Bis(4-hydroxyphenyl)sulfone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000082 G1/s transition of mitotic cell cycle Increases phenotype PMID:30684532
GO:0000084 Mitotic s phase Increases phenotype PMID:30684532; PMID:31601247; PMID:38211720
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:31601247
GO:0000165 Mapk cascade Affects phenotype PMID:24793377
GO:0001541 Ovarian follicle development Decreases phenotype PMID:30629253; PMID:31424294
GO:0001547 Antral ovarian follicle growth Increases phenotype PMID:31424294
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:37002642
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:34850234
GO:0001692 Histamine metabolic process Affects phenotype PMID:31778932
GO:0001825 Blastocyst formation Decreases phenotype PMID:33476676; PMID:37286763
GO:0001890 Placenta development Affects phenotype PMID:32071231
GO:0001958 Endochondral ossification Decreases phenotype PMID:34850234
GO:0002062 Chondrocyte differentiation Decreases phenotype PMID:34850234
GO:0002156 Negative regulation of thyroid hormone mediated signaling pathway Increases phenotype PMID:27213244
GO:0002157 Positive regulation of thyroid hormone mediated signaling pathway Increases phenotype PMID:29146198
GO:0003006 Developmental process involved in reproduction Increases phenotype PMID:30629253; PMID:31132128
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:37611474
GO:0004000 Adenosine deaminase activity Increases phenotype PMID:39577800
GO:0004053 Arginase activity Increases phenotype PMID:35900689
GO:0004111 Creatine kinase activity Increases phenotype PMID:35561261
GO:0004112 Cyclic-nucleotide phosphodiesterase activity Increases phenotype PMID:39577800
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:35561261
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:32742594; PMID:34838688; PMID:35561261
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:32742594; PMID:33098627; PMID:39059691; PMID:39793866
GO:0005245 Voltage-gated calcium channel activity Increases phenotype PMID:35457000
GO:0005911 Cell-cell junction Decreases phenotype PMID:28808208
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:32203925
GO:0006014 D-ribose metabolic process Affects phenotype PMID:32071231
GO:0006082 Organic acid metabolic process Affects phenotype PMID:32203925
GO:0006094 Gluconeogenesis Increases phenotype PMID:31344369
GO:0006096 Glycolytic process Affects phenotype PMID:36011004
GO:0006105 Succinate metabolic process Affects phenotype PMID:31778932
GO:0006171 Camp biosynthetic process Increases phenotype PMID:28858478
GO:0006306 Dna methylation Affects phenotype PMID:31683443
GO:0006338 Chromatin remodeling Increases phenotype PMID:33916708
GO:0006520 Amino acid metabolic process Affects phenotype PMID:32203925
GO:0006523 Alanine biosynthetic process Affects phenotype PMID:31121516
GO:0006537 Glutamate biosynthetic process Affects phenotype PMID:31121516
GO:0006545 Glycine biosynthetic process Affects phenotype PMID:31121516
GO:0006577 Amino-acid betaine metabolic process Affects phenotype PMID:31778932
GO:0006629 Lipid metabolic process Affects phenotype PMID:31820560
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:32071231; PMID:38908815
GO:0006633 Fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:31683443; PMID:35561261
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:30145421
GO:0006701 Progesterone biosynthetic process Decreases phenotype PMID:31424294
GO:0006749 Glutathione metabolic process Affects phenotype PMID:31778932; PMID:31875995; PMID:39736419
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34748853
GO:0006915 Apoptotic process Increases phenotype PMID:33749030; PMID:38908815; PMID:39577800
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:31881267; PMID:32244372
GO:0007005 Mitochondrion organization Decreases phenotype PMID:37286763
GO:0007056 Spindle assembly involved in female meiosis Decreases phenotype PMID:33476676
GO:0007281 Germ cell development Decreases phenotype PMID:29741722; PMID:31532523
GO:0007283 Spermatogenesis Decreases phenotype PMID:29741722; PMID:29940534; PMID:31532523; PMID:33098627; PMID:34838688
GO:0007565 Female pregnancy Decreases phenotype PMID:30629253
GO:0007566 Embryo implantation Affects phenotype PMID:34831106
GO:0007618 Mating Affects phenotype PMID:30629253
GO:0007631 Feeding behavior Increases phenotype PMID:35561261
GO:0008202 Steroid metabolic process Affects phenotype PMID:24563381
GO:0008206 Bile acid metabolic process Affects phenotype PMID:39298647
GO:0008210 Estrogen metabolic process Affects phenotype PMID:33753083; PMID:37357847
GO:0008234 Cysteine-type peptidase activity Increases phenotype PMID:33312107
GO:0008283 Cell population proliferation Increases phenotype PMID:25111128; PMID:28616630; PMID:28808208; PMID:30684532; PMID:28808208; PMID:30684532; PMID:28916285; PMID:30352284; PMID:30684532; PMID:30822521; PMID:31945527; PMID:33605785; PMID:36011004; PMID:37224786; PMID:37234927; PMID:37675141; PMID:37834465; PMID:38185387; PMID:39577800
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28591870; PMID:39032682; PMID:29146198; PMID:30099086; PMID:30196065; PMID:32023790; PMID:32105160; PMID:34270681; PMID:36565802; PMID:38657712
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30196065; PMID:32023790; PMID:32105160; PMID:32763284; PMID:34831106
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:27003841; PMID:27815650; PMID:30959087
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:31121516; PMID:31778932
GO:0009094 L-phenylalanine biosynthetic process Affects phenotype PMID:31121516
GO:0009099 Valine biosynthetic process Affects phenotype PMID:31121516
GO:0009441 Glycolate metabolic process Affects phenotype PMID:32071231
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:31601247
GO:0010452 Histone h3-k36 methylation Decreases phenotype PMID:37315367
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:25723814
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:35900689
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:28903498
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:27998958
GO:0010826 Negative regulation of centrosome duplication Decreases phenotype PMID:27998958
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:38588857
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:27273607
GO:0010906 Regulation of glucose metabolic process Increases phenotype PMID:37002642
GO:0010942 Positive regulation of cell death Increases phenotype PMID:30196065; PMID:32023790; PMID:34831106
GO:0014808 Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Increases phenotype PMID:25723814
GO:0015943 Formate biosynthetic process Affects phenotype PMID:31121516
GO:0016042 Lipid catabolic process Increases phenotype PMID:25111128; PMID:31424294; PMID:33098627; PMID:34838688
GO:0016049 Cell growth Decreases phenotype PMID:30352284
GO:0016477 Cell migration Increases phenotype PMID:28808208; PMID:36011004; PMID:37234927
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:29079494
GO:0018158 Protein oxidation Increases phenotype PMID:29079494; PMID:31344369
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:38908815
GO:0019413 Acetate biosynthetic process Affects phenotype PMID:31121516
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:25111128; PMID:30145421; PMID:31344369
GO:0019695 Choline metabolic process Affects phenotype PMID:31778932
GO:0022602 Ovulation cycle process Affects phenotype PMID:30629253
GO:0030182 Neuron differentiation Decreases phenotype PMID:39577800
GO:0030187 Melatonin biosynthetic process Affects phenotype PMID:33098627
GO:0030879 Mammary gland development Increases phenotype PMID:30102602
GO:0030954 Astral microtubule nucleation Increases phenotype PMID:27998958
GO:0031116 Positive regulation of microtubule polymerization Increases phenotype PMID:27998958
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:34174261
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:37002642
GO:0032776 Dna methylation on cytosine Increases phenotype PMID:30196065
GO:0032869 Cellular response to insulin stimulus Affects phenotype PMID:34186270
GO:0032929 Negative regulation of superoxide anion generation Increases phenotype PMID:37002642
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25371027; PMID:27213244; PMID:27473340; PMID:31388671; PMID:34831106
GO:0033601 Positive regulation of mammary gland epithelial cell proliferation Increases phenotype PMID:29526645
GO:0033685 Negative regulation of luteinizing hormone secretion Increases phenotype PMID:37002642
GO:0034440 Lipid oxidation Increases phenotype PMID:29199064; PMID:29940534; PMID:39577800; PMID:39793866
GO:0034454 Microtubule anchoring at centrosome Increases phenotype PMID:27998958
GO:0035148 Tube formation Affects phenotype PMID:30352284
GO:0035264 Multicellular organism growth Decreases phenotype PMID:36310694
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:30196065
GO:0035847 Uterine epithelium development Increases phenotype PMID:27473340
GO:0035936 Testosterone secretion Decreases phenotype PMID:31532523; PMID:37357847
GO:0035938 Estradiol secretion Increases phenotype PMID:30817981; PMID:31132128; PMID:31532523; PMID:32155818
GO:0036343 Psychomotor behavior Affects phenotype PMID:39577800
GO:0036440 Citrate synthase activity Decreases phenotype PMID:31344369
GO:0040016 Embryonic cleavage Decreases phenotype PMID:33476676; PMID:37286763
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:31532523; PMID:31683443; PMID:38338858
GO:0042126 Nitrate metabolic process Affects phenotype PMID:37002642; PMID:39793866
GO:0042127 Regulation of cell population proliferation Increases phenotype PMID:30196065
GO:0042214 Terpene metabolic process Affects phenotype PMID:38908815
GO:0042310 Vasoconstriction Increases phenotype PMID:36310694
GO:0042311 Vasodilation Increases phenotype PMID:36310694
GO:0042417 Dopamine metabolic process Affects phenotype PMID:32071231
GO:0042428 Serotonin metabolic process Affects phenotype PMID:32071231
GO:0042448 Progesterone metabolic process Affects phenotype PMID:37357847
GO:0042701 Progesterone secretion Decreases phenotype PMID:32155818; PMID:37182577
GO:0042755 Eating behavior Increases phenotype PMID:29909315
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:29741722; PMID:38134982
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:38657712
GO:0043396 Corticotropin-releasing hormone secretion Decreases phenotype PMID:30940137
GO:0043627 Response to estrogen Affects phenotype PMID:31201878
GO:0044030 Regulation of dna methylation Affects phenotype PMID:38338858
GO:0044237 Cellular metabolic process Affects phenotype PMID:31601247; PMID:31601247; PMID:33181973; PMID:37315367; PMID:31812737; PMID:32244372; PMID:33181973; PMID:33749030; PMID:33749030; PMID:34748853; PMID:34474090; PMID:34838688; PMID:35405288; PMID:35457000; PMID:35561261; PMID:36674557; PMID:37224786; PMID:37234927; PMID:37315367; PMID:37357847; PMID:39736419; PMID:39793866
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:30292839; PMID:31601247; PMID:35405288; PMID:37234927
GO:0044849 Estrous cycle Affects phenotype PMID:31132128
GO:0045019 Negative regulation of nitric oxide biosynthetic process Increases phenotype PMID:35900689
GO:0045023 G0 to g1 transition Affects phenotype PMID:38211720
GO:0045333 Cellular respiration Decreases phenotype PMID:37657410
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:38369087
GO:0045444 Fat cell differentiation Affects phenotype PMID:34186270
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:38588857
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:27273607
GO:0045624 Positive regulation of t-helper cell differentiation Increases phenotype PMID:32911021
GO:0045661 Regulation of myoblast differentiation Affects phenotype PMID:32750123
GO:0045786 Negative regulation of cell cycle Increases phenotype PMID:38301581
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:32023790
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:32023790
GO:0046034 Atp metabolic process Affects phenotype PMID:31778932
GO:0046085 Adenosine metabolic process Affects phenotype PMID:31778932
GO:0046102 Inosine metabolic process Affects phenotype PMID:31778932
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:39577800; PMID:39793866
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:31201878
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:27473340
GO:0046882 Negative regulation of follicle-stimulating hormone secretion Increases phenotype PMID:37002642
GO:0048143 Astrocyte activation Increases phenotype PMID:39577800
GO:0048484 Enteric nervous system development Affects phenotype PMID:36615857
GO:0048699 Generation of neurons Affects phenotype PMID:36615857
GO:0048863 Stem cell differentiation Increases phenotype PMID:36565802
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:33078840
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:31344369
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:35900689; PMID:37002642
GO:0051229 Meiotic spindle disassembly Increases phenotype PMID:31881267
GO:0051310 Metaphase plate congression Decreases phenotype PMID:33476676
GO:0051463 Negative regulation of cortisol secretion Increases phenotype PMID:38966215
GO:0051726 Regulation of cell cycle Increases phenotype PMID:31750923
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:33749030; PMID:37834465; PMID:39793866; PMID:39929295
GO:0051882 Mitochondrial depolarization Decreases phenotype PMID:39793866
GO:0051899 Membrane depolarization Affects phenotype PMID:39929295
GO:0052697 Xenobiotic glucuronidation Increases phenotype PMID:27213244
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:28858478; PMID:35561261
GO:0060137 Maternal process involved in parturition Decreases phenotype PMID:30629253
GO:0060180 Female mating behavior Affects phenotype PMID:31132128
GO:0060326 Cell chemotaxis Affects phenotype PMID:35405288; PMID:37224786; PMID:38185387
GO:0060548 Negative regulation of cell death Increases phenotype PMID:37487893
GO:0060603 Mammary gland duct morphogenesis Increases phenotype PMID:31201878
GO:0060648 Mammary gland bud morphogenesis Increases phenotype PMID:29526645
GO:0060763 Mammary duct terminal end bud growth Increases phenotype PMID:29526645
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28482050; PMID:31424294; PMID:33098627; PMID:33753083; PMID:37357847
GO:0061548 Ganglion development Affects phenotype PMID:36982030
GO:0070050 Neuron cellular homeostasis Affects phenotype PMID:39000048
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:35940389
GO:0070091 Glucagon secretion Decreases phenotype PMID:36674557
GO:0070192 Chromosome organization involved in meiotic cell cycle Affects phenotype PMID:31881267
GO:0070734 Histone h3-k27 methylation Increases phenotype PMID:31881267
GO:0070994 Detection of oxidative stress Affects phenotype PMID:32742594; PMID:35561261; PMID:37286763
GO:0071466 Cellular response to xenobiotic stimulus Affects phenotype PMID:30145421
GO:0071557 Histone h3-k27 demethylation Affects phenotype PMID:33476676
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:32023790; PMID:34748853; PMID:38211720; PMID:37357847; PMID:38211720; PMID:39736419; PMID:39793866
GO:0086003 Cardiac muscle cell contraction Increases phenotype PMID:25723814
GO:0090116 C-5 methylation of cytosine Affects phenotype PMID:31881267; PMID:32105160
GO:0090303 Positive regulation of wound healing Increases phenotype PMID:39032682
GO:0090598 Male anatomical structure morphogenesis Affects phenotype PMID:31201878
GO:0097621 Monoamine oxidase activity Increases phenotype PMID:39577800
GO:0097676 Histone h3-k36 dimethylation Decreases phenotype PMID:37315367
GO:0097722 Sperm motility Decreases phenotype PMID:33098627; PMID:34838688
GO:0098708 Glucose import across plasma membrane Increases phenotype PMID:25111128
GO:0110053 Regulation of actin filament organization Affects phenotype PMID:31750923
GO:0140042 Lipid droplet formation Increases phenotype PMID:32220626; PMID:33865937; PMID:35561261; PMID:35736896
GO:0140253 Cell-cell fusion Increases phenotype PMID:33605785
GO:1900110 Negative regulation of histone h3-k9 dimethylation Increases phenotype PMID:31532523
GO:1900113 Negative regulation of histone h3-k9 trimethylation Increases phenotype PMID:31532523
GO:1900194 Negative regulation of oocyte maturation Increases phenotype PMID:33476676
GO:1900825 Regulation of membrane depolarization during cardiac muscle cell action potential Affects phenotype PMID:38310357
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:29741722; PMID:31532523
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:29199064
GO:1901726 Negative regulation of histone deacetylase activity Increases phenotype PMID:36534918
GO:1901741 Positive regulation of myoblast fusion Increases phenotype PMID:32750123
GO:1901988 Negative regulation of cell cycle phase transition Increases phenotype PMID:37717640
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:35900689
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:37002642
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:31601247; PMID:38211720
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:29199064; PMID:31875995
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:28259788
GO:1903353 Regulation of nucleus organization Affects phenotype PMID:31750923
GO:1903409 Reactive oxygen species biosynthetic process Decreases phenotype PMID:36565802
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28259788; PMID:29940534; PMID:32023790; PMID:37944787; PMID:39059691
GO:1903709 Uterine gland development Increases phenotype PMID:27473340; PMID:37234927
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:35900689
GO:1903966 Monounsaturated fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:1904077 Negative regulation of estrogen biosynthetic process Increases phenotype PMID:37944787
GO:1904251 Regulation of bile acid metabolic process Affects phenotype PMID:33078840
GO:1904808 Positive regulation of protein oxidation Increases phenotype PMID:35900689
GO:1905517 Macrophage migration Increases phenotype PMID:38908815
GO:1990138 Neuron projection extension Decreases phenotype PMID:31812737
GO:2000035 Regulation of stem cell division Increases phenotype PMID:36565802
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:25576683
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:29940534
GO:2000278 Regulation of dna biosynthetic process Affects phenotype PMID:31750923
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:37002642
GO:2000469 Negative regulation of peroxidase activity Increases phenotype PMID:29940534
GO:2000613 Negative regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:37002642
GO:2000614 Positive regulation of thyroid-stimulating hormone secretion Increases phenotype PMID:37487893
GO:2000832 Negative regulation of steroid hormone secretion Increases phenotype PMID:38966215
GO:2000833 Positive regulation of steroid hormone secretion Increases phenotype PMID:37717640
GO:2000835 Negative regulation of androgen secretion Increases phenotype PMID:38966215
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29940534
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:30629253
GO:2000859 Negative regulation of aldosterone secretion Increases phenotype PMID:38966215
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:37002642
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:29741722; PMID:37717640
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:37002642; PMID:38966215
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:37717640
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.