulation of fatty acid metabolic process Affects phenotype PMID:23575800
GO:0046031 Adp metabolic process Affects phenotype PMID:35301063
GO:0046034 Atp metabolic process Affects phenotype PMID:35301063
GO:0046039 Gtp metabolic process Affects phenotype PMID:35301063
GO:0046415 Urate metabolic process Decreases phenotype PMID:33132242
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:33132242
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:23575800
GO:0046710 Gdp metabolic process Affects phenotype PMID:35301063
GO:0046960 Sensitization Increases phenotype PMID:31068537
GO:0047804 Cysteine-s-conjugate beta-lyase activity Decreases phenotype PMID:33599830
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:38485042
GO:0051767 Nitric-oxide synthase biosynthetic process Decreases phenotype PMID:31068537
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:25855085
GO:0051899 Membrane depolarization Increases phenotype PMID:25855085
GO:0055091 Phospholipid homeostasis Affects phenotype PMID:23575800
GO:0060326 Cell chemotaxis Increases phenotype PMID:34233590
GO:0061744 Motor behavior Decreases phenotype PMID:37669148
GO:0070994 Detection of oxidative stress Increases phenotype PMID:36849104
GO:0070997 Neuron death Increases phenotype PMID:33636387
GO:0072387 Flavin adenine dinucleotide metabolic process Affects phenotype PMID:35301063
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:25855085; PMID:29722447
GO:0072672 Neutrophil extravasation Increases phenotype PMID:38485042
GO:0072676 Lymphocyte migration Increases phenotype PMID:33930529
GO:0090659 Walking behavior Decreases phenotype PMID:37669148
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:30685357; PMID:32763311
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:37669148
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23559643
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:37669148
GO:2000321 Positive regulation of t-helper 17 cell differentiation Affects phenotype PMID:22490199
GO:2001022 Positive regulation of response to dna damage stimulus Increases phenotype PMID:29722447
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:25855085
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.